Letter of Intent: Jinping Neutrino Experiment

Jinping Neutrino Experiment (Jinping) is proposed to significantly improve measurements on solar neutrinos and geoneutrinos in China Jinping Laboratory - a lab with a number of unparalleled features, thickest overburden, lowest reactor neutrino background, etc., which identify it as the world-best low-energy neutrino laboratory. The proposed experiment will have target mass of 4 kilotons of liquid scintillator or water-based liquid scintillator, with a fiducial mass of 2 kilotons for neutrino-electron scattering events and 3 kilotons for inverse-beta interaction events. A number of initial sensitivities studies have been carried out, including on the transition phase for the solar neutrinos oscillation from the vacuum to the matter effect, the discovery of solar neutrinos from the carbon-nitrogen-oxygen (CNO) cycle, the resolution of the high and low metallicity hypotheses, and the unambiguous separation on U and Th cascade decays from the dominant crustal anti-electron neutrinos in China.Comment: Proposal for the Jinping Neutrino Experimen

Aurora A–Selective Inhibitor LY3295668 Leads to Dominant Mitotic Arrest, Apoptosis in Cancer Cells, and Shows Potent Preclinical Antitumor Efficacy

Although Aurora A, B, and C kinases share high sequence similarity, especially within the kinase domain, they function distinctly in cell-cycle progression. Aurora A depletion primarily leads to mitotic spindle formation defects and consequently prometaphase arrest, whereas Aurora B/C inactivation primarily induces polyploidy from cytokinesis failure. Aurora B/C inactivation phenotypes are also epistatic to those of Aurora A, such that the concomitant inactivation of Aurora A and B, or all Aurora isoforms by nonisoform–selective Aurora inhibitors, demonstrates the Aurora B/C-dominant cytokinesis failure and polyploidy phenotypes. Several Aurora inhibitors are in clinical trials for T/B-cell lymphoma, multiple myeloma, leukemia, lung, and breast cancers. Here, we describe an Aurora A–selective inhibitor, LY3295668, which potently inhibits Aurora autophosphorylation and its kinase activity in vitro and in vivo, persistently arrests cancer cells in mitosis, and induces more profound apoptosis than Aurora B or Aurora A/B dual inhibitors without Aurora B inhibition–associated cytokinesis failure and aneuploidy. LY3295668 inhibits the growth of a broad panel of cancer cell lines, including small-cell lung and breast cancer cells. It demonstrates significant efficacy in small-cell lung cancer xenograft and patient-derived tumor preclinical models as a single agent and in combination with standard-of-care agents. LY3295668, as a highly Aurora A–selective inhibitor, may represent a preferred approach to the current pan-Aurora inhibitors as a cancer therapeutic agent

Vibration Characteristics of Asymmetric Flexible Cantilever Beams Connected to a Central Rigid Body

A satellite with two solar wings can be modeled using a pair of symmetric flexible cantilever beams connected to a central rigid body. Due to certain reasons, the symmetric flexible cantilever beams may be turned into asymmetric ones, which will inevitably influence the vibration properties of the structural system. By changing the structural sizes and adding local mass on one side of the two beams, a structural system with asymmetric mass distribution is obtained and its vibration characteristics are investigated. Hamilton’s principle with the assumed mode method is employed to establish the equation of motion of the asymmetric structural system. The natural frequencies, mode shapes, frequency response curves and displacement time histories of the system are calculated, and they are compared with those of the structural system with a symmetric mass distribution. The correctness and feasibility of the present analytical method are verified by means of the finite element method (FEM) and a vibration experiment. The analytical results show that the mass asymmetry of the two beams leads to the mode localization phenomenon, and the coupling effect between the two beams and the central rigid body is enhanced. The larger the mass asymmetry is and the closer the position of the added local mass to the end of the cantilever beam is, the more obvious of the mode localization phenomenon is and the more obvious of the coupling effect between the two beams and the central rigid body is. The present investigation results are helpful for the dynamic analysis and design of spacecraft structures composed of flexible solar wings and a central rigid body

Digital preservation of classical gardens at the San Su Shrine

Abstract Chinese classical gardens, an essential part of World Cultural Heritage, are well exemplified by Xishu Garden as a notable branch of this tradition. This research focuses on the San Su Shrine—a quintessential example of Xishu Garden—and explores the application of digital technologies in the commemorative research and quantitative preservation of these gardens. By integrating terrestrial laser scanning and terrestrial digital photogrammetry, we acquired quantitative data and constructed digital models to innovate upon the methodological approach to garden conservation. The innovation of this study is its analysis of Xishu Garden’s commemorative spaces through both temporal and spatial dimensions. 1) Temporally, this study examines the evolution and stratification of the garden's commemorative elements across various historical periods. 2) Spatially, it explores the interconnectedness of commemorative elements within the garden's buildings, rockery stones, water landscape and plant landscape. This dual-faceted approach yields novel insights and methods for assessing the universal value of the commemorative aspects of Xishu Garden. Moreover, it promotes the application of digital technology in the study and preservation of Xishu and other Chinese classical gardens

Impact of Aerosols on the Macrophysical and Microphysical Characteristics of Ice-Phase and Mixed-Phase Clouds over the Tibetan Plateau

Using CloudSat/CALIPSO satellite data and ERA5 reanalysis data from 2006 to 2010, the effects of aerosols on ice- and mixed-phase, single-layer, non-precipitating clouds over the Tibetan Plateau during nighttime in the MAM (March to May), JJA (June to August), SON (September to November), and DJF (December to February) seasons were examined. The results indicated the following: (1) The macrophysical and microphysical characteristics of ice- and mixed-phase clouds exhibit a nonlinear trend with increasing aerosol optical depth (AOD). When the logarithm of AOD (lnAOD) was ≤−4.0, with increasing AOD during MAM and JJA nights, the cloud thickness and ice particle effective radius of ice-phase clouds and mixed-phase clouds, the ice water path and ice particle number concentration of ice-phase clouds, and the liquid water path and cloud fraction of mixed-phase clouds all decreased; during SON and DJF nights, the cloud thickness of ice-phase clouds, cloud top height, liquid droplet number concentration, and liquid water path of mixed-phase clouds all decreased. When the lnAOD was >−4.0, with increasing AOD during MAM and JJA nights, the cloud top height, cloud base height, cloud fraction, and ice particle number concentration of ice-phase clouds, and the ice water path of mixed-phase clouds all increased; during SON and DJF nights, the cloud fraction of mixed-phase clouds and the ice water path of ice-phase clouds all increased. (2) Under the condition of excluding meteorological factors, including the U-component of wind, V-component of wind, pressure vertical velocity, temperature, and relative humidity at the atmospheric pressure heights near the average cloud top height, within the cloud, and the average cloud base height, as well as precipitable water vapor, convective available potential energy, and surface pressure. During MAM and JJA nights. When the lnAOD was ≤−4.0, an increase in aerosols may have led to a decrease in the thickness of ice and mixed-phase cloud layers, as well as a reduction in cloud water path values. In contrast, when the lnAOD was >−4.0, an increase in aerosols may contribute to elevated cloud base and cloud top heights for ice-phase clouds. During SON and DJF nights, changes in various cloud characteristics may be influenced by both aerosols and meteorological factors

Additional file 4 of SETD8, a frequently mutated gene in cervical cancer, enhances cisplatin sensitivity by impairing DNA repair

Additional File 4: Figure S4. UNC0379 increased apoptosis inducted by cisplatin and impaired NHEJ repair efficiency in vivo and in vitro

Additional file 9 of SETD8, a frequently mutated gene in cervical cancer, enhances cisplatin sensitivity by impairing DNA repair

Additional File 9: Table S4