Evaluación in vitro de la actividad antihelmíntica de extractosmetanólicos de Guazuma ulmifolia frente anematodos Cyathostominae

The study evaluated the anti-hatching effect of methanolic extracts from the bark and leaf of Guazuma ulmifolia using the in vitro Nematode Egg Hatching Inhibition test. Concentrations of 1000, 500 and 250 µg/ml of each extract, a negative control (Dimethyl sulfoxide) and two positive controls (Fenbendazole and Lugol) were evaluated against nematodes of the Cyathostominae subfamily as a biological model. The three concentrations of the two extracts, as well as the two positive controls showed statistically similar results, but different compared to the negative control. The mean inhibition of egg hatching using bark and leaf was 49.73 and 45.22%, respectively, at the 1000 µg/ml concentration, 61.93 and 59.20% at the 500 µg/ml concentration, and 75.60 and 75.82% at the concentration of 250 µg/ml. The methanolic extracts of the bark and leaf of Guazuma ulmifolia showed an anti-hatching effect against Cyathostominae nematodes at the concentrations testedEl estudio evaluó el efecto anti-eclosión de extractos metanólicos de corteza y hojade Guazuma ulmifolia mediante la prueba in vitro de Inhibición de la Eclosión de huevosde nematodos. Se evaluaron las concentraciones de 1000, 500 y 250 μg/ml de cada extrac-to, un control negativo (Dimetil sulfóxido) y dos controles positivos (Fenbendazol yLugol) contra nematodos de la subfamilia Cyathostominae como modelo biológico. Lastres concentraciones de los dos extractos, así como los dos controles positivos presen-taron resultados estadísticamente similares, pero diferentes frente al control negativo. Lainhibición media de la eclosión de huevos usando corteza y hoja fue de 49.73 y 45.22%,respectivamente, en la concentración de 1000 μg/ml, de 61.93 y 59.20% en la concentra-ción de 500 μg/ml y de 75.60 y 75.82% en la concentración de 250 μg/ml. Los extractosmetanólicos de corteza y hoja de Guazuma ulmifolia mostraron un efecto anti-eclosióncontra nematodos Cyathostominae en las concentraciones evaluadasIncluye referencias bibliográfica

Delayed presentation of an arteriovenous malformation after cerebellar hemangioblastoma resection—Case report

AbstractIntroductionHaemangioblastoma has been uncommonly reported to occur in coexistence either temporally or spatially with the development of an arteriovenous malformations (AVM). We present a case of a delayed AVM following haemangioblastoma resection.Presentation of case44 year old female initially presented with a several week history of headaches, vertigo and nausea and emesis and was found to have a cystic lesion with a solid enhancing component on Magnetic Resonance Imaging (MRI) in the superior aspect of the vermis. She underwent gross total resection and final pathology was consistent with WHO grade I haemangioblastoma. One year later, patient re-presented with headaches, dizziness and left trochlear nerve palsy with rotary nystagmus. Imaging revealed a left posterior tentorial paramedian cerebellar vascular nidus with venous drainage into the left transverses sinus suspicious for arteriovenous malformation. She underwent gross total resection of the lesion. Final pathology confirmed the diagnosis of an arteriovenous malformation.DiscussionRecent research supports both haemangioblastoma and AVM are of embryologic origin but require later genetic alterations to develop into symptomatic lesions. It is unclear in our case if the AVM was present at the time of the initial haemangioblastoma resection or developed de novo after tumor resection. However, given the short time between tumor resection and presentation of AVM, de novo AVM although possible, appears less likely.ConclusionAVM and haemangioblastoma rarely presents together either temporally or spatially. We present a case of a delayed AVM following haemangioblastoma resection. More research is needed to elucidate the rare intermixture of these lesions

Winning versus losing during gambling and its neural correlates

Humans often make decisions which maximize an internal utility function. For example, humans often maximize their expected reward when gambling and this is considered as a "rational" decision. However, humans tend to change their betting strategies depending on how they "feel". If someone has experienced a losing streak, they may "feel" that they are more likely to win on the next hand even though the odds of the game have not changed. That is, their decisions are driven by their emotional state. In this paper, we investigate how the human brain responds to wins and losses during gambling. Using a combination of local field potential recordings in human subjects performing a financial decision-making task, spectral analyses, and non-parametric cluster statistics, we investigated whether neural responses in different cognitive and limbic brain areas differ between wins and losses after decisions are made. In eleven subjects, the neural activity modulated significantly between win and loss trials in one brain region: the anterior insula ($p=0.01$). In particular, gamma activity (30-70 Hz) increased in the anterior insula when subjects just realized that they won. Modulation of metabolic activity in the anterior insula has been observed previously in functional magnetic resonance imaging studies during decision making and when emotions are elicited. However, our study is able to characterize temporal dynamics of electrical activity in this brain region at the millisecond resolution while decisions are made and after outcomes are revealed

The Insula and Its Epilepsies

Insular seizures are great mimickers of seizures originating elsewhere in the brain. The insula is a highly connected brain structure. Seizures may only become clinically evident after ictal activity propagates out of the insula with semiology that reflects the propagation pattern. Insular seizures with perisylvian spread, for example, manifest first as throat constriction, followed next by perioral and hemisensory symptoms, and then by unilateral motor symptoms. On the other hand, insular seizures may spread instead to the temporal and frontal lobes and present like seizures originating from these regions. Due to the location of the insula deep in the brain, interictal and ictal scalp electroencephalogram (EEG) changes can be variable and misleading. Magnetic reso- nance imaging, magnetic resonance spectroscopy, magnetoencephalography, positron emission tomography, and single-photon computed tomography imaging may assist in establishing a diagnosis of insular epilepsy. Intracranial EEG recordings from within the insula, using stereo-EEG or depth electrode techniques, can prove insular seizure origin. Seizure onset, most commonly seen as low-voltage, fast gamma activity, however, can be highly localized and easily missed if the insula is only sparsely sampled. Moreover, seizure spread to the contralateral insula and other brain regions may occur rapidly. Extensive sampling of the insula with multiple electrode trajectories is necessary to avoid these pitfalls. Understanding the functional organization of the insula is helpful when interpreting the semiology produced by insular seizures. Electrical stimulation mapping around the central sulcus of the insula results in paresthesias, while stimulation of the posterior insula typically produces painful sensations. Visceral sensations are the next most common result of insular stimulation. Treatment of insular epilepsy is evolving, but poses challenges. Surgical resections of the insula are effective but risk significant morbidity if not carefully planned. Neurostimulation is an emerging option for treatment, especially for seizures with onset in the posterior insula. The close association of the insula with marked autonomic changes has led to interest in the role of the insula in sudden unexpected death in epilepsy and warrants additional study with larger patient cohorts

δ Sct pulsation in magnetic Ap stars: The discovery of δ Sct pulsations in HD 218994AB and measurement of the magnetic fields of HD 218994A and HD 21190

We have discovered that at least one component of the visual binary star HD 218994AB is a δ Sct star. The primary star of this system is a known rapidly oscillating Ap (roAp) star; therefore, it is possible that it is both an roAp star and a δ Sct star - a hybrid. There are no confirmed such hybrid roAp-δ Sct stars, and they are predicted theoretically not to exist. More probably, HD 218994B is the δ Sct star, as it is 0.54 mag fainter than the primary and also lies in the δ Sct instability strip. It then offers the potential to determine Teff and L for the primary which appears to be one of the more evolved roAp stars and an important test the theoretically calculated roAp star instability strip. In this case, the system also is important since the stars are a co-eval pair of very similar mass, yet one is a magnetic roAp star and the other is probably a non-magnetic δ Sct star with a normal spectrum. We detect a significant longitudinal magnetic field strength of 440 ± 23 G in the roAp star HD 218994A. We also present the first measurement of the longitudinal magnetic field strength for the δ Sct star HD 21190, the most-evolved Ap star known. We obtain a formally significant value of 47 ± 13 G. If confirmed, this will make HD 21190 the first magnetic δ Sct star known.Fil: Kurtz, D. W.. University of Central Lancashire; Estados UnidosFil: Hubrig, S.. European Southern Observatory Chile; ChileFil: Gonzalez, Jorge Federico. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Juan. Complejo Astronómico "El Leoncito". Universidad Nacional de Córdoba. Complejo Astronómico "El Leoncito". Universidad Nacional de la Plata. Complejo Astronómico "El Leoncito". Universidad Nacional de San Juan. Complejo Astronómico "El Leoncito"; ArgentinaFil: van Wyk, F.. South African Astronomical Observatory; SudáfricaFil: Martinez, P.. South African Astronomical Observatory; Sudáfric

Diabetes primary prevention program: new insights from data analysis of recruitment period

Primary Prevention of Diabetes Program in Buenos Aires Province evaluates the effectiveness of adopting healthy lifestyle to prevent type 2 diabetes (T2D) in people at high risk of developing it. We aimed to present preliminary data analysis of FINDRISC and laboratory measurements taken during recruitment of people for the Primary Prevention of Diabetes Program in Buenos Aires Province in the cities of La Plata, Berisso, and Ensenada, Argentina.Fil: Gagliardino, Juan Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - la Plata. Centro de Endocrinología Experimental y Aplicada. Universidad Nacional de la Plata. Facultad de Cs.médicas. Centro de Endocrinología Experimental y Aplicada; ArgentinaFil: Elgart, Jorge Federico. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - la Plata. Centro de Endocrinología Experimental y Aplicada. Universidad Nacional de la Plata. Facultad de Cs.médicas. Centro de Endocrinología Experimental y Aplicada; ArgentinaFil: Bourgeois, Marcelo Javier. Universidad Nacional de la Plata. Facultad de Cs.médicas. Centro Interdisc.universitario Para la Salud; ArgentinaFil: Etchegoyen, Graciela Susana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - la Plata. Centro de Endocrinología Experimental y Aplicada. Universidad Nacional de la Plata. Facultad de Cs.médicas. Centro de Endocrinología Experimental y Aplicada; ArgentinaFil: Fantuzzi, Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - la Plata. Centro de Endocrinología Experimental y Aplicada. Universidad Nacional de la Plata. Facultad de Cs.médicas. Centro de Endocrinología Experimental y Aplicada; ArgentinaFil: Ré, Matias. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - la Plata. Centro de Endocrinología Experimental y Aplicada. Universidad Nacional de la Plata. Facultad de Cs.médicas. Centro de Endocrinología Experimental y Aplicada; ArgentinaFil: Ricart, Juan P.. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - la Plata. Centro de Endocrinología Experimental y Aplicada. Universidad Nacional de la Plata. Facultad de Cs.médicas. Centro de Endocrinología Experimental y Aplicada; ArgentinaFil: García, Silvia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - la Plata. Centro de Endocrinología Experimental y Aplicada. Universidad Nacional de la Plata. Facultad de Cs.médicas. Centro de Endocrinología Experimental y Aplicada; ArgentinaFil: Giampieri, Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - la Plata. Centro de Endocrinología Experimental y Aplicada. Universidad Nacional de la Plata. Facultad de Cs.médicas. Centro de Endocrinología Experimental y Aplicada; ArgentinaFil: Gonzalez, Lorena. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - la Plata. Centro de Endocrinología Experimental y Aplicada. Universidad Nacional de la Plata. Facultad de Cs.médicas. Centro de Endocrinología Experimental y Aplicada; ArgentinaFil: Suárez Crivaro, Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - la Plata. Centro de Endocrinología Experimental y Aplicada. Universidad Nacional de la Plata. Facultad de Cs.médicas. Centro de Endocrinología Experimental y Aplicada; ArgentinaFil: Kronsbein, Peter. Niederrhein University of Applied Sciences Mönchengladbach; AlemaniaFil: Angelini, Julieta M.. Universidad Nacional de La Plata; ArgentinaFil: Martinez, Camilo. Universidad Nacional de La Plata; ArgentinaFil: Martinez, Jorge. Universidad Nacional de La Plata; ArgentinaFil: Ricart, Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones en Humanidades y Ciencias Sociales. Universidad Nacional de La Plata. Facultad de Humanidades y Ciencias de la Educación. Instituto de Investigaciones en Humanidades y Ciencias Sociales; ArgentinaFil: Spinedi, Eduardo Julio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - la Plata. Centro de Endocrinología Experimental y Aplicada. Universidad Nacional de la Plata. Facultad de Cs.médicas. Centro de Endocrinología Experimental y Aplicada; Argentin

The Usefulness of Intraoperative Cerebral C-Arm CT Angiogram for Implantation of Intracranial Depth Electrodes in Stereotactic Electroencephalography Procedure

Background: Stereotactic electroencephalography (SEEG) is an invasive diagnostic tool for localizing the epileptic zone in patients with medically refractory focal epilepsy. Despite technical and imaging advances in guiding the electrode placement, vascular injury is still one of its most serious complications. Object: To investigate the usefulness of intraoperative cerebral C-arm CT angiogram (CCTA) in avoiding intracranial hemorrhagic complications during SEEG electrode implantation. Methods: Trajectory data from 12 patients who underwent SEEG electrode implantation were studied in detail. This included an analysis of the implantation of 146 SEEG electrodes, which were guided by intraoperative CCTA, as well as the standard planning based on preoperative contrast-enhanced MRI. In addition, a prospective analysis of SEEG hemorrhagic complications using the studied methodology was performed in a total of 87 patients receiving 1,310 electrodes. Results: There was no complication related to the CCTA itself. Intraoperative CCTA entailed modification of the original trajectory based on the preoperative MRI in 27 of 146 electrode implantations (18.5%). In 10 of them, a severe vascular complication was adverted by intraoperative CCTA. The safety of this new approach was also confirmed by the analysis of postinterventional CT, which revealed a symptomatic hematoma caused by 1 single electrode out of the 1,310 implanted. Conclusions: This study showed that intraoperative CCTA in addition to preoperative MRI is useful in guiding a safer SEEG electrode implantation. The combination of both imaging modalities essentially minimizes the risk of serious hemorrhagic complications

Effects of splitter Blade Length on disc pump performance

The disc pump operates using boundary layer principle and viscous drag with a relatively low efficiency. There are methods to increase head and efficiency, one of them is the placing of blades sectors or splitter blades in discs. This method has been applied only in the low viscosity fluids pumping (v < 0.1 stokes). This study describe an experimental research in a hight viscocity fluid (v = 2 stokes) with exit angle (32 = 35° and different splitter blades Lengths (Ls) (75, 50, 25%). The purpose is to determinate the splitter blades length that achieves the most effective combination between the blade effect and boundary layer effect in order to increase the energy transmission efficiency from the impeller to the fluid. As result, it can be established that the use of spliter blades is an alternative to increase the performance of the disc pump. The highest efficiency and head were obtained for the gapsize between two discs (b) of 12 mm using a 50% spliter blades length of the main blade length