376 research outputs found

    Layers of Limbo: Governing Vulnerable & Displaced Populations in Thailand

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    In Thailand, the international community is confronted by one of the most protracted and complicated migration crises in the world. By examining this complex issue from the vantage point of a variety of stakeholders – the Royal Thai Government (RTG), United Nations High Commissioner for Refugees (UNHCR) and other international organizations, non-governmental organizations (NGOs), community-based organizations (CBOs), and donor governments (e.g. the United States) – our project aims to illuminate the divergent, at times contradictory, incentives that undermine cooperative efforts to find ‘durable solutions’ to protect vulnerable populations over the longer term. The project then draws from literature on experimental forms of governance to evaluate alternative pathways to overcome collective action problems that could have both theoretical and policy implications

    CAN THE SPLIT-STEP CUTTING TECHNIQUE REDUCE LOADING AND MAINTAIN PERFORMANCE?

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    INTRODUCTION: Cutting (evasive running) movements are integral to performance in many field- and court-based sports but have been associated with lower limb injuries. This injury risk is attributed to a combination of lower limb geometry and high forces acting together to stress anatomical structures, particularly at the ankle and knee joint. Alternative positioning of the stance foot and adjusted orientation of the lower limbs through changes to the cutting technique may reduce loading (e.g. Besier et al., 2001) but technique interventions for cutting have not been explicitly investigated in-depth. Therefore, the aim of this study was to compare the biomechanical characteristics of unplanned side-step (single foot contact) and split-step (double foot contact) cutting techniques, particularly relating to lower limb loading and ground reaction impulses generated during the primary cutting step. It was expected that the split-step would reduce joint loading and maintain performance requirements

    Treatment of malaria restricted to laboratory-confirmed cases: a prospective cohort study in Ugandan children.

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    BACKGROUND: Presumptive treatment of malaria in febrile children is widely advocated in Africa. This may occur in the absence of diagnostic testing or even when diagnostic testing is performed but fails to detect malaria parasites. Such over-treatment of malaria has been tolerated in the era of inexpensive and safe monotherapy. However, with the introduction of new artemisinin-based combination therapy (ACT), presumptive treatment becomes economically and clinically less acceptable. METHODS: The risks and benefits of only treating children with microscopy confirmed malaria using a prospective cohort design were investigated. A representative sample of 601 children between one and 10 years of age were recruited from a census population in Kampala, Uganda and were followed for all of their health care needs in a study clinic. Standard microscopy was performed each time a child presented with a new episode of fever and antimalarial therapy given only if the blood smear was positive. RESULTS: Of 5,895 visits for new medical problems 40% were for febrile illnesses. Of the 2,359 episodes of new febrile illnesses, blood smears were initially reported as negative in 1,608 (68%) and no antimalarial therapy was given. Six of these initially negative smears were reported to be positive following quality control reading of all blood smears: four of these patients were subsequently diagnosed with uncomplicated malaria and two cleared their parasites without antimalarial treatment. Of the 1,602 new febrile illnesses in which the final blood smear reading was classified as negative, only 13 episodes (0.8%) were diagnosed with malaria in the subsequent 7 days. All 13 of these episodes of malaria were uncomplicated and were successfully treated. CONCLUSION: In this urban setting, malaria was responsible for only 32% of febrile episodes. Withholding antimalarial therapy in febrile children with negative blood smears was safe and saved over 1,600 antimalarial treatments in 601 children over an 18-month period. In the era of expensive ACT, directing resources towards improving diagnostic and treatment practices may provide a cost-effective measure for promoting rational use of antimalarial therapy

    The Energy Sector and Groundwater

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    SPLIT-STEP VS SIDE-STEP EVASIVE RUNNING MANOEUVRES: WHICH IS MORE PROTECTIVE OF THE ACL?

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    Side-step movements are typically performed by athletes involved in sports that require the player to evade their opponents. However, the combination of internal rotation, valgus and flexion at the knee during side-stepping places high demands on the ACL such that these movements have been associated with a high incidence of ACL injury (Ebstrup & Bojsen-Moller, 2000). An alternative technique to the side-step is the split-step. Traditionally used in court sports, the split-step is characterised by a more symmetrical approach to the cut movement relative to the side-step and, due to the more even distribution of the ground reaction forces across two lower limbs, may provide greater protection to the ACL. However, as there has been no systematic comparison of the side-step versus the split-step technique, this study aimed to characterise differences in lower limb biomechanics during unplanned side-step and split-step movements, with implications for ACL injury prevention

    Factors predicting completion of a home visitation program by high-risk pregnant women: the North Carolina Maternal Outreach Worker Program

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    OBJECTIVES: This study sought to identify characteristics of high-risk pregnant women that predicted long-term participation in a home visitation program. METHODS: Data regarding sociodemographic characteristics, perceived needs, psychological functioning, substance use, and informal social support were collected prospectively from 152 short-term and 221 long-term program participants. RESULTS: In comparison with short-term participants, long-term participants were more likely to have been African American, married, nonsmokers, and enrolled in the program during their second trimester of pregnancy, and they were more likely to have had emotional and instrumental support needs. CONCLUSIONS: Women with greater social support needs and healthier behaviors were more receptive to long-term home visitation than other women

    Transcriptomic response of maize primary roots to low temperatures at seedling emergence

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    peer-reviewedBackground Maize (Zea mays) is a C4 tropical cereal and its adaptation to temperate climates can be problematic due to low soil temperatures at early stages of establishment. Methods In the current study we have firstly investigated the physiological response of twelve maize varieties, from a chilling condition adapted gene pool, to sub-optimal growth temperature during seedling emergence. To identify transcriptomic markers of cold tolerance in already adapted maize genotypes, temperature conditions were set below the optimal growth range in both control and low temperature groups. The conditions were as follows; control (18 °C for 16 h and 12 °C for 8 h) and low temperature (12 °C for 16 h and 6 °C for 8 h). Four genotypes were identified from the condition adapted gene pool with significant contrasting chilling tolerance. Results Picker and PR39B29 were the more cold-tolerant lines and Fergus and Codisco were the less cold-tolerant lines. These four varieties were subjected to microarray analysis to identify differentially expressed genes under chilling conditions. Exposure to low temperature during establishment in the maize varieties Picker, PR39B29, Fergus and Codisco, was reflected at the transcriptomic level in the varieties Picker and PR39B29. No significant changes in expression were observed in Fergus and Codisco following chilling stress. A total number of 64 genes were differentially expressed in the two chilling tolerant varieties. These two varieties exhibited contrasting transcriptomic profiles, in which only four genes overlapped. Discussion We observed that maize varieties possessing an enhanced root growth ratio under low temperature were more tolerant, which could be an early and inexpensive measure for germplasm screening under controlled conditions. We have identified novel cold inducible genes in an already adapted maize breeding gene pool. This illustrates that further varietal selection for enhanced chilling tolerance is possible in an already preselected gene pool

    DSM-5 criteria for substance use disorders: recommendations and rationale.

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    Since DSM-IV was published in 1994, its approach to substance use disorders has come under scrutiny. Strengths were identified (notably, reliability and validity of dependence), but concerns have also arisen. The DSM-5 Substance-Related Disorders Work Group considered these issues and recommended revisions for DSM-5. General concerns included whether to retain the division into two main disorders (dependence and abuse), whether substance use disorder criteria should be added or removed, and whether an appropriate substance use disorder severity indicator could be identified. Specific issues included possible addition of withdrawal syndromes for several substances, alignment of nicotine criteria with those for other substances, addition of biomarkers, and inclusion of nonsubstance, behavioral addictions.This article presents the major issues and evidence considered by the work group, which included literature reviews and extensive new data analyses. The work group recommendations for DSM-5 revisions included combining abuse and dependence criteria into a single substance use disorder based on consistent findings from over 200,000 study participants, dropping legal problems and adding craving as criteria, adding cannabis and caffeine withdrawal syndromes, aligning tobacco use disorder criteria with other substance use disorders, and moving gambling disorders to the chapter formerly reserved for substance-related disorders. The proposed changes overcome many problems, while further studies will be needed to address issues for which less data were available

    Temporal Trends in the Standing Broad Jump Performance of United States Children and Adolescents

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    Purpose: To estimate temporal trends in broad jump performance for United States youth, a marker of muscular fitness and health. Method: Electronic databases, topical systematic reviews, and personal libraries were systematically searched for studies reporting descriptive standing broad jump data for apparently healthy United States youth (age 10–17 years). Temporal trends at the sex-age level were estimated using sample-weighted regression models associating the year of testing to mean jump performance, with national trends standardized to the year 1985 using a post-stratified population-weighting procedure. Results: Collectively, there was a small increase of 12.6 cm (95%CI: 12.5 to 12.7) or 7.9% (95%CI: 7.1 to 8.6) in 65,527 United States youth between 1911 and 1990. Increases were greater for girls (change in means [95% CI]: 17.1 cm [16.9 to 17.3]; 11.4% [10.7 to 12.2]) compared to boys (change in means [95% CI]: 8.5 cm [8.3 to 8.7]; 4.6% [3.8 to 5.4]), but did not differ between children (10–12 years) and adolescents (13–17 years). Increases in broad jump performance were not always uniform across time, with steady and progressive increases observed for boys and children, respectively, and a diminishing rate of increase observed for girls and adolescents. Conclusions: Muscular fitness is a good marker of health, so greater broad jump performance from 1911 to 1990 may reflect corresponding changes in health. Routine assessment of broad jump performance may be useful to monitor trends in health and muscular fitness of United States youth due to its practicality, scalability, and predictive utility
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