Interim 2017/18 influenza seasonal vaccine effectiveness: Combined results from five European studies

Between September 2017 and February 2018, influenza A(H1N1)pdm09, A(H3N2) and B viruses (mainly B/Yamagata, not included in 2017/18 trivalent vaccines) co-circulated in Europe. Interim results from five European studies indicate that, in all age groups, 2017/18 influenza vaccine effectiveness was 25 to 52% against any influenza, 55 to 68% against influenza A(H1N1)pdm09, -42 to 7% against influenza A(H3N2) and 36 to 54% against influenza B. 2017/18 influenza vaccine should be promoted where influenza still circulates

Synthesis of Organic-Inorganic Hybrid Solids with Copper Complex Framework and Their Catalytic Activity for the S-Arylation and the Azide-Alkyne Cycloaddition Reactions

[EN] Two di¿erent diamines, namely, Tr¿oger base and dimethylethylene diamine (DMEDA) functionalized with disilane groups, have been condensed with silica precursors to form mesoporous hybrid organic-inorganic materials. After introduction of copper, the Cu-diamine complexes are produced. These hybrid solids have been fully characterized and are active catalysts for the S-arylation of aryl iodides and bromides with thiophenols and disul¿des. Additionally, the hybrids show catalytic activity for the cycloaddition reaction between azides and phenylacetylenes. The reaction conditions determine the recovery and reuse of the solid.Financial support by Consolider-Ingenio 2010 (proyecto MUL-TICAT) and PLE2009 project from MCIINN and King Saud University are acknowledged.Cabrero Antonino, JR.; García Fernández, MT.; Rubio Marqués, P.; Vidal Moya, JA.; Leyva Perez, A.; Al-Deyab, SS.; Al-Resayes, SI.... (2011). Synthesis of Organic-Inorganic Hybrid Solids with Copper Complex Framework and Their Catalytic Activity for the S-Arylation and the Azide-Alkyne Cycloaddition Reactions. ACS CATALYSIS. 1(2):147-158. https://doi.org/10.1021/cs100086yS1471581

FDG-PET/CT(A) imaging in large vessel vasculitis and polymyalgia rheumatica: joint procedural recommendation of the EANM, SNMMI, and the PET Interest Group (PIG), and endorsed by the ASNC

Large vessel vasculitis (LVV) is defined as a disease mainly affecting the large arteries, with two major variants, Takayasu arteritis (TA) and giant cell arteritis (GCA). GCA often coexists with polymyalgia rheumatica (PMR) in the same patient, since both belong to the same disease spectrum. FDG-PET/CT is a functional imaging technique which is an established tool in oncology, and has also demonstrated a role in the field of inflammatory diseases. Functional FDG-PET combined with anatomical CT angiography, FDG-PET/CT(A), may be of synergistic value for optimal diagnosis, monitoring of disease activity, and evaluating damage progression in LVV. There are currently no guidelines regarding PET imaging acquisition for LVV and PMR, even though standardization is of the utmost importance in order to facilitate clinical studies and for daily clinical practice. This work constitutes a joint procedural recommendation on FDG-PET/CT(A) imaging in large vessel vasculitis (LVV) and PMR from the Cardiovascular and Inflammation & Infection Committees of the European Association of Nuclear Medicine (EANM), the Cardiovascular Council of the Society of Nuclear Medicine and Molecular Imaging (SNMMI), and the PET Interest Group (PIG), and endorsed by the American Society of Nuclear Cardiology (ASNC). The aim of this joint paper is to provide recommendations and statements, based on the available evidence in the literature and consensus of experts in the field, for patient preparation, and FDG-PET/CT(A) acquisition and interpretation for the diagnosis and follow-up of patients with suspected or diagnosed LVV and/or PMR. This position paper aims to set an internationally accepted standard for FDG-PET/CT(A) imaging and reporting of LVV and PMR