Mapping same-sex couple family households in Australia

The map (1:1,218,987) accompanying this report is the first to depict the distribution of same-sex couple family households across Australia. The map and the report contribute to emerging scholarship combining critical geographies of sexualities with quantitative techniques and GIS in order to advance the political claims of sexual minorities. The data were collected through the 2006 Census and obtained via consultation with the Australian Bureau of Statistics. These data included the number of same-sex couple family households for all Statistical Divisions across Australia and for Statistical Sub-Divisions within metropolitan capital cities. Geographical concentrations of same-sex couple family households were determined by calculating the proportion of couple family households that were same-sex in each Statistical Division and Statistical Sub-Division, since the Census defines same-sex couples as a subset of couple family households. To visualise where the proportions fell above and below the national average, and thus where concentrations were found, these ratios were converted to location quotients using the Australian average as the denominator. The map combines different scales – Statistical Divisions and Statistical Sub-Divisions – to illustrate distributional patterns between inner-city and suburban areas, as well as between urban and regional localities, across Australia. While high concentrations are found in inner-cities, there are also significant suburban and regional concentrations, thus contesting assumptions about same-sex couples’ inner-city residential choices. Moreover, since same-sex couples were found in most Statistical Divisions, those areas below the national average cannot be considered devoid of these families, with implications for the effective operationalisation of equal rights legislation

Mapping same-sex couple family households in Australia

The map (1:1,218,987) accompanying this report is the first to depict the distribution of same-sex couple family households across Australia. The map and the report contribute to emerging scholarship combining critical geographies of sexualities with quantitative techniques and GIS in order to advance the political claims of sexual minorities. The data were collected through the 2006 Census and obtained via consultation with the Australian Bureau of Statistics. These data included the number of same-sex couple family households for all Statistical Divisions across Australia and for Statistical Sub-Divisions within metropolitan capital cities. Geographical concentrations of same-sex couple family households were determined by calculating the proportion of couple family households that were same-sex in each Statistical Division and Statistical Sub-Division, since the Census defines same-sex couples as a subset of couple family households. To visualise where the proportions fell above and below the national average, and thus where concentrations were found, these ratios were converted to location quotients using the Australian average as the denominator. The map combines different scales – Statistical Divisions and Statistical Sub-Divisions – to illustrate distributional patterns between inner-city and suburban areas, as well as between urban and regional localities, across Australia. While high concentrations are found in inner-cities, there are also significant suburban and regional concentrations, thus contesting assumptions about same-sex couples’ inner-city residential choices. Moreover, since same-sex couples were found in most Statistical Divisions, those areas below the national average cannot be considered devoid of these families, with implications for the effective operationalisation of equal rights legislation

Transient motion of a circular plate after an impact

The transient response of a flat circular plate to a sudden impact has been studied experimentally and theoretically. High-speed electronic speckle pattern interferometry reveals the presence of pulses that travel around the edge of the plate ahead of the bending motion initiated by the strike. It is found that the transient motion of the plate is well described by Kirchhoff thin-plate theory over a time approximately equal to the time required for the initial impulse to circumvent the plate; however, a more sophisticated model is required to describe the motion after this time has elapsed

Experimental demonstration of the relationship between the second- and third-order polarizabilities of conjugated donor-acceptor molecules

The dependence of the second- and third-order polarizabilities ((beta) and (gamma) ) on ground-state polarization was measured for a series of donor-acceptor polyenes using electric field induced second harmonic generation and third harmonic generation, respectively. The changes in ground-state polarization, associated with the donor/acceptor strength or solvent polarity, were probed by x-ray crystallography, 1H-NMR, electronic absorption, and Raman spectroscopies. The observed behavior of (beta) and (gamma) as a function of ground- state polarization agrees well with theoretical predictions. In particular, positive and negative peaks, as well as sign changes, were observed for both (beta) and (gamma) . The dependences for (beta) and (gamma) are consistent with a derivative relationship between them. In addition, the third-order polarizability of a series of molecules possessing zero bond length alternation was found to be negative, in agreement with predictions based on the relationship between the polarizabilities and ground-state geometry

Structural basis of allosteric and synergistic activation of AMPK by furan-2-phosphonic derivative C2 binding

The metabolic stress-sensing enzyme AMP-activated protein kinase (AMPK) is responsible for regulating metabolism in response to energy supply and demand. Drugs that activate AMPK may be useful in the treatment of metabolic diseases including type 2 diabetes. We have determined the crystal structure of AMPK in complex with its activator 5-(5-hydroxyl-isoxazol-3-yl)-furan-2-phosphonic acid (C2), revealing two C2-binding sites in the γ-subunit distinct from nucleotide sites. C2 acts synergistically with the drug A769662 to activate AMPK α1-containing complexes independent of upstream kinases. Our results show that dual drug therapies could be effective AMPK-targeting strategies to treat metabolic diseases

Highdicom: A Python library for standardized encoding of image annotations and machine learning model outputs in pathology and radiology

Machine learning is revolutionizing image-based diagnostics in pathology and radiology. ML models have shown promising results in research settings, but their lack of interoperability has been a major barrier for clinical integration and evaluation. The DICOM a standard specifies Information Object Definitions and Services for the representation and communication of digital images and related information, including image-derived annotations and analysis results. However, the complexity of the standard represents an obstacle for its adoption in the ML community and creates a need for software libraries and tools that simplify working with data sets in DICOM format. Here we present the highdicom library, which provides a high-level application programming interface for the Python programming language that abstracts low-level details of the standard and enables encoding and decoding of image-derived information in DICOM format in a few lines of Python code. The highdicom library ties into the extensive Python ecosystem for image processing and machine learning. Simultaneously, by simplifying creation and parsing of DICOM-compliant files, highdicom achieves interoperability with the medical imaging systems that hold the data used to train and run ML models, and ultimately communicate and store model outputs for clinical use. We demonstrate through experiments with slide microscopy and computed tomography imaging, that, by bridging these two ecosystems, highdicom enables developers to train and evaluate state-of-the-art ML models in pathology and radiology while remaining compliant with the DICOM standard and interoperable with clinical systems at all stages. To promote standardization of ML research and streamline the ML model development and deployment process, we made the library available free and open-source

Direct observation of reduced bond-length alternation in donor/acceptor polyenes

There has been tremendous interest in asymmetric cyanine and merocyanine compounds because of their applications as photographic sensitizers, membrane potential probe, and photochromic dyes for all-optical memory. On the basis of UV-visible spectroscopic data, Brooker suggested that merocyanine molecules could be described by a superposition of neutral and charge-separated canonical resonance forms and that, by changing the basicity of the endgroups and/or the solvent polarity, one could tune the molecular structure from neutral and polyene-like through polar and cyanine-like (with equal contributions from neutral and charge-separated resonance forms) to highly polar, charge-separated polyene-like

Direct observation of reduced bond-length alternation in donor/acceptor polyenes

There has been tremendous interest in asymmetric cyanine and merocyanine compounds because of their applications as photographic sensitizers, membrane potential probe, and photochromic dyes for all-optical memory. On the basis of UV-visible spectroscopic data, Brooker suggested that merocyanine molecules could be described by a superposition of neutral and charge-separated canonical resonance forms and that, by changing the basicity of the endgroups and/or the solvent polarity, one could tune the molecular structure from neutral and polyene-like through polar and cyanine-like (with equal contributions from neutral and charge-separated resonance forms) to highly polar, charge-separated polyene-like

Rapid identification of human muscle disease with fibre optic Raman spectroscopy

The diagnosis of muscle disorders (“myopathies”) can be challenging and new biomarkers of disease are required to enhance clinical practice and research. Despite advances in areas such as imaging and genomic medicine, muscle biopsy remains an important but time-consuming investigation. Raman spectroscopy is a vibrational spectroscopy application that could provide a rapid analysis of muscle tissue, as it requires no sample preparation and is simple to perform. Here, we investigated the feasibility of using a miniaturised, portable fibre optic Raman system for the rapid identification of muscle disease. Samples were assessed from 27 patients with a final clinico-pathological diagnosis of a myopathy and 17 patients in whom investigations and clinical follow-up excluded myopathy. Multivariate classification techniques achieved accuracies ranging between 71–77%. To explore the potential of Raman spectroscopy to identify different myopathies, patients were subdivided into mitochondrial and non-mitochondrial myopathy groups. Classification accuracies were between 74–89%. Observed spectral changes were related to changes in protein structure. These data indicate fibre optic Raman spectroscopy is a promising technique for the rapid identification of muscle disease that could provide real time diagnostic information. The application of fibre optic Raman technology raises the prospect of in vivo bedside testing for muscle diseases which would significantly streamline the diagnostic pathway of these disorders

The Lantern Vol. 63, No. 2, Spring 1996

• Poet, Lead Me On • St. Patrick\u27s Day • The Last Three Days • The Impressionable • Roundabout • The Bench • Carnivorous • Kyrie • Second Glance • Porch • Cruel Design • A Mime • Flaxen Crown • My Embryonic Ocean of Love • Stone Matrix • Voices from the Past • Skipping the Bullfight: Toreadors and Gaudi • Another Part of My Lacolonialism • Translucent Pane • Linguistics • Treehouse • A Disagreeable Music Piece • Vigil • A Brief History of American Poetry in Englishhttps://digitalcommons.ursinus.edu/lantern/1148/thumbnail.jp