684 research outputs found
Glucose availability and sensitivity to anoxia of isolated rat peripheral nerve
The contrast between resistance to ischemia and ischemic lesions in peripheral nerves of diabetic patients was explored by in vitro experiments. Isolated and desheathed rat peroneal nerves were incubated in the following solutions with different glucose availability: 1) 25 mM glucose, 2) 2.5 mM glucose, and 3) 2.5 mM glucose plus 10 mM 2-deoxy-D-glucose. Additionally, the buffering power of all of these solutions was modified. Compound nerve action potential (CNAP), extracellular pH, and extracellular potassium activity (aKe) were measured simultaneously before, during, and after a period of 30 min of anoxia. An increase in glucose availability led to a slower decline in CNAP and to a smaller rise in aKe during anoxia. This resistance to anoxia was accompanied by an enhanced extracellular acidosis. Postanoxic recovery of CNAP was always complete in 25 mM HCO3(-)-buffered solutions. In 5 mM HCO3- and in HCO3(-)-free solutions, however, nerves incubated in 25 mM glucose did not recover functionally after anoxia, whereas nerves bathed in solutions 2 or 3 showed a complete restitution of CNAP. We conclude that high glucose availability and low PO2 in the combination with decreased buffering power and/or inhibition of HCO3(-)-dependent pH regulation mechanisms may damage peripheral mammalian nerves due to a pronounced intracellular acidosis
NMR Evidence for Charge Inhomogeneity in Stripe Ordered La_{1.8-x}Eu_{0.2}Sr_{x}CuO_4
We report ^{17}O Nuclear Magnetic Resonance (NMR) results in the stripe
ordered La_{1.8-x}Eu_{0.2}Sr_{x}CuO_4 system. Below a temperature T_q ~ 80K,
the local electric field gradient (EFG) and the absolute intensity of the NMR
signal of the planar O site exhibit a dramatic decrease. We interpret these
results as microscopic evidence for a spatially inhomogeneous charge
distribution, where the NMR signal from O sites in the domain walls of the spin
density modulation are wiped out due to large hyperfine fields, and the
remaining signal arises from the intervening Mott insulating regions.Comment: 4 pages, to appear in Phys. Rev. Let
Sticking under wet conditions: the remarkable attachment abilities of the torrent frog, staurois guttatus
Tree frogs climb smooth surfaces utilising capillary forces arising from an air-fluid interface around their toe pads, whereas torrent frogs are able to climb in wet environments near waterfalls where the integrity of the meniscus is at risk. This study compares the adhesive capabilities of a torrent frog to a tree frog, investigating possible adaptations for adhesion under wet conditions. We challenged both frog species to cling to a platform which could be tilted from the horizontal to an upside-down orientation, testing the frogs on different levels of roughness and water flow. On dry, smooth surfaces, both frog species stayed attached to overhanging slopes equally well. In contrast, under both low and high flow rate conditions, the torrent frogs performed significantly better, even adhering under conditions where their toe pads were submerged in water, abolishing the meniscus that underlies capillarity. Using a transparent platform where areas of contact are illuminated, we measured the contact area of frogs during platform rotation under dry conditions. Both frog species not only used the contact area of their pads to adhere, but also large parts of their belly and thigh skin. In the tree frogs, the belly and thighs often detached on steeper slopes, whereas the torrent frogs increased the use of these areas as the slope angle increased. Probing small areas of the different skin parts with a force transducer revealed that forces declined significantly in wet conditions, with only minor differences between the frog species. The superior abilities of the torrent frogs were thus due to the large contact area they used on steep, overhanging surfaces. SEM images revealed slightly elongated cells in the periphery of the toe pads in the torrent frogs, with straightened channels in between them which could facilitate drainage of excess fluid underneath the pad
Bounded Leviathan: or why North & Weingast are only right on the right half
‘Constitutions and Commitments” has inspired the economic literature on the importance of “Legal origins” (LaPorta et al., 1998, 2008), which vindicates the notion that post-Glorious Revolution English institutions were particularly conducive to economic growth. More recently economists have acknowledged that growth in fact depends on “state capacity”. This encompasses not only investor protection (legal capacity) but also the ability of the state to finance itself, “fiscal capacity”.(Besley and Persson, 2009, 2010) show that the protection of private property rights and that of public property rights to taxation are linked and most likely co-evolutionary. However, the precise relation between the two is anything but clear. This paper argues that North and Weingast’s model’s one-sided focus on state coercion that threatened subjects’ property rights has obscured the relation between coercion used in revenue collection and total revenue role of fiscal capacity.
We suggest a very simple model to show that this relationship between state fiscal capacity and legal capacity is not linear, especially in the phase of nation state building. The case of Spain provides empirical evidence for the existence of states were an increase in coercion would have improved fiscal capacity, but high levels of legal capacity paradoxically prevented the ruler from adopting this path. We use financial market developments to show the serious welfare implications that resulted from such a lack of coordination and integration
Spin Gap in the Single Spin-1/2 Chain Cuprate SrCaCuO
We report Cu nuclear magnetic resonance and muon spin rotation
measurements on the S=1/2 antiferromagnetic Heisenberg spin chain compound
SrCaCuO. An exponentially decreasing spin-lattice
relaxation rate 1/T indicates the opening of a spin gap. This behavior is
very similar to what has been observed for the cognate zigzag spin chain
compound SrCaCuO, and confirms that the occurrence of a
spin gap upon Ca doping is independent of the interchain exchange coupling
. Our results therefore generally prove the appearance of a spin gap in an
antiferromagnetic Heisenberg spin chain induced by a local bond disorder of the
intrachain exchange coupling . A low temperature upturn of 1/T evidences
growing magnetic correlations. However, zero field muon spin rotation
measurements down to 1.5 K confirm the absence of magnetic order in this
compound which is most likely suppressed by the opening of the spin gap.Comment: 5 pages, 4 figure
AC susceptibility investigation of vortex dynamics in nearly-optimally doped REFeAsOF superconductors (RE = La, Ce, Sm)
Ac susceptibility and static magnetization measurements were performed in the
nearly-optimally doped LaFeAsOF and CeFeAsOF
superconductors, complementing earlier results on SmFeAsOF
[Phys. Rev. {\bf B 83}, 174514 (2011)]. The magnetic field -- temperature phase
diagram of the mixed superconducting state is drawn for the three materials,
displaying a sizeable reduction of the liquid phase upon increasing in
the range of applied fields ( T). This result indicates that
SmFeAsOF is the most interesting compound among the
investigated ones in view of possible applications. The field-dependence of the
intra-grain depinning energy exhibits a common trend for all the
samples with a typical crossover field value (2500 Oe Oe) separating regions where single and collective depinning processes
are at work. Analysis of the data in terms of a simple two-fluid picture for
slightly anisotropic materials allows to estimate the zero-temperature
penetration depth and the anisotropy parameter for
the three materials. Finally, a sizeable suppression of the superfluid density
is deduced in a two-gap scenario
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