13 research outputs found
Efficiency of Developing Renewable Energy Market in Russia
The goal of this study is to systematize and provide a quantitative and qualitative assessment of potential positive economic and non-economic effects of the implementation of a new mechanism for supporting renewable energy in Russia. It should result in achieving the national medium-term objective to increase the share of renewable energy in the wholesale electricity and capacity market to 2.5 % by 2024. The introduction examines the mechanism for supporting the generators of renewable energy by capacity charge in the wholesale electricity and capacity market. It is assumed that the main positive effects from implementing this mechanism will be the replacement of hydrocarbon fuels burned for generating the electricity in traditional coal or gas power plants; improvement in the trade balance; multiplier effects from the development of RES in related industrial sectors, new value added and jobs in the sectors producing the generating and auxiliary equipment for generators; reduction of carbon dioxide emissions; decrease in average prices in the wholesale electricity market; reduction of expenditure on environmental activities and measures to protect the health in the territories with traditional power plants; additional scal charges. As a result, the quantification of these effects amounts to 47.77 billion rubles in 2024. The authors rely on the experience of foreign countries, expert estimates, forecasts by the Russian Ministry of Energy and the Ministry of Economic Development, research by the Russian Energy Agency, International Energy Agency, International Renewable Energy Agency, Community for Renewable Energy Policy in the 21st Century (REN21), statistics of Russian Federal State Statistics Service.The article has been supported by the Russian Foundation for Basic Research as part of the project 14–06–00075 “National Economic and Environmental Security: Threats, Effects, and Scenario for Interaction of Economy and Environment.
Late Antiquity: The Regional Specific Nature of Intellectual Tradition
The primary purpose of the study is to investigate the specifics of the intellectual tradition prevailing in some regions of the Late Antique world. For the purpose of a comprehensive review of the problem, the authors focus on well-known intellectuals of the 5th–6th centuries, representing Gaul (Ausonius, Sidonius, Ennodius et al.), Alexandria (John Philoponus, Hypatia, Sinesius of Cyrene et al.), Africa (Fulgentius, Priscian, Corippus), Isauria (Candidus Isaurus). Despite the fact that, under the influence of objective factors (Christianization, barbarians), the intellectual tradition changed from its ancient model to the medieval one, it fulfilled its most important task - to preserve the best from the treasury of ancient thought and adapt the ancient heritage to a changing world. In conclusion, the outcomes of the study demonstrate various examples of intellectual tradition and the fortunes of “people of written culture” (literati)
Late Antiquity: the regional specific nature of intellectual tradition
The primary purpose of the study is to investigate the specifics of the intellectual tradition prevailing in some regions of the Late Antique world. For the purpose of a comprehensive review of the problem, the authors focus on wellknown intellectuals of the 5th-6th centuries, representing Gaul (Ausonius, Sidonius, Ennodius et al.), Alexandria (John Philoponus, Hypatia, Sinesius of Cyrene et al.), Africa (Fulgentius, Priscian, Corippus), Isauria (Candidus Isaurus
Неоперабельный гепатоцеллюлярный рак — перспективы лекарственной терапии ленватинибом
There is a number of unresolved issues regarding the systemic therapy administration for hepatocellular carcinoma (HCC). Their solution is facilitated by accumulating real‑world study results. Lenvatinib therapy is a recognized drug with a good efficacy and safety profile for the treatment of HCC. Subanalyses of the REFLECT study showed that the absence of stratification by baseline AFP and baseline liver function, as well as the lack of options for subsequent drug therapy after lenvatinib, also affects the outcomes. Once these factors are taken into account, the hypothesis of superiority of lenvatinib to sorafenib and other drugs can be tested. Real‑world clinical studies have demonstrated positive results of lenvatinib therapy in patients with Child‑Pugh class B liver function, provided recommendations on the sequence of systemic therapy after lenvatinib and on the use of lenvatinib in patients with BCLC stage B, along with considering the possibility of lenvatinib monotherapy and the prospects for its use in patients with nHCC. Further real‑world studies of lenvatinib for HCC in the Russian population are required.В подходах к назначению лекарственной терапии гепатоцеллюлярного рака (ГЦР) есть ряд еще нерешенных вопросов. Их решению способствует накопление результатов исследований в реальной клинической практике. Методом медикаментозной терапии ГЦР с хорошим профилем эффективности и безопасности признана терапия ленватинибом. В субанализах исследования REFLECT показано, что отсутствие стратификации по исходному уровню альфа-фетопротеина и оценке исходной функции печени, а также дефицит опций последующей после назначения ленватиниба медикаментозной терапии оказывают влияние на результаты. Учет этих факторов даст возможность проверить гипотезу превосходства терапии ленватинибом в сравнении с сорафенибом и другими препаратами. В исследованиях реальной клинической практики продемонстрированы положительные результаты применения ленватиниба у пациентов с нарушением функции печени класса B по шкале Чайлд-Пью, даны рекомендации по последовательности системной терапии после ленватиниба, применению ленватиниба у пациентов стадии BCLC B, а также рассмотрены возможности монотерапии ленватинибом и перспективы его применения у пациентов с нГЦК. Необходимы дальнейшие исследования ленватиниба при ГЦР в реальной клинической практике на российской популяции
Role of palbociclib in the treatment of hormone receptor-positive HER2-negative metastatic breast cancer. Generalizing results of randomized trials and real clinical practice
Palbociclib is the first-in-class drug of CDK 4/6 inhibitors group. The use of palbociclib in combination with endocrinotherapy (ET) opens up new possibilities for the treatment of metastatic hormone receptor-positive (HRP+) HER2-negative (HER2-) breast cancer (mBC). Palbociclib has gained world attention and is included in all clinical guidelines, both international and domestic, as a new standard of first- and second-line therapy of HRP+ HER2- mBC. The article presents the updated results of PALOMA-2 and PALOMA-3 studies and the results of use of palbociclib in combination with ET in real clinical practice
Relationship of structural changes in the surface of copper during anodic solution to the semiconductor properties of the film that arises
ВОЕННО-МОРСКОЙ ГИГИЕНИСТ Ю. Н. ПЕТРОВ: СЛУЖЕБНЫЙ ДОЛГ И ТВОРЧЕСКИЙ ПУТЬ
The paper sheds light on several episodes in the life of Yuri Nikolayevich Petrov, Candidate of Medical Sciences, navy doctor, radiation hygienist, veteran of the Department of Navy and Radiation Hygiene of S.M. Kirov Military Medical Academy, the author of dozens of inventions and innovation proposals. Many of navy hygienists in Russia esteem Yu. N. Petrov as their tutor. The principal features of his personality have ever been independence in thought, invariable adherence to principles, exclusive modesty, and outstanding benevolence. His life-long motto is the following phase taken from his autobiographic essay: «In any routine, it is possible and essential to find its interesting aspects and thus make it fascinating. Ever since, the routine turns into pleasure and life becomes wonderful». The highlights of his professional activities include involvement in the liquidation of the consequences of K-8 submarine wreck (13.10.1960), the detection of radioactive cloud after nuclear tests in China (1968), the discovery of a foreign nuclear submarine beneath the aircraft-carrying cruiser Minsk, involvement in radiation control during the first trips of soviet nuclear submarines and in associated studies of internal irradiation in humans, involvement in developing and implementing of systems for environmental radiation control at facilities having terrestrial nuclear reactors, studies of on-board water decontamination, and, after retirement, fifteen years of practice in the sphere of consumer rights protection.В статье приведены отдельные эпизоды из жизни военно-морского врача, специалиста по радиационной гигиене, ветерана кафедры военно-морской и радиационной гигиены Военно- медицинской академии имени С. М. Кирова, имеющего десятки изобретений и рационализаторских предложений, кандидата медицинских наук, Юрия Николаевича Петрова. Его считают своим наставником многие военно-морские гигиенисты нашей страны. Основными чертами его характера являются независимость мышления, неизменная принципиальность, исключительная скромность и удивительная доброжелательность. При этом мировоззренческим девизом всей жизни Юрия Николаевича стала фраза из его биографической монографии: «Главное в любой повседневной работе можно и нужно найти интересные стороны и превратить ее в увлекательное занятие. После этого работа становится удовольствием, а жизнь — прекрасной». Наиболее яркими страницами его профессиональной деятельности, безусловно, стали: участие в ликвидации последствий аварии на подводной лодке К-8 (13.10.1960); обнаружение радиоактивного облака от испытаний ядерного оружия на Новой Земле в 1961 г.; регистрация радиоактивного облака от ядерных испытаний в Китае в 1968 г.; обнаружение в Средиземном море иностранной атомной подводной лодки под днищем тяжелого авианесущего крейсера «Минск»; участие в исследованиях доз облучения в условиях походов на первых советских атомных подводных лодках и закономерностей внутреннего облучения человека; участие в разработке и реализации системы контроля за радиоактивностью окружающей среды на объектах с наземными ядерными реакторами; изучение особенностей обеззараживания питьевой воды на кораблях и (уже на пенсии) 15-летний опыт практической работы в сфере защиты прав потребителей. </p