Bubbles on Manifolds with a U(1) Isometry

We investigate the construction of five-dimensional, three-charge supergravity solutions that only have a rotational U(1) isometry. We show that such solutions can be obtained as warped compactifications with a singular ambi-polar hyper-Kahler base space and singular warp factors. We show that the complete solution is regular around the critical surface of the ambi-polar base. We illustrate this by presenting the explicit form of the most general supersymmetric solutions that can be obtained from an Atiyah-Hitchin base space and its ambi-polar generalizations. We make a parallel analysis using an ambi-polar generalization of the Eguchi-Hanson base space metric. We also show how the bubbling procedure applied to the ambi-polar Eguchi-Hanson metric can convert it to a global AdS_2xS^3 compactification.Comment: 33 pages, 5 figures, LaTeX; references adde

Tolerable Movement Criteria for Highway Bridges

DOT-FH-11-9440This investigation included (a) a state-of-the-art assessment of tolerable bridge movements based on a literature review, an appraisal of existing design specifications and practice, the collection and analysis of field data on foundation movements, structural damage and the tolerance to movements for a large number of bridges (314) in the Unites States and Canada, and an appraisal of the reliability of the methods currently used for settlement prediction; (b) a series of analytical studies to evaluate the effect of different magnitudes and rates of differential movement on the potential level of distress produced in a wide variety of steel and concrete bridge structures of different span lengths and stiffnesses; and (c) the development of methodology for the design of bridges and their foundations that embodies a rational set of criteria for tolerable bridge movements

Polymerized bovine hemoglobin solution as a replacement for allogeneic red blood cell transfusion after cardiac surgery: Results of a randomized, double-blind trial

AbstractBackground: Blood loss leading to reduced oxygen-carrying capacity is usually treated with red blood cell transfusions. This study examined the hypothesis that a hemoglobin-based oxygen-carrying solution can serve as an initial alternative to red blood cell transfusion. Methods: In a randomized, double-blind efficacy trial of HBOC-201, a total of 98 patients undergoing cardiac surgery and requiring transfusion were randomly assigned to receive either red blood cell units or HBOC-201 (Hemopure; Biopure Corporation, Cambridge, Mass) for the first three postoperative transfusions. Patients were monitored before and after transfusion, at discharge, and at 3 to 4 weeks after the operation for subsequent red blood cell use, hemodynamics, and clinical laboratory parameters. Results: The use of HBOC-201 eliminated the need for red blood cell transfusions in 34% of cases (95% confidence interval 21%-49%). Patients in the HBOC group received a mean of 1.72 subsequent units of red blood cells; those who received red blood cells only received a mean of 2.19 subsequent units (P =.05). Hematocrit values were transiently lower in the HBOC group but were similar in the two groups at discharge and follow-up. Oxygen extraction was greater in the HBOC group (P =.05). Mean increases in blood pressure were greater in the HBOC group, but not significantly so. Conclusion: HBOC-201 may be an initial alternative to red blood cell transfusions for patients with moderate anemia after cardiac surgery. In a third of cases, HBOC-201 eliminated the need for red blood cell transfusion, although substantial doses were needed to produce this modest degree of blood conservation.J Thorac Cardiovasc Surg 2002;124:35-4

Quantum Attractor Flows

Motivated by the interpretation of the Ooguri-Strominger-Vafa conjecture as a holographic correspondence in the mini-superspace approximation, we study the radial quantization of stationary, spherically symmetric black holes in four dimensions. A key ingredient is the classical equivalence between the radial evolution equation and geodesic motion of a fiducial particle on the moduli space M^*_3 of the three-dimensional theory after reduction along the time direction. In the case of N=2 supergravity, M^*_3 is a para-quaternionic-Kahler manifold; in this case, we show that BPS black holes correspond to a particular class of geodesics which lift holomorphically to the twistor space Z of M^*_3, and identify Z as the BPS phase space. We give a natural quantization of the BPS phase space in terms of the sheaf cohomology of Z, and compute the exact wave function of a BPS black hole with fixed electric and magnetic charges in this framework. We comment on the relation to the topological string amplitude, extensions to N>2 supergravity theories, and applications to automorphic black hole partition functions.Comment: 43 pages, 6 figures; v2: typos and references added; v3: published version, minor change

Stellar structure and compact objects before 1940: Towards relativistic astrophysics

Since the mid-1920s, different strands of research used stars as "physics laboratories" for investigating the nature of matter under extreme densities and pressures, impossible to realize on Earth. To trace this process this paper is following the evolution of the concept of a dense core in stars, which was important both for an understanding of stellar evolution and as a testing ground for the fast-evolving field of nuclear physics. In spite of the divide between physicists and astrophysicists, some key actors working in the cross-fertilized soil of overlapping but different scientific cultures formulated models and tentative theories that gradually evolved into more realistic and structured astrophysical objects. These investigations culminated in the first contact with general relativity in 1939, when J. Robert Oppenheimer and his students George Volkoff and Hartland Snyder systematically applied the theory to the dense core of a collapsing neutron star. This pioneering application of Einstein's theory to an astrophysical compact object can be regarded as a milestone in the path eventually leading to the emergence of relativistic astrophysics in the early 1960s.Comment: 83 pages, 4 figures, submitted to the European Physical Journal

Quantizing N=2 Multicenter Solutions

N=2 supergravity in four dimensions, or equivalently N=1 supergravity in five dimensions, has an interesting set of BPS solutions that each correspond to a number of charged centers. This set contains black holes, black rings and their bound states, as well as many smooth solutions. Moduli spaces of such solutions carry a natural symplectic form which we determine, and which allows us to study their quantization. By counting the resulting wavefunctions we come to an independent derivation of some of the wall-crossing formulae. Knowledge of the explicit form of these wavefunctions allows us to find quantum resolutions to some apparent classical paradoxes such as solutions with barely bound centers and those with an infinitely deep throat. We show that quantum effects seem to cap off the throat at a finite depth and we give an estimate for the corresponding mass gap in the dual CFT. This is an interesting example of a system where quantum effects cannot be neglected at macroscopic scales even though the curvature is everywhere small.Comment: 49 pages + appendice

Novel genetic loci associated with hippocampal volume

The hippocampal formation is a brain structure integrally involved in episodic memory, spatial navigation, cognition and stress responsiveness. Structural abnormalities in hippocampal volume and shape are found in several common neuropsychiatric disorders. To identify the genetic underpinnings of hippocampal structure here we perform a genome-wide association study (GWAS) of 33,536 individuals and discover six independent loci significantly associated with hippocampal volume, four of them novel. Of the novel loci, three lie within genes (ASTN2, DPP4 and MAST4) and one is found 200 kb upstream of SHH. A hippocampal subfield analysis shows that a locus within the MSRB3 gene shows evidence of a localized effect along the dentate gyrus, subiculum, CA1 and fissure. Further, we show that genetic variants associated with decreased hippocampal volume are also associated with increased risk for Alzheimer's disease (rg =-0.155). Our findings suggest novel biological pathways through which human genetic variation influences hippocampal volume and risk for neuropsychiatric illness

Track E Implementation Science, Health Systems and Economics

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/138412/1/jia218443.pd

New insights into the genetic etiology of Alzheimer's disease and related dementias

Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'proxy' AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele