A Service based Development Environment on Web 2.0 Platforms

Governments are investing on the IT adoption and promoting the socalled e-economies as a way to improve competitive advantages. One of the main government’s actions is to provide internet access to the most part of the population, people and organisations. Internet provides the required support for connecting organizations, people and geographically distributed developments teams. Software developments are tightly related to the availability of tools and platforms needed for products developments. Internet is becoming the most widely used platform. Software forges such as SourceForge provide an integrated tools environment gathering a set of tools that are suited for each development with a low cost. In this paper we propose an innovating approach based on Web2.0, services and a method engineering approach for software developments. This approach represents one of the possible usages of the internet of the future

Smoothable locally non Cohen-Macaulay multiple structures on curves

In this article we show that a wide range of multiple structures on curves arise whenever a family of embeddings degenerates to a morphism of degree . One could expect to see, when an embedding degenerates to such a morphism, the appearance of a locally Cohen-Macaulay multiple structure of certain kind (a so-called rope of multiplicity ). We show that this expectation is naive and that locally non Cohen-Macaulay multiple structures also occur in this situation. In seeing this we find out that many multiple structures can be smoothed. When we specialize to the case of double structures we are able to say much more. In particular, we find numerical conditions, in terms of the degree and the arithmetic genus, for the existence of many locally Cohen-Macaulay and non Cohen-Macaulay smoothable double structures. Also, we show that the existence of these double structures is determined, although not uniquely, by the elements of certain space of vector bundle homomorphisms, which are related to the first order infinitesimal deformations of . In many instances, we show that, in order to determine a double structure uniquely, looking merely at a first order deformation of is not enough; one needs to choose also a formal deformation.Depto. de Álgebra, Geometría y TopologíaFac. de Ciencias MatemáticasTRUEUCMSimons FoundationNSFpu

Differential prefrontal-like deficit in children after cerebellar astrocytoma and medulloblastoma tumor

Journal Article;BACKGROUND This study was realized thanks to the collaboration of children and adolescents who had been resected from cerebellar tumors. The medulloblastoma group (CE+, n = 7) in addition to surgery received radiation and chemotherapy. The astrocytoma group (CE, n = 13) did not receive additional treatments. Each clinical group was compared in their executive functioning with a paired control group (n = 12). The performances of the clinical groups with respect to controls were compared considering the tumor's localization (vermis or hemisphere) and the affectation (or not) of the dentate nucleus. Executive variables were correlated with the age at surgery, the time between surgery-evaluation and the resected volume. METHODS The executive functioning was assessed by means of WCST, Complex Rey Figure, Controlled Oral Word Association Test (letter and animal categories), Digits span (WISC-R verbal scale) and Stroop test. These tests are very sensitive to dorsolateral PFC and/or to medial frontal cortex functions. The scores for the non-verbal Raven IQ were also obtained. Direct scores were corrected by age and transformed in standard scores using normative data. The neuropsychological evaluation was made at 3.25 (SD = 2.74) years from surgery in CE group and at 6.47 (SD = 2.77) in CE+ group. RESULTS The Medulloblastoma group showed severe executive deficit (</= 1.5 SD below normal mean) in all assessed tests, the most severe occurring in vermal patients. The Astrocytoma group also showed executive deficits in digits span, semantic fluency (animal category) and moderate to slight deficit in Stroop (word and colour) tests. In the astrocytoma group, the tumor's localization and dentate affectation showed different profile and level of impairment: moderate to slight for vermal and hemispheric patients respectively. The resected volume, age at surgery and the time between surgery-evaluation correlated with some neuropsychological executive variables. CONCLUSION Results suggest a differential prefrontal-like deficit due to cerebellar lesions and/or cerebellar-frontal diaschisis, as indicate the results in astrocytoma group (without treatments), that also can be generated and/or increased by treatments in the medulloblastoma group. The need for differential rehabilitation strategies for specific clinical groups is remarked. The results are also discussed in the context of the Cerebellar Cognitive Affective Syndrome.This work was possible thanks to financial support from the MEC (DGICYT).Ye

Exercise Outcomes in Childhood Obesity-Related Inflammation and Oxidative Status

Childhood obesity is identified as one of the major public health issues to increase the risk for cardiometabolic diseases and related complications in adulthood. The literature has supported inflammation and oxidative stress as the primary underlying mechanisms involved in the pathogenesis of obesity-related diseases. Epidemiological evidence consistently shows the benefits of physical activity in the improvement of obesity-mediated inflammation and oxidative stress status. In this narrative mini-review, the available scientific evidence on the potential effects of exercise in alleviating these susceptibilities in childhood obesity will be assessed.S

Effects of exercise on exosome release and cargo in in vivo and ex vivo models: A systematic review

[EN] Exercise-released exosomes have been identified as novel players to mediate cell-to-cell communication in promoting systemic beneficial effects. This review aimed to systematically investigate the effects of exercise on exosome release and cargo, as well as provide an overview of their physiological implications. Among the 436 articles obtained in the database search (WOS, Scopus, and PubMed), 19 articles were included based on eligibility criteria. Results indicate that exercise promotes the release of exosomes without modification of its vesicle size. The literature has primarily shown an exercise-driven increase in exosome markers (Alix, CD63, CD81, and Flot-1), along with other exosome-carried proteins, into circulation. However, exosome isolation, characterization, and phenotyping methodology, as well as timing of sample recovery following exercise can influence the analysis and interpretation of findings. Moreover, a large number of exosome-carried microRNAs (miRNAs), including miR-1, miR-133a, miR-133b, miR-206, and miR-486, in response to exercise are involved in the modulation of proliferation and differentiation of skeletal muscle tissue, although antigen-presenting cells, leukocytes, endothelial cells, and platelets are the main sources of exosome release into the circulation. Collectively, with the physiological implications as evidenced by the ex vivo trials, the release of exercise-promoted exosomes and their cargo could provide the potential therapeutic applications via the role of intercellular communication.SIBrisamar Estébanez was supported by the Ministry of Education of Spain (FPU15/05051). David Jiménez‐Pathe IN MOTU SALUS Research Network on Molecular and Cellular Basis of Physical Exercise for Health and Performance (14/UPB/20)vón was supported by a grant from the Spanish Ministry of Science and Innovation ‐ MINECO (RYC‐2014‐16938). Supported by grants from the EXERNET Research Network on Physical Exercise and Health (09/UPB/20) an