An n-sided polygonal model to calculate the impact of cyber security events

This paper presents a model to represent graphically the impact of cyber events (e.g., attacks, countermeasures) in a polygonal systems of n-sides. The approach considers information about all entities composing an information system (e.g., users, IP addresses, communication protocols, physical and logical resources, etc.). Every axis is composed of entities that contribute to the execution of the security event. Each entity has an associated weighting factor that measures its contribution using a multi-criteria methodology named CARVER. The graphical representation of cyber events is depicted as straight lines (one dimension) or polygons (two or more dimensions). Geometrical operations are used to compute the size (i.e, length, perimeter, surface area) and thus the impact of each event. As a result, it is possible to identify and compare the magnitude of cyber events. A case study with multiple security events is presented as an illustration on how the model is built and computed.Comment: 16 pages, 5 figures, 2 tables, 11th International Conference on Risks and Security of Internet and Systems, (CRiSIS 2016), Roscoff, France, September 201

Adaptive use of the Marshall theatre building at 4th St. and Houston Ave., Manhattan, Kansas

Call number: LD2668 .T4 ARCH 1987 G72Master of ArchitectureArchitectur

Clinical epigenomics: Genome-wide DNA methylation analysis for the diagnosis of Mendelian disorders

PURPOSE: We describe the clinical implementation of genome-wide DNA methylation analysis in rare disorders across the EpiSign diagnostic laboratory network and the assessment of results and clinical impact in the first subjects tested. METHODS: We outline the logistics and data flow between an integrated network of clinical diagnostics laboratories in Europe, the United States, and Canada. We describe the clinical validation of EpiSign using 211 specimens and assess the test performance and diagnostic yield in the first 207 subjects tested involving two patient subgroups: the targeted cohort (subjects with previous ambiguous/inconclusive genetic findings including genetic variants of unknown clinical significance) and the screening cohort (subjects with clinical findings consistent with hereditary neurodevelopmental syndromes and no previous conclusive genetic findings). RESULTS: Among the 207 subjects tested, 57 (27.6%) were positive for a diagnostic episignature including 48/136 (35.3%) in the targeted cohort and 8/71 (11.3%) in the screening cohort, with 4/207 (1.9%) remaining inconclusive after EpiSign analysis. CONCLUSION: This study describes the implementation of diagnostic clinical genomic DNA methylation testing in patients with rare disorders. It provides strong evidence of clinical utility of EpiSign analysis, including the ability to provide conclusive findings in the majority of subjects tested

De novo variants of NR4A2 are associated with neurodevelopmental disorder and epilepsy

PURPOSE: This study characterizes the clinical and genetic features of nine unrelated patients with de novo variants in the NR4A2 gene. METHODS: Variants were identified and de novo origins were confirmed through trio exome sequencing in all but one patient. Targeted RNA sequencing was performed for one variant to confirm its splicing effect. Independent discoveries were shared through GeneMatcher. RESULTS: Missense and loss-of-function variants in NR4A2 were identified in patients from eight unrelated families. One patient carried a larger deletion including adjacent genes. The cases presented with developmental delay, hypotonia (six cases), and epilepsy (six cases). De novo status was confirmed for eight patients. One variant was demonstrated to affect splicing and result in expression of abnormal transcripts likely subject to nonsense-mediated decay. CONCLUSION: Our study underscores the importance of NR4A2 as a disease gene for neurodevelopmental disorders and epilepsy. The identified variants are likely causative of the seizures and additional developmental phenotypes in these patients

Combining Technical and Financial Impacts for Countermeasure Selection

Research in information security has generally focused on providing a comprehensive interpretation of threats, vulnerabilities, and attacks, in particular to evaluate their danger and prioritize responses accordingly. Most of the current approaches propose advanced techniques to detect intrusions and complex attacks but few of these approaches propose well defined methodologies to react against a given attack. In this paper, we propose a novel and systematic method to select security countermeasures from a pool of candidates, by ranking them based on the technical and financial impact associated to each alternative. The method includes industrial evaluation and simulations of the impact associated to a given security measure which allows to compute the return on response investment for different candidates. A simple case study is proposed at the end of the paper to show the applicability of the model.Comment: In Proceedings AIDP 2014, arXiv:1410.322

Comparison of Two Fixation Methods in Treating Displaced Pediatric Tibial Eminence Fractures at Boston Childrens Hospital

Introduction: Tibial eminence fractures (TEF) occur most often in children, and disrupt the bony attachment of the anterior cruciate ligament (ACL) to the tibia. Displaced TEF are managed surgically with reduction and fixation of the displaced fragment. This study compares the two most common methods of surgical fixation, suture and screw fixation. Methods: A retrospective case-study review of 78 patients treated at Boston Childrens Hospital for tibial eminence fractures comparing surgical results following suture or screw fixation. Results: Seventy-eight tibial spine injuries were analyzed with an average age at surgery of 11. Thirty-six knees were treated with sutures versus 35 with screws. Sport related injuries were found to be the most common cause of TEF. Mild activity-related pain was reported in 23% of patients. It was noticed that concurrent meniscal pathology leads to statistically significantly higher rates of loss of flexion. The total complication rate of the cohort was found to be 33%. Conclusions: We concluded that no major outcome differences were seen with suture vs. screw fixation. Numerous observations can be made from this study regarding percentage of complications and residual symptoms. Future work will aim to follow patients prospectively for assessment of knee function

Factores motivacionales asociados con la participación estudiantil en el voluntariado universitario

La presente investigación tiene como objetivo general analizar los factores motivacionales asociados a la participación estudiantil en el voluntariado universitario, a través de determinar el perfil del voluntariado universitario de acuerdo a las características sociodemográficas de quienes participan y a través de la descripción de las principales motivaciones que impulsan la participación en los voluntariados universitarios. La metodología utilizada para la presente investigación es de tipo cuantitativo, de tipo descriptivo, de diseño no experimental y transversal. El instrumento utilizado es la escala de funciones en el voluntariado desarrollada por Clary & Snyder (1998). Los resultados sugieren un efecto positivo asociado a los factores motivacionales y las características sociodemográficas de quienes participan, lo cual produce un interés de las universidades por promover la participación de los estudiantes en los voluntariados universitarios.MaestríaMagister en Desarrollo Socia

PTPN4 germline variants result in aberrant neurodevelopment and growth

Protein-tyrosine phosphatases (PTPs) are pleomorphic regulators of eukaryotic cellular responses to extracellular signals that function by modulating the phosphotyrosine of specific proteins. A handful of PTPs have been implicated in germline and somatic human disease. Using exome sequencing, we identified missense and truncating variants i