5,237 research outputs found

    On the "Poisson Trick" and its Extensions for Fitting Multinomial Regression Models

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    This article is concerned with the fitting of multinomial regression models using the so-called "Poisson Trick". The work is motivated by Chen & Kuo (2001) and Malchow-M{\o}ller & Svarer (2003) which have been criticized for being computationally inefficient and sometimes producing nonsense results. We first discuss the case of independent data and offer a parsimonious fitting strategy when all covariates are categorical. We then propose a new approach for modelling correlated responses based on an extension of the Gamma-Poisson model, where the likelihood can be expressed in closed-form. The parameters are estimated via an Expectation/Conditional Maximization (ECM) algorithm, which can be implemented using functions for fitting generalized linear models readily available in standard statistical software packages. Compared to existing methods, our approach avoids the need to approximate the intractable integrals and thus the inference is exact with respect to the approximating Gamma-Poisson model. The proposed method is illustrated via a reanalysis of the yogurt data discussed by Chen & Kuo (2001)

    Predicting On-axis Rotorcraft Dynamic Responses Using Machine Learning Techniques

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    Physical-law-based models are widely utilized in the aerospace industry. One such use is to provide flight dynamics models for use in flight simulators. For human-in-the-loop use, such simulators must run in real-time. Owing to the complex physics of rotorcraft flight, to meet this real-time requirement, simplifications to the underlying physics sometimes have to be applied to the model, leading to errors in the model's predictions of the real vehicle's response. This study investigated whether a machine-learning technique could be employed to provide rotorcraft dynamic response predictions. Machine learning was facilitated using a Gaussian process (GP) nonlinear autoregressive model, which predicted the on-axis pitch rate, roll rate, yaw rate, and heave responses of a Bo105 rotorcraft. A variational sparse GP model was then developed to reduce the computational cost of implementing the approach on large datasets. It was found that both of the GP models were able to provide accurate on-axis response predictions, particularly when the model input contained all four control inceptors and one lagged on-axis response term. The predictions made showed improvement compared to a corresponding physics-based model. The reduction of training data to one-third (rotational axes) or one-half (heave axis) resulted in only minor degradation of the sparse GP model predictions. response predictions. Machine learning was facilitated using a Gaussian process (GP) nonlinear autoregressive model, which predicted the on-axis pitch rate, roll rate, yaw rate, and heave responses of a Bo105 rotorcraft. A variational sparse GP model was then developed to reduce the computational cost of implementing the approach on large datasets. It was found that both of the GP models were able to provide accurate on-axis response predictions, particularly when the model input contained all four control inceptors and one lagged on-axis response term. The predictions made showed improvement compared to a corresponding physics-based model. The reduction of training data to one-third (rotational axes) or one-half (heave axis) resulted in only minor degradation of the sparse GP model predictions.</jats:p

    Structural and Financial Characteristics of U.S. Farms: 2001 Family Farm Report

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    Family farms vary widely in size and other characteristics, ranging from very small retirement and residential farms to establishments with sales in the millions of dollars. The farm typology developed by the Economic Research Service (ERS) categorizes farms into groups based primarily on occupation of the operator and sales class of the farm. The typology groups reflect operators' expectations from farming, position in the life cycle, and dependence on agriculture. The groups differ in their importance to the farm sector, product specialization, program participation, and dependence on farm income. These (and other) differences are discussed in this report.Agricultural Resource Management Study (ARMS), family farms, farm businesses, farm financial situation, farm operator household income, farm operators, farm structure, farm typology, female farm operators, government payments, spouses of farm operators, taxes, Agricultural Finance, Farm Management,

    Characterization of radiotherapy component impact on MR imaging quality for an MRgRT system

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    Radiotherapy components of an magnetic resonnace-guided radiotherapy (MRgRT) system can alter the magnetic fields, causing spatial distortion and image deformation, altering imaging and radiation isocenter coincidence and the accuracy of dose calculations. This work presents a characterization of radiotherapy component impact on MR imaging quality in terms of imaging isocenter variation and spatial integrity changes on a 0.35T MRgRT system, pre- and postupgrade of the system. The impact of gantry position, MLC field size, and treatment table power state on imaging isocenter and spatial integrity were investigated. A spatial integrity phantom was used for all tests. Images were acquired for gantry angles 0-330° at 30° increments to assess the impact of gantry position. For MLC and table power state tests all images were acquired at the home gantry position (330°). MLC field sizes ranged from 1.66 to 27.4 cm edge length square fields. Imaging isocenter shift caused by gantry position was reduced from 1.7 mm at gantry 150° preupgrade to 0.9 mm at gantry 120° postupgrade. Maximum spatial integrity errors were 0.5 mm or less pre- and postupgrade for all gantry angles, MLC field sizes, and treatment table power states. However, when the treatment table was powered on, there was significant reduction in SNR. This study showed that gantry position can impact imaging isocenter, but spatial integrity errors were not dependent on gantry position, MLC field size, or treatment table power state. Significant isocenter variation, while reduced postupgrade, is cause for further investigation

    Matched increases in cerebral artery shear stress, irrespective of stimulus, induce similar changes in extra-cranial arterial diameter in humans.

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    The mechanistic role of arterial shear stress in the regulation of cerebrovascular responses to physiological stimuli (exercise and hypercapnia) is poorly understood. We hypothesised that, if shear stress is a key regulator of arterial dilation, then matched increases in shear, induced by distinct physiological stimuli, would trigger similar dilation of the large extra-cranial arteries. Participants ( n = 10) participated in three 30-min experimental interventions, each separated by ≥48 h: (1) mild-hypercapnia (FICO2:∼0.045); (2) submaximal cycling (EX; 60%HRreserve); or (3) resting (time-matched control, CTRL). Blood flow, diameter, and shear rate were assessed (via Duplex ultrasound) in the internal carotid and vertebral arteries (ICA, VA) at baseline, during and following the interventions. Hypercapnia and EX produced similar elevations in blood flow and shear rate through the ICA and VA ( p < 0.001), which were both greater than CTRL. Vasodilation of ICA and VA diameter in response to hypercapnia (5.3 ± 0.8 and 4.4 ± 2.0%) and EX (4.7 ± 0.7 and 4.7 ± 2.2%) were similar, and greater than CTRL ( p < 0.001). Our findings indicate that matched levels of shear, irrespective of their driving stimulus, induce similar extra-cranial artery dilation. We demonstrate, for the first time in humans, an important mechanistic role for the endothelium in regulating cerebrovascular response to common physiological stimuli in vivo
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