Effects of Capsaicin and Evodiamine Ingestion on Energy Expenditure and Fat Oxidation at Rest and After Moderately-Intense Exercise in Young Men

Capsaicin and evodiamine are two thermogenic agents each recognized for their ability to stimulate the sympathetic nervous system and are thus found in many dietary supplements. Therefore, the purpose of this study was to observe the effects that capsaicin and evodiamine have on hemodynamics, energy expenditure, and markers of lipid oxidation while at rest and after a single bout of moderate-intensity exercise in young men. In a randomized, cross-over design, 11 men orally ingested 500 mg of capsaicin, evodiamine, or placebo while at rest after 30 minutes of resting energy expenditure assessment using open-circuit spirometry. After an additional 30 minutes of rest after supplement ingestion, resting energy expenditure was assessed again for 30 minutes. After the second resting energy expenditure assessment, treadmill exercise was performed until expending approximately 500 kilocalories (~30 minutes) at 65% peak oxygen consumption. Energy expenditure was assessed for another 30 minutes into the post-exercise period. Heart rate and blood pressure, core temperature, and venous blood samples were obtained 30 minutes before and one hour after supplement ingestion (i.e. immediately pre-exercise), and immediately after and 45 minutes post-exercise. Markers of lipid oxidation (serum glycerol, free fatty acids, serum glucose, epinephrine, and norepinephrine) were determined spectrophotometrically and with ELISA. Two-way analyses of variance (ANOVA) were performed for each dependent variable (p ≤ 0.05). Significant main effects for Time existed for hemodynamics, energy expenditure, serum catecholamines and markers of fat oxidation immediately following exercise (p \u3c 0.05). However, no significant Supplement x Time interactions were noted for any criterion variable (p \u3e 0.05), suggesting no preferential difference between supplements. Neither capsaicin nor evodiamine, at a single dose of 500 mg, are effective at inducing thermogenesis and increasing fat oxidation at rest or during exercise in young men

Efficacy of prenatal ultrasonography in diagnosing urogenital developmental anomalies in newborns.

BACKGROUND: Showing a prevalence rate of 0.5-0.8%, urogenital malformations discovered in newborns is regarded relatively common. The aim of this study is to examine the efficacy of ultrasound diagnostics in detecting developmental disorders in the urogenital system. METHODS: We have processed the prenatal sonographic and postnatal clinical details of 175 urogenital abnormalities in 140 newborns delivered with urogenital malformation according to EUROCAT recommendations over a 5-year period between 2006 and 2010. The patients were divided into three groups; Group 1: prenatal sonography and postnatal examinations yielded fully identical results. Group 2: postnatally detected urogenital changes were partially discovered in prenatal investigations. Group 3: prenatal sonography failed to detect the urogenital malformation identified in postnatal examinations. Urogenital changes representing part of certain multiple disorders associated with chromosomal aberration were investigated separately. RESULTS: Prenatal sonographic diagnosis and postnatal results completely coincided in 45%, i.e. 63/140 of cases in newborns delivered with urogenital developmental disorders. In 34/140 cases (24%), discovery was partial, while in 43/140 patients (31%), no urogenital malformation was detected prenatally. No associated malformations were observed in 108 cases, in 57 of which (53%), the results of prenatal ultrasonography and postnatal examinations showed complete coincidence. Prenatally, urogenital changes were found in 11 patients (10%), whereas no urogenital disorders were diagnosed in 40 cases (37%) by investigations prior to birth. Urogenital disorders were found to represent part of multiple malformations in a total of 28 cases as follows: prenatal diagnosis of urogenital malformation and the findings of postnatal examinations completely coincided in three patients (11%), partial coincidence was found in 22 newborns (79%) and in another three patients (11%), the disorder was not detected prenatally. In four newborns, chromosomal aberration was associated with the urogenital disorder; 45,X karyotype was detected in two patients, trisomy 9 and trisomy 18 were found in one case each. CONCLUSION: In approximately half of the cases, postnatally diagnosed abnormalities coincided with the prenatally discovered fetal urogenital developmental disorders. The results have confirmed that ultrasonography plays an important role in diagnosing urogenital malformations but it fails to detect all of the urogenital developmental abnormalities

SUCCOR Risk: Design and Validation of a Recurrence Prediction Index for Early-Stage Cervical Cancer

Objective: Based on the SUCCOR study database, our primary objective was to identify the independent clinical pathological variables associated with the risk of relapse in patients with stage IB1 cervical cancer who underwent a radical hysterectomy. Our secondary goal was to design and validate a risk predictive index (RPI) for classifying patients depending on the risk of recurrence. Methods: Overall, 1116 women were included from January 2013 to December 2014. We randomly divided our sample into two cohorts: discovery and validation cohorts. The test group was used to identify the independent variables associated with relapse, and with these variables, we designed our RPI. The index was applied to calculate a relapse risk score for each participant in the validation group. Results: A previous cone biopsy was the most significant independent variable that lowered the rate of relapse (odds ratio [OR] 0.31, 95% confidence interval [CI] 0.17–0.60). Additionally, patients with a tumor diameter >2 cm on preoperative imaging assessment (OR 2.15, 95% CI 1.33–3.5) and operated by the minimally invasive approach (OR 1.61, 95% CI 1.00–2.57) were more likely to have a recurrence. Based on these findings, patients in the validation cohort were classified according to the RPI of low, medium, or high risk of relapse, with rates of 3.4%, 9.8%, and 21.3% observed in each group, respectively. With a median follow-up of 58 months, the 5-year disease-free survival rates were 97.2% for the low-risk group, 88.0% for the medium-risk group, and 80.5% for the high-risk group (p < 0.001). Conclusion: Previous conization to radical hysterectomy was the most powerful protective variable of relapse. Our risk predictor index was validated to identify patients at risk of recurrence