Gold(I) complexes bearing phosphole ligands: Synthesis and antimalarial activity

AbstractA series of gold(I)-monophosphole complexes have been synthesized and characterized. The introduction of a nitrogen moiety in the complex structure was envisioned either by choosing the bis(trifluoromethanesulfonyl)imidate ligand as the X-ligand or by preparing a new pyrrolidinophosphole ligand as the L-ligand. All the complexes have been evaluated in vitro for their antimalarial activity. These gold–phosphole complexes showed moderate activities with IC50 values ranging from 9.7 to 24 μM against Plasmodium falciparum chloroquine-resistant strains

Reins polykystiques chez le Porc

Névot Armand, Gouygou Charles, Hautefort Maurice. Reins polykystiques chez le Porc. In: Bulletin de l'Académie Vétérinaire de France tome 101 n°9, 1948. pp. 365-367

Chiral rhodium complexes covalently anchored on carbon nanotubes for enantioselective hydrogenation

Chiral rhodium hybrid nanocatalysts have been prepared by covalent anchorage of pyrrolidine-based diphosphine ligands onto functionalized CNTs. This work constitutes the first attempt at covalent anchoring of homogeneous chiral catalysts on CNTs. The catalysts, prepared with two different chiral phosphines, were characterized by ICP, XPS, N2 adsorption and TEM, and have been tested in the asymmetric hydrogenation of two different substrates: methyl 2-acetamidoacrylate and α-acetamidocinnamic acid. The hybrid nanocatalysts have shown to be active and enantioselective in the hydrogenation of α-acetamidocinnamic acid. A good recyclability of the catalysts with low leaching and without loss of activity and enantioselectivity was observed.The authors acknowledge the financial support from the Institut National Polytechnique de Toulouse (ENSIACET), the Centre National de la Recherche Scientifique, MICINN, Project MAT2012-32832, GVA and FEDER, Project Prometeo 2009/047, and MEC for the FPU scholarship of C.C.G

Reaction d'ouverture des diphosphirannes : les diphosphapropenes

SIGLECNRS T Bordereau / INIST-CNRS - Institut de l'Information Scientifique et TechniqueFRFranc