The effect of spatial transverse coherence property of a thermal source on Ghost imaging and Ghost imaging via compressive sampling

Both ghost imaging (GI) and ghost imaging via compressive sampling (GICS) can nonlocally image an object. We report the influence of spatial transverse coherence property of a thermal source on GI and GICS and show that, using the same acquisition numbers, the signal-to-noise ratio (SNR) of images recovered by GI will be reduced while the quality of reconstructed images will be enhanced for GICS as the spatial transverse coherence lengths located on the object plane are decreased. Differences between GI and GICS, methods to further improve the quality and image extraction efficiency of GICS, and its potential applications are also discussed.Comment: 7 pages, 5 figure

LncRNA LINC01857 drives pancreatic adenocarcinoma progression via modulating miR-19a-3p/SMOC2

Objectives: Emerging evidence has demonstrated that LINC01857 exerts a pivotal function in many cancers. However, its function in Pancreatic Ductal Adenocarcinoma (PDAC) still remains unclear. This study was designed to investigate the regulatory character of LINC01857 in PDAC. Methods: Bioinformatic tools and databases were used to seek potential miRNAs and mRNAs. Gene expression was evaluated by Reverse Transcription quantitative real-time Polymerase Chain Reaction (RT-qPCR), and western blot was used for protein level detection. A subcellular fraction assay was done to ascertain the location of LINC01857 in PANC-1 and BxPC-3 human pancreatic cancer cells. CCK-8, EdU, wound healing and Transwell assays were performed to inquire into the influence of LINC01857, and SPARC -related Modular Calcium-binding protein-2 (SMOC2) on cell viability, proliferation, migration, and invasion, respectively. The interaction between LINC01857 and its downstream genes was explored by RNA immunoprecipitation and luciferase reporter assays. Results: LINC01857 levels were significantly elevated in PDAC. Knockdown of LINC01857 significantly restrained the proliferation, migration, invasion, and Epithelial-Mesenchymal Transition (EMT) process of PDAC cells. MiR-19a-3p was a downstream target of LINC01857, and miR-19a-3p levels were significantly decreased in PDAC cells. In addition, SMOC2 expression had a negative correlation with that of miR-19a-3p, and SMOC2 was a downstream target of miR-19a-3p. Furthermore, SMOC2 upregulation partially abolished the inhibitive influence of LINC01857 downregulation on cell proliferation, migration, invasion, and the EMT process. Conclusion: LINC01857 promotes malignant phenotypes of PDAC cells via upregulation of SMOC2 by interacting with miR-19a-3p

Deconfined quantum criticality with emergent symmetry in the extended Shastry-Sutherland model

Motivated by the exotic critical phenomena observed in the Shastry-Sutherland material $\rm SrCu_2(BO_3)_2$ \blue{[Jimenez {\it et al}, Nature {\bf 592}, 370 (2021); Cui {\it et al}, Science {\bf 380}, 1179 (2023)]}, we investigate the ground state nature of the extended Shastry-Sutherland model (SSM) by the state-of-the-art 2D tensor network method. Via large-scale simulations up to $20\times 20$ sites, we identify a continuous phase transition between the plaquette valence-bond solid (PVBS) phase and the antiferromagnetic (AFM) phase accompanied by an emergent O(4) symmetry, which strongly suggests a deconfined quantum critical point (DQCP). Furthermore, we map out the phase diagram of the extended SSM and observe the same type of DQCP phenomena with emergent O(4) symmetry and similar critical exponents along the whole critical line. Our results indicate a compelling scenario for understanding the origin of the proximate DQCP observed in recent experiments.Comment: 5+6 pages; 4+5 figures; 3 table

Dissolution rate enhancement of repaglinide by solid dispersion

Purpose: To enhance the solubility and dissolution rate of the antidiabetic drug repaglinide by solid dispersion (SD) techniqueMethod: The solid dispersion of repaglinide was prepared by solvent evaporation method using the hydrophilic carrier,  polyethylene glycol 4000 (PEG 4000) in three drug:PEG 4000 ratios (1:1, 1:3, 1:5). For comparison, physical mixtures of repaglinide and PEG 4000 in the same ratios were also prepared. The formulations were characterized by Fourier transformed infrared spectroscopy (FTIR), x-ray diffractometry (XRD) and differential scanning colorimetry (DSC). Phase solubility study of pure repaglinide, physical mixture and solid dispersion was performed in distilled water. Dissolution studies were carried out in pH 7.4 phosphate buffer.Results: DSC and XRD results indicate that repaglinide exists in amorphous form in solid dispersion. FT-IR analysis demonstrated the presence of intermolecular hydrogen bonding between repaglinide and PEG 4000 in the solid dispersion. The solubility of pure repaglinide was enhanced from 22.5± 5.0 to 235.5± 5.0 μg/mL in distilled water at 37 0C. Rapid burst release (80 - 86 %) from the solid dispersion formulations was observed within 15 min.Conclusion: The solubility and dissolution rate of repaglinide are enhanced by formulating SDs of repaglinide with PEG 4000. This will likely lead to increase in bioavailability which would be beneficial for better glucose control in diabetic patients.Keywords: Diabetes, Solid dispersion, Repaglinide, Solubility, Dissolution, Burst releas