Empirical comparison of diffusion kurtosis imaging and diffusion basis spectrum imaging using the same acquisition in healthy young adults

As diffusion tensor imaging gains widespread use, many researchers have been motivated to go beyond the tensor model and fit more complex diffusion models, to gain a more complete description of white matter microstructure and associated pathology. Two such models are diffusion kurtosis imaging (DKI) and diffusion basis spectrum imaging (DBSI). It is not clear which DKI parameters are most closely related to DBSI parameters, so in the interest of enabling comparisons between DKI and DBSI studies, we conducted an empirical survey of the interrelation of these models in 12 healthy volunteers using the same diffusion acquisition. We found that mean kurtosis is positively associated with the DBSI fiber ratio and negatively associated with the hindered ratio. This was primarily driven by the radial component of kurtosis. The axial component of kurtosis was strongly and specifically correlated with the restricted ratio. The joint spatial distributions of DBSI and DKI parameters are tissue-dependent and stable across healthy individuals. Our contribution is a better understanding of the biological interpretability of the parameters generated by the two models in healthy individuals

Early diagnosis, biomarkers and intervention in Alzheimer’s disease

New Trends in Dementia Diagnosis and CareDementia in Primary Care: Prevalence to Partnerships Thomas J. Grabowski MD Director, UW Memory and Brain Wellness Center Director, Alzheimer Disease Research Center University of Washingto

A role for left temporal pole in the retrieval of words for unique entities

r r Abstract: Both lesion and functional imaging studies have implicated sectors of high-order association cortices of the left temporal lobe in the retrieval of words for objects belonging to varied conceptual categories. In particular, the cortices located in the left temporal pole have been associated with naming unique persons from faces. Because this neuroanatomical-behavioral association might be related to either the specificity of the task (retrieving a name at unique level) or to the possible preferential processing of faces by anterior temporal cortices, we performed a PET imaging experiment to test the hypothesis that the effect is related to the specificity of the word retrieval task. Normal subjects were asked to name at unique level entities from two conceptual categories: famous landmarks and famous faces. In support of the hypothesis, naming entities in both categories was associated with increases in activity in the left temporal pole. No main effect of category (faces vs. landmarks/buildings) or interaction of task and category was found in the left temporal pole. Retrieving names for unique persons and for names for unique landmarks activate the same brain region. These findings are consistent with the notion that activity in the left temporal pole is linked to the level of specificity of word retrieval rather than the conceptual class to which the stimulus belongs. Hum. Brain Mapping 13:199–212, 2001. © 2001 Wiley-Liss, Inc. Key words: left temporal pole; language; word retrieval; functional imaging; face processing; naming r

The Prince William Sound Risk Assessment

After the grounding of the Exxon Valdez, and its subsequent oil spill, all parties with interests in Prince William Sound (PWS) were eager to prevent another major pollution event. While they implemented several measures to reduce the risk of an oil spill, the stakeholders disagreed about the effectiveness of these measures and the potential effectiveness of further proposed measures. They formed a steering committee to represent all the major stakeholders in the oil industry, in the government, in local industry and among the local citizens. The steering committee hired a consultant team, who created a detailed model of the PWS system, integrating system simulation, data analysis, and expert judgment. The model was capable of assessing the current risk of accidents involving oil tankers operating in the Prince William Sound and of evaluating measures aimed at reducing this risk. The risk model showed that actions taken prior to the study had reduced the risk of oil spill by 75 percent and identified measures estimated to reduce the accident frequency by an additional 68 percent, including improving the safety management systems of the oil companies and stationing an enhanced capability tug, called the Gulf Service, at Hinchinbrook Entrance. In all, various stakeholders made multi-million dollar investments to reduce the risk of further oil spills based on the results of the risk assessment

On the breakdown of perturbative integrability in large N matrix models

We study the perturbative integrability of the planar sector of a massive SU(N) matrix quantum mechanical theory with global SO(6) invariance and Yang-Mills-like interaction. This model arises as a consistent truncation of maximally supersymmetric Yang-Mills theory on a three-sphere to the lowest modes of the scalar fields. In fact, our studies mimic the current investigations concerning the integrability properties of this gauge theory. Like in the field theory we can prove the planar integrability of the SO(6) model at first perturbative order. At higher orders we restrict ourselves to the widely studied SU(2) subsector spanned by two complexified scalar fields of the theory. We show that our toy model satisfies all commonly studied integrability requirements such as degeneracies in the spectrum, existence of conserved charges and factorized scattering up to third perturbative order. These are the same qualitative features as the ones found in super Yang-Mills theory, which were enough to conjecture the all-loop integrability of that theory. For the SO(6) model, however, we show that these properties are not sufficient to predict higher loop integrability. In fact, we explicitly demonstrate the breakdown of perturbative integrability at fourth order.Comment: 27 page

The reorganization of proper nouns: treatment of proper noun retrieval deficits in an individual with temporal lobe epilepsy

The neural correlates of proper noun retrieval have been investigated through neuroimaging and lesion approaches. Neuroimaging studies investigating proper noun naming in neurologically healthy individuals have demonstrated the importance of the left anterior temporal lobe (ATL) to the integrity of proper noun naming (Gorno-Tempini, 2001; Grabowski, Damasio, & Tranel, 2000; Nakamura, et al., 2000; Tranel, 2009; Tsukiura, et al., 2002), while studies investigating proper noun production in individuals with left temporal lobe lesions have demonstrated a link between left ATL damage and proper noun retrieval deficits (Damasio, Grabowski, Tranel, Hichwa, & Damasio, 1996; Tranel, 2006, 2009; Tranel, Damasio, & Damasio, 1997; Tranel, Feinstein, & Manzel, 2008; Tsukiura, et al., 2002). Though patients with left temporal lobe epilepsy have mostly normal linguistic abilities, they consistently demonstrate deficits in proper noun retrieval (i.e., famous faces and places; Glosser, Salvucci, & Chiaravalloti, 2003; Griffith, et al., 2006; Seidenberg, et al., 2002; Viskontas, McAndrews, & Moscovitch, 2002)

Use of injectable hormonal contraception and women’s risk of herpes simplex virus type 2 acquisition: a prospective study of couples in Rakai, Uganda

Background The injectable hormonal contraceptive depo-medroxyprogesterone acetate (DMPA) has been associated with increased risk of HIV acquisition, but fi ndings are inconsistent. Whether DMPA increases the risk of other sexually transmitted viral infections is unknown. We assessed the association between DMPA use and incident herpes simplex virus type 2 (HSV2) infection in women. Methods In this prospective study, we enrolled HIV-negative and HSV2-negative women aged 15–49 years whose HIV-negative male partners were concurrently enrolled in a randomised trial of male circumcision in Rakai, Uganda. We excluded women if either they or their male partners HIV seroconverted. The primary outcome was HSV2 seroconversion, assessed annually. The male circumcision trial was registered with ClinicalTrials.gov, number NCT00425984. Findings Between Aug 11, 2003, and July 6, 2006, we enrolled 682 women in this study. We noted HSV2 seroconversions in 70 (10%) women. Incidence was 13·5 per 100 person-years in women consistently using DMPA (nine incident infections per 66·5 person-years), 4·3 per 100 person-years in pregnant women who were not using hormonal contraception (18 incident infections per 423·5 person-years), and 6·6 per 100 person-years in women who were neither pregnant nor using hormonal contraception (35 incident infections per 529·5 person-years). Women consistently using DMPA had an adjusted hazard ratio for HSV2 seroconversion of 2·26 (95% CI 1·09–4·69; p=0·029) compared with women who were neither pregnant nor using hormonal contraception. Of 132 women with HSV2-seropositive partners, seroconversion was 36·4 per 100 person-years in consistent DMPA users (four incident infections per 11 person-years) and 10·7 per 100 person-years in women who were neither pregnant nor using hormonal contraception (11 incident infections per 103 person-years; adjusted hazard ratio 6·23, 95% CI 1·49–26·3; p=0·012). Interpretation Consistent DMPA use might increase risk of HSV2 seroconversion; however, study power was low. These fi ndings should be assessed in larger populations with more frequent follow-up than in this study, and other contraceptive methods should also be assessed. Access to a wide range of highly eff ective contraceptive methods is needed for women, particularly in sub-Saharan Africa

Incidence of cognitively defined late-onset Alzheimer\u27s dementia subgroups from a prospective cohort study.

INTRODUCTION: There may be biologically relevant heterogeneity within typical late-onset Alzheimer\u27s dementia. METHODS: We analyzed cognitive data from people with incident late-onset Alzheimer\u27s dementia from a prospective cohort study. We determined individual averages across memory, visuospatial functioning, language, and executive functioning. We identified domains with substantial impairments relative to that average. We compared demographic, neuropathology, and genetic findings across groups defined by relative impairments. RESULTS: During 32,286 person-years of follow-up, 869 people developed Alzheimer\u27s dementia. There were 393 (48%) with no domain with substantial relative impairments. Some participants had isolated relative impairments in memory (148, 18%), visuospatial functioning (117, 14%), language (71, 9%), and executive functioning (66, 8%). The group with isolated relative memory impairments had higher proportions with ≥ APOE ε4 allele, more extensive Alzheimer\u27s-related neuropathology, and higher proportions with other Alzheimer\u27s dementia genetic risk variants. DISCUSSION: A cognitive subgrouping strategy may identify biologically distinct subsets of people with Alzheimer\u27s dementia

Regional brain response to visual food cues is a marker of satiety that predicts food choice

ABSTRACT Background: Neuronal processes that underlie the subjective experience of satiety after a meal are not well defined. Objective: We investigated how satiety alters the perception of and neural response to visual food cues. Design: Normal-weight participants (10 men, 13 women) underwent 2 fMRI scans while viewing images of high-calorie food that was previously rated as incompatible with weight loss and "fattening" and low-calorie, "nonfattening" food. After a fasting fMRI scan, participants ate a standardized breakfast and underwent reimaging at a randomly assigned time 15-300 min after breakfast to vary the degree of satiety. Measures of subjective appetite, food appeal, and ad libitum food intake (measured after the second fMRI scan) were correlated with activation by "fattening" (compared with "nonfattening") food cues in a priori regions of interest. Results: Greater hunger correlated with higher appeal ratings of "fattening" (r = 0.46, P = 0.03) but not "nonfattening" (r = 20.20, P = 0.37) foods. Fasting amygdalar activation was negatively associated with fullness (left: r = 20.52; right: r = 20.58; both P # 0.01), whereas postbreakfast fullness was positively correlated with activation in the dorsal striatum (right: r = 0.44; left: r = 0.45; both P , 0.05). After breakfast, participants with greater activation in 4 regions-medial orbital frontal cortex (r = 0.49, P , 0.05), left amygdala (r = 0.49, P , 0.05), left insula (r = 0.47, P , 0.05), and nucleus accumbens (right: r = 0.57, P , 0.01; left: r = 0.43, P , 0.05)-chose buffet foods with higher fat content. Conclusions: Postmeal satiety is shown in regional brain activation by images of high-calorie foods. Regions including the amygdala, nucleus accumbens, and dorsal striatum may alter perception of, and reduce motivation to consume, energy-rich foods, ultimately driving food choice. This trial was registered at clinicaltrials.gov as NCT01631045. Am J Clin Nutr 2012;96:989-99