Ameliorating the effect of Zingiber officinale (ginger) hydroethanolic extract on scopolamine-induced memory impairment in adult male rats

Background and aims: The spice Zingiber officinale or ginger possesses antioxidant and neuroprotective effects. In this study we hypothesized that treatment with hydroethanolic extract of ginger (50, 100 and 200 mg/kg, p.o) would have an effect on the scopolamine-induced memory impairment in rats. Methods: In this experimental study, 64 male Wistar rats were divided into eight groups (8 rats in each group): normal saline, scopolamine (1 mg/kg), ginger extract (50, 100 and 200 mg/kg), or scopolamine (1 mg/kg) plus ginger extract (50, 100 and 200 mg/kg). Memory impairment was induced with a single injection of scopolamine (1 mg/kg, i.p). Cognitive functions were evaluated using passive avoidance learning (PAL) task. Retention test was carried out 24 hours after training, and the latency of entering the dark compartment step-through latency (STL) and the total time in the dark compartment (TDC) were recorded. All statistical analysis was carried out at 5% level of significance using SPSS version 21. The data were analyzed by ANOVA followed by Tukey’s test. Results: The time latency in scopolamine-treated group was lower than control (p<0.001). Treatment of the animals by 100 and 200 mg/kg of ginger extract before the training trial increased the time latency at 24 h after the training trial (p<0.01). Also, administration of extract at doses of 100 and 200 mg/kg in scopolamine received groups before retention trials, increased the time latency than the scopolamine only treated groups (p<0.001). Conclusion: The results revealed that the ginger hydroethanolic extract attenuated scopolamine-induced memory impairment

Uniqueness of the Fock quantization of scalar fields and processes with signature change in cosmology

We study scalar fields subject to an equation of the Klein-Gordon type in nonstationary spacetimes, such as those found in cosmology, assuming that all the relevant spatial dependence is contained in the Laplacian. We show that the field description ---with a specific canonical pair--- and the Fock representation for the quantization of the field are fixed indeed in a unique way (except for unitary transformations that do not affect the physical predictions) if we adopt the combined criterion of (a) imposing the invariance of the vacuum under the group of spatial symmetries of the field equations and (b) requiring a unitary implementation of the dynamics in the quantum theory. Besides, we provide a spacetime interpretation of the field equations as those corresponding to a scalar field in a cosmological spacetime that is conformally ultrastatic. In addition, in the privileged Fock quantization, we investigate the generalization of the evolution of physical states from the hyperbolic dynamical regime to an elliptic regime. In order to do this, we contemplate the possibility of processes with signature change in the spacetime where the field propagates and discuss the behavior of the background geometry when the change happens, proving that the spacetime metric degenerates. Finally, we argue that this kind of signature change leads naturally to a phenomenon of particle creation, with exponential production.Comment: 11 pages, version accepted for publication in Physical Review

Prospects for detectability of classical novae with INTEGRAL

Classical novae are potential gamma-ray emitters, both in lines and in a continuum. Continuum emission (at energies between 20-30 and 511 keV) and line emission at 511 keV are related to positron annihilation and its Comptonization in the expanding shell; 18F is the main responsible of positron production. The lines at 478 and 1275 keV have their origin in the decay of the radioactive nuclei 7Be and 22Na. Updated models of nova explosions have been adopted for the computation of the gamma-ray emission. New yields of some radioactive isotopes directly translate into new detectability distances of classical novae with INTEGRAL.Comment: Contributed paper at the 4th INTEGRAL Workshop, 4-8 September 2000, Alicante (Spain). To be published in the ESA-SP series: 4 pages, 4 figure

Gamma-ray emission from novae related to positron annihilation: constraints on its observability posed by new experimental nuclear data

Classical novae emit gamma-ray radiation at 511 keV and below, with a cut-off at around (20-30) keV, related to positron annihilation and its Comptonization in the expanding envelope. This emission has been elusive up to now, because it occurs at epochs well before the maximum in optical luminosity, but it could be detected by some sensitive intrument on board a satellite, provided that the nova is close enough and that it is observed at the right moment. The detection of this emission, which is a challenge for the now available and for the future gamma-ray instruments, would shed light into the physical processes occurring in the early phases of the explosion, which are invisible in other lower energy ranges. A good prediction of the emitted fluxes and of the corresponding detectability distances with different instruments relies critically on a good knowledge of reaction rates relevant to f18 destruction, which have been subject to a strong revision after recent nuclear spectroscopy measurements. With respect to previous results, smaller ejected masses of f18 are predicted, leading to smaller emitted fluxes in the (20-511) keV range and shorter detectability distances.Comment: 9 pages, 2 figures, accepted for publication in Astrophys. J. Letter

Gamma-ray emission of classical novae and its detectability by INTEGRAL

A lot of information concerning the mechanism of nova explosions will be extracted from the possible future observations with INTEGRAL. In order to be prepared for this task, we are performing detailed models of the gamma-ray emission of classical novae, for a wide range of possible initial conditions. Spectra at different epochs after the explosion and light curves for the different lines (511, 478 and 1275 keV) and the continuum are presented, as well as the detectability distances with INTEGRAL spectrometer SPI. New results related to 18F synthesis related to very recent data of nuclear physics are advanced as preliminary.Comment: 4 pages, 2 figures, to appear in "3rd INTEGRAL Workshop: The Extreme Universe", Taormina (Italy

Unitary evolution and uniqueness of the Fock quantization in flat cosmologies with compact spatial sections

We study the Fock quantization of scalar fields with a time dependent mass in cosmological scenarios with flat compact spatial sections. This framework describes physically interesting situations like, e.g., cosmological perturbations in flat Friedmann-Robertson-Walker spacetimes, generally including a suitable scaling of them by a background function. We prove that the requirements of vacuum invariance under the spatial isometries and of a unitary quantum dynamics select (a) a unique canonical pair of field variables among all those related by time dependent canonical transformations which scale the field configurations, and (b) a unique Fock representation for the canonical commutation relations of this pair of variables. Though the proof is generalizable to other compact spatial topologies in three or less dimensions, we focus on the case of the three-torus owing to its relevance in cosmology, paying a especial attention to the role played by the spatial isometries in the determination of the representation.Comment: 23 pages. New section 4.2. Added references. Published in EJT

Uniqueness of the Fock quantization of scalar fields in spatially flat cosmological spacetimes

We study the Fock quantization of scalar fields in (generically) time dependent scenarios, focusing on the case in which the field propagation occurs in --either a background or effective-- spacetime with spatial sections of flat compact topology. The discussion finds important applications in cosmology, like e.g. in the description of test Klein-Gordon fields and scalar perturbations in Friedmann-Robertson-Walker spacetime in the observationally favored flat case. Two types of ambiguities in the quantization are analyzed. First, the infinite ambiguity existing in the choice of a Fock representation for the canonical commutation relations, understandable as the freedom in the choice of inequivalent vacua for a given field. Besides, in cosmological situations, it is customary to scale the fields by time dependent functions, which absorb part of the evolution arising from the spacetime, which is treated classically. This leads to an additional ambiguity, this time in the choice of a canonical pair of field variables. We show that both types of ambiguities are removed by the requirements of (a) invariance of the vacuum under the symmetries of the three-torus, and (b) unitary implementation of the dynamics in the quantum theory. In this way, one arrives at a unique class of unitarily equivalent Fock quantizations for the system. This result provides considerable robustness to the quantum predictions and renders meaningful the confrontation with observation.Comment: 15 pages, version accepted for publication in JCA

The 18F(p,a)15O reaction rate for application to nova gamma-ray emission

The 18F(p,a)15O reaction is recognized as one of the most important reaction for nova gamma-ray astronomy as it governs the early <= 511 keV emission. However, its rate remains largely uncertain at nova temperatures due to unknown low-energy resonance strengths. We report here on our last results concerning the study of the D(18F,pa)15N reaction, as well as on the determination of the 18F(p,a)15O reaction rate using the R-matrix theory. Remaining uncertainties are discussed.Comment: Contribution to the Eighth International Symposium on Nuclei in the Cosmos, Vancouver july 19-23. 4 pages and 2 figure

Implementación de un laboratorio de habilidades clínicas centralizado en la Facultad de Medicina de la Universitat de Barcelona. Cuatro años de experiencia

La Facultad de Medicina de la Universitat de Barcelona definió en su momento las competencias a adquirir por sus estudiantes y evaluó dicha adquisición, apreciándose un déficit en el ámbito de las habilidades clínicas y de los procedimientos técnicos. Para solventar estos déficit, la facultad decidió implementar un laboratorio de habilidades centralizado. Materiales y métodos. Describimos las diferentes fases del proceso de implementación y el desarrollo de un curso optativo sobre habilidades clínicas para adquirir experiencia en la gestión de dicho centro y dar a conocer el recurso entre los profesores de la facultad. Asimismo, hemos investigado el grado de aceptación de este recurso por los alumnos y profesores utilizando diversos cuestionarios. Resultados. En estos cuatro años de experiencia, aproximadamente 1.000 estudiantes cada año, de grado y de posgrado, han recibido docencia en el laboratorio. Los estudiantes consideran el laboratorio como un instrumento excelente para incrementar su competencia individual en habilidades clínicas y que deben extenderse sus prestaciones a todos los estudiantes. Los profesores consideran el laboratorio como un instrumento muy útil para mejorar la enseñanza clínica. Conclusiones. Consideramos que la experiencia ha sido muy positiva y puede ser útil para el proceso de cambio curricular actualmente en curso en la facultad. La experiencia, además, podría servir de modelo para la implementación de laboratorios de habilidades en otras facultades. Finalmente, la Facultad de Medicina debe incrementar su inversión para mejorar los recursos y la accesibilidad del laboratorio a todos los estudiantes y profesores