Herbal highs: review on psychoactive effects and neuropharmacology

Background: A new trend among users of new psychoactive substances’ the consumption of “herbal highs”: plant parts containing psychoactive substances. Most of the substances extracted from herbs, in old centuries were at the centre of religious ceremonies of ancient civilizations. Currently, these herbal products are mainly sold by internet web sites and easily obtained since some of them have no legal restriction. Objective: We reviewed psychoactive effects and neuropharmacology of the most used “herbal highs” with characterized active principles, with studies reporting mechanisms of action, pharmacological and subjective effects, eventual secondary effects including intoxications and/or fatalities Method: The PubMed database was searched using the following key.words: herbal highs, Argyreia nervosa, Ipomoea violacea and Rivea corymbosa; Catha edulis; Datura stramonium; Piper methysticum; Mitragyna speciosa. Results: Psychoactive plants here reviewed have been known and used from ancient times, even if for some of them limited information still exist regarding subjective and neuropharmacological effects and consequent eventual toxicity when plants are used alone or in combination with “classical” drugs of abuse. Conclusion: Some “herbal highs” should be classified as harmful drugs since chronic administration has been linked with addiction and cognitive impairment; for some others taking into consideration only the recent trends of abuse, studies investigating these aspects are lacking

Enumeration of RNA structures by Matrix Models

We enumerate the number of RNA contact structures according to their genus, i.e. the topological character of their pseudoknots. By using a recently proposed matrix model formulation for the RNA folding problem, we obtain exact results for the simple case of an RNA molecule with an infinitely flexible backbone, in which any arbitrary pair of bases is allowed. We analyze the distribution of the genus of pseudoknots as a function of the total number of nucleotides along the phosphate-sugar backbone.Comment: RevTeX, 4 pages, 2 figure

The educational turn in art: rewriting the hidden curriculum

Around 2006, the art world developed a prolonged fascination with questions of education, pedagogy and the art school. ‘The Educational Turn’ (Rogoff, 2008) as it became known, produced a plethora of artistic and curatorial practices that engage with educational paradigms and problematics. Prompted in part by the European Union Bologna Process, the Educational Turn provided a critique of education as one-directional knowledge transfer, and the framing of education as a commercialised industry, reduced to the utilitarianism of training for working life. At the same time, it established ‘education’ as a thematic for the art world, in most cases divorced from its capacity for producing change in the fields of art or education. This article asks, what is the hidden curriculum (Illich) of this Educational Turn? Drawing from the writings of Colin Crouch, Wolfgang Streeck and Paulo Virno among others, it suggests that such ‘turns’ without a vital link to the realm of action, contribute to the broader problematic of public programming without a public sphere, through which formerly democratic institutions (like art galleries) operate as shells in a capitalist environment that is increasingly incompatible with democracy. We read The Education Turn here as a missed opportunity to re-shape art curricula and institutions, to develop a movement to oppose the Bologna Accord and the brutal changes imposed on art education through austerity politics. Finally, we argue - citing the writings of Paulo Friere, the mutualist movements in Europe of the 18th and 19th centuries, the educational experiments of Celestin Freinet in and Fernand Oury in France in the 1950s and the pedagogies of feminist and post-colonial struggle - for a deeper connection to radical education genealogies and their contemporary counterparts in contemporary public programming today

Topology of Luminous Red Galaxies from the Sloan Digital Sky Survey

We present measurements of the genus topology of luminous red galaxies (LRGs) from the Sloan Digital Sky Survey (SDSS) Data Release 7 catalog, with unprecedented statistical significance. To estimate the uncertainties in the measured genus, we construct 81 mock SDSS LRG surveys along the past light cone from the Horizon Run 3, one of the largest N-body simulations to date that evolved 7210^3 particles in a 10815 Mpc/h size box. After carefully modeling and removing all known systematic effects due to finite pixel size, survey boundary, radial and angular selection functions, shot noise and galaxy biasing, we find the observed genus amplitude to reach 272 at 22 Mpc/h smoothing scale with an uncertainty of 4.2%; the estimated error fully incorporates cosmic variance. This is the most accurate constraint of the genus amplitude to date, which significantly improves on our previous results. In particular, the shape of the genus curve agrees very well with the mean topology of the SDSS LRG mock surveys in the LCDM universe. However, comparison with simulations also shows small deviations of the observed genus curve from the theoretical expectation for Gaussian initial conditions. While these discrepancies are mainly driven by known systematic effects such as those of shot noise and redshift-space distortions, they do contain important cosmological information on the physical effects connected with galaxy formation, gravitational evolution and primordial non-Gaussianity. We address here the key role played by systematics on the genus curve, and show how to accurately correct for their effects to recover the topology of the underlying matter. In a forthcoming paper, we provide an interpretation of those deviations in the context of the local model of non-Gaussianity.Comment: 23 pages, 18 figures. APJ Supplement Series 201

Unbiased estimates of galaxy scaling relations from photometric redshift surveys

Many physical properties of galaxies correlate with one another, and these correlations are often used to constrain galaxy formation models. Such correlations include the color-magnitude relation, the luminosity-size relation, the Fundamental Plane, etc. However, the transformation from observable (e.g. angular size, apparent brightness) to physical quantity (physical size, luminosity), is often distance-dependent. Noise in the distance estimate will lead to biased estimates of these correlations, thus compromising the ability of photometric redshift surveys to constrain galaxy formation models. We describe two methods which can remove this bias. One is a generalization of the V_max method, and the other is a maximum likelihood approach. We illustrate their effectiveness by studying the size-luminosity relation in a mock catalog, although both methods can be applied to other scaling relations as well. We show that if one simply uses photometric redshifts one obtains a biased relation; our methods correct for this bias and recover the true relation

Vibrational properties of inclusion complexes: the case of indomethacin-cyclodextrin

Vibrational properties of inclusion complexes with cyclodextrins are studied by means of Raman spectroscopy and numerical simulation. In particular, Raman spectra of the non-steroidal, anti-inflammatory drug indomethacin undergo notable changes in the energy range between 1600 and 1700 cm$^{-1}$ when inclusion complexes with cyclodextrins are formed. By using both \emph{ab initio} quantum chemical calculations and molecular dynamics, we studied how to relate such changes to the geometry of the inclusion process, disentangling single-molecule effects, from changes in the solid state structure or dimerization processes.Comment: 14 file figure

Hepatotoxicity induced by greater celandine (Chelidonium majus L.): a review of the literature

The available literature assessing Chelidonium majus L. (CM) hepatotoxicity potential, and its risk to benefit assessment has been reviewed in this paper. Identification of significant scientific literature was performed via the following research databases: Cochrane Central, Google Scholar, EMBASE, Medline, Science Direct, Scopus, Web of Science, using the following keywords: "Chelidonium majus", "greater celandine", "Hepatotoxicity", "Liver" "Injury", "Toxicity" individually investigated and then again in association. CM named also greater celandine, swallow-wort, or bai-qu-cai (Chinese), has been used for a long time in traditional Chinese medicine and phytotherapy. Its extracts have been claimed to display a wide variety of biological activities: antimicrobial, anti-inflammatory, spasmolytic, antineoplastic, hepatoprotective, and analgesic. Moreover, herbal medicine suggests this plant have numerous additional effects which have not yet been scientifically evaluated, such as antitussive, diuretic, and eye-regenerative. However, despite its claimed hepatoprotective effects, several hepatotoxicity cases have been reported to be probably or highly probably connected with CM exposure, after their evaluation through liver-targeted causality assessment methods. CM hepatotoxicity has been defined as a distinct form of herb-induced liver injury (HILI), due to an idiosyncratic reaction of the metabolic type. This evidence has to be considered in relationship with the absence of considerable benefits of CM therapy. Therefore, the risk to benefit ratio of the use of herbal products containing greater celandine can actually be considered as negative

Market Power and Patent Strategies: Evidence from Renaissance Venice

This paper exploits the introduction of the first regularized patent system, which appeared in the Venetian Republic in 1474, to examine the factors shaping inventors\u2019 propensity to use a new form of intellectual property. We combine detailed information on craft guilds and patents in Renaissance Venice and show a negative association between patenting activity and guild statutory norms that strongly restricted entry and price competition. Our analysis shows that the heterogeneity in patenting activity documented by the industrial organization literature is not a special feature of modern technologies, but is rather a persistent phenomenon affected by market power

Consciousness Explained or Described?

Consciousness is an unusual phenomenon to study scientifically. It is defined as a subjective, first-person phenomenon, and science is an objective, third-person endeavor. This misalignment between the means—science—and the end—explaining consciousness—gave rise to what has become a productive workaround: the search for ‘neural correlates of consciousness’ (NCCs). Science can sidestep trying to explain consciousness and instead focus on characterizing the kind(s) of neural activity that are reliably correlated with consciousness. However, while we have learned a lot about consciousness in the bargain, the NCC approach was not originally intended as the foundation for a true explanation of consciousness. Indeed, it was proposed precisely to sidestep the, arguably futile, attempt to find one. So how can an account, couched in terms of neural correlates, do the work that a theory is supposed to do: explain consciousness? The answer is that it cannot, and in fact most modern accounts of consciousness do not pretend to. Thus, here, we challenge whether or not any modern accounts of consciousness are in fact theories at all. Instead we argue that they are (competing) laws of consciousness. They describe what they cannot explain, just as Newton described gravity long before a true explanation was ever offered. We lay out our argument using a variety of modern accounts as examples and go on to argue that at least one modern account of consciousness, attention schema theory, goes beyond describing consciousness-related brain activity and qualifies as an explanatory theory