Innovation, e-learning and higher education: an example of a University’ LMS adoption process

The evolution of ICT has changed all sections of society and these changes have been creating an irreversible impact on higher education institutions, which are expected to adopt innovative technologies in their teaching practices. As theorical framework this study select Rogers theory of innovation diffusion which is widely used to illustrate how technologies move from a localized invented to a widespread evolution on organizational practices. Based on descriptive statistical data collected in a European higher education institution three years longitudinal study was conducted for analyzing and discussion the different stages of a LMS adoption process. Results show that ICT integration in higher education is not progressively successful and a linear process and multiple aspects must be taken into account

LMS in higher education: analysis of the effect of a critical factor ‘faculty training’

The purpose of this research is the analysis of the impact of ICT-related training in the adoption of a learning management systems (LMS) for teaching practicesby faculties in a higher education institution. Based on comparative analyses the impact will be obtained by the number of LMS courses created and managed by participants in ICT for teaching workshops and those who have not attended to any workshops. Involving near 1320 LMS courses and 265 faculties, the results evidence that(i) faculties who have not attend any workshop present a larger distribution of empty courses and (ii) faculties who have attended three or more workshops managed a higher distribution of courses with a considerable level of use intensity, when compared to the others groups. These findings supportthe idea that faculty training is a crucial factor in the process of LMS integration in higher education institutions and that faculties who have been enrolled in three or more workshops develop a higher level of technical and pedagogical proficiency in LMS

Growing evidence supporting the use of mesenchymal stem cell therapies in multiple sclerosis: a systematic review

Background: Multiple sclerosis (MS) typically arises in early/middle adulthood and is characterized by a progressive disability of the central nervous system (CNS). Currently approved therapies do not promote tissue repair or stop disease progression. Emerging data demonstrate that stem cells present a great potential in regenerative medicine and, consequently, have also been widely investigated as a potential treatment for MS. Therefore, the aim of this study was to conduct a systematic review to inquire into the safety, tolerability, and efficacy of mesenchymal stem cells (MSCs) therapies in MS. Methods: Three electronic databases (Web of Science, PubMed, and Cochrane) were searched from April until June 2019. Clinical trials or case reports with information related to the effects of MSC therapies in MS patients were considered for this review. Results: 10 manuscripts were selected, namely 7 uncontrolled clinical trials, 2 randomized controlled clinical trials, and 1 case report. The overall quality of the studies was considered good. Besides minor adverse events (AEs), it was reported one case of encephalopathy with seizures and two cases of iatrogenic meningitis, which were not related to the treatment, but with the administration route. The analyses of the expanded disability status scale (EDSS) in the uncontrolled clinical trials demonstrated that 48 patients improved, 39 maintained and 16 worsened their clinical condition. Regarding the randomized studies, one did not show statistically significant variations in the mean EDSS score and in the other the mean EDSS score was statistically significantly lower for the experimental group. The case report also showed an improvement in the EDSS score. Conclusions: MSCs transplantation proved to be a safe and tolerable therapy. Their potential therapeutic benefits were also validated. However, larger placebo controlled blinded clinical trials will be required to establish the long term safety and efficacy profile of these therapies for MS. Their translation into the clinical practice can provide a new hope for the patients of this highly debilitating disease

Contribuição para o conhecimento biológico das águas interiores da Graciosa

XI Expedição Científica do Departamento de Biologia - Graciosa 2004.Das três pequenas lagoas permanentes existentes na ilha até meados do século passado, duas desapareceram e a terceira está completamente artificializada. Neste momento as zonas húmidas dulçaquícolas naturais da ilha Graciosa reduzem-se a dois pequenos charcos (Barreiro e Tanque), ambos fortemente eutrofizados. São apresentadas listas das espécies de algas, plantas vasculares, invertebrados bênticos e vertebrados aí encontrados

genesis, development and main conclusions of the research project

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Culture collection of freshwater microalgae from the Azores archipelago: resource for taxonomic and phycoprospecting research

ABSTRACT: In recent years, much interest has been focused on the biotechnological potential of microalgae, mainly due to their rapid growth and the identification of several substances synthesized by these organisms. The isolation and in vitro cultivation of native microalgae species is very important for taxonomic and conservation studies and is the first step towards feasibility studies of local commercial productions. In this study 114 isolates of microalgae were obtained from samples collected in 23 locations of the island of Sao Miguel, Azores. From them, 60 species were identified comprising 39 Chlorophyta, 10 Ochrophyta, 6 Cyanophyta, 3 Charophyta, 1 Euglenozoa and 1 Cryptophyta. Eighteen of the species identified constitute new records for the Island of Sao Miguel.info:eu-repo/semantics/publishedVersio

Development of dioctadecyldimethylammonium bromide/monoolein liposomes for gene delivery

The artificial introduction of nucleic acids (NA) into mammalian cells (transfection) has become, in recent years, a well-established procedure in basic and applied research, which allowed the study of gene function and regulation. The advances in this area have made possible the use of these methods for gene-based medicines, which constitute alternative therapeutic approaches. One of the most prominent methods is lipofection that uses cationic liposome/NA complexes (a.k.a. lipoplexes) for the complexation, transport and release of therapeutic sequences into target cells. Although yielding lower transfection efficiencies compared with viral gene delivery, lipofection vectors are much safer for medical applications because no significant mutational or toxicological risk exist. Dioctadecyldimethylammonium Bromide (DODAB)/Monoolein (MO) liposomes have recently been described as a new promising alternative to common transfection reagents, due to the pioneering application of MO as helper lipid in lipoplex formulations. In this chapter, we will review the effect of MO on the physicochemical properties of DODAB/MO liposomes and pDNA/DODAB/MO lipoplexes. How lipoplex properties may affect the interaction with different extracellular components and their cell uptake and trafficking will be discussed. The importance of lipoplex biocompatibility towards efficient gene therapy will also be approached presenting pDNA/DODAB/MO system as a lipoplex model, supporting the use of MO as new helper lipid in lipofection.FCTCOMPETEThis work was supported by FCT research project PTDC/QUI/69795/2006, which is cofunded by the program COMPETE from QREN with co-participation from the European Community fund FEDER; CFUM [PEst-C/FIS/UI0607/2011]; CBMA [Pest C/BIA/UI4050/2011]; J.P.N. Silva holds a PhD Grant (SFRH/BD/46968/2008); A. C.N. Oliveira holds a PhD grant (SFRH/BD/68588/2010)

Investigations of Olive Oil Industry By-Products Extracts with Potential Skin Benefits in Topical Formulations

© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).The by-products of olive oil industry are a major ecological issue due to their phenolic content, highly toxic organic load, and low pH. However, they can be recovered and reused, since their components have antioxidant, anti-inflammatory, and photoprotector properties. In this work, oil-in-water creams containing three different olive oil industry by-products extracts were produced without the use of organic solvents. First, the extracts were thoroughly characterized in vitro for cytotoxicity, inhibition of skin enzymes, and antioxidant and photoprotection capacities. Safety studies were then performed, including ocular and skin irritation tests, ecotoxicity evaluation, and in vivo Human Repeat Insult Patch Test. The results obtained in this initial characterization supported the incorporation of the extracts in the cream formulations. After preparation, the creams were characterized for their organoleptic, physicochemical, droplet size and rheological properties, and microbial contamination. The results showed that all formulations were semi-solid creams, with stable pH, compatible with the skin, without microbial contamination, and with the expected droplet size range. The rheological analysis showed shear-thinning behavior with yield stress, with the viscosity decreasing with increasing shear rate. The oscillatory results suggest that the creams have a strong network structure, being easily rubbed into the skin. Finally, compatibility, acceptability and antioxidant efficacy were evaluated in vivo, in human volunteers. No adverse reactions were observed after application of the formulations on skin and the cream with the highest concentrations of phenolic compounds showed the highest antioxidant efficiency. In conclusion, the results suggest that olive oil industry by-products extracts have valuable properties that favor their re-use in the cosmetic industry. The example presented here showed their successful incorporation into creams and their impact in these formulations’ appearance, pH, and rheological performance, as well as their in vivo compatibility with skin and antioxidant efficiency.This work was supported by Sovena Portugal Consumer Goods through the project Oil4Health: From Olive to Health LISBOA-01-0247-FEDER-038554, funded by the Portugal 2020 program—Programa Operacional Regional de Lisboa. This research was also funded by FCT (Fundação para a Ciência e a Tecnologia) through iMed.ULisboa UID/DTP/04138/2019 and UIDB/04138/2020), principal investigator grants CEECIND/03143/2017 (L. M. Gonçalves). Joana Marto is financed through FCT, I.P., under the Scientific Employment Stimulus—Institutional Call (CEECINST/00145/2018). Marta Martins is financed through FCT, I.P., under the Scientific Employment Stimulus—Institutional Call (CEECINST/00102/2018). The work was supported by the Marine and Environmental Sciences Centre—MARE (UIDB04292/2020; UIDP/04292/2020).info:eu-repo/semantics/publishedVersio

Contribuição para a caracterização das águas interiores de superfície da ilha do Pico

XII Expedição Científica do Departamento de Biologia - Pico 2005.Com o objectivo de proceder à sua caracterização hidromorfológica, físico-química e biológica visitaram-se, entre 7 e 14 de Junho de 2005, 24 lagoas situadas na ilha do Pico (Açores). Todas as lagoas foram fotografadas e geo-referenciadas. Neste relatório são apresentados os resultados relativos à hidromorfologia, aos parâmetros físico-químicos da água, bem como parte dos elementos para a caracterização biológica, nomeadamente os que se referem aos peixes e às plantas vasculares

Reaction of carboxylic dyes with wool and polyamide. Part III: Effect of the activating agent

Dyes containing a carboxylic acid group had been shown to react with wool and polyamide fibres when activated with ethyl chloroformate (Parts I and II). One of the dyes, 3-aminobenzoic acid →N,N-dimethylaniline, was, in this work, activated with other chlorofirmates, so as to improve the dyeing conditions. Benzyl chloroformate was found to be a good substitute since it is not as volatile as ethyl chloroformate, which suggests that it will be easier to apply in practical dyeing conditions. The yield of the reaction with cyclohexylamine is similar to the one obtained with ethyl chloroformate, suggesting that the fixation of the dye on wool or polyamide will be much the same. The fastness results are also equivalent.FCT-Fundação para a Ciência e Tecnologi