Negative Linear Compressibility

While all materials reduce their intrinsic volume under hydrostatic (uniform) compression, a select few actually \emph{expand} along one or more directions during this process of densification. As rare as it is counterintuitive, such "negative compressibility" behaviour has application in the design of pressure sensors, artificial muscles and actuators. The recent discovery of surprisingly strong and persistent negative compressibility effects in a variety of new families of materials has ignited the field. Here we review the phenomenology of negative compressibility in this context of materials diversity, placing particular emphasis on the common structural motifs that recur amongst known examples. Our goal is to present a mechanistic understanding of negative compressibility that will help inform a clear strategy for future materials design.Comment: Submitted to PCC

Local movement: agent-based models of pedestrian flows

Modelling movement within the built environment has hitherto been focused on rather coarse spatial scales where the emphasis has been upon simulating flows of traffic between origins and destinations. Models of pedestrian movement have been sporadic, based largely on finding statistical relationships between volumes and the accessibility of streets, with no sustained efforts at improving such theories. The development of object-orientated computing and agent-based models which have followed in this wake, promise to change this picture radically. It is now possible to develop models simulating the geometric motion of individual agents in small-scale environments using theories of traffic flow to underpin their logic. In this paper, we outline such a model which we adapt to simulate flows of pedestrians between fixed points of entry - gateways - into complex environments such as city centres, and points of attraction based on the location of retail and leisure facilities which represent the focus of such movements. The model simulates the movement of each individual in terms of five components; these are based on motion in the direction of the most attractive locations, forward movement, the avoidance of local geometric obstacles, thresholds which constrain congestion, and movement which is influenced by those already moving towards various locations. The model has elements which enable walkers to self-organise as well as learn from their geometric experiences so far. We first outline the structure of the model, present a computable form, and illustrate how it can be programmed as a variant of cellular automata. We illustrate it using three examples: its application to an idealised mall where we show how two key components - local navigation of obstacles and movement towards points of global locational attraction - can be parameterised, an application to the more complex town centre of Wolverhampton (in the UK West Midlands) where the paths of individual walkers are used to explore the veracity of the model, and finally it application to the Tate Gallery complex in central London where the focus is on calibrating the model by letting individual agents learn from their experience of walking within the environment

Inevitable magic – reason, magic and manipulation

Magical thinking occurs when supernatural causes, as opposed to rational ones, are assumed in events that defy reasonable probability. To investigate magical thinking, 64 adults were tested in a novel experiment where they were told they were playing an online game with opposing players. However, neither the “Game” nor the opposing players were real. It was a presentation designed to provide an illusion of game play. The “game” consisted of two sessions, each showing three opposing players (six rounds each). Half the opposing players were “seen” (pre-recorded videos with confederates posing as players) and the other half were “unseen”. To play the “game”, participants were asked to choose a card (from a set of five) and then observe the opposing player attempt to guess that card without being able to see it. Participants were then shown that one-third of opposing players displayed “good luck” (many correct guesses, defined by an above average score), one-third “neutral luck” (some correct, defined by an average score), and one-third “bad luck” (almost none correct, defined by a below average score). After the game, participants were asked to score each player on how likely they are to choose that player for a second stage of the game (in reality, there was no second stage). In the results, there was a significant effect of “luck” (with higher preferences for higher luck). There was also a significant effect of visibility (seen players preferred over unseen). Participants also completed two questionnaires to assess their disposition for magical thinking. There was a weak effect of questionnaire scores on the preference for luck. Results are considered in the context of research in anthropology and psychology

Network Topology as a Driver of Bistability in the lac Operon

The lac operon in Escherichia coli has been studied extensively and is one of the earliest gene systems found to undergo both positive and negative control. The lac operon is known to exhibit bistability, in the sense that the operon is either induced or uninduced. Many dynamical models have been proposed to capture this phenomenon. While most are based on complex mathematical formulations, it has been suggested that for other gene systems network topology is sufficient to produce the desired dynamical behavior. We present a Boolean network as a discrete model for the lac operon. We include the two main glucose control mechanisms of catabolite repression and inducer exclusion in the model and show that it exhibits bistability. Further we present a reduced model which shows that lac mRNA and lactose form the core of the lac operon, and that this reduced model also exhibits the same dynamics. This work corroborates the claim that the key to dynamical properties is the topology of the network and signs of interactions.Comment: 15 pages, 13 figures, supplemental information include

The origin of very wide binary systems

The majority of stars in the Galactic field and halo are part of binary or multiple systems. A significant fraction of these systems have orbital separations in excess of thousands of astronomical units, and systems wider than a parsec have been identified in the Galactic halo. These binary systems cannot have formed through the 'normal' star-formation process, nor by capture processes in the Galactic field. We propose that these wide systems were formed during the dissolution phase of young star clusters. We test this hypothesis using N-body simulations of evolving star clusters and find wide binary fractions of 1-30%, depending on initial conditions. Moreover, given that most stars form as part of a binary system, our theory predicts that a large fraction of the known wide 'binaries' are, in fact, multiple systems.Comment: 4 pages, 1 figure, to appear in the proceedings of IAU Symposium 266, eds. R. de Grijs & J.R.D. Lepin

Relational Markets in Intimate Goods

Prof. Michelle B. Goodwin, Professor of Medicine and Public Health Everett Fraser Professor of Law University of Minnesota Law School

Perceptions and Challenges of Female Workplace Mediators and How They Overcome Them

This holistic case study with embedded units was conducted to understand and describe the perceptions of female workplace mediators and if they encounter stereotypes, bias, and other challenges as mediators in the state of Texas. Ten female workplace mediators in Texas participated with in-depth, semistructured interviews and an open-ended survey response describing a unique experience they had while mediating workplace disputes. A cross-case synthesis analysis of the results was then conducted with journal notes, literature on gender inequality, mediation, alternative dispute resolution, and Goffman’s theory of stigma. The results of this qualitative research can provide additional alternative dispute resolution techniques for female leaders and mediators as they provide workplace conflict management interventions

PI3K in juvenile myelomonocytic leukemia

Indiana University-Purdue University Indianapolis (IUPUI)Juvenile Myelomonocytic Leukemia (JMML) is rare, fatal myeloproliferative disease (MPD) affecting young children, and is characterized by expansion of monocyte lineage cells and hypersensitivity to Granulocyte Macrophage-Colony Stimulating Factor (GM-CSF) stimulation. JMML is frequently associated with gain-of-function mutations in the PTPN11 gene, which encodes the protein tyrosine phosphatase, Shp2. Activating Shp2 mutations are known to promote hyperactivation of the Ras-Erk signaling pathway, but Akt is also observed to have enhanced phosphorylation, suggesting a potential role for Phosphatidylinositol-3-Kinase (PI3K)-Akt signaling in mutant Shp2-induced GM-CSF hypersensitivity and leukemogenesis. Having demonstrated that Class IA PI3K is hyperactivated in the presence of mutant Shp2 and contributes to GM-CSF hypersensitivity, I hypothesized the hematopoietic-specific Class IA PI3K catalytic subunit p110δ is a crucial mediator of mutant Shp2-induced PI3K hyperactivation and GM-CSF hypersensitivity in vitro and MPD development in vivo. I crossed gain-of-function mutant Shp2 D61Y inducible knockin mice, which develop fatal MPD, with mice expressing kinase-dead mutant p110δ D910A to evaluate p110δ’s role in mutant Shp2-induced GM-CSF hypersensitivity in vitro and MPD development in vivo. As a comparison, I also crossed Shp2 D61Y inducible knockin mice with mice bearing inducible knockout of the ubiquitously expressed Class IA PI3K catalytic subunit, p110α. I found that genetic interruption of p110δ, but not p110α, significantly reduced GM-CSF-stimulated hyperactivation of both the Ras-Erk and PI3K-Akt signaling pathways, and as a consequence, resulted in reduced GM-CSF-stimulated hyper-proliferation in vitro. Furthermore, I found that mice bearing genetic disruption of p110δ, but not p110α, in the presence of gain-of-function mutant Shp2 D61Y, had on average, smaller spleen sizes, suggesting that loss of p110δ activity reduced MPD severity in vivo. I also investigated the effects of three PI3K inhibitors with high specificity for p110δ, IC87114, GDC-0941, and GS-9820 (formerly known as CAL-120), on mutant Shp2-induced GM-CSF hypersensitivity. These inhibitors with high specificity for p110δ significantly reduced GM-CSF-stimulated hyperactivation of PI3K-Akt and Ras-Erk signaling and reduced GM-CSF-stimulated hyperproliferation in cells expressing gain-of-function Shp2 mutants. Collectively, these findings show that p110δ-dependent PI3K hyperactivation contributes to mutant Shp2-induced GM-CSF hypersensitivity and MPD development, and that p110δ represents a potential novel therapeutic target for JMML