Circumnuclear Structures in Megamaser Host Galaxies

Using HST, we identify circumnuclear ($100$-$500$ pc scale) structures in nine new H$_2$O megamaser host galaxies to understand the flow of matter from kpc-scale galactic structures down to the supermassive black holes (SMBHs) at galactic centers. We double the sample analyzed in a similar way by Greene et al. (2013) and consider the properties of the combined sample of 18 sources. We find that disk-like structure is virtually ubiquitous when we can resolve $<200$ pc scales, in support of the notion that non-axisymmetries on these scales are a necessary condition for SMBH fueling. We perform an analysis of the orientation of our identified nuclear regions and compare it with the orientation of megamaser disks and the kpc-scale disks of the hosts. We find marginal evidence that the disk-like nuclear structures show increasing misalignment from the kpc-scale host galaxy disk as the scale of the structure decreases. In turn, we find that the orientation of both the $\sim100$ pc scale nuclear structures and their host galaxy large-scale disks is consistent with random with respect to the orientation of their respective megamaser disks.Comment: 24 pages, 16 figures, 4 tables; Resubmitted to ApJ after referee's comment

Optimal MRI sequences for 68Ga-PSMA-11 PET/MRI in evaluation of biochemically recurrent prostate cancer.

BackgroundPET/MRI can be used for the detection of disease in biochemical recurrence (BCR) patients imaged with 68Ga-PSMA-11 PET. This study was designed to determine the optimal MRI sequences to localize positive findings on 68Ga-PSMA-11 PET of patients with BCR after definitive therapy. Fifty-five consecutive prostate cancer patients with BCR imaged with 68Ga-PSMA-11 3.0T PET/MRI were retrospectively analyzed. Mean PSA was 7.9&nbsp;±&nbsp;12.9&nbsp;ng/ml, and mean PSA doubling time was 7.1&nbsp;±&nbsp;6.6&nbsp;months. Detection rates of anatomic correlates for prostate-specific membrane antigen (PSMA)-positive foci were evaluated on small field of view (FOV) T2, T1 post-contrast, and diffusion-weighted images. For prostate bed recurrences, the detection rate of dynamic contrast-enhanced (DCE) imaging for PSMA-positive foci was evaluated. Finally, the detection sensitivity for PSMA-avid foci on 3- and 8-min PET acquisitions was compared.ResultsPSMA-positive foci were detected in 89.1% (49/55) of patients evaluated. Small FOV T2 performed best for lymph nodes and detected correlates for all PSMA-avid lymph nodes. DCE imaging performed the best for suspected prostate bed recurrence, detecting correlates for 87.5% (14/16) of PSMA-positive prostate bed foci. The 8-min PET acquisition performed better than the 3-min acquisition for lymph nodes smaller than 1&nbsp;cm, detecting 100% (57/57) of lymph nodes less than 1&nbsp;cm, compared to 78.9% (45/57) for the 3-min acquisition.ConclusionPSMA PET/MRI performed well for the detection of sites of suspected recurrent disease in patients with BCR. Of the MRI sequences obtained for localization, small FOV T2 images detected the greatest proportion of PSMA-positive abdominopelvic lymph nodes and DCE imaging detected the greatest proportion of PSMA-positive prostate bed foci. The 8-min PET acquisition was superior to the 3&nbsp;min acquisition for detection of small lymph nodes

Insights from the 2006 Disease Management Colloquium

This roundtable discussion emanates from the presentations given and issues raised at the 2006 Disease Management Colloquium, which was held May 10–12, 2006 in Philadelphia, Pennsylvania

Megamaser Disks Reveal a Broad Distribution of Black Hole Mass in Spiral Galaxies

We use new precision measurements of black hole masses from water megamaser disks to investigate scaling relations between macroscopic galaxy properties and supermassive black hole (BH) mass. The megamaser-derived BH masses span 10^6-10^8 M_sun, while all the galaxy properties that we examine (including stellar mass, central mass density, central velocity dispersion) lie within a narrow range. Thus, no galaxy property correlates tightly with M_BH in ~L* spiral galaxies. Of them all, stellar velocity dispersion provides the tightest relation, but at fixed sigma* the mean megamaser M_BH are offset by -0.6+/-0.1 dex relative to early-type galaxies. Spiral galaxies with non-maser dynamical BH masses do not show this offset. At low mass, we do not yet know the full distribution of BH mass at fixed galaxy property; the non-maser dynamical measurements may miss the low-mass end of the BH distribution due to inability to resolve the spheres of influence and/or megamasers may preferentially occur in lower-mass BHs.Comment: 6 pages, 4 figures, replaced to fix error: NGC 4594 is not a maser galax

Advances in the Epidemiological Study of Oral-Facial Diseases

Both demographic patterns and disease distribution are changing rapidly in the United States. These developments have led to the recognition that the epidemiology of many conditions is poorly understood, and that other research has thus been hindered. Four areas of epidemiological study were chosen for detailed analysis of how new technology will affect the conduct of future research. These areas, selected because information about them will be increasingly needed in an aging society, were periodontitis, temporomandibular disorders (TMD) and other orofacial pain, salivary gland disturbances, and health services research. The potential effect of new technology was examined in the short, intermediate, and long term. While the nature of epidemiological study is unlikely to change with the advent of new technology, the scope of potential studies will become broader. Advances in diagnostic techniques from elsewhere will permit far more precise diagnosis than is possible at present. Computer technology will permit an efficient system of epidemiological surveillance to provide current data on trends in tooth loss, caries, and periodontitis—data which will complement the results of national surveys. Analytical studies to produce hypotheses on the etiology of oral conditions, especially in such poorly-understood areas as chronic pain and TMD, will help direct clinical research in those areas.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/66664/2/10.1177_08959374890030010301.pd