Control of rural house infestation by Triatoma infestans in the Bolivian Chaco using a microencapsulated insecticide formulation

Background: Triatoma infestans, the main vector of Trypanosoma cruzi (causative agent of Chagas disease) has been successfully eliminated over much of its original geographic distribution over the southern cone countries of South America. However, populations of the species are still infesting houses of rural communities of the Gran Chaco region of Argentina and Bolivia. This study reports for the first time a large-scale effect of a vector control intervention using a microencapsulated formulation of organophosphates and insect growth regulator on house infestation by T. infestans, in the southwestern region of Santa Cruz de la Sierra Department, within the Bolivian chaco. Methods: The vector control intervention included the treatment and entomological evaluation of 1626 individually coded and georeferenced houses with the microencapsulated formulation. House infestation by T. infestans was evaluated by active searches with fixed capture effort carried out before and after two, 16 and 32 months of the treatment application. Results: House infestation prevalence was 30.5% before the intervention, spatially aggregated in two clusters of 38 and 25 localities that showed 41% and 38% house infestation by T. infestans. Infestation prevalence was reduced to 2.4% two months after the intervention and remained very low (1.7%) until the end of the study after 32 months of the control intervention, without any other additional vector control intervention. Conclusions: The obtained results show an important long lasting effect on house protection against triatomine infestation in a region of known pyrethroid resistant populations of T. infestans, as the result of the slow release of the active ingredients, protected by the formulation microcapsule.Fil: Gorla, David Eladio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Regional de Investigaciones Cientificas y Transferencia Tecnológica de Anillaco; ArgentinaFil: Vargas Ortiz, Roberto. Servicio Departamental de Salud. Programa Chagas; ArgentinaFil: Catala, Silvia Susana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Regional de Investigaciones Cientificas y Transferencia Tecnológica de Anillaco; Argentin

Excesso de confiança do Chief Executive Officer e a prática de gerenciamento de resultados

Several studies have suggested that overconfidence leads to expectations of future performance, and managers can develop predisposition to earnings management. The objective of the study is to identify the influence of overconfident managers on Brazilian companies’ earning management practices. The methodology of the research is descriptive, with quantitative approach, through documentary research. The statistical methods used were: entropy, TOPSIS and multiple linear regression. The sample consisted of 127 Brazilian companies listed on the BM&FBovespa. It is concluded that lower overconfidence has a positive impact on earnings management, suggesting that less confident managers believe with less intensity in their abilities, and, in order to guarantee organizational results that satisfy the expectations of analysts, they conduct the earnings management in an opportunistic way so as to increase organizational results.Diversos estudos têm sugerido que o excesso de confiança leva a expectativas de desempenho futuro, e os gerentes podem desenvolver predisposição para o gerenciamento de resultados. O objetivo do estudo é identificar a influência do excesso de confiança de gestores nas práticas de gerenciamento de resultados das empresas brasileiras. A metodologia da pesquisa é descritiva, com abordagem quantitativa, por meio de pesquisa documental. Os métodos estatísticos utilizados foram: entropia, TOPSIS e a regressão linear múltipla. A amostra foi composta de 127 empresas brasileiras listadas na BM&FBovespa. Conclui-se que o menor excesso de confiança impacta positivamente no gerenciamento de resultados. Sugere que os gestores com menor confiança acreditam, com menor intensidade, em suas habilidades, e, para garantir resultados organizacionais que satisfaçam às expectativas de analistas, praticam o gerenciamento de resultados de maneira oportuna para aumentar os resultados organizacionais

O esporte como ferramenta de reconhecimento e valorizacão da pessoa com deficiência no Brasil

Esta entrevista apresenta experiências práticas e vividas no esporte para pessoas com deficiências. O professor Vanilton Senatore foi um dos precursores dessa área, atuando na prática e exercendo liderança na construção e implantação de políticas públicas. Tem formação em Educação Física, licenciado pela PUC Campinas em 1972 e atuante na Educação Física Escolar e Esportes para Pessoas com Deficiência desde 1974.Participou da Carta de Batatais” em dezembro de 1986, que institui a disciplina de Educação Física Adaptada nos currículos de formação superior em Educação Física. Também atuou em vários projetos em nível nacional envolvendo pessoas com deficiências. As experiências apontadas pelo professor Vanilton certamente contribuíram e contribuem para os avanços da área da Educação Física e Esportes para Pessoas com Deficiências

Isotopic characterization of groundwater for drinking use in multilayer aquifers of the Milano and Monza provinces

Groundwater, drinking water, isotopes, EU directives, hydrogeolog

Treatment of rheumatoid arthritis with anti-TNF-alpha agents: A reappraisal

It has been found that tumour necrosis factor(TNF)-alpha plays a pivotal role in the pathogenesis of rheumatoid arthritis (RA), and the development of drugs targeting this molecule has extended the therapeutical approaches to RA patients. A number of observational studies of large patient series have also been published over the last few years, many of which have been based on national registries designed to monitor the efficacy and safety of anti-TNF agents, and allow healthcare institutions to control expenditure. Registry data can also help in identifying clinical and laboratory findings capable of predicting response. It has been suggested that the percentage of responding patients is lower in everyday clinical practice than that observed in RCTs, possibly because of patient selection, the use of a washout period before inclusion (which may artificially increase disease activity), and differences in doses, co-morbidities and adherence to therapy. A number of safety concerns have been raised since the introduction of anti-TNF agents, and they are now contraindicated in patients with advanced heart failure; however, the most widely debated current issues regard infections and neoplastic diseases. Moreover, the marketing of new and expensive biological agents has made strictly necessary to create systems capable of monitoring their safety and effectiveness in everyday practice, including the use of longitudinal observational studies. As the first published registry of anti-TNFalpha-treated patients in Italy, Lombardy Rheumatology Network (LORHEN) is already making its contribution in this directio

Multi-isotopic regional-scale screening on drinking groundwater in Lombardy Region (Italy)

Groundwater represents the main and safest source of water that supply, for drinking purposes, numerous urban and rural communities all over the world. A deep knowledge of aquifer systems in terms of quality, vulnerability and renewability is fundamental to preserve groundwater resources. Thanks to the contribution of different members of Water Alliance in synergy with Sapienza University, during November 2019 a multi-isotopic analysis at regional scale on groundwater tapped for drinking purposes in a wide area of Lombardy Region, has been carried out. The study aimed to improve knowledge about recharge mechanisms, groundwater relative age and impact of human activities on groundwater quality Each Water Alliance supplier selected wells and springs for a total of 121 samples, catching different aquifer groups and distributed from North to South. Groundwater stable isotope analyses were performed on all the monitoring points, instead tritium, nitrogen isotopes (15N and 18O in nitrates), sulphate isotopes (34S and18O) and 13C isotope in Dissolved Inorganic Carbon (DIC), were analysed in selected monitoring wells basing on previous data and major ions concentrations results. Therefore, results confirmed the key role of multi-isotopic approach in defining aquifer recharge processes, relative groundwater age and origin of pollutants, offering a useful tool to point out local issues which can be deeply investigated by each water supplier

Bioinformatics analysis of circulating miRNAs related to cancer following spinal cord injury

Patients with spinal cord injury (SCI) have an increased risk of developing esophageal, bladder and hematologic malignancies compared with the normal population. In the present study, we aimed to identify, through in silico analysis, miRNAs and their target genes related to the three most frequent types of cancer in individuals with SCI. In a previous study, we reported a pattern of expression of miRNAs in 17 sedentary SCI males compared with 22 healthy able-bodied males by TaqMan OpenArray. This list of miRNAs deregulated in SCI patients was uploaded to miRWALK2.0 to predict the target genes and pathways of selected miRNAs. We used Cytoscape software to construct the network displaying the miRNAs and their gene targets. Among the down-regulated miRNAs in SCI, 21, 19 and 20 miRNAs were potentially associated with hematological, bladder and esophageal cancer, respectively, and three target genes (TP53, CCND1 and KRAS) were common to all three types of cancer. The three up-regulated miRNAs were potentially targeted by 18, 15 and 10 genes associated with all three types of cancer. Our current bioinformatics analysis suggests the potential influence of several miRNAs on the development of cancer in SCI. In general, these data may provide novel information regarding potential molecular mechanisms involved in the development of cancer among individuals with SCI. Further studies aiming at understanding how miRNAs contribute to the development of the major cancers that affect patients after SCI may help elucidate the role of these molecules in the pathophysiology of the disease.39CAPES - Coordenação de Aperfeiçoamento de Pessoal e Nível SuperiorFAPESP – Fundação de Amparo à Pesquisa Do Estado De São PauloSem informação2017/23563-

Handebol em cadeira de rodas

O objetivo deste estudo é identificar os conceitos básicos que contribuem para o desenvolvimento do Handebol em Cadeira de Rodas (HCR), tendo em vista a necessidade de estabelecimento de diretrizes que possam nortear os princípios do treinamento específico dessa modalidade. O texto está estruturado em três eixos: os princípios do HCR, os potenciais praticantes e o contexto de sua prática. Essas delimitações temáticas são provenientes de uma abordagem pautada na teoria da aprendizagem motora, avançando para além dos estudos já realizados acerca de conceitos e regras, ao reunir a estes os aspectos técnico-táticos do HCR. Dessa forma, esse estudo busca contribuir para tornar claros os conhecimentos específicos que devem ser considerados pelos técnicos envolvidos com a sua pratica ao elaborar o planejamento dos treinamentos, bem como as adequações das possíveis particularidades inerentes à população envolvida

Correlação entre Dois Testes de Agilidade Adaptados: Handebol em Cadeiras de Rodas

Este estudo teve como objetivo correlacionar a variável motora agilidade entre dois testes adaptados para atletas usuários de cadeira de rodas em desporto coletivo. A pesquisa foi realizada com um grupo de 21 sujeitos com deficiência física - poliomielite, amputação de membros inferiores, lesão medular e mielomeningocele - do sexo masculino, com idade média de 30 anos ± 1,94, praticantes da modalidade de Handebol em Cadeiras de Rodas. Realizou-se dois testes de agilidade - Agilidade Modificado e Shuttle Run adaptado - para usuários de cadeira de rodas. Utilizou-se a estatística descritiva e os procedimentos de correlação de Spearman. Os resultados obtidos demonstraram haver realmente uma correlação de 0,83 com nível de significância de p < 0,001, quando correlacionado com todos os sujeitos. Na classe de poliomielite, a correlação ficou em 0,61, na classe de amputados de 0,82 e na classe de lesão da medula espinhal a correlação ficou em 0,80. Dessa forma, o coeficiente de correlação (rho) é classificado, de forma geral, como forte e resulta em um coeficientede determinação (rho²) de 68%. Conclui-se que é possível utilizar ambos os testes para a medida da variável agilidade em usuários de cadeiras de rodas praticantes de modalidades coletivas