A study of variations in brachial artery and its branching pattern

Background: Knowledge of the normal and variant arterial anatomy of the upper extremity is of significant clinical importance for the vascular radiologist and surgeons for accurate diagnostic interpretation as well as in the conduct of interventional and surgical procedures on the upper extremity. The anatomical knowledge of the anomalous branching pattern of the brachial artery is important during percutaneous arterial catheterization, so as to prevent any complications arising from accidental damage to the anomalous vessel and knowledge of the variations are important for plastic surgeons using flaps for reconstructive surgeries.  Methods: The present study was undertaken on 50 upper limbs of both sexes from embalmed adult human cadaver used for undergraduate dissection from the department of Anatomy, Mandya Institute of Medical Sciences, Mandya.Results: In the present study, normal brachial artery was found in 42 specimens accounting for 84%. Variations were found in 8 specimens (16%); of these five specimens presented with trifurcation of brachial artery into radial, ulnar and radial recurrent arteries (10%); one specimen presented with double profunda brachii artery (2%); one specimen showed high origin of radial artery (2%) and one specimen presented with high division of brachial artery in the proximal third of arm (2%).  Conclusions: Accurate anatomical knowledge about the brachial artery and its branching pattern with their variations are important for physicians, cardiologists, vascular surgeons and interventional radiologists. Study of these variations and its awareness helps in avoiding the iatrogenic injuries of the blood vessels, in the management of accidental/traumatic injuries to arteries in upper limb and during diagnostic procedures (like arteriograms).

Performance of parthenocarpic and non-parthenocarpic grafts of cucumber

Effect of rootstock on yield and quality of cucumber scion was studied at Department of Vegetable Science, College of Agriculture, Vellayani, Thiruvananthapuram, Kerala during February-May, 2021. Parthenocarpic and non-parthenocarpic cucumber scions were grafted onto five different cultivated cucurbit species i.e. pumpkin, bottle gourd, oriental pickling melon, culinary melon and ash gourd. Significant variations were observed for all the traits under this study. The highest vine length (4.37 m) was observed in Heera scion grafted onto Lagenaria siceraria rootstock followed by Heera scion grafted onto Cucurbita moschata rootstock (4.13 m). The diameter of rootstock hypocotyl was higher in case of KPCH-1 grafted onto bottle gourd (1.48 mm) and Heera grafted onto bottle gourd (1.43 mm). KPCH-1 grafted on bottle gourd (29.33 days) and culinary melon (31 days) rootstocks showed early female flower initiation. The greater number of fruits was observed in graft combination of KPCH- 1 and bottle gourd (32) followed by parthenocarpic grafts with pumpkin (30.33) and ash gourd (30.33) rootstocks. A greater fruit weight was observed in graft combination of Heera and bottle gourd (7.51 kg) followed by Heera grafted onto pumpkin (7.38 kg). Results of this experiment suggest that these graft combinations can be employed in sustainable vegetable cultivation

Analytical assessment of Akika Pishti based on Ancient and Modern Parameters

Pishti Kalpana is one of the Kharaliya Kalpanas of Rasashastra which brings the heat sensitive substances to micro particle level without applying the heat for better therapeutic efficacy and is considered as Sukshma as Bhasma. In Rasa texts it is said that Marana of Ratna and Uparatna are not worthwhile hence, Pishti Kalpana is advocated. There is no direct reference for the Siddhilakshana of Pishti, but our Acharyas has mentioned that Pishti is a Anagnisidhdha Bhasma i.e. Pishti should be Bhasmavat, so the parameters mentioned for quality control of Bhasma in ancient text are applicable for assessing the Siddhilaxanas of Pishti. So an attempt has been made to study analytically Siddhilaxana of Pishti by both ancient and modern parameters with special reference to Akika Pishti. Akika is one of the semiprecious gem grouped under the Paradadi Varga, Uparatna Varga and Spatika Varga Ratna. In present study Pishti was prepared as per pharmacopeial standards and subjected to both ancient and modern tests to analyze viz. Pishtivarna, Mrudutva and Slakshanatva, Rekhapurnata, Varitara, Nirdhooma, Unama and Nischandratva tests according to classics and according to modern parameters like organoleptic tests, physio-chemical like LOD, pH, ash values, instrumental analysis like XRD , SEM-EDAX and particle size

Kinetics and mechanism of oxidation of erythro-series pentoses and hexoses by N-chloro-p-toluenesulfonamide

The kinetics and mechanism of oxidation of D-glucose, D-mannose, D-fructose, D-arabinose, and D-ribose with chloramine-T in alkaline medium were studied. The rate law, rate = k Chloramine-T] Sugar] HO-](2), was observed. The rate of the reaction was influenced by a change in ionic strength of the medium, and the dielectric effect was found to be negative. The latter enabled the computation of d(AB), the size of the activated complex. The reaction rate was almost doubled in deuterium oxide. Activation energies were calculated from the Arrhenius plots. HPLC and GLC-MS analyses of the products indicated that the sugars were oxidized to a mixture of aldonic acids, consisting of arabinonic, ribonic, erythronic, and glyceric acids. Based on these data, a plausible mechanism involving the aldo-enolic anions of pentoses and keto-enolic anions of hexoses is suggested. (C) 1998 Elsevier Science Ltd. All rights reserved

N-[(2-Hydr­oxy-1-naphth­yl)(2-hydroxy­phen­yl)meth­yl]acetamide

In the asymmetric unit of the title compound, C19H17NO3, there are two crystallographically independent mol­ecules, which are connected to each other by O—H⋯O hydrogen bonds, forming mol­ecular chains as well as cyclic centrosymmetric R 2 2(16) dimers

N-(Phenyl­sulfon­yl)naphtho­[2,1-b]furan-1-carboxamide

In the title compound, C19H13NO4S, the mol­ecule is twisted at the S atom with a C—S—N—C torsion angle of −65.2 (2)° between the benzene ring and the –SO2—NH—C=O segment. The dihedral angle between the benzene and the naphtho­furan ring system is 83.3 (1)°. In the crystal, mol­ecules are linked by N—H⋯O hydrogen bonds into chains running along the c axis. An intra­molecular N—H⋯O(furan) inter­action is also observed

Multicenter Validation of the Vasoactive-Ventilation-Renal Score as a Predictor of Prolonged Mechanical Ventilation After Neonatal Cardiac Surgery

Objectives: We sought to validate the Vasoactive-Ventilation-Renal score, a novel disease severity index, as a predictor of outcome in a multicenter cohort of neonates who underwent cardiac surgery. Design: Retrospective chart review. Setting: Seven tertiary-care referral centers. Patients: Neonates defined as age less than or equal to 30 days at the time of cardiac surgery. Interventions: Ventilation index, Vasoactive-Inotrope Score, serum lactate, and Vasoactive-Ventilation-Renal score were recorded for three postoperative time points: ICU admission, 6 hours, and 12 hours. Peak values, defined as the highest of the three measurements, were also noted. Vasoactive-Ventilation-Renal was calculated as follows: ventilation index + Vasoactive-Inotrope Score + Δ creatinine (change in creatinine from baseline × 10). Primary outcome was prolonged duration of mechanical ventilation, defined as greater than 96 hours. Receiver operative characteristic curves were generated, and abilities of variables to correctly classify prolonged duration of mechanical ventilation were compared using area under the curve values. Multivariable logistic regression modeling was also performed. Measurements and Main Results: We reviewed 275 neonates. Median age at surgery was 7 days (25th–75th percentile, 5–12 d), 86 (31%) had single ventricle anatomy, and 183 (67%) were classified as Society of Thoracic Surgeons-European Association for Cardio-Thoracic Surgery Congenital Heart Surgery Mortality Category 4 or 5. Prolonged duration of mechanical ventilation occurred in 89 patients (32%). At each postoperative time point, the area under the curve for prolonged duration of mechanical ventilation was significantly greater for the Vasoactive-Ventilation-Renal score as compared to the ventilation index, Vasoactive-Inotrope Score, and serum lactate, with an area under the curve for peak Vasoactive-Ventilation-Renal score of 0.82 (95% CI, 0.77–0.88). On multivariable analysis, peak Vasoactive-Ventilation-Renal score was independently associated with prolonged duration of mechanical ventilation, odds ratio (per 1 unit increase): 1.08 (95% CI, 1.04–1.12). Conclusions: In this multicenter cohort of neonates who underwent cardiac surgery, the Vasoactive-Ventilation-Renal score was a reliable predictor of postoperative outcome and outperformed more traditional measures of disease complexity and severity

An Hybrid Approach for Identification of Breast Cancer using Mammogram Images

Breast Cancer (BC) is the first among the cancer deaths in women all over the world. Mammography is broadly perceived as the best imaging methodology for the early location of BC. Mammography examination reduced the BC death in spite of increasing number of noticed malignancies during the last decade. Although it is the best reliable method for early location, it has several limitations. One essential viewpoint is that the exactness rate tends to diminishing when doctors' examined high volume of mammograms. This work mainly concentrates on identifying regions containing small clusters of micro calcifications to categorize the tissue as being regular or irregular. Potentially cancerous tissue is distinguished from normal tissue by analyzing features of a given region within a mammogram. Therefore, feature extraction and saliency play an important role in cancer detection

FORMULATION DEVELOPMENT AND EVALUATION OF ALMOND GUM BASED SUSTAINED RELEASE MATRIX TABLET OF INDOMETHACIN

Objective: The aspiration of the current research involves employing various concentrations of polymer and filler to develop indomethacin sustained release (SR) matrix tablets. The objective of this research work is to reduce dosing frequency thereby increasing patients compliance and enhanced therapeutic activity.Methods: Polymers such as Almond gum (AG), polyvinylpyrrolidone (PVP), and starch at different concentrations were used for formulating SR polymeric matrix tablets. Evaluation of pre-compression and post-compression parameters was done for both granules and formulated tablets.Results: Results obtained from pre-compression parameters and post-compression parameters suggested that all the parameters are within the prescribed limits, demonstrating that formulated granules had shown better flow properties. The morphological characteristics of the developed tablet were observed by employing scanning electron microscope where the surface of the tablet was found to be smooth from the in vitro dissolution study, combination of AG (30 mg) with PVP (30 mg), and starch used as a filler has sustained the release of drug up to 10 h.Conclusion: Therefore, developed polymeric matrix tablet exhibited enhanced potency over a conventional tablet by exhibiting an excellent dissolution profile for a period of 10 h