Improved respiratory motion tracking through a novel fiducial marker placement guidance system during electromagnetic navigational bronchoscopy (ENB)

Background: Stereotactic ablative radiotherapy (SABR) is a treatment option for patients with early stage non-small cell lung cancer (NSCLC) and recurrent or oligometastatic disease who are not surgical candidates. Due to the continuous motion of tumors within the lungs, implementing a strategy to track the target lesion is crucial. One method is to place fiducial markers which the robotic SABR system is able to track during treatment. However, placing these markers in a manner that maximizes tracking efficacy can be challenging. Using a novel fiducial placement guidance system (FPGS) during fiducial deployment may offer a way to improve the quantity of fiducials tracked by the robotic SABR system. Method: This was an institutional, retrospective review identifying all patients who received robotic SABR for lung tumors from May 2015 until January 2017. The FPGS was instituted in May 2016. The median number of fiducials tracked and the rate of complication was compared between patients whose fiducials were placed using FPGS versus those that were not. Results: A total of 128 patients with 147 treated lung lesions were identified. Of the lesions that utilized FPGS (n = 44), 28 had 2 tracked fiducials (63.6%), 14 had 3 (31.8%) and 2 had 4 (4.6%). Of the lesions treated without FPGS (n = 103), 5 had 1 tracked fiducial (4.9%), 91 had 2 (88.4%), 6 had 3 (5.8%), and 2 had 4 (1.9%). A significant improvement in the median number of fiducials tracked per fraction was observed for the lesions with fiducials placed using FPGS on Wilcoxon rank sum test (p < 0.001). The rate of complication was low and not statistically different between cohorts (p = 0.44). Conclusions: The FPGS can be used during the deployment of fiducial markers and may increase the number of fiducials tracked

Libro Digital Proyectos Posgrados 2016-30

MaestríaDoctoradoDoctor en Ingeniería Eléctrica y ElectrónicaDoctor en Ingeniería CivilDoctor en Ingeniería de Sistemas y ComputaciónDoctor en Ingeniería IndustrialDoctor en Ingeniería MecánicaMagister en Gobierno de Tecnología InformáticaMagister en Ingeniería AdministrativaMagister en Ingeniería AmbientalMagister en Ingeniería CivilMagister en Ingeniería de Sistemas y ComputaciónMagister en Ingeniería EléctricaMagister en Ingeniería ElectrónicaMagister en Ingeniería IndustrialMagister en Ingeniería Mecánic

Perspectivas. Revista de historia, geografía, arte y cultura (Año 2 no. 4 jul-dic 2014)

Perspectivas: Revista de historia, geografía, arte y cultura; es un órgano de difusión periódica de trabajos arbitrados de la Universidad Nacional Experimental Rafael María Baralt (UNERMB), cuya esencia es dar a conocer las investigaciones en el área de las Ciencias Sociales. Debido a su naturaleza interdisciplinaria, se divide en cuatro áreas temáticas: historia, geografía, arte y cultura en lo concerniente a trabajos científicos. Asimismo, cuenta con un apartado para conferencias, ensayos, entrevistas, textos de carácter histórico, jurídico, acuerdos, declaraciones, reseñas de libros y revistas entre otros. Su publicación es semestral por año y número. Cada número está representado por artículos en cada una de las áreas temáticas de la revista. Por su carácter histórico y patrimonial la revista está adscrita al Centro de Estudios Socio Históricos y Culturales y al Proyecto de Ciencias Sociales de la UNERMB.Reflexiones Teóricas del Antiguo Régimen: Poder y Simbología p. 13 Rituales funerarios. El entierro en el Cementerio Corazón de Jesús de la ciudad de Maracaibo p. 35 Santiago del Estero a los ojos de viajeros y del cancionero: entre el estigma y la realidad p.47 Acercamiento a la valoración patrimonial del Cementerio El Cuadrado a través de la fotografía p.63 Plan estratégico para la promoción del balneario Agua Hedionda como potencial geoturístico en el municipio Rosario de Perijá p.83 La evolución histórica de los partidos políticos en la región andina venezolana hasta 1988 p.107 El Cabimo y Burro Negro conforma un pueblo de la Costa Oriental del Lago p.131 El problema en la investigación en historia: El conocimiento y el método. Un debate en el marco de la postmodernidad p.14

Phenotypic expansion of CACNA1C-associated disorders to include isolated neurological manifestations

International audiencePurpose:CACNA1C encodes the alpha-1-subunit of a voltage-dependent L-type calcium channel expressed in human heart and brain. Heterozygous variants in CACNA1C have previously been reported in association with Timothy syndrome and long QT syndrome. Several case reports have suggested that CACNA1C variation may also be associated with a primarily neurological phenotype.Methods:We describe 25 individuals from 22 families with heterozygous variants in CACNA1C, who present with predominantly neurological manifestations.Results:Fourteen individuals have de novo, nontruncating variants and present variably with developmental delays, intellectual disability, autism, hypotonia, ataxia, and epilepsy. Functional studies of a subgroup of missense variants via patch clamp experiments demonstrated differential effects on channel function in vitro, including loss of function (p.Leu1408Val), neutral effect (p.Leu614Arg), and gain of function (p.Leu657Phe, p.Leu614Pro). The remaining 11 individuals from eight families have truncating variants in CACNA1C. The majority of these individuals have expressive language deficits, and half have autism.Conclusion:We expand the phenotype associated with CACNA1C variants to include neurodevelopmental abnormalities and epilepsy, in the absence of classic features of Timothy syndrome or long QT syndrome