Premisas para la reparación transformadora en el reconocimiento de vulneración a bienes constitucionales y convencionales en el marco de la responsabilidad del estado en Colombia.

El presente trabajo de grado tiene la finalidad de sumergirse entre las reflexiones del derecho de daños, para lograr identificar y establecer los presupuestos necesarios para el reconocimiento de los perjuicios inmateriales causados por afectaciones a bienes constitucionales y convencionales en el marco de la responsabilidad del Estado colombiano, haciendo especial énfasis en la vocación transformadora como medida para consolidar un proyecto jurídico, político y ético del aparato estatal acorde a las demandas de la actual sociedad, logro que se alcanza a través de los postulados de la justicia distributiva y la dignidad humana, sin olvidar los lineamientos otorgados por la compresión del enfoque diferencial

Effect of 15 BMI-Associated polymorphisms, reported for europeans, across ethnicities and degrees of amerindian ancestry in mexican children

In Mexico, the genetic mechanisms underlying childhood obesity are poorly known. We evaluated the effect of loci, known to be associated with childhood body mass index (BMI) in Europeans, in Mexican children from different ethnic groups. We performed linear and logistic analyses of BMI and obesity, respectively, in Mestizos and Amerindians (Seris, Yaquis and Nahuatl speakers) from Northern (n = 369) and Central Mexico (n = 8545). We used linear models to understand the effect of degree of Amerindian ancestry (AMA) and genetic risk score (GRS) on BMI z-score. Northern Mexican Mestizos showed the highest overweight-obesity prevalence (47.4%), followed by Seri (36.2%) and Central Mexican (31.5%) children. Eleven loci (SEC16B/rs543874, OLFM4/rs12429545/rs9568856, FTO/rs9939609, MC4R/rs6567160, GNPDA2/rs13130484, FAIM2/rs7132908, FAM120AOS/rs944990, LMX1B/rs3829849, ADAM23/rs13387838, HOXB5/rs9299) were associated with BMI and seven (SEC16B/rs543874, OLFM4/rs12429545/rs9568856, FTO/rs9939609, MC4R/rs6567160, GNPDA2 rs13130484, LMX1B/rs3829849) were associated with obesity in Central Mexican children. One SNP was associated with obesity in Northern Mexicans and Yaquis (SEC16B/rs543874). We found higher BMI z-score at higher GRS (β = 0.11, p = 0.2 × 10−16) and at lower AMA (β = −0.05, p = 6.8 × 10−7). The GRS interacts with AMA to increase BMI (β = 0.03, p = 6.08 × 10−3). High genetic BMI susceptibility increase the risk of higher BMI, including in Amerindian children

Effect of multi-component school-based program on body mass index, cardiovascular and diabetes risks in a multi-ethnic study

Background: Mexico occupies one of the first places worldwide in childhood obesity. Its Mestizo and Indigenous communities present different levels of westernization which have triggered different epidemiological diseases. We assessed the effects of a multi-component school-based intervention program on obesity, cardiovascular and diabetes risk factors. Methods: A physical activity, health education and parent involvement (PAHEPI) program was developed and applied in six urban (Mestizo ethnic group) and indigenous (Seri and Yaqui ethnic groups) primary schools for 12 weeks. A total of 320 children aged 4–12 years participated in intervention program; 203 under Treatment 1 (PAHEPI program) and 117, only from Mestizo groups, under Treatment 2 (PAHEPI+ school meals). For Body Mass Index (BMI), cardiovascular and diabetes factors, pairwise comparisons of values at baseline and after treatments were done using Wilcoxon signed rank test. Generalized linear models were applied to assess the intervention effect by age, sex and nutritional status in relation to ethnicity and treatment. Results: We observed improvements on BMI in children with overweight-obesity and in triglycerides in the three ethnic groups. The Mestizo ethnic group showed the largest improvements under Treatment 2. While Seris showed improvements only in cardiovascular risk factors, Yaquis also showed improvements in diabetes risk factors, though not in BMI. Conclusions: This study showed that the same intervention may have positive but different effects in different ethnic groups depending on their lifestyle and their emerging epidemiological disease. Including this type of intervention as part of the school curriculum would allow to adapt to ethnic group in order to contribute more efficiently to child welfare

Composite films combining electrospun fiber network and epitaxial oxide by chemical solution deposition

We report the preparation of a novel type of composites films by chemical solution deposition. It consists of an epitaxial oxide on a single crystal template inside which an oxide fiber network is dispersed. Electrospinning is used for the deposition of the fiber network whereas the continuous epitaxial phase is spin-coated. Good coating is observed between the liquid precursor of the continuous oxide and the fibers and remarkably, epitaxial (001) growth of the YBa2Cu3O7-x is not affected by the presence of the fiber network because both oxides do not react to each other. Topological continuity of the continuous phase is probed by electrical conductivity measurements, rendering nearly the same values reported for fiber-free films. Mechanical properties are determined by nanoindentation at low penetration depths to avoid the effect of the single crystal beneath the composite. Enhanced mechanical properties are found (hardness, Young's modulus, elastic recovery and wear resistance)

Chemical Solution Deposition of Insulating Yttria Nanolayers as Current Flow Diverter in Superconducting GdBa2Cu3O7-δ Coated Conductors

The primary benefit of a metallic stabilization/shunt in high temperature superconductor (HTS) coated conductors (CCs) is to prevent joule heating damage by providing an alternative path for the current flow during the HTS normal state transition (i.e., quench). However, the shunt presence in combination with unavoidable fluctuations in the critical current (I c) of the HTS film can develop a localized quench along the CC's length if the operational current is kept close to I c. This scenario, also known as the hot-spot regime, can lead to the rupture of the CC if the local quench does not propagate fast enough. The current flow diverter (CFD) is the CC architecture concept that has proven to increase the conductor's robustness against a hot-spot regime by simply boosting the quench velocity in the CC, which avoids the shunt compromise in some applications. This work investigates a practical manufacturing route for incorporating the CFD architecture in a reel-to-reel system via the preparation of yttrium oxide (Y2O3) as an insulating thin nanolayer (∼100 nm) on top of a GdBa2Cu3O7 (GdBCO) superconductor. Chemical solution deposition (CSD) using ink jet printing (IJP) is shown to be a suitable manufacturing approach. Two sequences of the experimental steps have been investigated, where oxygenation of the GdBCO layer is performed after or before the solution deposition and the Y2O3 nanolayer thermal treatment formation step. A correlated analysis of the microstructure, in situ oxygenation kinetics, and superconducting properties of the Ag/Y2O3/GdBCO trilayer processed under different conditions shows that a new customized functional CC can be prepared. The successful achievement of the CFD effect in the case of the preoxygenated customized CC was confirmed by measuring the current transfer length, thus demonstrating the effectiveness of the CSD-IJP as a processing method.We acknowledge the funding of this research by FASTGRID Project (EU-H2020, 721019); the Projects COACHSUPENERGY (MAT2014-51778-C2-1-R) and SUMATE (RTI2018-095853-BC21 and RTI2018-095853-B-C22) from the Spanish Ministry of Economy and Competitiveness, which were cofunded by the European Regional Development Fund; and the Project 2017-SGR 753 from Generalitat de Catalunya and the COST Action NANOCOHYBRI (CA16218). ICMAB authors also acknowledge the Center of Excellence awards Severo Ochoa SEV-2015-0496 and CEX2019-000917-SWith funding from the Spanish government through the ‘Severo Ochoa Centre of Excellence’ accreditation (CEX2019-000917-S).Peer reviewe

Knowledge Graphs Evolution and Preservation -- A Technical Report from ISWS 2019

One of the grand challenges discussed during the Dagstuhl Seminar "Knowledge Graphs: New Directions for Knowledge Representation on the Semantic Web" and described in its report is that of a: "Public FAIR Knowledge Graph of Everything: We increasingly see the creation of knowledge graphs that capture information about the entirety of a class of entities. [...] This grand challenge extends this further by asking if we can create a knowledge graph of "everything" ranging from common sense concepts to location based entities. This knowledge graph should be "open to the public" in a FAIR manner democratizing this mass amount of knowledge." Although linked open data (LOD) is one knowledge graph, it is the closest realisation (and probably the only one) to a public FAIR Knowledge Graph (KG) of everything. Surely, LOD provides a unique testbed for experimenting and evaluating research hypotheses on open and FAIR KG. One of the most neglected FAIR issues about KGs is their ongoing evolution and long term preservation. We want to investigate this problem, that is to understand what preserving and supporting the evolution of KGs means and how these problems can be addressed. Clearly, the problem can be approached from different perspectives and may require the development of different approaches, including new theories, ontologies, metrics, strategies, procedures, etc. This document reports a collaborative effort performed by 9 teams of students, each guided by a senior researcher as their mentor, attending the International Semantic Web Research School (ISWS 2019). Each team provides a different perspective to the problem of knowledge graph evolution substantiated by a set of research questions as the main subject of their investigation. In addition, they provide their working definition for KG preservation and evolution

Mammal responses to global changes in human activity vary by trophic group and landscape

Wildlife must adapt to human presence to survive in the Anthropocene, so it is critical to understand species responses to humans in different contexts. We used camera trapping as a lens to view mammal responses to changes in human activity during the COVID-19 pandemic. Across 163 species sampled in 102 projects around the world, changes in the amount and timing of animal activity varied widely. Under higher human activity, mammals were less active in undeveloped areas but unexpectedly more active in developed areas while exhibiting greater nocturnality. Carnivores were most sensitive, showing the strongest decreases in activity and greatest increases in nocturnality. Wildlife managers must consider how habituation and uneven sensitivity across species may cause fundamental differences in human–wildlife interactions along gradients of human influence.Peer reviewe

Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality

self-management information model in the sales force and leaders of Banco Davivienda S.A.

Este proyecto de investigación busca desarrollar desde el área de comunicaciones comerciales del Banco Davivienda S.A. un modelo de autogestión en las herramientas de comunicación interna autorizadas por la organización, Workplace y Conecta, basado en la comunicación efectiva, trabajo en equipo e integración de la organización, con el fin de promover en los líderes y la fuerza comercial un proceso detallado para adquirir información funcional para sus tareas cotidianas. En el desarrollo de este, se generaron actividades cualitativas que permitieron comprender las necesidades de los funcionarios en cuanto a las preferencias de formatos para la presentación de la información al igual que las oportunidades de mejora que identificaron en estas dos herramientas, las que conllevaron al desarrollo de una nueva campaña enfocada en la autogestión. Al considerar la implementación de una autogestión adecuada por parte de los funcionarios, se cree que se puede aumentar su desempeño laboral e incrementar la productividad de estos en sus jornadas cotidianas. Así mismo, se considera este el primer paso para el desarrollo de un modelo de autogestión completamente eficiente por parte de los funcionarios de Davivienda, implicando así que se deben continuar las diferentes supervisiones y controles para el desarrollo de nuevos modelos de autogestión. Finalmente, una de las principales recomendaciones es promover el uso de la herramienta de comunicación Workchat, con el fin de estimular la autogestión a través de la implementación del modelo de autogestión propuesto en este trabajo con capacitaciones en las herramientas Workplace y Conecta.This research project seeks to develop from the commercial communications area of Banco Davivienda S.A. a self-management model in the internal communication tools authorized by the organization, Workplace and Conecta, based on effective communication, teamwork, and integration of the organization, to promote in the leaders and the sales force a detailed process to acquire functional information for their daily tasks. In the development of this work, qualitative activities were generated that made it possible to understand the needs of the employees in terms of the preferences of formats for the presentation of the information as well as the opportunities for improvement that they identified in these two tools, which led to the development of a new campaign focused on self-management. By considering the implementation of adequate self-management by employees, it is believed that their work performance can be increased, and their productivity increased in their daily work. Likewise, this is considered the first step for the development of a completely efficient self-management model by Davivienda officials, thus implying that the different supervisions and controls should be continued for the development of new self-management models. Finally, one of the main recommendations is to promote the use of Workchat communication tool, to stimulate self-management through the implementation of the self-management model proposed in this work with training in Workplace tools and Conecta.Administrador (a) de EmpresasPregrad