Structural members comprised of composite wood material and having zones of diverse density

The disclosed invention includes an improved construction of structural members such as railroad crossties, highway spin posts and highway guard posts and to construction of said members from composite wood material including elongated wood flakes and to a method for making such improved structures.https://digitalcommons.mtu.edu/patents/1124/thumbnail.jp

Woodfordian Glacial History of the Champlain Lowland, Burlington to Brandon, Vermont

Guidebook for field trips in Vermont: 64th annual meeting October 13, 14, 15, 1972 Burlington, Vermont: Trip G-

Fan-shaped loader for making a loosely felted mat of aligned wood flakes

Apparatus for forming an elongated continuous mat of elongated wood flakes mixed with a binder and adapted to be compressed to form a densified composite wood product for continuously depositing wood flakes on that supporting surface and for aligning the elongated wood flakes being deposited in mutually parallel relation and in alignment with the direction of movement of the supporting surface. A hopper for containing wood flakes deposits wood flakes into the upper end of a fan-shaped flake loader comprised of a plurality of channels positioned in side-by-side relation and sloping downwardly from the hopper to a supporting surface. The channels are generally V-shaped in cross-section and converge toward their lower ends such that the wood flakes deposited in the upper ends of the channels become aligned in mutually parallel relation as the flakes slide down the channels and are deposited on the supporting surface.https://digitalcommons.mtu.edu/patents/1106/thumbnail.jp

Method and apparatus for making aligned flake composite wood material including integral baffles

A method and apparatus for forming a loosely felted mat of elongated wood flakes mixed with a binder, the mat including a longitudinal axis and the wood flakes being aligned in mutually parallel relation and parallel to the longitudinal axis of the mat. The wood flakes are held in alignment in the mat by a plurality of closely spaced thin planar baffles, the baffles being comprised of a material which can form an integral part of the mat.https://digitalcommons.mtu.edu/patents/1120/thumbnail.jp

Real-Time Hemodynamic Evidence Supporting the Safety of Acute Isometric Exercise

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Static dropless flake aligner for producing composite wood material

Apparatus are provided for forming a loosely felted mat of elongated wood flakes, the wood flakes being supported on an elongated caul. The flakes are deposited between a plurality of closely spaced parallel baffles so as to be aligned in mutually parallel relation. The caul is supported adjacent the lower edges of the baffles and is support for vertical movement to facilitate buildup of the mat. Apparatus movable back and forth along the length of the caul is provided to deposit wood flakes in an evenly dispursed manner. At least one picker wheel also moves along the length of the baffles, the picker wheel including fingers extending downwardly between baffles and adapted to engage the flakes to cause them to fall between the baffles.https://digitalcommons.mtu.edu/patents/1107/thumbnail.jp

The Influence of E - Stim on Posture and Respiratory Function to Improve Aerobic Capacity: A Pilot

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A single H/ACA small nucleolar RNA mediates tumor suppression downstream of oncogenic RAS.

Small nucleolar RNAs (snoRNAs) are a diverse group of non-coding RNAs that direct chemical modifications at specific residues on other RNA molecules, primarily on ribosomal RNA (rRNA). SnoRNAs are altered in several cancers; however, their role in cell homeostasis as well as in cellular transformation remains poorly explored. Here, we show that specific subsets of snoRNAs are differentially regulated during the earliest cellular response to oncogenic RASG12V expression. We describe a novel function for one H/ACA snoRNA, SNORA24, which guides two pseudouridine modifications within the small ribosomal subunit, in RAS-induced senescence in vivo. We find that in mouse models, loss of Snora24 cooperates with RASG12V to promote the development of liver cancer that closely resembles human steatohepatitic hepatocellular carcinoma (HCC). From a clinical perspective, we further show that human HCCs with low SNORA24 expression display increased lipid content and are associated with poor patient survival. We next asked whether ribosomes lacking SNORA24-guided pseudouridine modifications on 18S rRNA have alterations in their biophysical properties. Single-molecule Fluorescence Resonance Energy Transfer (FRET) analyses revealed that these ribosomes exhibit perturbations in aminoacyl-transfer RNA (aa-tRNA) selection and altered pre-translocation ribosome complex dynamics. Furthermore, we find that HCC cells lacking SNORA24-guided pseudouridine modifications have increased translational miscoding and stop codon readthrough frequencies. These findings highlight a role for specific snoRNAs in safeguarding against oncogenic insult and demonstrate a functional link between H/ACA snoRNAs regulated by RAS and the biophysical properties of ribosomes in cancer

Survey of variation in human transcription factors reveals prevalent DNA binding changes

Published in final edited form as: Science. 2016 Mar 25; 351(6280): 1450–1454. Published online 2016 Mar 24. doi: 10.1126/science.aad2257Sequencing of exomes and genomes has revealed abundant genetic variation affecting the coding sequences of human transcription factors (TFs), but the consequences of such variation remain largely unexplored. We developed a computational, structure-based approach to evaluate TF variants for their impact on DNA binding activity and used universal protein-binding microarrays to assay sequence-specific DNA binding activity across 41 reference and 117 variant alleles found in individuals of diverse ancestries and families with Mendelian diseases. We found 77 variants in 28 genes that affect DNA binding affinity or specificity and identified thousands of rare alleles likely to alter the DNA binding activity of human sequence-specific TFs. Our results suggest that most individuals have unique repertoires of TF DNA binding activities, which may contribute to phenotypic variation.National Institutes of Health; NHGRI R01 HG003985; P50 HG004233; A*STAR National Science Scholarship; National Science Foundatio