Vocal music of the Anglo-Boer War (1899-1902) : insights into processes of affect and meaning in music

The focus of this study was to locate the lacuna that exists between cultural history and musicology, in order to assess processes of affect and meaning in vocal music as a vehicle for understanding the South African Boer psyche and circumstances during the war. The pursuit of locating the lacuna was best served by employing qualitative research methods that reflect the phenomenological paradigm. This allowed for an in-depth understanding of the Boers in terms of their own interpretations of reality, as well as the understanding of society in terms of the meanings that people ascribe to the societal practices in that society. A cultural-historical approach was necessary in order to highlight the experiential world of the Boers and gain some insider perspectives of the war. This approach did not, however, have much to say about the role of Boer vocal music in generating and articulating social and cultural meanings. On the other hand, the musicological approach which was based on research grounded in an examination of hand-notated musical scores, drew little attention to the role of music’s meanings in the social, historical and cultural circumstances of the Boer people during the war. After the historical context, which generated the vocal music was understood; the researcher was able to identify the lacuna as an aural void, due to the fact that affect and meaning cannot be grounded exclusively in an examination of cultural history or musical symbols decontextualised from sound. The background information allowed for the lyrics to be interpreted in melodic configurations, which were equated with particular moods, emotions and cultural meanings. This thesis thus responded to and succeeded in assessing insight and understanding into the psyche and circumstances of white South Africans during the Anglo Boer War. The thesis concluded by proving that by highlighting the aural void it was possible to move cultural history towards an accommodation with musicology. Through Boer vocal music it was thus possible to critically shape understanding of the experiential world of the Boer during the Anglo-Boer War.Thesis (DMus)--University of Pretoria, 2005.Musicunrestricte

Epigenetics Underpinning the Regulation of the CXC (ELR+) Chemokines in Non-Small Cell Lung Cancer

Background: Angiogenesis may play a role in the pathogenesis of Non-Small Cell Lung cancer (NSCLC). The CXC (ELR+) chemokine family are powerful promoters of the angiogenic response. Methods: The expression of the CXC (ELR+) family members (CXCL1-3/GROα-γ, CXCL8/IL-8, CXCR1/2) was examined in a series of resected fresh frozen NSCLC tumours. Additionally, the expression and epigenetic regulation of these chemokines was examined in normal bronchial epithelial and NSCLC cell lines. Results: Overall, expression of the chemokine ligands (CXCL1, 2, 8) and their receptors (CXCR1/2) were down regulated in tumour samples compared with normal, with the exception of CXCL3. CXCL8 and CXCR1/2 were found to be epigenetically regulated by histone post-translational modifications. Recombinant CXCL8 did not stimulate cell growth in either a normal bronchial epithelial or a squamous carcinoma cell line (SKMES-1). However, an increase was observed at 72 hours post treatment in an adenocarcinoma cell line. Conclusions: CXC (ELR+) chemokines are dysregulated in NSCLC. The balance of these chemokines may be critical in the tumour microenvironment and requires further elucidation. It remains to be seen if epigenetic targeting of these pathways is a viable therapeutic option in lung cancer treatment. © 2011 Baird et al

In the Open

The exhibition 'In the Open' took place at Sheffield Institute of Arts Gallery, Sheffield Hallam University, Cantor Building and Bank Street Arts, 32-40 Bank Street, Sheffield, S1 2DS from September 6th - 29th 2017. The exhibition featured my collaborative digital film ‘Longdendale Lights to Shining Clough’ made with American poet Laura-Gray Street (Associate Professor of English at Randolph College, Virginia, USA). This work was made in response to an invitation to work collaboratively to make a new artwork for the 'In the Open', Sheffield, an exhibition of collaborative artworks around place, landscape and environment. The exhibition complemented the conference: 'Cross, Multi, Inter,Trans: Association for the Study of Literature and Environment, U.K. and Ireland Biennial Conference 2017' (UK and Ireland) 6-8 September 2017, in association with LAND2: a landscape, place and visual arts research network. Overall, the exhibition 'In the Open' reflected artists’ preoccupation with and experimentation with space on the wall and within the book-space in relation to landscape. Works include artists’ books, texts, images, videos, paintings and objects. The exhibition will incorporate poetry and text on the windows and walls to be read in relation to the visual works hung on the wall. The digital film Street and Creamer made for 'In the Open', '‘Longdendale Lights to Shining Clough’, is a 11 minute film made in situ in the Longdendale valley in the Peak District, near to the city of Sheffield in the UK. Creamer filmed, recorded the visual elements of a work that is edited around a performative and adapted reading of a new long-form poem Street wrote on the occasion of their collaboration, taking the valley and its haunted history as a subject for thought about the complex entanglement of place, memory and landscape. 'In the Open' was reviewed in Plumwood Mountain, which featured '‘Longdendale Lights to Shining Clough’', an Australian Journal of Ecopoetry and Ecopoetics. It is the focus of a forthcoming special edition of peer reviewed journal Green Letters, published by Taylor and Francis. The work featured in this exhibition, 'Longdendale Lights to Shining Clough', also features on the following UAL Research Online web-pages: • The First Biennial Sino-British Contemporary Art Exhibition - book: https://ualresearchonline.arts.ac.uk/13678/ • Conference paper: 'Longdendale Lights: Perspectives (I) and Longdendale Lights: Perspectives (II)., presented at 'Cross, Multi, Intra, Trans conference at Sheffield Arts Institute, Sheffield Hallam University, as part of the Land2 research and Association for the Study of Literature and Environment, U.K. and Ireland research networks. https://ualresearchonline.arts.ac.uk/13675/ • The art work itself, ‘Longdendale Lights to Shining Clough’ https://ualresearchonline.arts.ac.uk/13902

Longdendale Lights: Perspectives (I) and Longdendale Lights: Perspectives (II)

A collaborative video and a conference paper relating to the wider ideas and processes applied, made with American poet Laura-Gray Street, 'From Longdendale valley to Shinning Clough', was presented as part of an international conference 'Cross, Multi, Intra, Trans' conference at the Sheffield Arts Institute, Sheffield Hallam University, UK in September 2017. The Cross, Multi, Intra, Trans conference was presented by two research networks; The Biennial Conference of the Association for the Study of Literature and Environment, U.K. and Ireland in association with LAND2. The 'Cross, Multi, Intra, Trans' conference featured an international range of speakers from the United Kingdom, Ireland, Holland, Germany and the USA, and Canada. It took place over 2 days in September 2017. Street and Creamer presented a paper, 'Longdendale Lights: Perspectives (I) and (II)', outlining the history of their collaboration and the wider issues their work raised in the context of the conference, as part of a panel called 'Inter-genre Inter-national: Artists in Collaboration'. American poet Laura-Gray Street is Associate Professor of English, Director of Creative Writing and Visiting Writers Series Program at Randolph College, USA. Details of the Panel Street and Creamer featured also included: Panel 1: Cantor 9024 Inter-genre Inter-national: Artists in Collaboration CHAIR: Judith Tucker Anne-Marie Creamer and Laura-Gray Street - Longdendale Lights: Perspectives (I) and Longdendale Lights: Perspectives (II). Ann Fisher-Wirth and Barbara Howey - Damage Poison Beauty Ooze: a poet and a painter respond to contemporary landscapes All those taking part were interested in place, landscape and environment, also featuring field trips around a richly diverse area so, aptly, we know where we are. The conference allowed participants to fully engage with “the challenge of the environmental humanities as a transdisciplinary matrix” (Heise) and aimed to deepen analysis of what it is to work across disciplines; the conference remit aimed to bring critical and aesthetic enquiry into dialogue to explore how creative practice not only informs critical analysis, but is also a critical tool in itself. The conference panel I was part set out to encourage CROSS MULTI INTER TRANS thinking. Other important UAL Research Online links about this work: • Details of the art-work that is the subject of this conference presentation and paper, 'From Longdendale valley to Shinning Clough' https://ualresearchonline.arts.ac.uk/13902/ • 'In the Open' exhibition at Sheffield Institute of Arts Gallery: featuring the collaborative digital film ‘Longdendale Lights to Shining Clough’, made with American poet Laura-Gray Street. https://ualresearchonline.arts.ac.uk/13679/ • 'From Longdendale valley to Shinning Clough' was also featured in the exhibition and book, The First Biennial Sino-British Contemporary Art Exhibition, which can be found at this UAL Research On-line link; http://ualresearchonline.arts.ac.uk/13678

Carcinogenesis in Prostate Cancer: The role of Long Non-Coding RNAs

LncRNAs appear to play a considerable role in tumourigenesis through regulating key processes in cancer cells such as proliferative signalling, replicative immortality, invasion and metastasis, evasion of growth suppressors, induction of angiogenesis and resistance to apoptosis. LncRNAs have been reported to play a role in prostate cancer, particularly in regulating the androgen receptor signalling pathway. In this review article, we summarise the role of 34 lncRNAs in prostate cancer with a particular focus on their role in the androgen receptor signalling pathway and the epithelial to mesenchymal transition pathway

Have e-cigarettes renormalised or displaced youth smoking? Results of a segmented regression analysis of repeated cross-sectional survey data in England, Scotland and Wales

Objectives: To examine whether during a period of limited e-cigarette regulation and rapid growth in their use, smoking began to become renormalised among young people. Design: Interrupted time-series analysis of repeated cross-sectional time-series data. Setting: Great Britain Participants: 248 324 young people aged approximately 13 and 15 years, from three national surveys during the years 1998–2015. Intervention Unregulated growth of e-cigarette use (following the year 2010, until 2015). Outcome measures: Primary outcomes were prevalence of self-reported ever smoking and regular smoking. Secondary outcomes were attitudes towards smoking. Tertiary outcomes were ever use of cannabis and alcohol. Results: In final models, no significant change was detected in the pre-existing trend for ever smoking (OR 1.01, CI 0.99 to 1.03). There was a marginally significant slowing in the rate of decline for regular smoking (OR 1.04, CI 1.00 to 1.08), accompanied by a larger slowing in the rate of decline of cannabis use (OR 1.21, CI 1.18 to 1.25) and alcohol use (OR 1.17, CI 1.14 to 1.19). In all models and subgroup analyses for smoking attitudes, an increased rate of decline was observed after 2010 (OR 0.88, CI 0.86 to 0.90). Models were robust to sensitivity analyses. Conclusions: There was a marginal slowing in the decline in regular smoking during the period following 2010, when e-cigarettes were emerging but relatively unregulated. However, these patterns were not unique to tobacco use and the decline in the acceptability of smoking behaviour among youth accelerated during this time. These analyses provide little evidence that renormalisation of youth smoking was occurring during a period of rapid growth and limited regulation of e-cigarettes from 2011 to 2015

Mapping and characterization of the amplicon near APOA2 in 1q23 in human sarcomas by FISH and array CGH

BACKGROUND: Amplification of the q21-q23 region on chromosome 1 is frequently found in sarcomas and a variety of other solid tumours. Previous analyses of sarcomas have indicated the presence of at least two separate amplicons within this region, one located in 1q21 and one located near the apolipoprotein A-II (APOA2) gene in 1q23. In this study we have mapped and characterized the amplicon in 1q23 in more detail. RESULTS: We have used fluorescence in situ hybridisation (FISH) and microarray-based comparative genomic hybridisation (array CGH) to map and define the borders of the amplicon in 10 sarcomas. A subregion of approximately 800 kb was identified as the core of the amplicon. The amplification patterns of nine possible candidate target genes located to this subregion were determined by Southern blot analysis. The genes activating transcription factor 6 (ATF6) and dual specificity phosphatase 12 (DUSP12) showed the highest level of amplification, and they were also shown to be over-expressed by quantitative real-time reverse transcription PCR (RT-PCR). In general, the level of expression reflected the level of amplification in the different tumours. DUSP12 was expressed significantly higher than ATF6 in a subset of the tumours. In addition, two genes known to be transcriptionally activated by ATF6, glucose-regulated protein 78 kDa and -94 kDa (GRP78 and GRP94), were shown to be over-expressed in the tumours that showed over-expression of ATF6. CONCLUSION: ATF6 and DUSP12 seem to be the most likely candidate target genes for the 1q23 amplification in sarcomas. Both genes have possible roles in promoting cell growth, which makes them interesting candidate targets

The Grizzly, April 24, 2003

Queen Noor to Address Ursinus Graduates • Car-Sharing with Zipcar: the Newest Way to Travel • New Orientation Assistants Chosen • Opinions: Human Life Impossible?; Is Campus Parking Really a Big Deal?; Room Lottery and Selection: No Hard Feelings • Behind the Scenes of Psycho Beach Party • Greek Week • Women\u27s Lacrosse Starting to Heat Up • UC Softball Drops Two to Haverfordhttps://digitalcommons.ursinus.edu/grizzlynews/1536/thumbnail.jp

The Grizzly, February 13, 2003

Iraqi Speaker Describes his Country as a Prison of Suffering • Ursinus Student Heroes 30 Years Ago • To Fight or not to Fight: You May not Have the Option • Opinions: Skiing Fun Close to Home; Lonely this Valentine\u27s Day? • Female Pride, Guerrilla Warfare • First of Pew Fellows Speaks • Francis Moore Lappe to Visit Ursinus on February 19th • Ursinus Swimmers Look Towards Champions Meet • Men\u27s Basketball Dominate Centennial Conference • Track Handling Business Indoors • Women\u27s Basketball Can\u27t Find the Right Touchhttps://digitalcommons.ursinus.edu/grizzlynews/1529/thumbnail.jp

The Grizzly, May 1, 2003

Political Theorist Discusses Democracy and Terrorism • Ursinus Students Celebrate Spring with a Fling • Opinions: More Responses to Berliner\u27s Article; Greek Week a Blast! • New in Berman • Annual Student Exhibition 2003 Award Recipients • UC Women\u27s LAX Fall to Washington, Invest in Bulletproof Jackets • Dr. D Says Farewell with a Fantastic Finish • Men\u27s Tennis Looks to Rebound Next Season • UC Baseball Wins Eight Straight • Men\u27s Lax Records Two Wins • Women\u27s Golf Hurt by Weather, Injuries • Final Exam Schedulehttps://digitalcommons.ursinus.edu/grizzlynews/1537/thumbnail.jp