Influence of L-carnitine on growth and plasma IGF-I from gilts harvested at three gestation lengths

Swine research, 2005 is known as Swine day, 2005A total of 59 gilts were used to determine the effects of supplemental L-carnitine on gilt growth and maternal insulin-like growth factor- I (IGF-I). Experimental treatments were arranged in a 2 × 3 factorial with main effects of L-carnitine (0 or 50 ppm) and day of gestation (40, 55, or 70). All gilts received a constant feed allowance of 3.86 lb/day and a topdress containing either 0 or 88 mg of Lcarnitine, starting on the first day of breeding. No differences (P>0.05) between treatments were observed for BW, estimated protein mass, or estimated fat mass at any gestation length. At d 70 of gestation, there was a numeric increase (P>0.10) in BW for the gilts fed L-carnitine, compared with those fed the control diet. At d 40 of gestation, gilts fed Lcarnitine tended to have greater (P = 0.10) backfat, compared with the gilts fed the control diet; but no differences (P>0.05) were observed in backfat on d 0, 55, or 70 of gestation. In addition, no differences (P>0.05) were observed in maternal IGF-I between treatments at any gestation length. Total and free plasma L-carnitine concentrations were similar (P>0.10) at d 0 of gestation, but concentrations were higher (P<0.01) by d 40 of gestation in the gilts fed L-carnitine. These results show that supplemental L-carnitine numerically increases BW of gestating gilts. This data represents the first part of an ongoing study, with the rest of the data being reported in subsequent publications

Application of zebrafish oculomotor behavior to model human disorders

To ensure high acuity vision, eye movements have to be controlled with astonishing precision by the oculomotor system. Many human diseases can lead to abnormal eye movements, typically of the involuntary oscillatory eye movements type called nystagmus. Such nystagmus can be congenital (infantile) or acquired later in life. Although the resulting eye movements are well characterized, there is only little information about the underlying etiology. This is in part owing to the lack of appropriate animal models. In this review article, we describe how the zebrafish with its quick maturing visual system can be used to model oculomotor pathologies. We compare the characteristics and assessment of human and zebrafish eye movements. We describe the oculomotor properties of the zebrafish mutant belladonna, which has non-crossing optical fibers, and is a particularly informative model for human oculomotor deficits. This mutant displays a reverse optokinetic response, spontaneous oscillations that closely mimic human congenital nystagmus and abnormal motor behavior linked to circular vection