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Beyond 'Negotiation' Challenges of Participatory Projects for the Anthropology of Development

The notion of 'negotiated development' implies the 'unpacking' of a predetermined technological package by local brokers in accordance with their own needs and interests. Studies elaborating this proposition have given rise to a stimulating literature which generally defends the thesis that development interventions must be studied as only one element of a broader process of social change . I have been much inspired by the methodological foundations of this perspective, at the roots of which..

Beyond 'Negotiation' Challenges of Participatory Projects for the Anthropology of Development

The notion of 'negotiated development' implies the 'unpacking' of a predetermined technological package by local brokers in accordance with their own needs and interests. Studies elaborating this proposition have given rise to a stimulating literature which generally defends the thesis that development interventions must be studied as only one element of a broader process of social change . I have been much inspired by the methodological foundations of this perspective, at the roots of which..

The relationship between isometric mid-thigh pull force-time characteristics and swing performance in high-level youth golfers

The production of vertical ground reaction force has been suggested to relate directly to club head speed (CHS) in golfers, providing a rationale for the implementation of strength and conditioning to enhance performance. The aim of the study was to determine the relationship between isometric mid-thigh pull (IMTP) force-time characteristics and measures of swing performance (CHS and Carry) in high-level youth golfers. Thirteen high-level youth golfers selected for their National Squad performed IMTP and swing testing using a TrackMan launch monitor across two testing sessions. Results revealed significant correlations between IMTP Peak Force (PF) and 6-iron Carry (r=0.91, p<0.001), Driver Carry (r=0.91, p<0.001), 6-iron CHS (r=0.89, p<0.001) and Driver CHS (r=0.88, p<0.001). All other variables showed trivial to large non-significant correlations. Findings support the use of the IMTP as a testing tool in high-level youth golfers and emphasise the importance of strength training within this population

Embeddings, dimension groups and presentations of AF algebras, and the index of subfactors

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Cost-effectiveness of Implementing Low-Tidal Volume Ventilation in Patients With Acute Lung Injury

Background: Despite widespread guidelines recommending the use of lung-protective ventilation (LPV) in patients with acute lung injury (ALI), many patients do not receive this lifesaving therapy. We sought to estimate the incremental clinical and economic outcomes associated with LPV and determined the maximum cost of a hypothetical intervention to improve adherence with LPV that remained cost-effective. Methods: Adopting a societal perspective, we developed a theoretical decision model to determine the cost-effectiveness of LPV compared to non-LPV care. Model inputs were derived from the literature and a large population-based cohort of patients with ALI. Cost-effectiveness was determined as the cost per life saved and the cost per quality-adjusted life-years (QALYs) gained. Results: Application of LPV resulted in an increase in QALYs gained by 15% (4.21 years for non-LPV vs 4.83 years for LPV), and an increase in lifetime costs of $7,233 per patient with ALI ($99,588 for non-LPV vs $106,821 for LPV). The incremental cost-effectiveness ratios for LPV were$22,566 per life saved at hospital discharge and $11,690 per QALY gained. The maximum, cost-effective, per patient investment in a hypothetical program to improve LPV adherence from 50 to 90$9,482. Results were robust to a wide range of economic and patient parameter assumptions. Conclusions: Even a costly intervention to improve adherence with low-tidal volume ventilation in patients with ALI reduces death and is cost-effective by current societal standards.NIH F32HL090220.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/84154/1/Cooke - CEA LPV.pd

Characterisation of GLUT4 trafficking in HeLa cells: comparable kinetics and orthologous trafficking mechanisms to 3T3-L1 adipocytes

Insulin-stimulated glucose transport is a characteristic property of adipocytes and muscle cells and involves the regulated delivery of glucose transporter (GLUT4)-containing vesicles from intracellular stores to the cell surface. Fusion of these vesicles results in increased numbers of GLUT4 molecules at the cell surface. In an attempt to overcome some of the limitations associated with both primary and cultured adipocytes, we expressed an epitope- and GFP-tagged version of GLUT4 (HA–GLUT4–GFP) in HeLa cells. Here we report the characterisation of this system compared to 3T3-L1 adipocytes. We show that insulin promotes translocation of HA–GLUT4–GFP to the surface of both cell types with similar kinetics using orthologous trafficking machinery. While the magnitude of the insulin-stimulated translocation of GLUT4 is smaller than mouse 3T3-L1 adipocytes, HeLa cells offer a useful, experimentally tractable, human model system. Here, we exemplify their utility through a small-scale siRNA screen to identify GOSR1 and YKT6 as potential novel regulators of GLUT4 trafficking in human cells