4 research outputs found
Antioxidant, Antinociceptive, and Anti-inflammatory Properties of the Ethanolic Extract of Combretum duarteanum in Rodents
This is a copy of an article published in the Journal of Medicinal Food© 2011 - copyright Mary Ann Liebert, Inc.; Journal of Medicinal Food is available online at: http://online.liebertpub.comThe antioxidant, antinociceptive, and anti-inflammatory activities of the ethanolic extract from leaves of Combretum duarteanum (EEC) were assessed in rodents through in vitro tests. The antioxidant activity was investigated by using thiobarbituric acid reactive species (TBARS), hydroxyl radical–scavenging, and scavenging activity of nitric oxide
assays. The antinociceptive activity was investigated by using acetic acid–induced writhing, formalin, and hot-plate tests in
mice. The anti-inflammatory activity was assessed in rats by using the carrageenan-induced hind-paw edema test and arachidonic acid–induced paw edema test. EEC possesses a strong antioxidant potential according to the TBARS, nitric oxide, and hydroxyl radical–scavenging assays; it also presented scavenger activity in all in vitro
tests. After intraperitoneal injection, EEC (100, 200, and 400 mg/kg) significantly reduced the number of writhes (38.1%, 90.6%, and 97.8%, respectively) in a writhing test and the number of paw licks during phase 1 (30.5% and 69.5%, higher doses) and phase 2 (38.1%, 90.6%, and 97.8%, all doses) of a formalin test when compared with the control group. Naloxone (1.5 mg/kg, intraperito-
neally) antagonized the antinociceptive action of EEC (400 mg/kg), and this finding suggests participation of the opioid
system. Administration of 200 and 400 mg/kg (intraperitoneally) of EEC exhibited an anti-inflammatory activity in the
carrageenin test, which was based on interference with prostaglandin synthesis. This finding was confirmed by the arachidonic
acid test. Together, these results indicate that properties of EEC might be further explored in the search for newer tools to treat painful inflammatory conditions, including those related to pro-oxidant states
Quality of life, socioeconomic and clinical factors, and physical exercise in persons living with HIV/AIDS
OBJETIVO Analisar se aspectos socioeconĂ´micos, clĂnicos e de hábitos de vida saudável estĂŁo associados Ă qualidade de vida em pessoas vivendo com HIV/aids. MÉTODOS Pesquisa quantitativa exploratĂłria de corte transversal, com 227 pessoas vivendo com HIV/aids, atendidos em dois hospitais de referĂŞncia entre os perĂodos de abril 2012 a junho de 2014. Foram utilizados questionários estruturados para avaliar aspectos socioeconĂ´micos (sexo, idade, escolaridade, estado civil, cor de pele, status socioeconĂ´mico, dependentes da renda familiar, vĂnculo empregatĂcio), parâmetros clĂnicos (tempo de diagnĂłstico da doença, uso e tempo de medicação, contagem de cĂ©lulas TCD4 e carga viral) e prática de exercĂcio fĂsico. Para avaliar qualidade de vida, utilizou-se o questionário Quality of Life (HAT-QoL). Para caracterização dos dados socioeconĂ´micos, clĂnicos e domĂnios da qualidade de vida, conduzimos análise descritiva (frequĂŞncia simples, mĂ©dias e desvios-padrĂŁo). Aplicamos regressĂŁo linear, seguindo um modelo hierárquico para cada domĂnio da qualidade de vida. RESULTADOS Os domĂnios que apresentaram menores mĂ©dias para a qualidade de vida foram preocupação financeira, preocupação com sigilo, função geral e satisfação com a vida. Foram encontradas associações com as variáveis status socioeconĂ´mico e exercĂcio fĂsico; terapia; e exercĂcio fĂsico para os dois Ăşltimos domĂnios, consecutivamente. CONCLUSĂ•ES A qualidade de vida de pessoas vivendo com HIV/aids apresentam prejuĂzos, principalmente nas questões financeiras e de sigilo, seguidos da função geral do corpo e satisfações com a vida, em que os aspectos socioeconĂ´micos, clĂnicos e hábitos de vida saudável, como a prática de exercĂcio fĂsico, sĂŁo fatores determinantes para essa realidade.OBJECTIVE To analyze whether socioeconomic and clinical aspects and the aspects of healthy life habits are associated with the quality of life of persons living with HIV/AIDS. METHODS This is a cross-sectional exploratory quantitative research, with 227 persons living with HIV/AIDS, treated at two hospitals of reference between April 2012 and June 2014. We used structured questionnaires to assess socioeconomic aspects (gender, age, education level, marital status, race, socioeconomic status, dependents on family income, employment relationship), clinical parameters (time of disease diagnosis, use and time of medication, CD4 T-cell count, and viral load), and practice of physical exercise. To assess quality of life, we used the Quality of Life questionnaire (HAT-QoL). For characterization of the socioeconomic and clinical data and domains of quality of life, we conducted a descriptive analysis (simple frequency, averages, and standard deviations). We applied linear regression, following a hierarchical model for each domain of quality of life. RESULTS The domains that presented lower averages for quality of life were financial concern, concern with confidentiality, general function, and satisfaction with life. We found associations with the variables of socioeconomic status and physical exercise, therapy, and physical exercise for the last two domains, consecutively. CONCLUSIONS The quality of life of persons living with HIV/AIDS shows losses, especially in the financial and confidentiality areas, followed by general function of the body and satisfaction with life, in which socioeconomic and clinical aspects and healthy living habits, such as the practice of physical exercise, are determining factors for this reality
MalĂcia honey (Mimosa quadrivalvis L.) produced by the jandaĂra bee (Melipona subnitida D.) improves anxious-like behaviour and has anti-adiposity effect in cafeteria diet-induced obese rats
This study evaluated the anti-adiposity and anxiolytic effects of malĂcia honey (MH) on obese rats. A total of 40 male Wistar rats were initially randomized into four groups: healthy (HG); obese (OG); and healthy (HGH) and obese (OGH) both treated with malĂcia honey by gavage (1000Â mg/kg). The rats consumed a control or cafeteria diet for 16Â weeks. Body weight, food intake, adiposity index, anxious-like behaviour and concentration of organic acids in the brain, intestine and faeces were analysed. Histological analyses were performed on adipose tissue and brain. MH showed procyanidin B1 and B2, epicatechin, and naringenin as the main polyphenols. The OGH had lower caloric intake (18Â %), body weight (12Â %) and lower adipocyte area compared to the OG. MH increased organic acids in biological materials and prevented the appearance of ischemic neurons. MH had an anti-adiposity effect, protected the nerve tissue and reversed anxious-like behaviour in obesity-induced rats