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Origins of Neural Progenitor Cell-Derived Axons Projecting Caudally after Spinal Cord Injury.
Neural progenitor cells (NPCs) transplanted into sites of spinal cord injury (SCI) extend large numbers of axons into the caudal host spinal cord. We determined the precise locations of neurons in the graft that extend axons into the caudal host spinal cord using AAV9-Cre-initiated retrograde tracing into floxed-TdTomato-expressing NPC grafts. 7,640 ± 630 grafted neurons extended axons to a single caudal host spinal cord site located 2 mm beyond the lesion, 5 weeks post injury. While caudally projecting axons arose from neurons located in all regions of the graft, the majority of caudally projecting graft neurons (53%) were located within the caudal one-third of the graft. Numerous host corticospinal axons formed monosynaptic projections onto caudally projecting graft neurons; however, we find that the majority of host axonal neuronal projections formed by neural progenitor cell interneuronal "relays" across sites of SCI are likely polysynaptic in nature
On spin-1 massive particles coupled to a Chern-Simons field
We study spin one particles interacting through a Chern-Simons field. In the
Born approximation, we calculate the two body scattering amplitude considering
three possible ways to introduce the interaction: (a) a Proca like model
minimally coupled to a Chern-Simons field, (b) the model obtained from (a) by
replacing the Proca's mass by a Chern-Simons term and (c) a complex
Maxwell-Chern-Simons model minimally coupled to a Chern-Simons field. In the
low energy regime the results show similarities with the Aharonov-Bohm
scattering for spin 1/2 particles. We discuss the one loop renormalization
program for the Proca's model. In spite of the bad ultraviolet behavior of the
matter field propagator, we show that, up to one loop the model is power
counting renormalizable thanks to the Ward identities satisfied by the
interaction vertices.Comment: 14 pages, 5 figures, revte
Acoustic Emission from crumpling paper
From magnetic systems to the crust of the earth, many physical systems that
exibit a multiplicty of metastable states emit pulses with a broad power law
distribution in energy. Digital audio recordings reveal that paper being
crumpled, a system that can be easily held in hand, is such a system. Crumpling
paper both using the traditional hand method and a novel cylindrical geometry
uncovered a power law distribution of pulse energies spanning at least two
decades: (exponent 1.3 - 1.6) Crumpling initally flat sheets into a compact
ball (strong crumpling), we found little or no evidence that the energy
distribution varied systematically over time or the size of the sheet. When we
applied repetitive small deformations (weak crumpling) to sheets which had been
previously folded along a regular grid, we found no systematic dependence on
the grid spacing. Our results suggest that the pulse energy depends only weakly
on the size of the paper regions responsible for sound production.Comment: 12 pages of text, 9 figures, submitted to Phys. Rev. E, additional
information availible at http://www.msc.cornell.edu/~houle/crumpling
An efficient semiparametric maxima estimator of the extremal index
The extremal index , a measure of the degree of local dependence in
the extremes of a stationary process, plays an important role in extreme value
analyses. We estimate semiparametrically, using the relationship
between the distribution of block maxima and the marginal distribution of a
process to define a semiparametric model. We show that these semiparametric
estimators are simpler and substantially more efficient than their parametric
counterparts. We seek to improve efficiency further using maxima over sliding
blocks. A simulation study shows that the semiparametric estimators are
competitive with the leading estimators. An application to sea-surge heights
combines inferences about with a standard extreme value analysis of
block maxima to estimate marginal quantiles.Comment: 17 pages, 7 figures. Minor edits made to version 1 prior to journal
publication. The final publication is available at Springer via
http://dx.doi.org/10.1007/s10687-015-0221-
The pattern of xylan acetylation suggests xylan may interact with cellulose microfibrils as a twofold helical screw in the secondary plant cell wall of Arabidopsis thaliana.
The interaction between xylan and cellulose microfibrils is important for secondary cell wall properties in vascular plants; however, the molecular arrangement of xylan in the cell wall and the nature of the molecular bonding between the polysaccharides are unknown. In dicots, the xylan backbone of β-(1,4)-linked xylosyl residues is decorated by occasional glucuronic acid, and approximately one-half of the xylosyl residues are O-acetylated at C-2 or C-3. We recently proposed that the even, periodic spacing of GlcA residues in the major domain of dicot xylan might allow the xylan backbone to fold as a twofold helical screw to facilitate alignment along, and stable interaction with, cellulose fibrils; however, such an interaction might be adversely impacted by random acetylation of the xylan backbone. Here, we investigated the arrangement of acetyl residues in Arabidopsis xylan using mass spectrometry and NMR. Alternate xylosyl residues along the backbone are acetylated. Using molecular dynamics simulation, we found that a twofold helical screw conformation of xylan is stable in interactions with both hydrophilic and hydrophobic cellulose faces. Tight docking of xylan on the hydrophilic faces is feasible only for xylan decorated on alternate residues and folded as a twofold helical screw. The findings suggest an explanation for the importance of acetylation for xylan-cellulose interactions, and also have implications for our understanding of cell wall molecular architecture and properties, and biological degradation by pathogens and fungi. They will also impact strategies to improve lignocellulose processing for biorefining and bioenergy.The work conducted by TT and NN was supported by a grant from the BBSRC:
BB/G016240/1 BBSRC Sustainable Energy Centre Cell Wall Sugars Programme
(BSBEC) to PD and DNB. The work of PD was supported by the European
Community’s Seventh Framework Programme SUNLIBB (FP7/2007-2013) under the
grant agreement #251132. The NMR facility infrastructure was supported by the
BBSRC and the Wellcome Trust. TCFG thanks CNPq (Brazil) for a graduate
fellowship (grant # 140978/2009-7). MSS thanks CEPROBIO (grant # 490022/2009-
0) and FAPESP for funding (grant #2013/08293-7).This is the accepted version of the following article: "Busse-Wicher, M; Gomes, T.C.F; Tryfona, T; Nikolovski, N; Stott, K; Grantham, N.J; Bolam, D.N; Skaf, M.S; Dupree, P. (2014) "The pattern of xylan acetylation suggests xylan may interact with cellulose microfibrils as a two-fold helical screw in the secondary plant cell wall of Arabidopsis thaliana." The Plant Journal. Accepted article [electronic] 10.1111/tpj.12575", which has been published in final form at http://onlinelibrary.wiley.com/doi/10.1111/tpj.12575/abstrac
Subgingival Microbiome Colonization and Cytokine Production during Early Dental Implant Healing
Little is known about longitudinal development of the peri-implant subgingival microbiome and cytokine production as a new sulcus forms after dental implant placement. Therefore, the purpose of this observational study was to evaluate simultaneous longitudinal changes in the oral microbiome and cytokine production in the developing peri-implant sulcus compared to control natural teeth. Four and 12 weeks after implant placement and abutment connection, a dental implant and a natural tooth were sampled in 25 patients for subgingival plaque and gingival crevicular fluid (GCF [around teeth] and peri-implant crevicular fluid [PICF] around implants). DNA from plaque samples was extracted and sequenced using Illumina-based 16S rRNA sequencing. GCF and PICF samples were analyzed using a customized Milliplex human cytokine and chemokine magnetic bead panel. Beta diversity analysis revealed that natural teeth and implants had similar subgingival microbiomes, while teeth had greater alpha diversity than implants. At the genus level, however, few differences were noted between teeth and dental implants over 12 weeks. Specifically, Actinomyces and Selenomonas were significantly elevated around teeth versus dental implants at both 4 weeks and 12 weeks, while Corynebacterium and Campylobacter were significantly elevated only at 4 weeks around teeth. The only difference between PICF and GCF biomarkers was significantly elevated granulocyte-macrophage colony-stimulating factor levels around teeth versus dental implants at the 4-week visit. The subgingival microbiome and cytokine production were similar between teeth and implants during early healing, suggesting that these profiles are driven by the patient following dental implant placement and are not determined by anatomical niche
Imaging infective endocarditis:Adherence to a diagnostic flowchart and direct comparison of imaging techniques
BACKGROUND: Multimodality imaging is recommended to diagnose infective endocarditis. Value of additional imaging to echocardiography in patients selected by a previously proposed flowchart has not been evaluated. METHODS: An observational single-center study was performed. Adult patients suspected of endocarditis/device infection were prospectively and consecutively enrolled from March 2016 to August 2017. Adherence to a diagnostic imaging-in-endocarditis-flowchart was evaluated in 176 patients. Imaging techniques were compared head-to-head in 46 patients receiving echocardiography (transthoracic plus transesophageal), multi-detector computed tomography angiography (MDCTA), and 18F-fluorodeoxyglucose positron emission tomography (FDG-PET/CT). RESULTS: 69% of patients (121/176) adhered to the flowchart. Sensitivity of echocardiography, MDCTA, FDG-PET/CT in patients without prosthesis was 71%, 57%, 29% (86% when combined), while specificity was 100%, 75%, 100%, respectively. Sensitivity in patients with prosthesis was 75%, 75%, 83%, respectively (100% when combined), while specificity was 86% for all three modalities. Echocardiography performed best in the assessment of vegetations, morphological valve abnormalities/dehiscence, septum defects, and fistula formation. MDCTA performed best in the assessment of abscesses and ventricular assist device infection. FDG-PET/CT performed best in the assessment of cardiac device infection, extracardiac infectious foci, and alternative diagnoses. CONCLUSIONS: This study demonstrates that the evaluated imaging-in-endocarditis-flowchart is applicable in daily clinical practice. Echocardiography, MDCTA, and FDG-PET/CT provide relevant complementary diagnostic information, particularly in patients with intracardiac prosthetic material
The MATHUSLA Test Stand
The rate of muons from LHC collisions reaching the surface above the
ATLAS interaction point is measured and compared with expected rates from
decays of and bosons and - and -quark jets. In addition, data
collected during periods without beams circulating in the LHC provide a
measurement of the background from cosmic ray inelastic backscattering that is
compared to simulation predictions. Data were recorded during 2018 in a 2.5
2.5 6.5~ active volume MATHUSLA test stand detector
unit consisting of two scintillator planes, one at the top and one at the
bottom, which defined the trigger, and six layers of RPCs between them, grouped
into three -measuring layers separated by 1.74 m from each other.
Triggers selecting both upward-going tracks and downward-going tracks were
used.Comment: 18 pages, 11 figures, 1 tabl
COVID-19 Control by Computer Vision Approaches: A Survey
The COVID-19 pandemic has triggered an urgent call to contribute to the fight against an immense threat to the human population. Computer Vision, as a subfield of artificial intelligence, has enjoyed recent success in solving various complex problems in health care and has the potential to contribute to the fight of controlling COVID-19. In response to this call, computer vision researchers are putting their knowledge base at test to devise effective ways to counter COVID-19 challenge and serve the global community. New contributions are being shared with every passing day. It motivated us to review the recent work, collect information about available research resources, and an indication of future research directions. We want to make it possible for computer vision researchers to find existing and future research directions. This survey article presents a preliminary review of the literature on research community efforts against COVID-19 pandemic.ISSN:2169-353
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