Thyroid stimulating hormone levels and geriatric syndromes : secondary nested case–control study of the Mexican Health and Aging Study

Q3Q3Abstract Purpose To determine the incidence of geriatric syndromes (GS) in community dwelling older adults with subclinical hypothyroidism. Methods This is an analysis from the Mexican Health and Aging Study, of a subsample of 2089 subjects with TSH determination. From this last subsample, we included 1628 individuals with TSH levels in the subclinical range (4.5–10 µU/ml). Results The multivariate analysis showed that when comparing data obtained from the 2012 wave with the 2015 wave results, there was a signifcant incidence of some GS such as falls (OR 1.79, CI 1.16–2.77, p=0.0116), fatigue (OR 2.17, CI 1.40–3.38, p=0.0348) and depression (OR 1.70, CI 1.06–2.71, p=0.0246) among the subclinical hypothyroidism group. Conclusion This study showed a greater incidence of GS in subjects 50 years and older with sub-clinical hypothyroidism, when compared to those with normal thyroid function. Keywords Thyroid stimulating hormone · Aging · Geriatric syndromes · Chronic disease · Subclinical hypothyroidismhttps://orcid.org/0000-0002-1652-5042https://scholar.google.com/citations?user=qUwLuswAAAAJ&hl=es&oi=aohttps://scienti.minciencias.gov.co/cvlac/visualizador/generarCurriculoCv.do?cod_rh=0000136038Revista Internacional - Indexad

Retos de la atención a las personas mayores con COVID-19 a nivel hospitalario

La infección por COVID-19 es una enfermedad nueva a la cual la población de mayor edad es especialmente vulnerable, como también lo es a desarrollar procesos de mayor gravedad. El aumento de morbimortalidad en el paciente mayor se ha asociado tanto a las comorbilidades, especialmente la enfermedad cardiovascular, como a la situación de fragilidad que conlleva una respuesta inmunológica más pobre. Al producirse en el contexto de una población envejecida, esta pandemia provoca manifestaciones clínicas diversas que incluyen cuadros respiratorios desde enfermedad no complicada dada por síntomas locales en vías respiratorias y síntomas inespecíficos como fiebre y dolor muscular, hasta neumonía grave con insuficiencia respiratoria aguda, shock séptico y falla multiorgánica. La población de edad avanzada presenta una mayor susceptibilidad a la infección y a las formas más graves de la misma. De este modo, la atención de las personas mayores con COVID-19 a nivel hospitalario trae múltiples retos.Adultos mayoresRevista Nacional - Indexad

Tuberculosis of the central nervous system in an elderly patient : case report

La tuberculosis (TB) es una patología prevalente en nuestra sociedad, y la población anciana es una de las más susceptibles a desarrollarla, dada la presencia de condiciones especiales, como inmunosenescencia, pluripatología, polifarmacia, desnutrición, entre otros. Se presenta el caso de una mujer anciana que ingresó al servicio de urgencias por deterioro clínico secundario a alteración del estado de conciencia en quien se descartaron causas principales como traumatismo craneoencefálico, sangrado o eventos isquémicos cerebrales y estado convulsivo. Al reinterrogarla se encontraron síntomas respiratorios de larga data con hallazgos radiográficos de TB, confirmados por tomografía de tórax, con hallazgos posteriores de neuroinfección, dada la persistencia de alteración del estado de conciencia y el reporte de la punción lumbar.Tuberculosis (TB) is a pathology prevalent at a global level in our society, the elderly population being one of the most susceptible to develop it given the presence of special conditions such as: immunosenescence, pluripatology, polypharmacy, malnutrition, among others. The case of an elderly patient who is admitted to the emergency department due to clinical deterioration secondary to altered state of consciousness is presented below. Primary causes such as TBI, bleeding or cerebral ischemic events and seizure status are ruled out. Upon interrogation, long-standing respiratory symptoms were found with radiographic findings of tuberculosis, confirmed by chest CT, with subsequent neuroinfection findings given the persistence of altered state of consciousness and the report of lumbar puncture.Revista Nacional - Indexad

Propuesta de evaluación del anciano con COVID-19 (caso confirmado o sospechoso) basada en la valoración geriátrica integral

El paciente geriátrico tiene características particulares que hacen necesario un abordaje diferente de aquel que usualmente se emplea para evaluar a la población adulta en general, situación tangible y evidente en la actual pandemia del COVID-19, reconociendo que la población mayor es una población muy heterogénea y que sus necesidades son diferentes y, por lo tanto, la toma de decisiones clínicas no puede basrase exclusivamente en la edad. La valoración geriátrica integral (VGI) es una herramienta dinámica, multidimensional e interdisciplinaria que permite identificar y cuantificar los problemas que pueda presentar el anciano, priorizar y definir el plan de tratamiento y seguimiento acorde a las necesidades de la persona; es por esti que se presenta una propuesta de evaluación abreviada en urgencias del paciente anciano con sospecha o caso confirmado de COVID-19 teniendo en cuneta herramientas de la VGI para ser aplicada al momento del ingreso y orientar el plan de tratamientoAdultos mayoresRevista Nacional - Indexad

Association of Malnutrition with Functionaland Cognitive Trajectories in People Livingwith Dementia: A Five-Year Follow-UpStudy

Q1Background:In dementia, functional status depends on multiple factors in addition to cognition. Nutritional status is apotentially modifiable factor related to homeostasis and proper functioning of body systems and may contribute to cognitiveand functional decline.Objective:This paper aims to analyze the association of malnutrition with the course of cognitive and functional decline inpeople living with dementia.Methods:This is an analysis of a longitudinal cohort study, the Dementia Study of Western Norway. Data of 202 patientsdiagnosed with mild dementia were analyzed; Alzheimer’s disease (AD) (n= 103), Lewy body dementia (LBD) (n= 74),and other dementias (OD) (n= 25). Cognition was assessed with the Mini-Mental State Examination and functional declinethrough the activities of daily living included in the Rapid Disability Rating Scale. The Global Leadership Initiative onMalnutrition Index was used to determine nutritional status. Associations of nutritional status with cognitive and functionaldecline were evaluated through adjusted linear mixed models. Results:At baseline, the prevalence of general malnutrition was 28.7%; 17.3% were classified as moderate malnutrition and11.38% as severe malnutrition (there were no significant differences between AD and LBD). Malnutrition at diagnosis andover follow-up was a significant predictor of functional-decline, but not of cognitive decline.Conclusion:According to our results malnutrition was associated with faster functional loss but, not cognitive decline inolder adults with dementia. A more comprehensive dementia approach including nutritional assessments could improveprognosis.https://orcid.org/0000-0001-5832-0603https://orcid.org/0000-0001-8260-9108https://orcid.org/0000-0002-8584-3191https://orcid.org/0000-0002-6471-9693https://orcid.org/0000-0001-5680-7880Revista Internacional - No indexad

Search for nuclear modifications of B+^+ meson production in pPb collisions at sNN\sqrt{s_\mathrm{NN}} = 8.16 TeV

International audienceNuclear medium effects on B$^+$ meson production are studied using the binary-collision scaled cross section ratio between events of different multiplicities from proton-lead collisions. Data, collected by the CMS experiment in 2016 at a nucleon-nucleon center-of-mass energy of $\sqrt{s_\mathrm{NN}}$ = 8.16 TeV, corresponding to an integrated luminosity of 175 nb$^{-1}$, were used. The scaling factors in the ratio are determined using a novel approach based on the Z $\to$$\mu^+\mu^-$ cross sections measured in the same events. The scaled ratio for B$^+$ is consistent with unity for all event multiplicities, putting stringent constraints on nuclear modification for heavy flavor

Search for nuclear modifications of B+^+ meson production in pPb collisions at sNN\sqrt{s_\mathrm{NN}} = 8.16 TeV

International audienceNuclear medium effects on B$^+$ meson production are studied using the binary-collision scaled cross section ratio between events of different multiplicities from proton-lead collisions. Data, collected by the CMS experiment in 2016 at a nucleon-nucleon center-of-mass energy of $\sqrt{s_\mathrm{NN}}$ = 8.16 TeV, corresponding to an integrated luminosity of 175 nb$^{-1}$, were used. The scaling factors in the ratio are determined using a novel approach based on the Z $\to$$\mu^+\mu^-$ cross sections measured in the same events. The scaled ratio for B$^+$ is consistent with unity for all event multiplicities, putting stringent constraints on nuclear modification for heavy flavor

Search for nuclear modifications of B+^+ meson production in pPb collisions at sNN\sqrt{s_\mathrm{NN}} = 8.16 TeV

International audienceNuclear medium effects on B$^+$ meson production are studied using the binary-collision scaled cross section ratio between events of different multiplicities from proton-lead collisions. Data, collected by the CMS experiment in 2016 at a nucleon-nucleon center-of-mass energy of $\sqrt{s_\mathrm{NN}}$ = 8.16 TeV, corresponding to an integrated luminosity of 175 nb$^{-1}$, were used. The scaling factors in the ratio are determined using a novel approach based on the Z $\to$$\mu^+\mu^-$ cross sections measured in the same events. The scaled ratio for B$^+$ is consistent with unity for all event multiplicities, putting stringent constraints on nuclear modification for heavy flavor

Search for nuclear modifications of B+^+ meson production in pPb collisions at sNN\sqrt{s_\mathrm{NN}} = 8.16 TeV

International audienceNuclear medium effects on B$^+$ meson production are studied using the binary-collision scaled cross section ratio between events of different multiplicities from proton-lead collisions. Data, collected by the CMS experiment in 2016 at a nucleon-nucleon center-of-mass energy of $\sqrt{s_\mathrm{NN}}$ = 8.16 TeV, corresponding to an integrated luminosity of 175 nb$^{-1}$, were used. The scaling factors in the ratio are determined using a novel approach based on the Z $\to$$\mu^+\mu^-$ cross sections measured in the same events. The scaled ratio for B$^+$ is consistent with unity for all event multiplicities, putting stringent constraints on nuclear modification for heavy flavor

Search for CPCP violation in D0^0→\to KS0^0_\mathrm{S}KS0^0_\mathrm{S} decays in proton-proton collisions at s\sqrt{s} = 13 TeV

International audienceA search is reported for charge-parity D$^0$$\to$ K$^0_\mathrm{S}$K$^0_\mathrm{S}$$CP$ violation in D$^0$$\to$ K$^0_\mathrm{S}$K$^0_\mathrm{S}$ decays, using data collected in proton-proton collisions at $\sqrt{s}$ = 13 TeV recorded by the CMS experiment in 2018. The analysis uses a dedicated data set that corresponds to an integrated luminosity of 41.6 fb$^{-1}$, which consists of about 10 billion events containing a pair of ẖadrons, nearly all of which decay to charm hadrons. The flavor of the neutral D meson is determined by the pion charge in the reconstructed decays D$^{*+}$$\to$ D$^0\pi^+$ and D$^{*-}$$\to$ D$^0\pi^-$. The D$^0$$\to$ K$^0_\mathrm{S}$K$^0_\mathrm{S}$$CP$ asymmetry in D$^0$$\to$ K$^0_\mathrm{S}$K$^0_\mathrm{S}$ is measured to be $A_{CP}$( K$^0_\mathrm{S}$K$^0_\mathrm{S}$) = (6.2 $\pm$ 3.0 $\pm$ 0.2 $\pm$ 0.8)%, where the three uncertainties represent the statistical uncertainty, the systematic uncertainty, and the uncertainty in the measurement of the D$^0$ $\to$ K$^0_\mathrm{S}$K$^0_\mathrm{S}$ $CP$ asymmetry in the D$^0$ $\to$ K$^0_\mathrm{S}\pi^+\pi^-$ decay. This is the first D$^0$ $\to$ K$^0_\mathrm{S}$K$^0_\mathrm{S}$ $CP$ asymmetry measurement by CMS in the charm sector as well as the first to utilize a fully hadronic final state