Book Reviews

Review of Prehistory, by Derek Roe; Aspects of Prehistory, by Grahame Clark; World Prehistory, by Grahame Clark; Introductory Readings in Archaeology, by Brian M. Fagan, ed.; The Origins of Civilization, by Carroll L. Riley; The Archaeology of Early Man, by J. M. Coles and E. S. Higgs; Shipwrecks and Archaeology, by Peter Throckmorton; A History of Dyed Textiles, by Stuart Robinson; Food in Antiquity, by Don and Patricia Brothwell; World Archaeology, Vol. 1, nos. 1, 2, 3, by Roy Hodson and Colin Platt, eds.; The Structure and Growth of Australia's Aboriginal Population, by F. Lancaster Jones; Attitudes and Social Conditions, by Ronald Taft, John L. M. Dawson, and Pamela Beasley; Aboriginal Settlements, by J. P. M. Long; The Destruction of Aboriginal Society, by C. D. Rowley; Aboriginal Advancement to Integration, by H. P. Schapper

Spinor condensates and light scattering from Bose-Einstein condensates

These notes discuss two aspects of the physics of atomic Bose-Einstein condensates: optical properties and spinor condensates. The first topic includes light scattering experiments which probe the excitations of a condensate in both the free-particle and phonon regime. At higher light intensity, a new form of superradiance and phase-coherent matter wave amplification were observed. We also discuss properties of spinor condensates and describe studies of ground--state spin domain structures and dynamical studies which revealed metastable excited states and quantum tunneling.Comment: 58 pages, 33 figures, to appear in Proceedings of Les Houches 1999 Summer School, Session LXXI

Clientelistic networks and local corruption: Evidence from Western Crete DIMITRIOS CHRISTOPOULOS

In this article, the attitudes and interaction of local political and business elites in western Crete are examined by means of an attitudinal survey, triangulated with data from in-depth interviews, conducted between July and October 1991. The data examined indicate that the endemic prevalence of clientelistic networks creates the background for corruption, although evidence of corrupt practice is not strong. In this analysis it is presumed that the attitudes and perceptions of key actors are affected by a definition of corruption that is relevant to their particular civil society alone. Data analyzed here suggest that local élite attitudes towards corruption are not perceived to affect the standards of conduct at the local level. It can also be deduced that if corruption is linked to the problems of administrative efficiency and economic development of the region, these can be related to vertical clientelistic networks with the national centre

Updated Nucleosynthesis Constraints on Unstable Relic Particles

We revisit the upper limits on the abundance of unstable massive relic particles provided by the success of Big-Bang Nucleosynthesis calculations. We use the cosmic microwave background data to constrain the baryon-to-photon ratio, and incorporate an extensively updated compilation of cross sections into a new calculation of the network of reactions induced by electromagnetic showers that create and destroy the light elements deuterium, he3, he4, li6 and li7. We derive analytic approximations that complement and check the full numerical calculations. Considerations of the abundances of he4 and li6 exclude exceptional regions of parameter space that would otherwise have been permitted by deuterium alone. We illustrate our results by applying them to massive gravitinos. If they weigh ~100 GeV, their primordial abundance should have been below about 10^{-13} of the total entropy. This would imply an upper limit on the reheating temperature of a few times 10^7 GeV, which could be a potential difficulty for some models of inflation. We discuss possible ways of evading this problem.Comment: 40 pages LaTeX, 18 eps figure

Whole-genome sequencing reveals host factors underlying critical COVID-19

Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic variation influences the development of illness requiring critical care1 or hospitalization2,3,4 after infection with SARS-CoV-2. The GenOMICC (Genetics of Mortality in Critical Care) study enables the comparison of genomes from individuals who are critically ill with those of population controls to find underlying disease mechanisms. Here we use whole-genome sequencing in 7,491 critically ill individuals compared with 48,400 controls to discover and replicate 23 independent variants that significantly predispose to critical COVID-19. We identify 16 new independent associations, including variants within genes that are involved in interferon signalling (IL10RB and PLSCR1), leucocyte differentiation (BCL11A) and blood-type antigen secretor status (FUT2). Using transcriptome-wide association and colocalization to infer the effect of gene expression on disease severity, we find evidence that implicates multiple genes—including reduced expression of a membrane flippase (ATP11A), and increased expression of a mucin (MUC1)—in critical disease. Mendelian randomization provides evidence in support of causal roles for myeloid cell adhesion molecules (SELE, ICAM5 and CD209) and the coagulation factor F8, all of which are potentially druggable targets. Our results are broadly consistent with a multi-component model of COVID-19 pathophysiology, in which at least two distinct mechanisms can predispose to life-threatening disease: failure to control viral replication; or an enhanced tendency towards pulmonary inflammation and intravascular coagulation. We show that comparison between cases of critical illness and population controls is highly efficient for the detection of therapeutically relevant mechanisms of disease