Understanding the relationship between human rights abuse, state dysfunction and postcolonial sovereignty in Africa

This article explores the interrelationship between the phenomena of state dysfunction, human rights abuse and postcolonial states in the African context.  The incidence and extent of state dysfunction and human rights abuse are evaluated empirically, which reveals that dysfunctional states in Africa are generally guilty of neglecting human rights.  I attempting to understand this apparent correlation, the politico-juridical construct of negative sovereignty, as formulated by Robert Jackson, is analysed with specific reference to postcolonial African states.  The analysis suggests, paradoxically, dysfunctional states may utilise the same normative precepts that served as justifications for decolonisation (such as self-determination and non-intervention) to obfuscate or obstruct the scrutiny of human rights domestically. From these insights it is posited that functional states, both in institutional and political terms, may serve as the most effective bulwark of human rights in Africa, and that the phenomenon of state dysfunction as it relates to domestic human rights violations warrants more consideration.https://doi.org/10.19108/KOERS.82.1.230

Die universiteitswese in Suid-Afrika: ’n Bestekopname van huidige tendense en die vooruitsig vir Afrikaans

Die doel van hierdie artikel is die identifisering en analitiese omskrywing van die mees prominente politieke tendense wat tans die Suid-Afrikaanse universiteitswese beïnvloed, met spesifieke verwysing na Afrikaanse universiteite en hoër onderwys. Die bydrae neem as vertrekpunt die teoretiese beginsel van transformasie, en die spesifieke en eiesoortige ideologiese toepassing van dié konstruk in Suid-Afrika sedert 1994.  Die ingrypende invloed van hierdie ideologiese transformasiebeskouing op openbare instellings in Suid-Afrika bespreek, insluitend die institusionele en sosio-politiese impak op universiteite.  Teen hierdie teoretiese agtergrond word sleutelkwessies bespreek wat betrekking het op die Suid-Afrikaanse universiteitswese en die plek en rol van Afrikaans in besonder, insluitend in ?n bestekopname van die posisie van Afrikaans in die hoër onderwyssektor; ?n evaluasie van die transformasie van die hoër onderwyssektor; die rasionele argumente en gronde vir die behoud en bevordering van Afrikaans in die sektor; en die reaksie vanuit die Afrikaanssprekende gemeenskap teenoor die marginalisering van die taal by universiteite ?n Evaluerende toekomsperspektief word gebied waarin die behoud van Afrikaans oorweeg word, met inbegrip van aktivisme, geregtelike strategieë en die uitbouing van Afrikaans deur middel van ?n privaat hoër onderwysinstelling. https://doi.org/10.19108/KOERS.81.3.225

Hypertriglyceridaemia and the risk of pancreatitis six months post lopinavir/ritonavir initiation

Background: Hypertriglyceridaemia (HTG) is an important risk factor for pancreatitis and cardiovascular disease (CVD), depending on severity. Hypertriglyceridaemia is common in human immunodeficiency virus (HIV) infection and is also a common complication of lopinavir/ritonavir (LPV/r).Objectives: To evaluate the risk of pancreatitis associated with HTG in patients six months post initiation of LPV/r-based therapy in a regional public hospital.Methods: Triglyceride (TG), serum amylase (s-amylase) and CD4+ count values were retrospectively investigated six months post LPV/r-based initiation. Age, gender, previous antiretroviral regimen and period since HIV diagnosis were also recorded.Results: The final sample consisted of 194 patients, 50 males and 144 females; mean (± standard deviation [s.d.]) age was 39.52 (± 9.98) years, and the mean (± s.d.) period since HIV diagnosis was 91.32 (± 25.18) months. Normal TG levels (< 1.70 mmol/L) were detected in only 55% of patients and the rest presented with some degree of HTG. The mean (± s.d.) TG for the entire sample was elevated at 1.94 (± 1.30) mmol/L with the mean (± s.d.) of the males at 2.36 (± 1.74) – statistically higher compared to the females at 1.79 (± 1.08) mmol/L (p = 0.034). No cases of pancreatitis were recorded and the time since HIV diagnosis did not indicate any statistically significant differences in the means of the TG, serum amylase or CD4 count values.Conclusion: Triglyceride levels were not substantially elevated to induce pancreatitis at six months post initiation of LPV/r, but were elevated above the accepted upper normal limit of 1.70 mmol/L which may have implications for cardiovascular risk

Towards a typology of government interventionism in municipalities

Although significant progress has been made since democratisation in 1994, much still needs to be done before all local, district and metropolitan municipalities in South Africa are fully functional, sustainable, and developmental. In response to general municipal dysfunctionalism with inadequate service delivery levels and rising levels of public protest, the South African Government has a statutory and moral obligation to intervene in the affairs of municipalities. The nature, scope, and intensions of such interventions are, however, not always clear. It is evident though that Government increasingly views interventionism as a viable approach. Embracing such an interventionist paradigm in government requires scholars to more closely scrutinise municipal interventions, not as loose-standing and isolated occurrences, but as part of an emergent strategy in South African governance. The purpose of this article is to make a contextual and conceptual contribution to the analysis of interventionism by developing a theoretical construct in the form of a typology. This typology could stimulate further scholarly perspectives into the phenomenon of government interventionism in South African municipalities

Section 139 interventions in South African local government, 1994-2015

Recent trends point to the fact that national and provincial government interventions in the local sphere of government in South Africa have become more commonplace. These trends can be seen, within the broader context of state dysfunction, to constitute a novel and discernible phenomenon, namely “interventionism”. Furthermore, the theoretical body of knowledge related to the phenomenon of state dysfunction suggests that issues of poor service delivery and “bad” governance are not exclusively at play in interventionism. Political factors that are indicative of state dysfunction may also serve as more covert reasons to intervene in municipalities in order to influence the balance of political power in a given province, municipality, or within a party itself. The purpose of this article is to analyse past interventions, premised upon Section 139 of the Constitution in local government, during the period 1994 to 2015. The intention is to explore both the trends (i.e. frequency analysis) and nature of such interventions (i.e. qualitative analysis through case studies and contemporary sources) and to make certain deductions regarding interventionism within the context of state dysfunction in South African local government. Factors are identified that suggest that electoral, factionalist and political motives may rival and surpass constitutional and governance reasons for implementing such interventions

COMT val158met Polymorphism and Neural Pain Processing

A functional polymorphism (val158met) of the gene coding for Catechol-O-methyltransferase (COM) has been demonstrated to be related to processing of emotional stimuli. Also, this polymorphism has been found to be associated with pain regulation in healthy subjects. Therefore, we investigated a possible influence of this polymorphism on pain processing in healthy persons as well as in subjects with markedly reduced pain sensitivity in the context of Borderline Personality Disorder (BPD). Fifty females (25 patients with BPD and 25 healthy control participants) were included in this study. Genotype had a significant – though moderate - effect on pain sensitivity, but only in healthies. The number of val alleles was correlated with the BOLD response in several pain-processing brain regions, including dorsolateral prefrontal cortex, posterior parietal cortex, lateral globus pallidus, anterior and posterior insula. Within the subgroup of healthy participants, the number of val alleles was positively correlated with the BOLD response in posterior parietal, posterior cingulate, and dorsolateral prefrontal cortex. BPD patients revealed a positive correlation between the number of val alleles and BOLD signal in anterior and posterior insula. Thus, our data show that the val158met polymorphism in the COMT gene contributes significantly to inter-individual differences in neural pain processing: in healthy people, this polymorphism was more related to cognitive aspects of pain processing, whereas BPD patients with reduced pain sensitivity showed an association with activity in brain regions related to affective pain processing

T-cell responses induced by ChAdOx1 nCoV-19 (AZD1222) vaccine to wild-type severe acute respiratory syndrome coronavirus 2 among people with and without HIV in South Africa

Objective(s): This study aimed to investigate severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-specific T-cell responses 14 days after single-dose ChAdOx1 nCoV-19 (AZD1222) vaccination in black Africans with and without HIV in South Africa, as well as determine the effect of AZD1222 vaccination on cell-mediated immune responses in people with HIV (PWH) with prior SARS-CoV-2 infection. Methods: A total of 70 HIV-uninfected people and 104 PWH were prospectively enrolled in the multicentre, randomized, double-blinded, placebo-controlled, phase Ib/IIa trial (COV005). Peripheral blood mononuclear cells (PBMCs) were collected from trial participants 14 days after receipt of first dose of study treatment (placebo or AZD1222 vaccine). T-cell responses against the full-length spike (FLS) glycoprotein of wild-type SARS-CoV-2 and mutated S-protein regions found in the Alpha, Beta and Delta variants were assessed using an ex-vivo ELISpot assay. Results: Among AZD1222 recipients without preceding SARS-CoV-2 infection, T-cell responses to FLS of wild-type SARS-CoV-2 were similarly common in PWH and HIV-uninfected people (30/33, 90.9% vs. 16/21, 76.2%; P = 0.138); and magnitude of response was similar among responders (78 vs. 56 SFCs/106 PBMCs; P = 0.255). Among PWH, AZD1222 vaccinees with prior SARS-CoV-2 infection, displayed a heightened T-cell response magnitude compared with those without prior infection (186 vs. 78 SFCs/106 PBMCs; P = 0.001); and similar response rate (14/14, 100% vs. 30/33, 90.9%; P = 0.244). Conclusion: Our results indicate comparable T-cell responses following AZD1222 vaccination in HIV-uninfected people and PWH on stable antiretroviral therapy. Our results additionally show that hybrid immunity acquired through SARS-CoV-2 infection and AZD1222 vaccination, induce a heightened T-cell response

Oxytocin neurones: intrinsic mechanisms governing the regularity of spiking activity

Oxytocin neurones of the rat supraoptic nucleus are osmoresponsive and, with all other things being equal, they fire at a mean rate that is proportional to the plasma sodium concentration. However, individual spike times are governed by highly stochastic events, namely the random occurrences of excitatory synaptic inputs, the probability of which is increased by increasing extracellular osmotic pressure. Accordingly, interspike intervals (ISIs) are very irregular. In the present study, we show, by statistical analyses of firing patterns in oxytocin neurones, that the mean firing rate as measured in bins of a few seconds is more regular than expected from the variability of ISIs. This is consistent with an intrinsic activity‐dependent negative‐feedback mechanism. To test this, we compared observed neuronal firing patterns with firing patterns generated by a leaky integrate‐and‐fire model neurone, modified to exhibit activity‐dependent mechanisms known to be present in oxytocin neurones. The presence of a prolonged afterhyperpolarisation (AHP) was critical for the ability to mimic the observed regularisation of mean firing rate, although we also had to add a depolarising afterpotential (DAP; sometimes called an afterdepolarisation) to the model to match the observed ISI distributions. We tested this model by comparing its behaviour with the behaviour of oxytocin neurones exposed to apamin, a blocker of the medium AHP. Good fits indicate that the medium AHP actively contributes to the firing patterns of oxytocin neurones during non‐bursting activity, and that oxytocin neurones generally express a DAP, even though this is usually masked by superposition of a larger AHP

Dehydration-induced modulation of kappa-opioid inhibition of vasopressin neurone activity

Dehydration increases vasopressin (antidiuretic hormone) secretion from the posterior pituitary gland to reduce water loss in the urine. Vasopressin secretion is determined by action potential firing in vasopressin neurones, which can exhibit continuous, phasic (alternating periods of activity and silence), or irregular activity. Autocrine κ-opioid inhibition contributes to the generation of activity patterning of vasopressin neurones under basal conditions and so we used in vivo extracellular single unit recording to test the hypothesis that changes in autocrine κ-opioid inhibition drive changes in activity patterning of vasopressin neurones during dehydration. Dehydration increased the firing rate of rat vasopressin neurones displaying continuous activity (from 7.1 ± 0.5 to 9.0 ± 0.6 spikes s(−1)) and phasic activity (from 4.2 ± 0.7 to 7.8 ± 0.9 spikes s(−1)), but not those displaying irregular activity. The dehydration-induced increase in phasic activity was via an increase in intraburst firing rate. The selective κ-opioid receptor antagonist nor-binaltorphimine increased the firing rate of phasic neurones in non-dehydrated rats (from 3.4 ± 0.8 to 5.3 ± 0.6 spikes s(−1)) and dehydrated rats (from 6.4 ± 0.5 to 9.1 ± 1.2 spikes s(−1)), indicating that κ-opioid feedback inhibition of phasic bursts is maintained during dehydration. In a separate series of experiments, prodynorphin mRNA expression was increased in vasopressin neurones of hyperosmotic rats, compared to hypo-osmotic rats. Hence, it appears that dynorphin expression in vasopressin neurones undergoes dynamic changes in proportion to the required secretion of vasopressin so that, even under stimulated conditions, autocrine feedback inhibition of vasopressin neurones prevents over-excitation