Critique of Microcredit as a Development Model

The field of microcredit (otherwise known as microfinance, microlending, or microcapital) has expanded rapidly since the 1980s as an economic means of lifting people out of poverty. Generally, microcredit has been accepted as an effective method for empowering both individuals and communities. In recent years, however, critics have brought to light some of the problems associated with microlending, such as the complex socioeconomic factors that can cause loan programs to fail. These problems stem from the basic tenet of microfinance: the need for lending programs to be managed locally in order to understand the needs of a community and assess the sustainability of each project. Lending programs vary a great deal around the world due to cultural differences, and the success of each must be evaluated in a geographic context. The industry of microfinance cannot be standardized due to these vitally important differences, and there are few organizations which have the ability to watch over the practices of individual lenders. As a result, microfinance institutions are largely free to practice autonomously; this independence is vital to the success of each project but also creates a void of authority

Building the Democracy We Need for the Twenty-First Century

This toolkit situates collaborative governance, also known as "co-governance," within a framework for building community that sees civic education, relationship building, and leadership development as essential first steps toward an effective and sustained participatory process. It offers key takeaways and best practices from effective, ongoing collaborative governance projects between communities and decision makers. The best of these projects shift decision-making power to the hands of communities to make room for more deliberation, consensus, and lasting change. Building on the lessons of successful case studies from across the United States, including Georgia, Kentucky, New York, and Washington, this toolkit aims to support local leaders inside and outside government as they navigate and execute co-governance models in their communities

Polynomials with the half-plane property and matroid theory

A polynomial f is said to have the half-plane property if there is an open half-plane H, whose boundary contains the origin, such that f is non-zero whenever all the variables are in H. This paper answers several open questions regarding multivariate polynomials with the half-plane property and matroid theory. * We prove that the support of a multivariate polynomial with the half-plane property is a jump system. This answers an open question posed by Choe, Oxley, Sokal and Wagner and generalizes their recent result claiming that the same is true whenever the polynomial is also homogeneous. * We characterize multivariate multi-affine polynomial with real coefficients that have the half-plane property (with respect to the upper half-plane) in terms of inequalities. This is used to answer two open questions posed by Choe and Wagner regarding strongly Rayleigh matroids. * We prove that the Fano matroid is not the support of a polynomial with the half-plane property. This is the first instance of a matroid which does not appear as the support of a polynomial with the half-plane property and answers a question posed by Choe et al. We also discuss further directions and open problems.Comment: 17 pages. To appear in Adv. Mat

Interventions to improve or maintain lower-limb function among ambulatory adolescents with cerebral palsy: a cross-sectional survey of current practice in the UK.

2 Objectives: To describe physiotherapy management to improve or maintain lower-limb 1 function among adolescents with cerebral palsy, classified in Gross Motor Function 2 Classification System levels I-III, in the United Kingdom. 3 Methods: A list of interventions was identified using a nominal group technique and 4 developed into a survey, which was distributed to approximately 2,100 paediatric 5 physiotherapists in the UK through the Association of Paediatric Chartered Physiotherapists 6 and a private physiotherapy clinic in London between April and June 2015. One-hundred and 7 thirty-five physiotherapists completed the survey. Survey respondents indicated how 8 frequently they used each intervention (i.e. “frequently”, “sometimes”, “rarely”, “never”) in 9 the past year. 10 Results: Provision of explanations to the child, liaison with families, liaison with health 11 professionals, provision of advice to schools, and stretching were the most frequently used 12 interventions with 90%, 90%, 86%, 79%, and 76% of respondents, respectively, reporting 13 that they frequently used each. The interventions most commonly reported as “never” used 14 were conductive education (88%), MOVE programme (85%), functional electrical 15 stimulation (82%), body-weight supported treadmill training (80%), and rebound therapy 16 (71%). 17 Conclusions: This study suggests that a large number of interventions are used by 18 physiotherapists in the UK to improve or maintain lower-limb function among adolescents 19 with CP, not all of which are evidence-based

The Lee-Yang and P\'olya-Schur Programs. II. Theory of Stable Polynomials and Applications

In the first part of this series we characterized all linear operators on spaces of multivariate polynomials preserving the property of being non-vanishing in products of open circular domains. For such sets this completes the multivariate generalization of the classification program initiated by P\'olya-Schur for univariate real polynomials. We build on these classification theorems to develop here a theory of multivariate stable polynomials. Applications and examples show that this theory provides a natural framework for dealing in a uniform way with Lee-Yang type problems in statistical mechanics, combinatorics, and geometric function theory in one or several variables. In particular, we answer a question of Hinkkanen on multivariate apolarity.Comment: 32 page

Revitalizing Civic Engagement through Collaborative Governance: Stories of Success From Around the United States

A growing level of political dysfunction and hyper-partisan polarization has led us to a critical point in the way we govern. With democracy under threat and deep distrust of democratic institutions, how can we instill innovative reforms centered around real influence and decision-making power? At a moment of extreme vulnerability, communities and civic organizations need to have genuine political agency by directly influencing policy decision-making. Collaborative governance—or "co-governance"—offers an opportunity to create new forms of civic power. This report offers lessons from across local, city, state, and federal policymaking and highlights effective models of co-governance from community leaders and those in government

Treatment outcomes of new tuberculosis patients hospitalized in Kampala, Uganda: a prospective cohort study.

BACKGROUND: In most resource limited settings, new tuberculosis (TB) patients are usually treated as outpatients. We sought to investigate the reasons for hospitalisation and the predictors of poor treatment outcomes and mortality in a cohort of hospitalized new TB patients in Kampala, Uganda. METHODS AND FINDINGS: Ninety-six new TB patients hospitalised between 2003 and 2006 were enrolled and followed for two years. Thirty two were HIV-uninfected and 64 were HIV-infected. Among the HIV-uninfected, the commonest reasons for hospitalization were low Karnofsky score (47%) and need for diagnostic evaluation (25%). HIV-infected patients were commonly hospitalized due to low Karnofsky score (72%), concurrent illness (16%) and diagnostic evaluation (14%). Eleven HIV uninfected patients died (mortality rate 19.7 per 100 person-years) while 41 deaths occurred among the HIV-infected patients (mortality rate 46.9 per 100 person years). In all patients an unsuccessful treatment outcome (treatment failure, death during the treatment period or an unknown outcome) was associated with duration of TB symptoms, with the odds of an unsuccessful outcome decreasing with increasing duration. Among HIV-infected patients, an unsuccessful treatment outcome was also associated with male sex (P = 0.004) and age (P = 0.034). Low Karnofsky score (aHR = 8.93, 95% CI 1.88 - 42.40, P = 0.001) was the only factor significantly associated with mortality among the HIV-uninfected. Mortality among the HIV-infected was associated with the composite variable of CD4 and ART use, with patients with baseline CD4 below 200 cells/µL who were not on ART at a greater risk of death than those who were on ART, and low Karnofsky score (aHR = 2.02, 95% CI 1.02 - 4.01, P = 0.045). CONCLUSION: Poor health status is a common cause of hospitalisation for new TB patients. Mortality in this study was very high and associated with advanced HIV Disease and no use of ART

Quantitative cross-species extrapolation between humans and fish: The case of the anti-depressant fluoxetine

This article has been made available through the Brunel Open Access Publishing Fund.Fish are an important model for the pharmacological and toxicological characterization of human pharmaceuticals in drug discovery, drug safety assessment and environmental toxicology. However, do fish respond to pharmaceuticals as humans do? To address this question, we provide a novel quantitative cross-species extrapolation approach (qCSE) based on the hypothesis that similar plasma concentrations of pharmaceuticals cause comparable target-mediated effects in both humans and fish at similar level of biological organization (Read-Across Hypothesis). To validate this hypothesis, the behavioural effects of the anti-depressant drug fluoxetine on the fish model fathead minnow (Pimephales promelas) were used as test case. Fish were exposed for 28 days to a range of measured water concentrations of fluoxetine (0.1, 1.0, 8.0, 16, 32, 64 μg/L) to produce plasma concentrations below, equal and above the range of Human Therapeutic Plasma Concentrations (HTPCs). Fluoxetine and its metabolite, norfluoxetine, were quantified in the plasma of individual fish and linked to behavioural anxiety-related endpoints. The minimum drug plasma concentrations that elicited anxiolytic responses in fish were above the upper value of the HTPC range, whereas no effects were observed at plasma concentrations below the HTPCs. In vivo metabolism of fluoxetine in humans and fish was similar, and displayed bi-phasic concentration-dependent kinetics driven by the auto-inhibitory dynamics and saturation of the enzymes that convert fluoxetine into norfluoxetine. The sensitivity of fish to fluoxetine was not so dissimilar from that of patients affected by general anxiety disorders. These results represent the first direct evidence of measured internal dose response effect of a pharmaceutical in fish, hence validating the Read-Across hypothesis applied to fluoxetine. Overall, this study demonstrates that the qCSE approach, anchored to internal drug concentrations, is a powerful tool to guide the assessment of the sensitivity of fish to pharmaceuticals, and strengthens the translational power of the cross-species extrapolation

Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations.

Asthma is a common disease with a complex risk architecture including both genetic and environmental factors. We performed a meta-analysis of North American genome-wide association studies of asthma in 5,416 individuals with asthma (cases) including individuals of European American, African American or African Caribbean, and Latino ancestry, with replication in an additional 12,649 individuals from the same ethnic groups. We identified five susceptibility loci. Four were at previously reported loci on 17q21, near IL1RL1, TSLP and IL33, but we report for the first time, to our knowledge, that these loci are associated with asthma risk in three ethnic groups. In addition, we identified a new asthma susceptibility locus at PYHIN1, with the association being specific to individuals of African descent (P = 3.9 × 10(-9)). These results suggest that some asthma susceptibility loci are robust to differences in ancestry when sufficiently large samples sizes are investigated, and that ancestry-specific associations also contribute to the complex genetic architecture of asthma

Convection and Retro-Convection Enhanced Delivery: Some Theoretical Considerations Related to Drug Targeting

Delivery of drugs and macromolecules into the brain is a challenging problem, due in part to the blood–brain barrier. In this article, we focus on the possibilities and limitations of two infusion techniques devised to bypass the blood–brain barrier: convection enhanced delivery (CED) and retro-convection enhanced delivery (R-CED). CED infuses fluid directly into the interstitial space of brain or tumor, whereas R-CED removes fluid from the interstitial space, which results in the transfer of drugs from the vascular compartment into the brain or tumor. Both techniques have shown promising results for the delivery of drugs into large volumes of tissue. Theoretical approaches of varying complexity have been developed to better understand and predict brain interstitial pressures and drug distribution for these techniques. These theoretical models of flow and diffusion can only be solved explicitly in simple geometries, and spherical symmetry is usually assumed for CED, while axial symmetry has been assumed for R-CED. This perspective summarizes features of these models and provides physical arguments and numerical simulations to support the notion that spherical symmetry is a reasonable approximation for modeling CED and R-CED. We also explore the potential of multi-catheter arrays for delivering and compartmentalizing drugs using CED and R-CED