Risk factors for periodontitis in HIV+ patients

Objectives: The purpose of this study was to identify risk factors for periodontitis in HIV+ patients. Methods: 152 HIV+ patients were recruited. Clinical measurements, gingival crevicular fluid (GCF) and plaque samples were taken from 8 sites of each patient at baseline and 6-month visits. GCF elastase was determined by measurement of p-Nitroanalide resulting from hydrolysis of a specific peptide. GCF b-glucuronidase (bG) was determined by release of 4-methylumbelliferone from hydrolysis of a specific substrate. An immunoassay was used to detect bacteria in plaque samples. Results: Viral load, age, smoking, P. intermedia (Pi) , F. nucleatum (Fn), A. actinomycetemcomitans (Aa), P. gingivalis, elastase, bG were correlated with clinical measurements (0.0001bG, (Pi), (Fn),and (Aa) were found at progressing sites than in nonprogressing sites (0.001Conclusions: These data indicate that age, smoking, viral load, (Pi), (Fn), (Aa), elastase and bG are risk factors for periodontitis in HIV+ patients. This study was supported by NIDCR grant DE12417