Material and magnetic properties of Sm2(Co, Fe, Cu, Zr)17permanentmagnets processed by Spark Plasma Sintering

Improvements to the properties of Rare Earth Permanent Magnets (REPMs) are needed to advance the capabilities of electric motors and generators, and refinement of the microstructure by the use of different approaches to processing may be a key means to achieving this. We report here a systematic study into the use of Spark Plasma Sintering to process Sm2(Co, Fe, Cu, Zr)17permanent magnets. This unfamiliar method for Sm2(Co, Fe, Cu, Zr)17offers the potential for efficiency savings in reduced processing temperatures and times versus the industry standard vacuum sinter powder metallurgical route, and also offers a refined microstructure of the materials produced. The optimised processing conditions for achieving near-to-theoretical density are reported, and the microstructure and magnetic properties of the materials produced are compared with conventional vacuum sintering. The results provide a basis for further optimisation of these materials

The Effect of Electronic Structure on the Phases Present in High Entropy Alloys

Multicomponent systems, termed High Entropy Alloys (HEAs), with predominantly single solid solution phases are a current area of focus in alloy development. Although different empirical rules have been introduced to understand phase formation and determine what the dominant phases may be in these systems, experimental investigation has revealed that in many cases their structure is not a single solid solution phase, and that the rules may not accurately distinguish the stability of the phase boundaries. Here, a combined modelling and experimental approach that looks into the electronic structure is proposed to improve accuracy of the predictions of the majority phase. To do this, the Rigid Band model is generalised for magnetic systems in prediction of the majority phase most likely to be found. Good agreement is found when the predictions are confronted with data from experiments, including a new magnetic HEA system (CoFeNiV). This also includes predicting the structural transition with varying levels of constituent elements, as a function of the valence electron concentration, n, obtained from the integrated spin-polarised density of states. This method is suitable as a new predictive technique to identify compositions for further screening, in particular for magnetic HEAs

Principles for transformative ocean governance

With a focus on oceans, we collaborated across ecological, social and legal disciplines to respond to the United Nations call for transformation in the ‘2030 Agenda for Sustainable Development’. We developed a set of 13 principles that strategically and critically connect transformative ocean research to transformative ocean governance (complementing the UN Decade for Ocean Science). We used a rigorous, iterative and transparent consensus-building approach to define the principles, which can interact in supporting, neutral or sometimes conflicting ways. We recommend that the principles could be applied as a comprehensive set and discuss how to learn from their interactions, particularly those that reveal hidden tensions. The principles can bring and keep together partnerships for innovative ocean action. This action must respond to the many calls to reform current ocean-use practices which are based on economic growth models that have perpetuated inequities and fuelled conflict and environmental decline

Spondylarthropathies (including psoriatic arthritis): 244. Validity of Colour Doppler and Spectral Doppler Ultrasound of Sacroilicac Joints Againts Physical Examination as Gold Standard

Background: Sacroiliac joints (SJ) involvement is a distinctive and charasteristic feature of Spondyloarthritis (SpA) and x-ray is the test routinely used to make a diagnosis. However, x-ray reveals late structural damage but cannot detect active inflammation. The objective of this study was to assess the validity of Doppler ultrasound in SJ. Methods: Prospective blinded and controlled study of SJ, in which three populations were compared. We studied 106 consecutive cases, who were divided into three groups: a) 53 patients diagnosed with SpA who had inflammatory lumbar and gluteal pain assessed by a rheumatologist; b) 26 patients diagnosed with SpA who didn't have SJ tenderness and had normal physical examination; c) control group of 27 subjects (healthy subjetcs or with mechanical lumbar pain). All patients included that were diagnosed with SpA met almost the European Spondyloarthropathy Study Group (ESSG) classification criteria. Physical examination of the SJ included: sacral sulcus tenderness, iliac gapping, iliac compression, midline sacral thrust test, Gaenslen's test, and Patrick s test were used as gold standard. Both SJ were examined with Doppler ultrasound (General Electric Logiq 9, Wauwatosa WI, USA) fitted with a 9-14 Mhz lineal probe. The ultrasonographer was blinded to clinical data. Doppler in SJ was assessed as positive when both Doppler colour and resistance index (RI) < 0.75 within the SJ area were present. Statistical analysis was performed estimating sensitivity and specificity against gold standard. The Kappa correlation coefficient was used for reliability study. Results: 106 cases (53 female, 55 male; mean age 36 10 years) were studied. There were no statistical differences between groups related to age or sex. Physical examination of SJ was positive in 38 patients (59 sacroiliac joints). US detected Doppler signal within SJ in 37 patients (58 SJ): 33 of them were symptomatic SpA (52 SJ), one of them were asymptomatic SpA (1 SJ) and one was a healthy control (1 SJ). The accuracy of US when compared to clinical data as gold standard at subject level in the overall group was: sensitivity of 68.6% and specificity of 85.7%, positive predictive value of 70.5% and negative predictive value of 84.5%. A positive likelihood ratio of 4.8, a negative likelihood ratio of 0.36 and a kappa coefficient of 0.55 were achieved. Conclusions: Doppler US of SJ seems to be a valid method to detect active SJ inflammation. Disclosure statement: The authors have declared no conflicts of interes

A trans-acting locus regulates an anti-viral expression network and type 1 diabetes risk

Combined analyses of gene networks and DNA sequence variation can provide new insights into the aetiology of common diseases that may not be apparent from genome-wide association studies alone. Recent advances in rat genomics are facilitating systems-genetics approaches. Here we report the use of integrated genome-wide approaches across seven rat tissues to identify gene networks and the loci underlying their regulation. We defined an interferon regulatory factor 7 (IRF7)-driven inflammatory network (IDIN) enriched for viral response genes, which represents a molecular biomarker for macrophages and which was regulated in multiple tissues by a locus on rat chromosome 15q25. We show that Epstein-Barr virus induced gene 2 (Ebi2, also known as Gpr183), which lies at this locus and controls B lymphocyte migration, is expressed in macrophages and regulates the IDIN. The human orthologous locus on chromosome 13q32 controlled the human equivalent of the IDIN, which was conserved in monocytes. IDIN genes were more likely to associate with susceptibility to type 1 diabetes (T1D)-a macrophage-associated autoimmune disease-than randomly selected immune response genes (P = 8.85 x 10(-6)). The human locus controlling the IDIN was associated with the risk of T1D at single nucleotide polymorphism rs9585056 (P = 7.0 x 10(-10); odds ratio, 1.15), which was one of five single nucleotide polymorphisms in this region associated with EBI2 (GPR183) expression. These data implicate IRF7 network genes and their regulatory locus in the pathogenesis of T1D

The taxonomic identity and distribution of the eel cod Muraenolepis (Gadiformes: Muraenolepididae) around South Georgia and the South Sandwich Islands

Fishes of the genus Muraenolepis are regularly caught in commercial and research fishing in the waters around South Georgia and the South Sandwich Islands, but for many years there has been uncertainty about the specific identity of the species being caught. Here, we used morphological and molecular data to clarify the identity of specimens of Muraenolepis caught in trawl surveys and longline fisheries in South Georgia and South Sandwich Island waters. Type specimens of M. marmorata, M. microps and M. orangiensis were examined, together with specimens caught in trawl surveys around South Georgia. Morphological and molecular (mitochondrial 16S and cox1 sequence) data from specimens collected throughout the Southern Ocean indicate four clades and confirm the presence of just one species (M. marmorata) on the South Georgia continental shelf. The data also confirm that M. microps is a junior synonym of M. marmorata, which has a broad distribution around sub-Antarctic islands in the Southern Ocean extending as far south as the South Orkneys and the southern South Sandwich Islands. Muraenolepis evseenkoi is the main species caught in longline fisheries in the South Sandwich Islands and, with a more southerly distribution, is not known from around South Georgia. A third species (M. kuderskii) is also reported from around South Georgia and one specimen was considered to belong to this species. In total, there are eight recognised species of muraenolepidids in two genera, with six species having an Antarctic distribution

Pairwise dilatational strain as a parametric model describing potential secondary phase formation and high-angle grain misorientation in as-cast high-entropy alloys

Crystallographic strain in high-entropy alloys (HEAs) can affect not only structure stability, but also their mechanical properties. This is studied by comparing the effects of different alloying additions in CoCrFeNi-Ax (A: Mn, V0.3, Ti0.4, Pd1, and Pd1.5) FCC HEAs on their calculated dilatational strains. Dilatational strain values are found to be proportional to the EBSD population of misoriented microstructures at 53–60°. Larger magnitudes of the dilatational strain are exhibited by FCC-stabilising alloying additions. EBSD and TEM suggest increased twin presence for higher strain compositions. This means that HEAs can be designed to present higher ductility if dilatational strain can be maximised when structural stability can be maintained. These model-property relationships can be incorporated into metaheuristic objective functions as an alloy design strategy