1,236 research outputs found
Legal Incentives For Reduction, Reuse, And Recycling: A New Approach To Hazardous Waste Management
Spitzer Survey of the Large Magellanic Cloud, Surveying the Agents of a Galaxy's Evolution (SAGE) I: Overview and Initial Results
We are performing a uniform and unbiased, ~7x7 degrees imaging survey of the
Large Magellanic Cloud (LMC), using the IRAC and MIPS instruments on board the
Spitzer Space Telescope in order to survey the agents of a galaxy's evolution
(SAGE), the interstellar medium (ISM) and stars in the LMC. The detection of
diffuse ISM with column densities >1.2x10^21 H cm^-2 permits detailed studies
of dust processes in the ISM. SAGE's point source sensitivity enables a
complete census of newly formed stars with masses >3 solar masses that will
determine the current star formation rate in the LMC. SAGE's detection of
evolved stars with mass loss rates >1x10^-8 solar masses per year will quantify
the rate at which evolved stars inject mass into the ISM of the LMC. The
observing strategy includes two epochs in 2005, separated by three months, that
both mitigate instrumental artifacts and constrain source variability. The SAGE
data are non-proprietary. The data processing includes IRAC and MIPS pipelines
and a database for mining the point source catalogs, which will be released to
the community in support of Spitzer proposal cycles 4 and 5. We present initial
results on the epoch 1 data with a special focus on the N79 and N83 region. The
SAGE epoch 1 point source catalog has ~4 million sources. The point source
counts are highest for the IRAC 3.6 microns band and decrease dramatically
towards longer wavelengths consistent with the fact that stars dominate the
point source catalogs and that the dusty objects, e.g. young stellar objects
and dusty evolved stars that detected at the longer wavelengths, are rare in
comparison. We outline a strategy for identifying foreground MW stars, that may
comprise as much as 18% of the source list, and background galaxies, that may
comprise ~12% of the source list.Comment: Accepted by the Astronomical Journa
Spitzer survey of the Large Magellanic Cloud, surveying the agents of a galaxy's evolution (SAGE). IV. Dust properties in the interstellar medium
The goal of this paper is to present the results of a preliminary analysis of the extended infrared (IR) emission by dust in the interstellar medium (ISM) of the Large Magellanic Cloud (LMC). We combine Spitzer Surveying the Agents of Galaxy Evolution (SAGE) and Infrared Astronomical Satellite (IRAS) data and correlate the infrared emission with gas tracers of H I, CO, and Hα. We present a global analysis of the infrared emission as well as detailed modeling of the spectral energy distribution (SED) of a few selected regions. Extended emission by dust associated with the neutral, molecular, and diffuse ionized phases of the ISM is detected at all IR bands from 3.6 μm to 160 μm. The relative abundance of the various dust species appears quite similar to that in the Milky Way (MW) in all the regions we have modeled. We construct maps of the temperature of large dust grains. The temperature map shows variations in the range 12.1-34.7 K, with a systematic gradient from the inner to outer regions, tracing the general distribution of massive stars and individual H II regions as well as showing warmer dust in the stellar bar. This map is used to derive the far-infrared (FIR) optical depth of large dust grains. We find two main departures in the LMC with respect to expectations based on the MW: (1) excess mid-infrared (MIR) emission near 70 μm, referred to as the 70 μm excess, and (2) departures from linear correlation between the FIR optical depth and the gas column density, which we refer to as FIR excess emission. The 70 μm excess increases gradually from the MW to the LMC to the Small Magellanic Cloud (SMC), suggesting evolution with decreasing metallicity. The excess is associated with the neutral and diffuse ionized gas, with the strongest excess region located in a loop structure next to 30 Dor. We show that the 70 μm excess can be explained by a modification of the size distribution of very small grains with respect to that in the MW, and a corresponding mass increase of ≃13% of the total dust mass in selected regions. The most likely explanation is that the 70 μm excess is due to the production of large very small grains (VSG) through erosion of larger grains in the diffuse medium. This FIR excess could be due to intrinsic variations of the dust/gas ratio, which would then vary from 4.6 to 2.3 times lower than the MW values across the LMC, but X_(CO) values derived from the IR emission would then be about three times lower than those derived from the Virial analysis of the CO data. We also investigate the possibility that the FIR excess is associated with an additional gas component undetected in the available gas tracers. Assuming a constant dust abundance in all ISM phases, the additional gas component would have twice the known H I mass. We show that it is plausible that the FIR excess is due to cold atomic gas that is optically thick in the 21 cm line, while the contribution by a pure H_2 phase with no CO emission remains a possible explanation
Nature of b-1,3-Glucan-Exposing Features on Candida albicans Cell Wall and Their Modulation
Funding Information: This work was supported by a programme grant from the UK Medical Research Council (MR/M026663/1; MR/M026663/2) and by the Medical Research Council Centre for Medical Mycology (MR/N006364/1; MR/N006364/2). NARG acknowledges Wellcome support for a Senior Investigator (101873/Z/13/Z), Collaborative (200208/A/15/Z; 215599/Z/19/Z) and Strategic Awards (097377/Z11/Z). MGN was supported by an ERC Advanced Grant (833247) and a Spinoza Grant of the Netherlands Organization for Scientific Research.Peer reviewedPublisher PD
Understanding Radio-Selected Thermal Sources in M 33: Ultraviolet, Optical, Near-Infrared, Spitzer Mid-Infrared, and Radio Observations
We present ultraviolet, optical, near-infrared, Spitzer mid-infrared, and
radio images of 14 radio-selected objects in M 33. These objects are thought to
represent the youngest phase of star cluster formation. We have detected the
majority of cluster candidates in M 33 at all wavelengths. From the near-IR
images, we derived ages 2-10 Myr, K_S-band extinctions (A_K_S) of 0-1 mag, and
stellar masses of 10^3-10^4 M_solar. We have generated spectral energy
distributions (SEDs) of each cluster from 0.1 micron to 160 microns. From these
SEDs, we have modeled the dust emission around these star clusters to determine
the dust masses (1-10^3 M_solar) and temperatures (40-90 K) of the clusters'
local interstellar medium. Extinctions derived from the JHK_S, Halpha, and UV
images are similar to within a factor of 2 or 3. These results suggest that
eleven of the fourteen radio-selected objects are optically-visible young star
clusters with a surrounding H II region, that two are background objects,
possibly AGN, and that one is a Wolf-Rayet star with a surrounding H II region.Comment: 57 pages total; 20 figures; 3 tables under review by ApJS; first
review complet
Vitamin C and isovitamin C derived chemistry. 2. Synthesis of some enantiomerically pure 4,5,6-trihydroxylated norleucines
Genomic, Pathway Network, and Immunologic Features Distinguishing Squamous Carcinomas
This integrated, multiplatform PanCancer Atlas study co-mapped and identified distinguishing
molecular features of squamous cell carcinomas (SCCs) from five sites associated with smokin
Pan-Cancer Analysis of lncRNA Regulation Supports Their Targeting of Cancer Genes in Each Tumor Context
Long noncoding RNAs (lncRNAs) are commonly dys-regulated in tumors, but only a handful are known toplay pathophysiological roles in cancer. We inferredlncRNAs that dysregulate cancer pathways, onco-genes, and tumor suppressors (cancer genes) bymodeling their effects on the activity of transcriptionfactors, RNA-binding proteins, and microRNAs in5,185 TCGA tumors and 1,019 ENCODE assays.Our predictions included hundreds of candidateonco- and tumor-suppressor lncRNAs (cancerlncRNAs) whose somatic alterations account for thedysregulation of dozens of cancer genes and path-ways in each of 14 tumor contexts. To demonstrateproof of concept, we showed that perturbations tar-geting OIP5-AS1 (an inferred tumor suppressor) andTUG1 and WT1-AS (inferred onco-lncRNAs) dysre-gulated cancer genes and altered proliferation ofbreast and gynecologic cancer cells. Our analysis in-dicates that, although most lncRNAs are dysregu-lated in a tumor-specific manner, some, includingOIP5-AS1, TUG1, NEAT1, MEG3, and TSIX, synergis-tically dysregulate cancer pathways in multiple tumorcontexts
Pan-cancer Alterations of the MYC Oncogene and Its Proximal Network across the Cancer Genome Atlas
Although theMYConcogene has been implicated incancer, a systematic assessment of alterations ofMYC, related transcription factors, and co-regulatoryproteins, forming the proximal MYC network (PMN),across human cancers is lacking. Using computa-tional approaches, we define genomic and proteo-mic features associated with MYC and the PMNacross the 33 cancers of The Cancer Genome Atlas.Pan-cancer, 28% of all samples had at least one ofthe MYC paralogs amplified. In contrast, the MYCantagonists MGA and MNT were the most frequentlymutated or deleted members, proposing a roleas tumor suppressors.MYCalterations were mutu-ally exclusive withPIK3CA,PTEN,APC,orBRAFalterations, suggesting that MYC is a distinct onco-genic driver. Expression analysis revealed MYC-associated pathways in tumor subtypes, such asimmune response and growth factor signaling; chro-matin, translation, and DNA replication/repair wereconserved pan-cancer. This analysis reveals insightsinto MYC biology and is a reference for biomarkersand therapeutics for cancers with alterations ofMYC or the PMN
Spatial Organization and Molecular Correlation of Tumor-Infiltrating Lymphocytes Using Deep Learning on Pathology Images
Beyond sample curation and basic pathologic characterization, the digitized H&E-stained images
of TCGA samples remain underutilized. To highlight this resource, we present mappings of tumorinfiltrating lymphocytes (TILs) based on H&E images from 13 TCGA tumor types. These TIL
maps are derived through computational staining using a convolutional neural network trained to
classify patches of images. Affinity propagation revealed local spatial structure in TIL patterns and
correlation with overall survival. TIL map structural patterns were grouped using standard
histopathological parameters. These patterns are enriched in particular T cell subpopulations
derived from molecular measures. TIL densities and spatial structure were differentially enriched
among tumor types, immune subtypes, and tumor molecular subtypes, implying that spatial
infiltrate state could reflect particular tumor cell aberration states. Obtaining spatial lymphocytic
patterns linked to the rich genomic characterization of TCGA samples demonstrates one use for
the TCGA image archives with insights into the tumor-immune microenvironment
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