3,353 research outputs found
Correlations for determining thermodynamic properties of hydrogen-helium gas mixtures at temperatures from 7,000 to 35,000 K
Simple relations for determining the enthalpy and temperature of hydrogen-helium gas mixtures were developed for hydrogen volumetric compositions from 1.0 to 0.7. These relations are expressed as a function of pressure and density and are valid for a range of temperatures from 7,000 to 35,000 K and pressures from 0.10 to 3.14 MPa. The proportionality constant and exponents in the correlation equations were determined for each gas composition by applying a linear least squares curve fit to a large number of thermodynamic calculations obtained from a detailed computer code. Although these simple relations yielded thermodynamic properties suitable for many engineering applications, their accuracy was improved significantly by evaluating the proportionality constants at postshock conditions and correlating these values as a function of the gas composition and the product of freestream velocity and shock angle. The resulting equations for the proportionality constants in terms of velocity and gas composition and the corresponding simple realtions for enthalpy and temperature were incorporated into a flow field computational scheme. Comparison was good between the thermodynamic properties determined from these relations and those obtained by using a detailed computer code to determine the properties. Thus, an appreciable savings in computer time was realized with no significant loss in accuracy
Sub-picosecond compression by velocity bunching in a photo-injector
We present an experimental evidence of a bunch compression scheme that uses a
traveling wave accelerating structure as a compressor. The bunch length issued
from a laser-driven radio-frequency electron source was compressed by a factor
>3 using an S-band traveling wave structure located immediately downstream from
the electron source. Experimental data are found to be in good agreement with
particle tracking simulations.Comment: 19 pages, 9 figures, submitted to Phys. Rev. Spec. Topics A&
Effect of suspension systems on the physiological and psychological responses to sub-maximal biking on simulated smooth and bumpy tracks
The aim of this study was to compare the physiological and psychological responses of cyclists riding on a hard tail bicycle and on a full suspension bicycle. Twenty males participated in two series of tests. A test rig held the front axle of the bicycle steady while the rear wheel rotated against a heavy roller with bumps (or no bumps) on its surface. In the first series of tests, eight participants (age 19 – 27 years, body mass 65 – 82 kg) were tested on both the full suspension and hard tail bicycles with and without bumps fitted to the roller. The second series of test repeated the bump tests with a further six participants (age 22 – 31 years, body mass 74 – 94 kg) and also involved an investigation of familiarization effects with the final six participants (age 21 – 30 years, body mass 64 – 80 kg). Heart rate, oxygen consumption (VO<sub>2</sub>), rating of perceived exertion (RPE) and comfort were recorded during 10 min sub-maximal tests. Combined data for the bumps tests show that the full suspension bicycle was significantly different (P < 0.001) from the hard tail bicycle on all four measures. Oxygen consumption, heart rate and RPE were lower on average by 8.7 (s = 3.6) ml · kg<sup>-1</sup> · min<sup>-1</sup>, 32.1 (s = 12.1) beats · min<sup>-1</sup> and 2.6 (s = 2.0) units, respectively. Comfort scores were higher (better) on average by 1.9 (s = 0.8) units. For the no bumps tests, the only statistically significant difference (P = 0.008) was in VO<sub>2</sub>, which was lower for the hard tail bicycle by 2.2 (s = 1.7) ml · kg-1 · min<sup>-1</sup>. The results indicate that the full suspension bicycle provides a physiological and psychological advantage over the hard tail bicycle during simulated sub-maximal exercise on bumps
Ensemble Simulations and Experimental Free Energy Distributions: Evaluation and Characterization of Isoxazole Amides as SMYD3 Inhibitors
Optimization of binding affinities for ligands to their target protein is a primary objective in rational drug discovery. Herein, we report on a collaborative study that evaluates various compounds designed to bind to the SET and MYND domain-containing protein 3 (SMYD3). SMYD3 is a histone methyltransferase and plays an important role in transcriptional regulation in cell proliferation, cell cycle, and human carcinogenesis. Experimental measurements using the scintillation proximity assay show that the distributions of binding free energies from a large number of independent measurements exhibit non-normal properties. We use ESMACS (enhanced sampling of molecular dynamics with approximation of continuum solvent) and TIES (thermodynamic integration with enhanced sampling) protocols to predict the binding free energies and to provide a detailed chemical insight into the nature of ligand-protein binding. Our results show that the 1-trajectory ESMACS protocol works well for the set of ligands studied here. Although one unexplained outlier exists, we obtain excellent statistical ranking across the set of compounds from the ESMACS protocol and good agreement between calculations and experiments for the relative binding free energies from the TIES protocol. ESMACS and TIES are again found to be powerful protocols for the accurate comparison of the binding free energies
Highly Efficient TADF OLEDs: How the Emitter–Host Interaction Controls Both the Excited State Species and Electrical Properties of the Devices to Achieve Near 100% Triplet Harvesting and High Efficiency
New emitters that can harvest both singlet and triplet excited states to give 100% internal conversion of charge into light, are required to replace Ir based phosphors in organic light emitting diodes (OLEDs). Molecules that have a charge transfer (CT) excited state can potentially achieve this through the mechanism of thermally activated delayed fluorescence (TADF). Here, it is shown that a D–A charge transfer molecule in the solid state, can emit not only via an intramolecular charge transfer (ICT) excited state, but also from exciplex states, formed between the molecule and the host material. OLEDs based on a previously studied D–A–D molecule in a host TAPC achieves >14% external electroluminescence yield and shows nearly 100% efficient triplet harvesting. In these devices, it is unambiguously established that the triplet states are harvested via TADF, but more interestingly, these results are found to be independent of whether the emitter is the ICT state or the D–A–D/host exciplex
Power requirements for electron cyclotron current drive and ion cyclotron resonance heating for sawtooth control in ITER
13MW of electron cyclotron current drive (ECCD) power deposited inside the q
= 1 surface is likely to reduce the sawtooth period in ITER baseline scenario
below the level empirically predicted to trigger neo-classical tearing modes
(NTMs). However, since the ECCD control scheme is solely predicated upon
changing the local magnetic shear, it is prudent to plan to use a complementary
scheme which directly decreases the potential energy of the kink mode in order
to reduce the sawtooth period. In the event that the natural sawtooth period is
longer than expected, due to enhanced alpha particle stabilisation for
instance, this ancillary sawtooth control can be provided from > 10MW of ion
cyclotron resonance heating (ICRH) power with a resonance just inside the q = 1
surface. Both ECCD and ICRH control schemes would benefit greatly from active
feedback of the deposition with respect to the rational surface. If the q = 1
surface can be maintained closer to the magnetic axis, the efficacy of ECCD and
ICRH schemes significantly increases, the negative effect on the fusion gain is
reduced, and off-axis negative-ion neutral beam injection (NNBI) can also be
considered for sawtooth control. Consequently, schemes to reduce the q = 1
radius are highly desirable, such as early heating to delay the current
penetration and, of course, active sawtooth destabilisation to mediate small
frequent sawteeth and retain a small q = 1 radius.Comment: 29 pages, 16 figure
Statistical features of edge turbulence in RFX-mod from Gas Puffing Imaging
Plasma density fluctuations in the edge plasma of the RFX-mod device are
measured through the Gas Puffing Imaging Diagnostics. Statistical features of
the signal are quantified in terms of the Probability Distribution Function
(PDF), and computed for several kinds of discharges. The PDFs from discharges
without particular control methods are found to be adequately described by a
Gamma function, consistently with the recent results by Graves et al [J.P.
Graves, et al, Plasma Phys. Control. Fusion 47, L1 (2005)]. On the other hand,
pulses with external methods for plasma control feature modified PDFs. A first
empirical analysis suggests that they may be interpolated through a linear
combination of simple functions. An inspection of the literature shows that
this kind of PDFs is common to other devices as well, and has been suggested to
be due to the simultaneous presence of different mechanisms driving
respectively coherent bursts and gaussian background turbulence. An attempt is
made to relate differences in the PDFs to plasma conditions such as the local
shift of the plasma column. A simple phenomenological model to interpret the
nature of the PDF and assign a meaning to its parameters is also developed.Comment: 27 pages. Published in PPC
Classical model of elementary particle with Bertotti-Robinson core and extremal black holes
We discuss the question, whether the Reissner-Nordstr\"{o}m RN) metric can be
glued to another solutions of Einstein-Maxwell equations in such a way that (i)
the singularity at r=0 typical of the RN metric is removed (ii), matching is
smooth. Such a construction could be viewed as a classical model of an
elementary particle balanced by its own forces without support by an external
agent. One choice is the Minkowski interior that goes back to the old Vilenkin
and Fomin's idea who claimed that in this case the bare delta-like stresses at
the horizon vanish if the RN metric is extremal. However, the relevant entity
here is the integral of these stresses over the proper distance which is
infinite in the extremal case. As a result of the competition of these two
factors, the Lanczos tensor does not vanish and the extremal RN cannot be glued
to the Minkowski metric smoothly, so the elementary-particle model as a ball
empty inside fails. We examine the alternative possibility for the extremal RN
metric - gluing to the Bertotti-Robinson (BR) metric. For a surface placed
outside the horizon there always exist bare stresses but their amplitude goes
to zero as the radius of the shell approaches that of the horizon. This limit
realizes the Wheeler idea of "mass without mass" and "charge without charge".
We generalize the model to the extremal Kerr-Newman metric glued to the
rotating analog of the BR metric.Comment: 23 pages. Misprints correcte
Compact x-ray source based on burst-mode inverse Compton scattering at 100 kHz
A design for a compact x-ray light source (CXLS) with flux and brilliance
orders of magnitude beyond existing laboratory scale sources is presented. The
source is based on inverse Compton scattering of a high brightness electron
bunch on a picosecond laser pulse. The accelerator is a novel high-efficiency
standing-wave linac and RF photoinjector powered by a single ultrastable RF
transmitter at x-band RF frequency. The high efficiency permits operation at
repetition rates up to 1 kHz, which is further boosted to 100 kHz by operating
with trains of 100 bunches of 100 pC charge, each separated by 5 ns. The entire
accelerator is approximately 1 meter long and produces hard x-rays tunable over
a wide range of photon energies. The colliding laser is a Yb:YAG solid-state
amplifier producing 1030 nm, 100 mJ pulses at the same 1 kHz repetition rate as
the accelerator. The laser pulse is frequency-doubled and stored for many
passes in a ringdown cavity to match the linac pulse structure. At a photon
energy of 12.4 keV, the predicted x-ray flux is
photons/second in a 5% bandwidth and the brilliance is in pulses with RMS pulse
length of 490 fs. The nominal electron beam parameters are 18 MeV kinetic
energy, 10 microamp average current, 0.5 microsecond macropulse length,
resulting in average electron beam power of 180 W. Optimization of the x-ray
output is presented along with design of the accelerator, laser, and x-ray
optic components that are specific to the particular characteristics of the
Compton scattered x-ray pulses.Comment: 25 pages, 24 figures, 54 reference
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