Music enrichment for gifted children in the first grade

Thesis (Ed.M.)--Boston Universit

Family health narratives : midlife women’s concepts of vulnerability to illness

Perceptions of vulnerability to illness are strongly influenced by the salience given to personal experience of illness in the family. This article proposes that this salience is created through autobiographical narrative, both as individual life story and collectively shaped family history. The paper focuses on responses related to health in the family drawn from semi-structured interviews with women in a qualitative study exploring midlife women’s health. Uncertainty about the future was a major emergent theme. Most respondents were worried about a specified condition such as heart disease or breast cancer. Many women were uncertain about whether illness in the family was inherited. Some felt certain that illness in the family meant that they were more vulnerable to illness or that their relatives’ ageing would be mirrored in their own inevitable decline, while a few expressed cautious optimism about the future. In order to elucidate these responses, we focused on narratives in which family members’ appearance was discussed and compared to that of others in the family. The visualisation of both kinship and the effects of illness, led to strong similarities being seen as grounds for worry. This led to some women distancing themselves from the legacies of illness in their families. Women tended to look at the whole family as the context for their perceptions of vulnerability, developing complex patterns of resemblance or difference within their families

Black Women in the Economy: Facing Glass Ceilings in Academia

The shrinking population of Black male doctoral degree holders may hold much of the key to the problems of Black women. Declines in Black male interest in doctoral degrees, has clearly not spelled gains for the recruitment of Black female scholars. New evidence of these patterns is visible in the latest government data on academic achievement of Black women and teaching job success. While Black women are achieving at high rates, they are also systematically by-passed by an expanded recruitment of African and Caribbean males to fill teaching positions in doctoral and research institutions. This new trend has probably reduced Black women\u27s chances more than any other. Second, the new found Black male networks have had major success in assuring members get support and information on academic jobs. Major questions need to be raised about these trends and more attention focused on unearthing and correcting root causes of specific discriminatory treatment of Black women in university faculty hiring and promotion

Interference of the T cell and antigen-presenting cell costimulatory pathway using CTLA4-Ig (abatacept) prevents Staphylococcal enterotoxin B pathology

Abstract Staphylococcal enterotoxin B (SEB) is a bacterial superantigen that binds the receptors in the APC/T cell synapse and causes increased proliferation of T cells and a cytokine storm syndrome in vivo. Exposure to the toxin can be lethal and cause significant pathology in humans. The lack of effective therapies for SEB exposure remains an area of concern, particularly in scenarios of acute mass casualties. We hypothesized that blockade of the T cell costimulatory signal by the CTLA4-Ig synthetic protein (abatacept) could prevent SEB-dependent pathology. In this article, we demonstrate mice treated with a single dose of abatacept 8 h post SEB exposure had reduced pathology compared with control SEB-exposed mice. SEB-exposed mice showed significant reductions in body weight between days 4 and 9, whereas mice exposed to SEB and also treated with abatacept showed no weight loss for the duration of the study, suggesting therapeutic mitigation of SEB-induced morbidity. Histopathology and magnetic resonance imaging demonstrated that SEB mediated lung damage and edema, which were absent after treatment with abatacept. Analysis of plasma and lung tissues from SEB-exposed mice treated with abatacept demonstrated significantly lower levels of IL-6 and IFN-γ (p &amp;lt; 0.0001), which is likely to have resulted in less pathology. In addition, exposure of human and mouse PBMCs to SEB in vitro showed a significant reduction in levels of IL-2 (p &amp;lt; 0.0001) after treatment with abatacept, indicating that T cell proliferation is the main target for intervention. Our findings demonstrate that abatacept is a robust and potentially credible drug to prevent toxic effects from SEB exposure.</jats:p

Utilization of Genetic Counseling after Direct‐to‐Consumer Genetic Testing: Findings from the Impact of Personal Genomics (PGen) Study

Direct‐to‐consumer personal genomic testing (DTC‐PGT) results lead some individuals to seek genetic counseling (GC), but little is known about these consumers and why they seek GC services. We analyzed survey data pre‐ and post‐PGT from 1026 23andMe and Pathway Genomics customers. Participants were mostly white (91%), female (60%), and of high socioeconomic status (80% college educated, 43% household income of ≥$100,000). After receiving PGT results, 43 participants (4%) made or planned to schedule an appointment with a genetic counselor; 390 (38%) would have used in‐person GC had it been available. Compared to non‐seekers, GC seekers were younger (mean age of 38 vs 46 years), more frequently had children <18 (26% vs 16%), and were more likely to report previous GC (37% vs 7%) and genetic testing (30% vs 15%). In logistic regression analysis, seeking GC was associated with previous GC use (OR = 6.5, CI = 3.1–13.8), feeling motivated to pursue DTC‐PGT for health reasons (OR = 4.3, CI = 1.8–10.1), fair or poor self‐reported health (OR = 3.1, CI = 1.1–8.3), and self‐reported uncertainty about the results (OR = 1.8, CI = 1.1–2.7). These findings can help GC providers anticipate who might seek GC services and plan for clinical discussions of DTC‐PGT results.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/146977/1/jgc41270.pd

Presentation by the University of Nevada, Las Vegas: College of Fine Arts

Program listing performers and works performe

System Modeling of Lunar Oxygen Production: Mass and Power Requirements

A systems analysis tool for estimating the mass and power requirements for a lunar oxygen production facility is introduced. The individual modeling components involve the chemical processing and cryogenic storage subsystems needed to process a beneficiated regolith stream into liquid oxygen via ilmenite reduction. The power can be supplied from one of six different fission reactor-converter systems. A baseline system analysis, capable of producing 15 metric tons of oxygen per annum, is presented. The influence of reactor-converter choice was seen to have a small but measurable impact on the system configuration and performance. Finally, the mission concept of operations can have a substantial impact upon individual component size and power requirements