Factors Effecting Hospitalization Frequency of Sickle Cell Anemia Patients

Purpose: In this study, we aimed to find factors effecting hospitalization frequency of our sickle cell anemia (SCA) patients with painful crisis. Material and Methods: Eighty four SCA patients in steady-state condition participated to the study: Seventy with homozygous, and 14 with sickle cell-beta thalassemia disease. In this study we also reported demographic and clinical data of our patients from February 2010 to October 2012. Results and Conclusion: We found that patients using hydroxyurea and penicillin prophylaxis stayed in hospital more times than the others. No relationship between high hospitalization and other variables have been found. However genetic differences may be present among these patients which warrant further studies

Seroprevalence of Hepatitis B, Hepatitis C and HIV in Patients with Hemoglobinopathy Patients

Purpose: Thalassemia and sickle cell anemia patients have frequent transfusions. Hepatitis B (HBV), hepatitis C (HCV) and human immunodeficiency virus (HIV) are tramsmitted infections with blood. The objective of this study is to determine frequency of these infections in our hemoglobinopathy patients. Material and Methods: We investigated 410 hemoglobinopathy patients. Viral serologies were detected with second-generation enzyme-linked immunosorbent assay method. In 410 patients (116 thalassemia major, 16 thalassemia intermedia, 12 hemoglobin H, 222 sickle cell anemia, 43 sickle-beta thalassemia and 1 Hb SE), there were 258 males and 152 females. Results: The rate of HBV is 1,2%, HCV is 3,2% and HIV is 0%. Our results shows that transfusion transmitted viral infection prevelance is not high compared to the literature. Conclusion: Using sensitive screening tests with periodically and right donor selection are very important for preventing these infections in hemoglobinopathy patients who are under high risk. [Cukurova Med J 2014; 39(4.000): 784-787

Reachthem: Baseline Characteristics of a 3 Year Prospective Registry of Children with Hemoglobinopathies Receiving Oral Iron Chelators in the Treatment of Transfusional Iron Overload

54th Annual Meeting and Exposition of the American-Society-of-Hematology (ASH) -- DEC 08-11, 2012 -- Atlanta, GAWOS: 000314049605419…Amer Soc Hematol (ASH

Hemoglobin SE disease in Hatay, in the southern part of Turkey

WOS: 000366114600002Double heterozygosity for hemoglobin (Hb) E and S, known as HbSE disease, is a rare, clinically benign condition involving mild hemolysis. Only 25 cases have been reported to date. The current literature generally associates HbSE with a benign clinical course, although vaso-occlusive complications have been reported. Although only single case reports were previously available, we have observed 20 cases of HbSE and wish to report them. We examined the records of patients presenting to our hemoglobinopathy center in 2001-2013. High performance liquid chromatography (HPLC) was used for hematological assessment of blood samples with ethylenediaminetetraacetic acid. Eight patients were male and 12 female. Mean hemoglobin electrophoresis values were Hb Al: 6.3%, Hb E 34.5%, HbS: 59.5% and Hb F: 1.9%. Three patients (15%) were symptomatic with vaso-occlusive crisis and one had cerebral stroke. These were siblings. The patient with cerebral stroke was using hydroxyurea. The incidence of HbSE disease is rising due to population admixtures and racial intermarriages. Increased numbers of cases of HbSE have been detected after premarital hemoglobinopathy screening in the Antakya and Cukurova regions of Turkey. The aim of this study was to report large numbers of patients with HbSE diagnosed through the routine HPLC method. The secondary aim was to emphasize that severe vaso-occlusive crisis such as infarction symptoms could be seen in HbSE.Hemoglobinopathy Center, Hatay Antakya Government Hospital, Turkeythis study was supported bythe Hemoglobinopathy Center, Hatay Antakya Government Hospital, Turke

The antioxidant and anti-inflammatory efficiency of hyaluronic acid after third molar extraction

Purpose: Hyaluronic acid (HA) has a number of clinical applications in current practice. Therefore, correlation of HA with free radicals and inflammatory cells is clinically important. The purpose of this study is to measure the efficacy of high molecular weight HA on the oxidative stress of oral wounds (glutathione (GSH) and lipid peroxidation (LPO) levels), the inflammatory reaction (leucocytes, collagen and angiogenesis content), pain (visual analogue scale (VAS) records) and trismus (maximum interincisal opening (MIO) records) after third molar (M3) extraction. Patients and methods: 40 patients were included in this study. 0.2 ml 0.8% HA was applied immediately after surgery within the HA group (n = 20). Nothing was applied to the control group (n = 20). The primary outcome variables were the changes in the inflammatory reaction (leucocyte, angiogenesis and collagen content), oxidative stress (GSH, LPO) and clinical parameters (VAS, MIO). Results were compared immediately after extraction (TO) and 1 week after surgery (T1). Bivariate analyses were used to assess the differences between the HA and control groups for each study variable. Results: There was a statistically significant difference of leucocyte infiltration and angiogenesis between the groups at T1. The HA group showed less leucocyte infiltration and more angiogenesis than the control group. There was no statistically significant difference in oxidative stress, VAS or MIO levels between the groups. Conclusion: Our results confirm the hypothesis that HA has an anti-inflammatory effect following M3 extraction. However, the oxidative stress levels and clinical outcomes were similar after one week. Further studies examining these parameters at different times are necessary. (C) 2015 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved

Autoimmune Thrombocytopenic Purpura in Hepatitis A Infection

In undeveloped countries, Hepatitis A is common and endemic because of unimmunization, unhygienic nutrition and poor living conditions. Secondary immune thrombocytopenia is frequently seen in hepatitis B and C infections. It is rarely reported with acute hepatitis A. Two cases of autoimmune thrombocytopenic purpura with acute hepatitis A is presented here. [Cukurova Med J 2014; 39(3.000): 646-649

Predictive Factors and Management of Steinstrasse After Shock Wave Lithotripsy in Pediatric Urolithiasis-A Multivariate Analysis Study

OBJECTIVE To define the predictive factors for the formation of steinstrasse (SS) after shock wave lithotripsy (SWL) and determine the treatment strategies for this complication in pediatric urolithiasis

Evaluation of drug adherence in patients with non-valvular atrial fibrillation according to geographic regions of Turkey: an analysis from NOAC-TR study

Drug adherence to novel oral anticoagulants (NOAC) varied by countries and popuplations. As a result of NOAC-TR study, in Turkey, drug adhrence to NOACs is poor comparing to other real world studies. However it is not known whether there is a difference between geographic regions of Turkey in terms of NOAC adherence. In this study we aim to investigate the NOAC adherence in patients with non-valvular atrial fibrillation according to the geographic regions in Turkey Method: This cros-sectional study was designed as a subgroup study of NOAC-TR (Drug Adherence in patients with non valvular atrial fibrillation taking non-vitamin K antagonist oral anticoagulants in Turkey). A total of 2802 patients (59% female) taking NOAC (Dabigatran, apixaban, rivaroxaban) due to NVAF at least 3 months, were included. Morisky-8 item drug adherence scale was used. Patients were divided in 3 groups (high, moderate and low adherent) based on drug adherence Results: Of the patients 24% were adherent, 26% were moderate adhererent and 50% were low adherent to NOAC treatment. Drug adhrence was different between geographic regions (p [Med-Science 2017; 6(4.000): 689-695