625 research outputs found
A three-dimensional multidimensional gas-kinetic scheme for the Navier-Stokes equations under gravitational fields
This paper extends the gas-kinetic scheme for one-dimensional inviscid
shallow water equations (J. Comput. Phys. 178 (2002), pp. 533-562) to
multidimensional gas dynamic equations under gravitational fields. Four
important issues in the construction of a well-balanced scheme for gas dynamic
equations are addressed. First, the inclusion of the gravitational source term
into the flux function is necessary. Second, to achieve second-order accuracy
of a well-balanced scheme, the Chapman-Enskog expansion of the Boltzmann
equation with the inclusion of the external force term is used. Third, to avoid
artificial heating in an isolated system under a gravitational field, the
source term treatment inside each cell has to be evaluated consistently with
the flux evaluation at the cell interface. Fourth, the multidimensional
approach with the inclusion of tangential gradients in two-dimensional and
three-dimensional cases becomes important in order to maintain the accuracy of
the scheme. Many numerical examples are used to validate the above issues,
which include the comparison between the solutions from the current scheme and
the Strang splitting method. The methodology developed in this paper can also
be applied to other systems, such as semi-conductor device simulations under
electric fields.Comment: The name of first author was misspelled as C.T.Tian in the published
paper. 35 pages,9 figure
The atypical chemokine receptor Ackr2 constrains NK cell migratory activity and promotes metastasis
Chemokines have been shown to be essential players in a range of cancer contexts. In this study, we demonstrate that mice deficient in the atypical chemokine receptor Ackr2 display impaired development of metastasis in vivo in both cell line and spontaneous models. Further analysis reveals that this relates to increased expression of the chemokine receptor CCR2, specifically by KLRG1+ NK cells from the Ackr2−/− mice. This leads to increased recruitment of KLRG1+ NK cells to CCL2-expressing tumors and enhanced tumor killing. Together, these data indicate that Ackr2 limits the expression of CCR2 on NK cells and restricts their tumoricidal activity. Our data have important implications for our understanding of the roles for chemokines in the metastatic process and highlight Ackr2 and CCR2 as potentially manipulable therapeutic targets in metastasis
Exploring the Quality of Life of People in North Eastern and Southern Thailand.
The assumption that development brings not only material prosperity but also a better overall quality of life lies at the heart of the development project. Against this, critics assert that development can undermine social cohesion and threaten cultural integrity. Rarely, however, is the impact of development on wellbeing rigourously analysed using empirical data. This is what the Wellbeing in Developing Countries Group at the University of Bath aims to do drawing on fieldwork carried out in four developing countries, which addresses the themes of resources, needs, agency and structure, and subjective Quality of life (QoL). The first phase of the QoL research in Thailand aimed to explore the categories and components of quality of life for people from different backgrounds and locations with the aim of developing methods for QoL assessment in the third phase of the WeD QoL research. The study presents data obtained from rural and peri-urban sites in Southern and Northeastern Thailand (two villages in Songkhla and three in Khon Kaen, Mukdaharn, and Roi-et). Participants were divided into six groups by gender and age, and were divided again by religion (Buddhist and Muslim) and wealth status in the South. Data collection was conducted between October and December 2004 using focus group discussions, semi-structured interviews, and the Person Generated Index. Content analysis was used for data analysis. The use of a qualitative approach enabled the gathering of empirical data that reflects the sources of difficulty and happiness in the lives of participants. Respondents identified 26 aspects to their quality of life, including family relations, health and longevity, income and having money, jobs, housing, education, debt, and so on. The results reveal clear similarities and differences in the role of traditions, religious beliefs, and values in the lives of people living in remote rural or peri-urban areas in Northeastern and Southern Thailand. These results, together with the findings from Peru, Ethiopia, and Bangladesh, will inform the rest of the WeD research and be used to develop measures to assess the quality of life of people living in developing countries
Measurement of D-meson production at mid-rapidity in pp collisions at √s=7 TeV
The production cross sections for prompt charmed mesons D0, D+, D∗+ and D+s were measured at mid-rapidity in proton–proton collisions at a centre-of-mass energy √s=7 TeV with the ALICE detector at the Large Hadron Collider (LHC). D mesons were reconstructed from their decays D0→K−π+, D+→K−π+π+, D∗+→D0π+, D+s→ϕπ+→K−K+π+, and their charge conjugates.With respect to previous measurements in the same rapidity region, the coverage in transverse momentum (pT) is extended and the uncertainties are reduced by a factor of about two. The accuracy on the estimated total ccbar production cross section is likewise improved. The measured pT-differential cross sections are compared with the results of three perturbative QCD calculations.<br/
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