66 research outputs found
Subluxación vertebral como complicación a una descompresión ventral-cervical slot
Este trabajo describe un caso clínico de hernia discal cervical Hansen tipo I en un perro de raza Alaska malamute de 4 años de edad que fue resuelta mediante descompresión ventral, creando un slot con el fin de retirar el material extruido. La evolución fue buena pero, a las 5 semanas de la cirugía, se produjo una subluxación y colapso vertebral en el lugar donde se había practicado la descompresión. Se trató la inestabilidad mediante tornillos. de 4 mm de diámetro anclados en los cuerpos vertebrales adyacentes y cemento de metil-metacrilato.A case of Hansen Type I cervical disk herniation in a 4-year-old Alaska malamute is described. Surgical treatment consisted of a ventral decompression through a slot in order to retrieve the extruded material. The follow-up period was uneventful until subluxation and vertebral collapse ocurred at the surgical site 5 weeks postoperatively. The subluxation was stabilized with 4 mm. screws and methylmetacrilate bone cement
Hepatozoonosis canina.Estudio retrospectivo de 8 casos clínicos
Se describen ocho casos de hepatozonoosis canina diagnosticados en la Clínica Veterinaria Canis mediante identificación del microorganismo en extensiones de sangre y lo médula ósea. Se incluyen el cuadro clínico, pruebas laboratoriales de diagnóstico, pautas de tratamiento y evolución clínica.Hight cases of canine hepatozoonosis diagnosed at Clinica Veterinaria Canis by identzfication of the organism on blood and/or bone marrow smears are descried. Clinical signs, hematologic and biochemistry findings, diferent treatment, protocols and jollow up are included
Eficacia de la ivermectina oral en el tratamiento de la sarna demodécica canina resistente al almitraz
Se describen dos casos de sarna demodécica canina resistente al amitraz, tratados con ivermectina por vía oral a dosis de 600 mcg/kg durante 3 y 5 meses respectivamente.Two cases of amitraz-resistant generalized demodicosis treated with ivermectin 600 mcg/kg during 3 and 5 months respectiuely
Investigating SSH Research and Publication Practices in Disciplinary and Institutional Contexts. A Survey-Based Comparative Approach in Two Universities
In this paper, we comparatively analyze, present and discuss the results from a survey on increasing the visibility of research achievements in the social sciences and humanities (SSH) that was carried out at the University of Vienna (Austria) and the University of Navarra (Spain) in 2016 and 2017. Covering four major topics—searching and finding literature, publishing, the visibility of research, and the assessment of research outputs—we ask the following questions: are there disciplinary differences to be identified, and how do they present themselves in the two institutional contexts? Discussing the results, we showcase how disciplinary and institutional traditions and contexts are important factors that influence research and publication practices in the SSH. Our results indicate that the practices of searching and finding literature as well as publication practices and behavior are shaped by disciplinary traditions and epistemic cultures. On the contrary, assessment and valuation of research outputs are influenced by institutional and national contexts in which SSH research is organized and carried out
Reviewing, indicating, and counting books for modern research evaluation systems
In this chapter, we focus on the specialists who have helped to improve the
conditions for book assessments in research evaluation exercises, with
empirically based data and insights supporting their greater integration. Our
review highlights the research carried out by four types of expert communities,
referred to as the monitors, the subject classifiers, the indexers and the
indicator constructionists. Many challenges lie ahead for scholars affiliated
with these communities, particularly the latter three. By acknowledging their
unique, yet interrelated roles, we show where the greatest potential is for
both quantitative and qualitative indicator advancements in book-inclusive
evaluation systems.Comment: Forthcoming in Glanzel, W., Moed, H.F., Schmoch U., Thelwall, M.
(2018). Springer Handbook of Science and Technology Indicators. Springer Some
corrections made in subsection 'Publisher prestige or quality
Local delivery of optimized nanobodies targeting the PD-1/PD-L1 axis with a self-amplifying RNA viral vector induces potent antitumor responses
Despite the success of immune checkpoint blockade for cancer therapy, many patients do not respond
adequately. We aimed to improve this therapy by optimizing both the antibodies and their delivery route, using
small monodomain antibodies (nanobodies) delivered locally with a self-amplifying RNA (saRNA) vector based
on Semliki Forest virus (SFV). We generated nanobodies against PD-1 and PD-L1 able to inhibit both human and
mouse interactions. Incorporation of a dimerization domain reduced PD-1/PD-L1 IC50 by 8- and 40-fold for antiPD-L1 and anti-PD-1 nanobodies, respectively. SFV viral particles expressing dimeric nanobodies showed a
potent antitumor response in the MC38 model, resulting in >50% complete regressions, and showed better
therapeutic efficacy compared to vectors expressing conventional antibodies. These effects were also observed in
the B16 melanoma model. Although a short-term expression of nanobodies was observed due to the cytopathic
nature of the saRNA vector, it was enough to generate a strong proinflammatory response in tumors, increasing
infiltration of NK and CD8+ T cells. Delivery of the SFV vector expressing dimeric nanobodies by local plasmid
electroporation, which could be more easily translated to the clinic, also showed a potent antitumor effect
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