Quasi-separatrix layers and three-dimensional reconnection diagnostics for line-tied tearing modes

In three-dimensional magnetic configurations for a plasma in which no closed field line or magnetic null exists, no magnetic reconnection can occur, by the strictest definition of reconnection. A finitely long pinch with line-tied boundary conditions, in which all the magnetic field lines start at one end of the system and proceed to the opposite end, is an example of such a system. Nevertheless, for a long system of this type, the physical behavior in resistive magnetohydrodynamics (MHD) essentially involves reconnection. This has been explained in terms comparing the geometric and tearing widths [1, 2]. The concept of a quasi-separatrix layer[3, 4] was developed for such systems. In this paper we study a model for a line-tied system in which the corresponding periodic system has an unstable tearing mode. We analyze this system in terms of two magnetic field line diagnostics, the squashing factor[3-5] and the electrostatic potential difference used in kinematic reconnection studies[6, 7]. We discuss the physical and geometric significance of these two diagnostics and compare them in the context of discerning tearing-like behavior in line-tied modes. [1] G. L. Delzanno and J. M. Finn. Physics of Plasmas, 15(3):032904, 2008. [2] Y.-M. Huang and E. G. Zweibel. Physics of Plasmas, 16(4):042102, 2009. [3] E. R. Priest and P. D\'emoulin. J. Geophys. Res., 100(A12):23443-23463, 1995. [4] P. D\'emoulin, J. C. Henoux, E. R. Priest, and C. H. Mandrini. Astron. Astrophys., 308:643-655, Apr. 1996. [5] V. S. Titov and G. Hornig. Advances in Space Research, 29(7):1087-1092, 2002. [6] Y. Lau and J. M. Finn. The Astrophysical Journal, 350:672-691, Feb. 1990. [7] Y. Lau and J. M. Finn. The Astrophysical Journal, 366:577-591, 1991.Comment: 13 pages, 9 figures, Submitted to Commun Nonlinear Sci Numer Simula

Activation and repression of mammalian gene expression by the c-myc protein.

One mechanism by which nuclear-localized oncogenes might transform cells is through an ability to regulate gene expression. We show that the c-myc protein stimulates the level of appropriately initiated expression from the human heat shock protein 70 (hsp70) promoter. Sequences required for full activation lie upstream of the transcription initiation site and are distinct from sequences necessary for basal expression. These sequences also appear distinct from promoter sequences necessary for heat induction, serum induction, and induction by the papovavirus T antigens. The c-myc protein inhibits appropriately initiated expression from the mouse metallothionein I (MT-I) promoter. A mutation that removes 138 amino acids of exon 2 produces a c-myc gene product that is capable of activating the hsp70 promoter but is no longer capable of inhibiting MT-I expression, suggesting that these two properties reside in different domains of the c-myc protein. Expression from the adenovirus EII promoter is slightly inhibited, while expression from the SV40 early promoter is minimally affected by the c-myc protein. Both the spectrum of promoters regulated by the c-myc protein and the sequence requirements for that regulation differ from those of previously characterized viral trans-activating proteins. The data suggest that the c-myc protein can both stimulate and inhibit transcription from mammalian promoters in a novel manner

Approximate Solution of the effective mass Klein-Gordon Equation for the Hulthen Potential with any Angular Momentum

The radial part of the effective mass Klein-Gordon equation for the Hulthen potential is solved by making an approximation to the centrifugal potential. The Nikiforov-Uvarov method is used in the calculations. Energy spectra and the corresponding eigenfunctions are computed. Results are also given for the case of constant mass.Comment: 12 page

Emergence of Anti-Cancer Drug Resistance: Exploring the Importance of the Microenvironmental Niche via a Spatial Model

Practically, all chemotherapeutic agents lead to drug resistance. Clinically, it is a challenge to determine whether resistance arises prior to, or as a result of, cancer therapy. Further, a number of different intracellular and microenvironmental factors have been correlated with the emergence of drug resistance. With the goal of better understanding drug resistance and its connection with the tumor microenvironment, we have developed a hybrid discrete-continuous mathematical model. In this model, cancer cells described through a particle-spring approach respond to dynamically changing oxygen and DNA damaging drug concentrations described through partial differential equations. We thoroughly explored the behavior of our self-calibrated model under the following common conditions: a fixed layout of the vasculature, an identical initial configuration of cancer cells, the same mechanism of drug action, and one mechanism of cellular response to the drug. We considered one set of simulations in which drug resistance existed prior to the start of treatment, and another set in which drug resistance is acquired in response to treatment. This allows us to compare how both kinds of resistance influence the spatial and temporal dynamics of the developing tumor, and its clonal diversity. We show that both pre-existing and acquired resistance can give rise to three biologically distinct parameter regimes: successful tumor eradication, reduced effectiveness of drug during the course of treatment (resistance), and complete treatment failure

Constraining the primordial spectrum of metric perturbations from gravitino and moduli production

We consider the production of gravitinos and moduli fields from quantum vacuum fluctuations induced by the presence of scalar metric perturbations at the end of inflation. We obtain the corresponding occupation numbers, up to first order in perturbation theory, in terms of the power spectrum of the metric perturbations. We compute the limits imposed by nucleosynthesis on the spectral index $n_s$ for different models with constant $n_s$. The results show that, in certain cases, such limits can be as strong as $n_s<1.12$, which is more stringent than those coming from primordial black hole production.Comment: 16 pages, LaTeX, 5 figures. Corrected figures, new references included. Final version to appear in Phys. Rev.

Approximate solution of the Duffin-Kemmer-Petiau equation for a vector Yukawa potential with arbitrary total angular momenta

The usual approximation scheme is used to study the solution of the Duffin-Kemmer-Petiau (DKP) equation for a vector Yukawa potential in the framework of the parametric Nikiforov-Uvarov (NU) method. The approximate energy eigenvalue equation and the corresponding wave function spinor components are calculated for arbitrary total angular momentum in closed form. Further, the approximate energy equation and wave function spinor components are also given for case. A set of parameter values is used to obtain the numerical values for the energy states with various values of quantum levelsComment: 17 pages; Communications in Theoretical Physics (2012). arXiv admin note: substantial text overlap with arXiv:1205.0938, and with arXiv:quant-ph/0410159 by other author

de Sitter Vacua in String Theory

We outline the construction of metastable de Sitter vacua of type IIB string theory. Our starting point is highly warped IIB compactifications with nontrivial NS and RR three-form fluxes. By incorporating known corrections to the superpotential from Euclidean D-brane instantons or gaugino condensation, one can make models with all moduli fixed, yielding a supersymmetric AdS vacuum. Inclusion of a small number of anti-D3 branes in the resulting warped geometry allows one to uplift the AdS minimum and make it a metastable de Sitter ground state. The lifetime of our metastable de Sitter vacua is much greater than the cosmological timescale of 10^10 years. We also prove, under certain conditions, that the lifetime of dS space in string theory will always be shorter than the recurrence time.Comment: 12 pages, 2 figs, added comments on the thin wall approximation to tunnelin

Flow characteristics of Newtonian and non-Newtonian fluids in a vessel stirred by a 60° pitched blade impeller

Mean and rms velocity characteristics of two Newtonian flows at Reynolds numbers of 12,800 (glycerin solution) and 48,000 (water) and of a non-Newtonian flow (0.2% CMC solution, at a power number similar to the Newtonian glycerin flow) in a mixing vessel stirred by a 60° pitched blade impeller have been measured by laser Doppler velocimetry (LDV). The velocity measurements, resolved over 360° and 1.08° of impeller rotation, showed that the mean flow of the two power number matched glycerin and CMC flows were similar to within 3% of the impeller tip velocity and the turbulence intensities generally lower in the CMC flow by up to 5% of the tip velocity. The calculated mean flow quantities showed similar discharge coefficient and pumping efficiency in all three flows and similar strain rate between the two power number matched glycerin and CMC flows; the strain rate of the higher Reynolds number Newtonian flow was found to be slightly higher. The energy balance around the impeller indicated that the CMC flow dissipated up to 9% more of the total input power and converted 7% less into the turbulence compared to the glycerin flow with the same power input which could lead to less effective mixing processes where the micro-mixing is important

Inflation and Preheating in NO models

We study inflationary models in which the effective potential of the inflaton field does not have a minimum, but rather gradually decreases at large $\phi$. In such models the inflaton field does not oscillate after inflation, and its effective mass becomes vanishingly small, so the standard theory of reheating based on the decay of the oscillating inflaton field does not apply. For a long time the only mechanism of reheating in such non-oscillatory (NO) models was based on gravitational particle production in an expanding universe. This mechanism is very inefficient. We will show that it may lead to cosmological problems associated with large isocurvature fluctuations and overproduction of dangerous relics such as gravitinos and moduli fields. We also note that the setting of initial conditions for the stage of reheating in these models should be reconsidered. All of these problems can be resolved in the context of the recently proposed scenario of instant preheating if there exists an interaction ${g^2} \phi^2\chi^2$ of the inflaton field $\phi$ with another scalar field $\chi$. We show that the mechanism of instant preheating in NO models is much more efficient than the usual mechanism of gravitational particle production even if the coupling constant $g^2$ is extremely small, $10^{-14} \ll g^2 \ll 1$.Comment: 10 pages, revte