Dynamics of development of investment processes in Belgorod Region

The present paper investigated results of an analysis of dynamics of changes in the investment structure of Belgorod region on the basis of private and integral indices characterizing the dynamics of structural changes. Structural changes in Belgorod region concerning investment capital were different from corresponding calculated figures in the Central Federal Distric. The revealed differences characterized features of the development in the investment processes and indicated changes in priorities of those investing in the economy of this regio

Dynamics of development of investment processes in the Belgorod region

This paper deals with the results of the analysis of the dynamics of changes in the investment structure of the Belgorod region, conducted on the basis of private and integral indicators characterizing the dynamics of structural changes. The structural changes in the Belgorod region concerning investment capital are different from the corresponding figures calculated in the Central Federal District. The revealed differences characterize features of the development of investment processes and indicate a change in the priorities of those investing in the economy of the regio

Rhizobacteria Effect on Arsenic Migration and Translocation of Biogenic Elements in Plants

The study was aimed at the transformation of arsenic compounds in the rhizosphere, its accumulation in plants, P and Si translocation to plants under the influence of Bacillus megaterium var. phosphaticum, and Bacillus mucilaginosus with various forms of As compounds in the soil. The authors describe the maximum effect of Bacillus megaterium var. Phosphaticum strain on As migration, its mobilization and immobilization in the rhizosphere due to arsenic leaching from mineral and difficult-todestroy compounds and its accumulation in plants. The forms of arsenic compounds were isolated from the rhizosphere based on sequential extraction procedures. The features of the inter-element As-P interaction in plants were established. With the intense accumulation of As in the rhizosphere inoculated with rhizobacteria, the intake of phosphorus into plants was not observed, as contrary to Si. The study of As and biogenic elements behavior under the influence of rhizobacteria is of great importance in the development of ecobiotechnologies related to soil remediation and crop production

Record electron self-cooling in cold-electron bolometers with a hybrid superconductor-ferromagnetic nanoabsorber and traps

The Cosmic Microwave Background (CMB) radiation is the only observable that allows studying the earliest stage of the Universe. Radioastronomy instruments for CMB investigation require low working temperatures around 100 mK to get the necessary sensitivity. On-chip electron cooling of receivers is a pathway for future space missions due to problems of dilution fridges at low gravity. Here, we demonstrate experimentally that in a Cold-Electron Bolometer (CEB) a theoretical limit of electron cooling down to 65 mK from phonon temperature of 300 mK can be reached. It is possible due to effective withdrawing of hot electrons from the tunnel barrier by double stock, special traps and suppression of Andreev Joule heating in hybrid Al/Fe normal nanoabsorber

Experience of long-term use of anti-IgE therapy in a patient with chronic spontaneous urticarial

Chronic spontaneous urticaria is an urgent health problem. Recurrent urticarial rashes, angioedema and severe itching reduce the quality of life of patients. The ineffectiveness of standard therapy requires the search for new modern methods of treating this disease. Taking into account the current data on the pathogenesis, the third line of therapy for chronic spontaneous urticaria is the addition of anti-IgE therapy (omalizumab) to antihistamines of the 2nd generation. The presented clinical case is devoted to the experience of long-term use of omalizumab in a patient with chronic spontaneous urticaria. Having a disease duration of about a year, the patient was thoroughly examined, all concomitant diseases were identified and compensated, parasitic invasion was treated, but this did not lead to a regression of symptoms. Antihistamines of the 2nd generation in standard and increased doses (up to 4 times) did not control the disease, systemic glucocorticosteroids stopped the symptoms for a short time, and therefore, in  the future, the  patient began to use them independently and uncontrollably. Almost daily use of  corticosteroids for 6 months caused the development of complications in the form of weight gain and Cushing’s syndrome. Omalizumab completely stopped all the symptoms during the first day, no side effects were detected. The clinical effect lasted from 3 to 4 weeks. Thus, omalizumab therapy allowed the patient to almost completely get rid of the symptoms of CSC, which significantly improved the quality of life and made it possible to cancel systemic glucocorticosteroids. The peculiarity of the presented case is the duration of the use of omalizumab (more than 2 years) with the inability to cancel due to the return of urticarial rashes and itching

Efficiency of Using the Hydrogen Peroxide Vapor Generator “Fhileas 75” for Disinfection of the Air Ducts of separately Ventilated system for Infected Animal Housing

The aim of the work was to evaluate the efficiency of using the “Fhileas 75” hydrogen peroxide vapor generator for decontaminating the air ducts of the individually ventilated system, “Bio A.S.”, for housing of infected animals.Materials and methods. The hydrogen peroxide vapor generator “Fhileas 75” (France), a disinfectant manufactured by “FHILEASAFE” (7 % hydrogen peroxide solution and 0.15 % peracetic acid solution), separately ventilated system “Bio A.S.” (Germany) for the infected animal housing were applied in the work. Serratia marcescens 9 was used as test-culture.Results and discussion. The efficiency of using the hydrogen peroxide vapor generator “Fhileas 75” for decontamination of air ducts and internal surfaces of the rack of the individually ventilated system “Bio A.S.” on the test-culture S. marcescens 9 at 1·106 mc/ml concentration has been established (operation parameters of the individually ventilated system unit are as follows: air exchange rate – 60 changes per hour, air flow volume – 28 m3/hour, number of disinfection cycles – 5, disinfectant spraying time – 97 min, exposure time – 24 hours)

Academic Motivation of Elementary School Children in Two Educational Approaches — Innovative and Traditional

Background. While the current literature provides valuable insight into how school climate perceptions and student motivation impact academic achievement, research examining the mediating efects of motivation in the linking of an innovative educational system, school climate, and achievement is limited. Tis study considers the potential of the El’konin–Davydov system of developmental education as a basis for educational innovation. Self-determination theory is applied as a useful theoretical framework that allows for consideration of both the intensity and the quality of academic motivation. Objective. Te study examines a model that illustrates the role of intrinsic and different types of extrinsic motivation in linking the El’konin–Davydov system of developmental education (DE) and school climate to the academic achievement of elementary schoolchildren. Design. Participants were 345 third and fourth graders drawn from four public schools in Moscow, with some (N = 192, 2 schools) educated in the traditional system and others (N = 153, 2 schools) in one that follows the DE system. A cross-sectional design was implemented. Results. Students in the DE system showed signifcantly lower external motivation for all three subscales (Parents, Teachers, General) and perceived school climate more favorably. Structural equation modeling showed that the hypothesized model ft the data well, supporting the hypothesis that student external motivation plays a mediating role in linking educational system (innovative vs. traditional) with academic achievement. Students’ autonomous motivation was shown to play a mediating role in linking positive perceptions of school climate with academic achievement. Conclusion. Te elementary school students from developmental education classes compared to their peers from traditional education classes demonstrate more positive profle of academic motivation including lower external motivation, more positive attitude towards school and study; however, the two groups do not difer in the level of intrinsic, identifed, and introjected motivations

Experience with the triple fixed combination in patients with chronic obstructive pulmonary disease

Chronic obstructive pulmonary disease (COPD) is one of the most important problems of modern medicine associated with a high mortality rate, high costs of treatment and relief of exacerbations of COPD. The main objectives of COPD treatment are symptom control, reduce the frequency of exacerbations and hospitalizations, and reduced risk of exacerbation in the future. The recommendations of the GOLD initiative propose a treatment approach based on the assessment of exacerbation rates external respiratory function indicators (spirometric classification of GOLD), the severity of symptoms assessed on the CAT test and mMRC. When choosing therapy, the physician must first of all take into account the effectiveness, safety of the drug, adherence to treatment in order to achieve the therapeutic goals of treating patients with COPD. The change in therapeutic approaches in COPD treatment is associated with the accumulation of knowledge in physiology, clinical pharmacology, and the isolation of new clinical phenotypes of COPD. Currently, the main classes of drugs for the treatment of COPD are long-acting beta-agonists (LABA), longacting anticholinergics (LAMA), and inhaled glucocorticosteroids (ICS). The evolution of therapeutic approaches in COPD treatment has led to the creation of new fixed inhalation combinations of the main groups of drugs for COPD treatment. The therapeutic strategies recommended by GOLD and the Russian Federal Guidelines determine the long-term goals of COPD treatment – the impact on the risk of exacerbations in the future. The presented clinical observation of a patient with severe COPD demonstrates the effectiveness of a triple fixed combination vilanterol/umeclidinium/fluticasone furoate 55/22/92 μg as a basic therapy. The  chosen treatment strategy not only reduces the  severity of  the  symptoms of  the  disease, but also reduces the  risk of exacerbations in the future

Improvement of the Normative-Regulatory Framework Concerning Anti-Epidemic Procedures for Works with Infectious Disease Agents in Mobile Laboratories of Specialized Anti-Epidemic Teams (SAET)

Carried out is a range of investigations aimed at the improvement of the anti-epidemic procedures for works with infectious disease agents (herein biological safety provision) in mobile laboratories of specialized anti-epidemic teams (SAET). Evaluation of the operational experience of stationary and field laboratories, as well as comparative analysis of the national safety requirements for works with pathogenic biological agents and WHO international regulations in the sphere of biological safety provision in laboratories, has made it possible to outline common for all types of microbiological laboratories principles for biosafety provision. With due consideration of these principles formulated are the core requirements for the provision of biological safety of SAET activities. Based on the results of biorisk and biohazard assessment which have to do with innovative mobile laboratories, worked out is a system of anti-epidemic procedures aimed towards establishment of the conditions that offer as low as practically achievable level of risk for personnel of SAET mobile laboratories, for population and human environment too. These practices, designed for biological safety provision among the personnel of mobile laboratories (ML), have been played back in a number of standard operational procedures. With a view to establishing of the environment with acceptable level of biorisk for the personnel and population when ML are used for various purposes and in various contingencies (in full force, single unit or several modules), worked out are the algorithms of decision-making support as regards selection of modules and optional accessories. However, there is a need for emergency response plans and training programs for the personnel on the provision of biosafety in ML to ensure and maintain acceptable level of biorisk connected with ML functioning

Free-radical oxidation as a pathogenetic factor of metabolic syndrome

The medical and social significance of cardiovascular diseases remains high. One of the factors that determine cardiovascular risks is metabolic syndrome. As a result of excessive accumulation of lipid and carbohydrate metabolism products in metabolic syndrome, oxidative (oxidative) stress develops. The article considers both domestic and foreign scientific studies, which highlight various aspects of the influence of reactive oxygen and nitrogen species, as well as other free radicals on the formation of oxidative stress in pathological conditions that are part of the metabolic syndrome complex. This describes the mechanisms of the formation of chronic inflammation through excessive secretion of pro-inflammatory cytokines and adipokines, activation of the transcription factor NF-kB, as well as damage to the antioxidant system in obesity. Separately, a number of mechanisms of the stimulating effect of adipokines: leptin, adiponectin, chimerine, omentin 1, resistin, on the formation of oxidative stress have been noted. The ways of activating the polyol pathway, as well as diacyl-glycerol — protein kinase C — the signaling pathway of oxidative stress, the formation of mitochondrial dysfunction is described. As a result of which there is an excessive production of free radicals in insulin resistance, diabetes mellitus and macroand microvascular complications of diabetes. In addition, the influence of oxidative stress directly on the formation of cardiovascular diseases of atherosclerotic genesis, as well as arterial hypertension, has been shown