Future Trends in UK Housebuilding

published_or_final_versio

Planning for peak oil: learning from Cuba's special period

It is against recent experiences of proliferative consumption of the earth’s resources that planners and politicians must confront the challenge of peak oil over the coming years. With so few examples of peak oil available worldwide, this paper explores the realities of this in Cuba after the collapse of the Soviet Union in 1989 – the so-called special period, which decimated the country’s imports of energy, food and other vital supplies. Drawing on primary research collected in Cuba during 2008 and in an attempt to stimulate debate about how western countries and cities might respond to future losses of global resources, this paper examines the policy responses implemented in Cuba in the fields of transport, spatial planning, agriculture and energy. Despite the Cuban situation being politically different from other countries and the fact that the loss of resources during the special period were abrupt and unplanned, it is argued that there is still considerable scope for a wider application of the concepts to other towns and cities, if not countries and cultures

Methods of editing cloud and atmospheric layer affected pixels from satellite data

The location and migration of cloud, land and water features were examined in spectral space (reflective VIS vs. emissive IR). Daytime HCMM data showed two distinct types of cloud affected pixels in the south Texas test area. High altitude cirrus and/or cirrostratus and "subvisible cirrus" (SCi) reflected the same or only slightly more than land features. In the emissive band, the digital counts ranged from 1 to over 75 and overlapped land features. Pixels consisting of cumulus clouds, or of mixed cumulus and landscape, clustered in a different area of spectral space than the high altitude cloud pixels. Cumulus affected pixels were more reflective than land and water pixels. In August the high altitude clouds and SCi were more emissive than similar clouds were in July. Four-channel TIROS-N data were examined with the objective of developing a multispectral screening technique for removing SCi contaminated data

Differential activation of CD57-defined natural killer cell subsets during recall responses to vaccine antigens

Natural killer (NK) cells contribute to the effector phase of vaccine-induced adaptive immune responses, secreting cytokines and releasing cytotoxic granules. The proportion of responding NK cells varies between individuals and by vaccine, suggesting that functionally discrete subsets of NK cells with different activation requirements may be involved. Here, we have used responses to individual components of the DTP vaccine [tetanus toxoid (TT), diphtheria toxoid (DT), whole cell inactivated pertussis] to characterize the NK cell subsets involved in interleukin-2-dependent recall responses. Culture with TT, DT or pertussis induced NK cell CD25 expression and interferon-γ production in previously vaccinated individuals. Responses were the most robust against whole cell pertussis, with responses to TT being particularly low. Functional analysis of discrete NK cell subsets revealed that transition from CD56bright to CD56dim correlated with increased responsiveness to CD16 cross-linking, whereas increasing CD57 expression correlated with a loss of responsiveness to cytokines. A higher frequency of CD56dim CD57− NK cells expressed CD25 and interferon-γ following stimulation with vaccine antigen compared with CD56dim CD57+ NK cells and made the largest overall contribution to this response. CD56dim CD57int NK cells represent an intermediate functional phenotype in response to vaccine-induced and receptor-mediated stimuli. These findings have implications for the ability of NK cells to contribute to the effector response after vaccination and for vaccine-induced immunity in older individuals

Calorie Restriction Attenuates Terminal Differentiation of Immune Cells

Immune senescence is a natural consequence of aging and may contribute to frailty and loss of homeostasis in later life. Calorie restriction increases healthy life-span in C57BL/6J (but not DBA/2J) mice, but whether this is related to preservation of immune function, and how it interacts with aging, is unclear. We compared phenotypic and functional characteristics of natural killer (NK) cells and T cells, across the lifespan, of calorie-restricted (CR) and control C57BL/6 and DBA/2 mice. Calorie restriction preserves a naïve T cell phenotype and an immature NK cell phenotype as mice age. The splenic T cell populations of CR mice had higher proportions of CD11a-CD44locells, lower expression of TRAIL, KLRG1, and CXCR3, and higher expression of CD127, compared to control mice. Similarly, splenic NK cells from CR mice had higher proportions of less differentiated CD11b-CD27+cells and correspondingly lower proportions of highly differentiated CD11b+CD27-NK cells. Within each of these subsets, cells from CR mice had higher expression of CD127, CD25, TRAIL, NKG2A/C/E, and CXCR3 and lower expression of KLRG1 and Ly49 receptors compared to controls. The effects of calorie restriction on lymphoid cell populations in lung, liver, and lymph nodes were identical to those seen in the spleen, indicating that this is a system-wide effect. The impact of calorie restriction on NK cell and T cell maturation is much more profound than the effect of aging and, indeed, calorie restriction attenuates these age-associated changes. Importantly, the effects of calorie restriction on lymphocyte maturation were more marked in C57BL/6 than in DBA/2J mice indicating that delayed lymphocyte maturation correlates with extended lifespan. These findings have implications for understanding the interaction between nutritional status, immunity, and healthy lifespan in aging populations

Factors influencing the market for branded mass customized buildings

The concept of mass customisation is not new yet the UK construction industry has yet to grasp this opportunity to deliver greater value to its customers. The government report Rethinking Construction [Egan 1998] clearly identifies this issue: ‘ We have repeatedly heard the claim that construction is different from manufacturing because every product is unique. We do not agree. Not only are many buildings such as houses, essentially repeat products which can be continually improved but, more importantly, the process of construction is itself repeated in its essentials from project to project.’ Egan delivered this report in 1998 but CLASP, for example, highlighted the advantages of standardisation in 1959 in the conclusions to their Annual Report [CLASP 1959]:’The consortium is now an established and powerful force in building, responsible for a significant number of the country’s new schools as well as for a growing number of other public buildings. The second year of operations has confirmed that the consortium with its big orders and its design resources, is the kind of organization most capable of realizing the full economic advantage of factory production methods. It leads therefore towards the more enlightened building industry for which we all strive.’ A review of government funded construction reports between 1944-98 [Murray 2003] emphasises the continued presence of these recurring themes in appraisal of the construction process. The opportunity is seemingly clear. Designing and constructing from scratch, each time a client requires building infrastructure, is wasteful and inefficient. A radical market change is needed where built environment customers experience much greater certainty and value whilst retaining choice, and at the same time enabling constructors to improve their profit margins by sharing the rewards of jointly maximising value. This vision requires the replacement of a significant portion of the current bespoke market for the design, delivery and procurement of non-residential buildings with a combination of standardised and customised product offerings. This paper details information obtained to date from an ongoing IMCRC funded study entitled ‘Building the Brand’ at Loughborough University

A human endogenous retrovirus encoded protease potentially cleaves numerous cellular proteins

Background: A considerable portion of the human genome derives from retroviruses inherited over millions of years. Human endogenous retroviruses (HERVs) are usually severely mutated, yet some coding-competent HERVs exist. The HERV-K(HML-2) group includes evolutionarily young proviruses that encode typical retroviral proteins. HERV-K(HML-2) has been implicated in various human diseases because transcription is often upregulated and some of its encoded proteins are known to affect cell biology. HERV-K(HML-2) Protease (Pro) has received little attention so far, although it is expressed in some disease contexts and other retroviral proteases are known to process cellular proteins. Results:We set out to identify human cellular proteins that are substrates of HERV-K(HML-2) Pro employing a modified Terminal Amine Isotopic Labeling of Substrates (TAILS) procedure. Thousands of human proteins were identified by this assay as significantly processed by HERV-K(HML-2) Pro at both acidic and neutral pH. We confirmed cleavage of a majority of selected human proteins in vitro and in co-expression experiments in vivo. Sizes of processing products observed for some of the tested proteins coincided with product sizes predicted by TAILS. Processed proteins locate to various cellular compartments and participate in diverse, often disease-relevant cellular processes. A limited number of HERV-K(HML-2) reference and non-reference loci appears capable of encoding active Pro. Conclusions:Our findings from an approach combining TAILS with experimental verification of candidate proteins in vitro and in cultured cells suggest that hundreds of cellular proteins are potential substrates of HERV-K(HML-2) Pro. It is therefore conceivable that even low-level expression of HERV-K(HML-2) Pro affects levels of a diverse array of proteins and thus has a functional impact on cell biology and possible relevance for human diseases. Further studies are indicated to elucidate effects of HERV-K(HML-2) Pro expression regarding human substrate proteins, cell biology, and disease. The latter also calls for studies on expression of specific HERV-K(HML-2) loci capable of encoding active Pro. Endogenous retrovirus-encoded Pro activity may also be relevant for disease development in species other than human.Deutsche Forschungsgemeinschaft; HOMFO

Moiré interferometry applied to fracture in titanium tubes

Despite there being a substantial body of evidence to the contrary, moiré interferometry is often regarded - even by some adherents - as a curiosity of the optics lab. The present work seeks to demonstrate still further that the method can be an effective tool for practical materials research and assessment, in this case, in a novel and challenging experimental application involving fracture testing of heat exchanger tube material, the work being conducted in a conventional materials test laboratory setting. The key to the utility of the present setup lies with the priority given to its optical efficiency. In standard fracture toughness tests, it is axiomatic that standard specimen geometries be used. A dilemma arises when a material's properties are transformed to a substantial degree by the final stages of its process of manufacture, and when the very nature of the finished form dictates that standard geometries cannot be produced. The focus of this investigation was to measure crack-tip opening displacements (CTODs) in thin-walled titanium tubes. Fringe patterns corresponding to in-plane displacement contours were obtained interferometrically and the method for extracting CTODs from these is described. Significant differences in yield, ultimate strength, elongation, and fracture behaviour were observed for different material orientations

Long-term performance of surface impregnation of reinforced concrete structures with silane

The South Asia Research and Information Institute (SARII) in Dallas, Texas, USA, organizes a one-day conference on ”Cities, Courts, and Saints: Muslim Cultures of South Asia” on Saturday 22 September 2012, 09.00–17.00. The conference is co-organised by the The Asian Studies Program at Southern Methodist University, also in Dallas. Venue for the  conference: McCord Auditorium, Dallas Hall, Southern Methodist University. his conference brings together the leading historians of South Asia and sp..