The Effect of Walkthrough Observations on Teacher Perspectives in Christian Schools

This study investigated the effects on teacher perceptions of frequent, brief classroom observations in Christian schools. Teachers (N=111) responded to 13 belief and value statements prior to and after the term during which administrators conducted weekly, brief, unannounced observations in their classes. Teachers reported significant positive change regarding (a) analyzing reasons for selecting methods to assess learning, (b) being encouraged after class observations, and (c) being encouraged after receiving feedback related to the observations

Designing Sugaropolis:digital games as a medium for conveying transnational narratives

In this paper, the authors present a case study of ‘Sugaropolis’: a two-year practice-based project that involved interdisciplinary co-design and stakeholder evaluation of two digital game prototypes. Drawing on the diverse expertise of the research team (game design and development, human geography, and transnational narratives), the paper aims to contribute to debates about the use of digital games as a medium for representing the past. With an emphasis on design-as-research, we consider how digital games can be (co-)designed to communicate complex histories and geographies in which people, objects, and resources are connected through space and time

Phonographic neighbors, not orthographic neighbors, determine word naming latencies

The orthographic neighborhood size (N) of a word—the number of words that can be formed from that word by replacing one letter with another in its place—has been found to have facilitatory effects in word naming. The orthographic neighborhood hypothesis attributes this facilitation to interactive effects. A phonographic neighborhood hypothesis, in contrast, attributes the effect to lexical print-sound conversion. According to the phonographic neighborhood hypothesis, phonographic neighbors (words differing in one letter and one phoneme, e.g., stove and stone) should facilitate naming, and other orthographic neighbors (e.g., stove and shove) should not. The predictions of these two hypotheses are tested. Unique facilitatory phonographic N effects were found in four sets of word naming mega-study data, along with an absence of facilitatory orthographic N effects. These results implicate print-sound conversion—based on consistent phonology—in neighborhood effects rather than word-letter feedback

Modeling lexical decision : the form of frequency and diversity effects

What is the root cause of word frequency effects on lexical decision times? W. S. Murray and K. I. Forster (2004) argued that such effects are linear in rank frequency, consistent with a serial search model of lexical access. In this article, the authors (a) describe a method of testing models of such effects that takes into account the possibility of parametric overfitting; (b) illustrate the effect of corpus choice on estimates of rank frequency; (c) give derivations of nine functional forms as predictions of models of lexical decision; (d) detail the assessment of these models and the rank model against existing data regarding the functional form of frequency effects; and (e) report further assessments using contextual diversity, a factor confounded with word frequency. The relationship between the occurrence distribution of words and lexical decision latencies to those words does not appear compatible with the rank hypothesis, undermining the case for serial search models of lexical access. Three transformations of contextual diversity based on extensions of instance models do, however, remain as plausible explanations of the effect

Methods of testing and diagnosing model error : dual and single route cascaded models of reading aloud

Models of visual word recognition have been assessed by both factorial and regression approaches. Factorial approaches tend to provide a relatively weak test of models, and regression approaches give little indication of the sources of models’ mispredictions, especially when parameters are not optimal. A new alternative method, involving regression on model error, combines these two approaches with parameter optimization. The method is illustrated with respect to the dual route cascaded model of reading aloud. In contrast to previous investigations, this method provides clear evidence that there are parameter-independent problems with the model, and identifies two specific sources of misprediction made by model

Production of a Novel Copper-Binding Ligand by Marine Synechococcus (Cyanobacteria) in Response to Toxic Concentrations of Copper

Marine Synechococcus spp. are extremely sensitive to copper toxicity. Some strains have been shown to produce high-affinity, extracellular ligands of unknown structure which form complexes with free cupric ion. They are also known to produce metallothioneins (MT) in response to cadmium and zinc stress. In the present study, marine Synechococcus PCC 73109 (Agmenellum quadruplicatum BG-1) (Van Baalen) was exposed to three concentrations of CuSO4 for various times. Size exclusion chromatography, atomic absorption spectrophotometry, and reverse phase HPLC were used to isolate an intracellular copper binding ligand of low molecular weight (\u3c 6,500 Da). The ligand was detected after exposure to ≥ 8 μM CuSO4 for 2 hr in BG-11 medium. The intracellular ligand was characterized by electrospray mass spectrometry, amino acid analysis and a universal assay for siderophores. The ligand was not MT, phytochelatin or a siderophore. It is not a peptide but it contains lysine and an unidentified UV 254-absorbing constituent. This compound is a novel copper-binding ligand previously not reported in Synechococcus spp

A co-ordinated interaction between CTCF and ER in breast cancer cells.

BACKGROUND: CCCTC-binding factor (CTCF) is a conserved zinc finger transcription factor that is involved in both intra- and interchromasomal looping. Recent research has shown a role for CTCF in estrogen receptor (ER) biology, at some individual loci, but a multi-context global analysis of CTCF binding and transcription activity is lacking. RESULTS: We now map CTCF binding genome wide in breast cancer cells and find that CTCF binding is unchanged in response to estrogen or tamoxifen treatment. We find a small but reproducible set of CTCF binding events that overlap with both the nuclear receptor, estrogen receptor, and the forkhead protein FOXA1. These overlapping binding events are likely functional as they are biased towards estrogen-regulated genes, compared to regions lacking either CTCF or ER binding. In addition we identify cell-line specific CTCF binding events. These binding events are more likely to be associated with cell-line specific ER binding events and are also more likely to be adjacent to genes that are expressed in that particular cell line. CONCLUSION: The evolving role for CTCF in ER biology is complex, but is likely to be multifunctional and possibly influenced by the specific genomic locus. Our data suggest a positive, pro-transcriptional role for CTCF in ER-mediated gene expression in breast cancer cells. CTCF not only provides boundaries for accessible and 'protected' transcriptional blocks, but may also influence the actual binding of ER to the chromatin, thereby modulating the estrogen-mediated gene expression changes observed in breast cancer cells.RIGHTS : This article is licensed under the BioMed Central licence at http://www.biomedcentral.com/about/license which is similar to the 'Creative Commons Attribution Licence'. In brief you may : copy, distribute, and display the work; make derivative works; or make commercial use of the work - under the following conditions: the original author must be given credit; for any reuse or distribution, it must be made clear to others what the license terms of this work are

Microwave Gaseous Discharges

Contains reports on four research projects.Atomic Energy Commission under Contract AT(30-1)-184

Patient-reported experience and quality of care for people with schizophrenia

BACKGROUND: Evidence is mounting that patient-reported experience can provide a valuable indicator of the quality of healthcare services. However, little is known about the relationship between the experiences of people with severe mental illness and the quality of care they receive. We conducted a study to examine the relationship between patient-reported experience and the quality of care provided to people with schizophrenia. METHODS: We calculated a composite global rating of quality of care for people with schizophrenia using data from an audit of 64 mental health providers. We then examined associations between these ratings and mean patient satisfaction and patient-rated outcome using data from a survey of 5608 schizophrenic patients treated in these services. RESULTS: Global rating of quality of care was positively correlated with patient-rated outcome (r = 0.33; p = 0.01) but not with patient satisfaction (r = 0.21, p = 0.10). Patient-rated outcome was also positively correlated with patient involvement (r = 0.26, p = 0.04) and the quality of prescribing practice (r = 0.31, p = 0.02). High patient satisfaction scores were significantly associated with the extent of use of care plans within each organisation (r = 0.27, p = 0.03). CONCLUSIONS: Among people with schizophrenia, patient-rated outcome provides a better guide to the quality of care than patient-rated satisfaction. Greater use of patient-reported outcome measures should be made when assessing the quality of care provided to people with psychosis

Virtua Walker '87

Virtua Walker ’87 is an experimental VR installation that explores current nostalgia for period game technologies and consumer electronics. Virtua Walker ’87 is a playable critique of audience assumptions about VR and the walking simulator genre, informed by Hutcheon’s theory of parody (1989).In the game, players are tasked with walking along a virtual recreation of a real Scottish beach. They control their movement by physically walking on the spot, barefoot inside a custom, sand-filled controller. Player steps are captured by two force sensitive resistors that serve as inputs for the VR-based game. The game world is presented to the player in 2-bit colour (reminiscent of the Nintendo Game Boy), with 8-bit audio and purposefully constrained gameplay. Interaction is limited to walking and looking, with few points of interest along the 4-kilometer stretch of beach. As a practice-based research project, Virtua Walker ’87 sought to explore a number of ideas around virtual reality and walking as a mechanic, including: how contemporary VR can be understood as a form of technostalgia; why VR as a technology often falls short of user expectations in terms of affordances and player control; and how the act of walking is understood and appreciated by players within the wider context of a videogame. Importantly, Virtua Walker ’87 aimed to explore dissonant aesthetics in games, contrasting rich tactile experience (the act of walking barefoot on natural materials) with the disenchantment that results from antiquated sound and graphics and a monotonous ludic interface.<br/