4 research outputs found
MĂ©todo para el diagnĂłstico de las relaciones intersectoriales en el modelo de desarrollo municipal
- Author
- Publication venue
- Facultad de Ciencias Agropecuarias, Universidad de CamagĂŒey Ignacio Agramonte Loynaz
- Publication date
- 01/09/2017
- Field of study
Con el objetivo de diseñar un mĂ©todo que permita el diagnĂłstico de las relaciones intersectoriales, y la coordinaciĂłn entre las estrategias de desarrollo, y los sectores claves de la economĂa en el sistema de gestiĂłn estratĂ©gica del municipio de Nuevitas, provincia de CamagĂŒey, se utilizaron los mĂ©todos de anĂĄlisis, sĂntesis, el sistĂ©mico para concebir el carĂĄcter de las interacciones entre sus componentes, las entrevistas, encuestas, y el anĂĄlisis documental, los que posibilitaron caracterizar la situaciĂłn actual del municipio. Se develĂł en el diagnĂłstico que no se introduce el anĂĄlisis de las relaciones intersectoriales, lo cual se encuentra influenciado, por las deficiencias que aĂșn existen en cuanto al diseño de la metodologĂa para el diagnĂłstico estratĂ©gico situacional. De acuerdo a los resultados obtenidos, se identificaron las insuficiencias existentes en cuanto al estado de las relaciones intersectoriales en las entidades seleccionadas, lo cual manifiesta una deficiente coordinaciĂłn entre los diferentes sectores, evidenciando las potencialidades y restricciones, debilidades y amenazas, fortalezas y oportunidades que existen en el municipio, siendo necesario se elabore en el diagnĂłstico la problemĂĄtica que afecta las relaciones intersectoriales en las estrategias de desarrollo. La propuesta metodolĂłgica para el diagnĂłstico tiene como principales supuestos, que los diagnĂłsticos deben establecer mĂ©todos para incluir el anĂĄlisis de las relaciones horizontales entre los diferentes sectores, hacia el logro de la convergencia con la estrategia de desarrollo en el municipio y una mayor eficiencia en los programas de desarrollo integral.
 
The risk of COVID-19 death is much greater and age dependent with type I IFN autoantibodies
- Author
- Abad Jorge
- Abel Laurent
- Abel Laurent
- Abel Laurent
- Abel Laurent
- Accordino Giulia
- Achille Cristian
- Acosta-Ampudia Yeny
- Agra Juan José Cåceres
- Aguilera-Albesa Sergio
- AguilĂł-Cucurull Aina
- Aiuti Alessandro
- Aiuti Alessandro
- Aiuti Alessandro
- Akcan Ăzge Metin
- Al-Muhsen Saleh
- Al-Mulla Fahd
- Alavoine Loubna
- Albert Matthew
- Albisures Jonathan Antonio Roblero
- Alcover Andres
- Aldave Juan
- Algera Anne Geke
- Aliberti Anna
- Alkan Gulsum
- Alkhater Suzan
- Alkhater Suzan
- Allardet-Servent Jerome
- Allavena Clotilde
- Allende Luis
- Alonso-Arias Rebeca
- Alshahrani Mohammed
- Alsina Laia
- Alvarez Josep Trenado
- Alyanakian Marie-Alexandra
- Amador-Borrero Blanca
- Amat Karine
- Amoura Zahir
- Anaya Juan-Manuel
- Anderson Mark
- Anderson Mark
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- Andreakos Evangelos
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- Andrés Ana De
- Anglicheau Dany
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- Appelman Brent
- Arias Andrés
- Arias Andrés Augusto
- Arkin Lisa
- Arquero Miguel Fernandez
- Arranz MarĂa JesĂșs
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- Rigo-Bonnin RaĂșl
- Rigo-Bonnin RaĂșl
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- RiviĂšre Jacques
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- Rodero Mathieu
- Rodrigo Carlos
- Rodriguez Luis Antonio
- Rodriguez-Gallego Carlos
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- RodrĂguez-Gallego Carlos
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- SeppÀnen Mikko R.J.
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- Shcherbina Anna
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- Taccone Fabio
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- Tancevski Ivan
- Tancevski Ivan
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- Tandjaoui-Lambiotte Yacine
- Tangy Frédéric
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- Tangye Stuart
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- Taupin Jean-Luc
- Tavernier Simon
- Tayoun Ahmad Abou
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- Terrier Benjamin
- Terrier Olivier
- Teunissen Charlotte
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- Tiberghien Pierre
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- Tolstrup Martin
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- Trouillet-Assant Sophie
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- Troya JesĂșs
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- Tso Eugene
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- Tsumura Miyuki
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- Tubiana Sarah
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- Turvey Stuart
- Tzourio Christophe
- Téoulé François
- Uddin K.
- Uddin Mohammed
- Ungeheuer Marie-Noëlle
- Ursini Matilde Valeria
- Utsumi Takanori
- Uzunhan Yurdagul
- Vabres Pierre
- Valencia-Ramos Juan
- Valsecchi Maria Grazia
- van Agtmael Michiel
- van Baarle Frank
- van Braeckel Eva
- van de Beek Diederik
- van de Beek Diederik
- van de Beek Diederik
- van den Rym Ana Maria
- van der Poll Tom
- van der Valk Marc
- van der Werf Sylvie
- van der Werf Sylvie
- van Mourik Niels
- van Praet Jens
- van Vugt MichĂšle
- Vanderlinden Dimitri
- Vandernoot Isabelle
- Vanel Noémie
- Vasse Marc
- Veelo Denise
- Veislinger Aurélie
- Velez-Santamaria Valentina
- Veliz Silvia Patricia Zuniga
- Venet Fabienne
- Vergara José Alejandro Daza
- Vidaur Loreto
- Vidaur Loreto
- Vidigal Mateus
- Vidigal Mateus
- Viel SĂ©bastien
- Vignali Valérie
- Vilaire-Meunier Marie
- Villain CĂ©dric
- Villar-GarcĂa Judit
- Vincent Audrey
- Vinh Donald
- Vinh Donald
- Visseaux Benoit
- Visseaux Benoit
- Vlaar Alexander
- Vogt Guillaume
- Voiriot Guillaume
- Volleman Carolien
- Volokha Alla
- von Bernuth Horst
- von Stemann Jakob Hjorth
- Vught Lonneke
- Vuotto Fanny
- VĂ©lez VerĂłnica Posada
- Waucquier Nawal
- Wauters Els
- Wauters Joost
- Wauters Joost
- Wauters Joost
- Wiedemann Aurélie
- Wiersinga W. Joost
- Wouters Dorien
- Wu Alan
- Wu Tak-Chiu
- YahĆi Aysun
- Yang Rui
- Yasar Kadriye Kart
- Yazdanpanah Yazdan
- Yazdanpanah Yazdan
- Yepes Jairo David Torres
- Yesilbas Osman
- Yildiz Mehmet
- Young Barnaby
- YĂŒkselmiĆ Ufuk
- Zatz Mayana
- Zatz Mayana
- Zatz Mayana
- Zawadzki Pawel
- Zhang Peng
- Zhang Qian
- Zhang Shen-Ying
- Zhang Yu
- Zimmer Christophe
- Zins Marie
- Zins Marie
- Zuccaro Valentina
- Zwinderman A.
- Ăñigo-Campos Antonio
- Ăz Ćadiye KĂŒbra TĂŒter
- Ăzkan Esra AkyĂŒz
- Ăzçelik Tayfun
- Publication venue
- 'Proceedings of the National Academy of Sciences'
- Publication date
- 24/05/2022
- Field of study
International audienceSignificance There is growing evidence that preexisting autoantibodies neutralizing type I interferons (IFNs) are strong determinants of life-threatening COVID-19 pneumonia. It is important to estimate their quantitative impact on COVID-19 mortality upon SARS-CoV-2 infection, by age and sex, as both the prevalence of these autoantibodies and the risk of COVID-19 death increase with age and are higher in men. Using an unvaccinated sample of 1,261 deceased patients and 34,159 individuals from the general population, we found that autoantibodies against type I IFNs strongly increased the SARS-CoV-2 infection fatality rate at all ages, in both men and women. Autoantibodies against type I IFNs are strong and common predictors of life-threatening COVID-19. Testing for these autoantibodies should be considered in the general population
The risk of COVID-19 death is much greater and age dependent with type I IFN autoantibodies
- Author
- Abad Jorge
- Abel Laurent
- Abel Laurent
- Abel Laurent
- Abel Laurent
- Accordino Giulia
- Achille Cristian
- Acosta-Ampudia Yeny
- Agra Juan José Cåceres
- Aguilera-Albesa Sergio
- AguilĂł-Cucurull Aina
- Aiuti Alessandro
- Aiuti Alessandro
- Aiuti Alessandro
- Akcan Ăzge Metin
- Al-Muhsen Saleh
- Al-Mulla Fahd
- Alavoine Loubna
- Albert Matthew
- Albisures Jonathan Antonio Roblero
- Alcover Andres
- Aldave Juan
- Algera Anne Geke
- Aliberti Anna
- Alkan Gulsum
- Alkhater Suzan
- Alkhater Suzan
- Allardet-Servent Jerome
- Allavena Clotilde
- Allende Luis
- Alonso-Arias Rebeca
- Alshahrani Mohammed
- Alsina Laia
- Alvarez Josep Trenado
- Alyanakian Marie-Alexandra
- Amador-Borrero Blanca
- Amat Karine
- Amoura Zahir
- Anaya Juan-Manuel
- Anderson Mark
- Anderson Mark
- Andreakos Evangelos
- Andreakos Evangelos
- Andrejak Claire
- Andrés Ana De
- Anglicheau Dany
- Angoulvant François
- Annereau Jean-Philippe
- AntolĂ Arnau
- Appelman Brent
- Arias Andrés
- Arias Andrés Augusto
- Arkin Lisa
- Arquero Miguel Fernandez
- Arranz MarĂa JesĂșs
- Arrestier Romain
- Arrestier Romain
- Asano Takaki
- Aschard Hugues
- Aubart MĂ©lodie
- Auguet Teresa
- Avramenko Iryna
- Aytekin Gökhan
- Aytekin Selma Erol
- Azot Axelle
- Azoulay Cecile
- Bachelet Delphine
- Bahram Seiamak
- Bajolle Fanny
- Baldanti Fausto
- Baldolli Aurélie
- Ballester Maite
- Baris-Feldman Hagit
- Barreiros Lucila
- Barrou Benoit
- Bartoli Marie
- Barzaghi Federica
- Basmaci Romain
- Basso Sabrina
- Bastard Paul
- Batten Isabella
- Bauters Fré
- Bax Diane
- Bayhan Gulsum Iclal
- Behillil Sylvie
- Behillill Sylvie
- Bellani Giacomo
- Belot Alexandre
- Belot Alexandre
- Belot Alexandre
- Beluze Marine
- Benech Nicolas
- Benkerrou Dehbia
- Beretta Ilaria
- Bergin Colm
- Bertholon Frédérique
- Bettini Laura Rachele
- Beudel Martijn
- Bezrodnik Liliana
- Bhavsar Krishna
- Biggs Catherine
- Biggs Catherine
- Bilbao Agurtzane
- Bilguvar Kaya
- Biondi Andrea
- Bitker Laurent
- Bizien Lucy
- Blanchard-Rohner Geraldine
- Blanco Ignacio
- BlandiniĂšres Adeline
- Bleibtreu Alexandre
- Bloomfield Marketa
- BlĂĄzquez-Gamero Daniel
- Bogaard Harm Jan
- Bogunovic Dusan
- Boisson Bertrand
- Bolivar-Prados Mireia
- Bolze Alexandre
- Bomers Marije
- Bondarenko Anastasiia
- Bondarenko Anastasiia
- Bondarenko Anastasiia
- Bonfanti Paolo
- Bonneaudeau Brigitte
- Bonta Peter
- Borghesi Alessandro
- Borie Raphael
- Borrero Blanca Amador
- Bos Lieuwe
- Bosteels CĂ©dric
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- Botelho-Nevers Elisabeth
- Botta Michela
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- Bouadma Lila
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- Boudhabhay Idris
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- Bourke Nollaig
- Bourke Nollaig
- Bourke Nollaig
- Bouscambert-Duchamp Maude
- Bousfiha Ahmed
- Bousfiha Ahmed
- Bousfiha Ahmed
- Bousquet Aurore
- Bousso Philippe
- Boutolleau David
- Bouvattier Claire
- Boyarchuk Oksana
- Boyarchuk Oksana
- Bozdemir Ćefika Elmas
- Bravais Juliette
- Briones M. Luisa
- Briseño-Roa Luis
- Brodin Petter
- Brodin Petter
- Brouwer Matthijs
- Bruhns Pierre
- Bruneau LĂ©a
- Brunner Marie-Eve
- Bruno Raffaele
- Bryceson Yenan
- Bueno Maria Rita P.
- Bugiani Marianna
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- Bulle Esther
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- Burdet Charles
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- Ceschi Alessandro
- Chahine Abir
- Chair Anissa
- Chakravorty Samya
- Chalumeau Martin
- Charbit Bruno
- Charpentier Charlotte
- Chauvineau-Grenier Angélique
- Chen Jie
- Cheng Matthew
- Chirouze Catherine
- Chirouze Catherine
- Chouchane Osoul
- Chrabieh Maya
- Christodoulou John
- Ciceri Fabio
- Citerio Giuseppe
- Clavé Pere
- Clercq Jozefien De
- Cloherty Alex
- Clotet Bonaventura
- Cobat Aurélie
- Codina Anna
- Coelho Alexandra
- Coeuret-Pellicer Mireille
- Cognasse Fabrice
- Cognasse Fabrice
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- Colobran Roger
- Comarmond Cloé
- Combes Alain
- Comoli Patrizia
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- Conlon Niall
- Connolly Emma
- Constantinescu Stefan
- Conti Francesca
- Contro Ernesto
- Cooper Megan
- Cordel Hugues
- Correales Luisa Paola Duarte
- Corsico Angelo
- Couffignal Camille
- Couffin-Cadiergues Sandrine
- Couffin-Cadiergues Sandrine
- Coulongeat Matthieu
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- Cuadros Esmeralda Nuñez
- Cumano Ana
- Cvetkovski Aleksandar
- Cyrus Cyril
- Daganou Maria
- Dalgard Clifton
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- Dalmau David
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- Darazam Ilad Alavi
- Darley David Ross
- Das Vincent
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- Dauger Stéphane
- de Brabander Justin
- de Bree Godelieve
- de Bruin Sanne
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- Debette Stéphanie
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- Dechanet Aline
- Dehban Amin
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- Demirkol Yasemin Kendir
- Demoule Alexandre
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- Deplanque Dominique
- Deriano Ludovic
- Desai Murkesh
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- Descamps Diane
- Desguerre Isabelle
- Desille-Dugast Mireille
- Desmarets Maxime
- Desvallée Mathilde
- Di Sabatino Antonio
- Di Santo James
- Diallo Alpha
- Diego Rebeca PĂ©rez De
- Diehl Jean-Luc
- Diehl Jean-Luc
- Dijkstra Mirjam
- Dillies Marie-AgnĂšs
- Ding Li
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- Djossou FĂ©lix
- Dobbelaere Stephanie
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- Dromer Françoise
- Dubos François
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- Duffy Darragh
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- Dufouil Carole
- Dujardin Romein
- Dunne Jean
- Dupont Annabelle
- Duval Xavier
- Duval Xavier
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- Dyer Adam
- Dâangio Mariella
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- Ecobichon Jean-Luc
- Ekwall Olov
- El Baghdadi Jamila
- El Bakkouri Jalila
- Elbers Paul
- Elnagdy Marwa
- Eloy Philippine
- Emiroglu Melike
- Endo Akifumi
- Enninga Jost
- Enouf Vincent
- Enouf Vincent
- Epaulard Olivier
- Erdeniz Emine Hafize
- Erikstrup Christian
- Erikstrup Christian
- Esperou HĂ©lĂšne
- Espinosa-Padilla Sara
- Esposito-Farase Marina
- Espérou HélÚne
- Etienne Manuel
- Eto Shohei
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- Fabio Giovanna
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- Falck Antonin
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- Fartoukh Muriel
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- Fellay Jacques
- Fellay Jacques
- Fellay Jacques
- Ferrer Ricard
- Ferreres Jose
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- Fouchard Julie
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- Franco José Luis
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- Frezouls Wahiba
- Froidure Antoine
- FumadĂł Victoria
- Fung Kitty
- Fusco Francesca
- Gagneux-Brunon Amandine
- Gagro Alenka
- Gallian Pierre
- Garcia-Prat Marina
- GarcĂa Paula Andrea Gaviria
- Garot Denis
- Garçon Pierre
- Gatineau Audrey Giraud
- Gaudet Alexandre
- Gault Nathalie
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- Gaymard Alexandre
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- Geerlings Suzanne
- Geijtenbeek Theo
- Gentile Stéphanie
- Gervais Adrian
- Ghirardello Stefano
- Ghosn Jade
- Gigante Tristan
- Gil-Herrera Juana
- Gilardin Laurent
- Gilardin Laurent
- Gilg Morgane
- Girbes Armand
- Girona-AlarcĂłn MĂČnica
- Gissot Valérie
- GodĂnez Karen Alejandra Cifuentes
- Goehringer François
- Goffard Jean-Christophe
- Goldberg Marcel
- Gomperts-Boneca Ivo
- Gonzales Nacho
- Gonzalez-Granado Luis
- GonzĂĄlez-Montelongo Rafaela
- Goorhuis Bram
- Gorochov Guy
- Got Stéphane Le
- Gregersen Peter
- Gregersen Peter
- Gribouval Olivier
- Grimbacher Bodo
- Grobusch Martin
- Guaqueta Jeser Santiago Grass
- Guedj Jérémie
- Guerder Antoine
- Gumucio Victor Daniel
- Gunst Jan
- Gut Marta
- Gålvez-Romero José Luis
- GĂ©rardin Patrick
- GĂłmez Oscar
- GĂŒlhan Belgin
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- Haerynck Filomeen
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- Morel Pascal
- Morel Pascal
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- Morio Tomohiro
- Morio Tomohiro
- Mouly Stéphane
- Mouquet Hugo
- Mouquet Hugo
- Mullaert Jimmy
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- MĂšge Jean-Louis
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- Ng Lisa
- Ng Lisa
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- Nguyen Duc
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- Nielly Hubert
- Noonan Claire
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- Nossent Esther
- Notarangelo Luigi
- Notarangelo Luigi
- Nouroudine Mariama
- Novelli Antonio
- Novelli Giuseppe
- Nukui Yoko
- Nussenzweig Michel
- Ocejo-Vinyals J. Gonzalo
- Okada Satoshi
- Okada Satoshi
- Okamoto Keisuke
- Okamoto Keisuke
- Oriol Roger Colobran
- Ostrowski Sisse Rye
- Oualha Mehdi
- Ouedrani Amani
- Ozcelik Tayfun
- Ozcelik Tayfun
- Ozguler Anna
- Ozkaya-Parlakay Aslinur
- Oâfarrelly Cliona
- Oâfarrelly Cliona
- Oâfarrelly Cliona
- Pagani Michele
- Pan-Hammarström Qiang
- Pan-Hammarström Qiang
- Pan-Hammarström Qiang
- Papadaki Maria
- Papadopoulos Aurélie
- Pape Jean
- Paris Christophe
- Parizot Christophe
- Parola Philippe
- Parra-MartĂnez Alba
- Pascreau Tiffany
- Patin Etienne
- Paul Christelle
- Paul Stéphane
- Paul Stéphane
- Paulsen Isabella Worlewenut
- Paulus Frederique
- Payet Christine
- Paz Pauline Caraux
- Paz-Artal Estela
- Pedersen Ole Birger
- Pedraza-SĂĄnchez Sigifredo
- Peiffer-Smadja Nathan
- Peigne Vincent
- Pelet Anna
- Pelet Sophie
- Pellecer Nancy Carolina GonzĂĄlez
- Pellegrini Sandra
- Pellegrini Silvia
- Pereira Jesus Marquez
- Perez-Tur Jordi
- Perlin David
- Perreau Pauline
- Perroquin Magali
- Pesci Alberto
- Pesole Graziano
- Pession Andrea
- Peters Edgar
- Peterson PĂ€rt
- Petrov-Sanchez Ventzislava
- Peytavin Gilles
- Pham Huong
- Philippe Aurélien
- Philippot Quentin
- Philippot Quentin
- Picod Adrien
- Picone Olivier
- Piemonti Lorenzo
- Pina-Fuentes Dan
- Piquard Valentine
- Piquard Valentine
- Piralla Antonio
- Pistone Thierry
- Planas Anna
- Planas Anna
- Planas-Serra Laura
- Ploin Dominique
- Poissy Julien
- Poissy Julien
- Poissy Julien
- Poncelet GĂ©raldine
- Poulakou Garyphallia
- Pouletty Marie
- Pourshahnazari Persia
- Prado Maria Yolanda Ruiz Del
- Prando Carolina
- Prando Carolina
- Preckel Bennedikt
- Prins Jan
- Puel Anne
- Pueyo David MartĂnez
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- Pujol Aurora
- Puéchal Oriane
- PĂ©rez Cristian Alejandro Ricaurte
- PĂ©rez-DĂaz Carlos
- Pérez-Fernåndez Xosé Luis
- Qiu-Chen Jia Li
- Quaresima Virginia
- Quentric Paul
- Quintana-Murci Lluis
- Quintana-Murci Lluis
- Quintana-Murci Lluis
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- Ramaswamy Sathishkumar
- Rambaud Thomas
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- Raoult Didier
- Raoult Didier
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- Rebillat Anne-Sophie
- Reddy Conor
- Redin Claire
- Reijnders Tom
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- Richard Pascale
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- Su Helen
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- Taccone Fabio
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- Tancevski Ivan
- Tancevski Ivan
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- Tangy Frédéric
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- Trouillet-Assant Sophie
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- Troya JesĂșs
- Tsang Owen
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- Tubiana Sarah
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- Téoulé François
- Uddin K.
- Uddin Mohammed
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- Utsumi Takanori
- Uzunhan Yurdagul
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- Valencia-Ramos Juan
- Valsecchi Maria Grazia
- van Agtmael Michiel
- van Baarle Frank
- van Braeckel Eva
- van de Beek Diederik
- van de Beek Diederik
- van de Beek Diederik
- van den Rym Ana Maria
- van der Poll Tom
- van der Valk Marc
- van der Werf Sylvie
- van der Werf Sylvie
- van Mourik Niels
- van Praet Jens
- van Vugt MichĂšle
- Vanderlinden Dimitri
- Vandernoot Isabelle
- Vanel Noémie
- Vasse Marc
- Veelo Denise
- Veislinger Aurélie
- Velez-Santamaria Valentina
- Veliz Silvia Patricia Zuniga
- Venet Fabienne
- Vergara José Alejandro Daza
- Vidaur Loreto
- Vidaur Loreto
- Vidigal Mateus
- Vidigal Mateus
- Viel SĂ©bastien
- Vignali Valérie
- Vilaire-Meunier Marie
- Villain CĂ©dric
- Villar-GarcĂa Judit
- Vincent Audrey
- Vinh Donald
- Vinh Donald
- Visseaux Benoit
- Visseaux Benoit
- Vlaar Alexander
- Vogt Guillaume
- Voiriot Guillaume
- Volleman Carolien
- Volokha Alla
- von Bernuth Horst
- von Stemann Jakob Hjorth
- Vught Lonneke
- Vuotto Fanny
- VĂ©lez VerĂłnica Posada
- Waucquier Nawal
- Wauters Els
- Wauters Joost
- Wauters Joost
- Wauters Joost
- Wiedemann Aurélie
- Wiersinga W. Joost
- Wouters Dorien
- Wu Alan
- Wu Tak-Chiu
- YahĆi Aysun
- Yang Rui
- Yasar Kadriye Kart
- Yazdanpanah Yazdan
- Yazdanpanah Yazdan
- Yepes Jairo David Torres
- Yesilbas Osman
- Yildiz Mehmet
- Young Barnaby
- YĂŒkselmiĆ Ufuk
- Zatz Mayana
- Zatz Mayana
- Zatz Mayana
- Zawadzki Pawel
- Zhang Peng
- Zhang Qian
- Zhang Shen-Ying
- Zhang Yu
- Zimmer Christophe
- Zins Marie
- Zins Marie
- Zuccaro Valentina
- Zwinderman A.
- Ăñigo-Campos Antonio
- Ăz Ćadiye KĂŒbra TĂŒter
- Ăzkan Esra AkyĂŒz
- Ăzçelik Tayfun
- Publication venue
- 'Proceedings of the National Academy of Sciences'
- Publication date
- 24/05/2022
- Field of study
International audienceSignificance There is growing evidence that preexisting autoantibodies neutralizing type I interferons (IFNs) are strong determinants of life-threatening COVID-19 pneumonia. It is important to estimate their quantitative impact on COVID-19 mortality upon SARS-CoV-2 infection, by age and sex, as both the prevalence of these autoantibodies and the risk of COVID-19 death increase with age and are higher in men. Using an unvaccinated sample of 1,261 deceased patients and 34,159 individuals from the general population, we found that autoantibodies against type I IFNs strongly increased the SARS-CoV-2 infection fatality rate at all ages, in both men and women. Autoantibodies against type I IFNs are strong and common predictors of life-threatening COVID-19. Testing for these autoantibodies should be considered in the general population