Mathematical modeling labor market processes by the example of unemployment

The officially registered unemployed dynamics in Russia is considered. Based on the second order differential equation, econometric analysis of unemployment is carried. Then using logistic functions, seasonal component decomposition takes place. As a result of synthesis, the mathematical model of the seasonal component dynamics has been created depending on the relevant factors which adequately describe the process on Russian labor market

Nucleon resonance contributions to unpolarised inclusive electron scattering

The first CLAS12 experiments will provide high-precision data on inclusive electron scattering observables at a photon virtuality $Q^2$ ranging from 0.05 GeV$^2$ to 12 GeV$^2$ and center-of-mass energies $W$ up to 4 GeV. In view of this endeavour, we present the modeling of the resonant contributions to the inclusive electron scattering observables. As input, we use the existing CLAS electrocoupling results obtained from exclusive meson electroproduction data off protons, and evaluate for the first time the resonant contributions based on the experimental results on the nucleon resonance electroexcitation. The uncertainties are given by the data and duly propagated through a Monte Carlo approach. In this way, we obtain estimates for the resonant contributions, important for insight into the nucleon parton distributions in the resonance region and for the studies of quark-hadron duality

Changes in haemogram of pulmоnary TB patients during positive clіnical and radiology improvement

We studied changes in the complete blood count in 48 patients with infiltrative and disseminated pulmonary tuberculosis before and after treatment against positive clinical and radiographic improvement. The haemogram of patients with tuberculosis varies during the treatment. The mean concentration of haemoglobin in red blood cells and the count of red blood cells in peripheral blood of patients with infiltrative (in 60% of cases) and disseminated (in 45% of cases) tuberculosis increased equally: Hb to 139.5 and 139.3 g/l; RBC to 4.33∙10^12/l and 4.4∙10^12/l, respectively. In 9 (36 ± 9.2%) patients with infiltrative tuberculosis, there was a reduction in the average haemoglobin content in red blood cells of patients to 117.7 g/l, while in disseminated tuberculosis, haemoglobin level did not fall below 132.7 g/l. The obtained results are explained both by a more intensive haematotoxic effect of tuberculosis infection (in case of significant infiltration) and by a toxic adverse effect of prolonged specific chemotherapy, which these patients require. In the haemogram of patients with infiltrative tuberculosis, there was a greater severity of inflammation events, and in disseminated form – of allergic and autoimmune processes. In favourable cases, quantity and quality of blood cells become normal, reflecting the cessation of bacterial excretion, toxicity, and discussion of foci and areas of infiltration. Allergenic or toxic effects of different antibacterial medicines on haematopoiesis cannot be excluded. They often caused eosinophilia, in some cases - leukocytosis, band left shift, lymphocytosis, rarely leukopenia, which may stimulate the lymphoid and reticular reaction. The results indicate the feasibility to add TB chemotherapy with cytoprotective medicines

The introduction of health-technology in the educational process as a way to good health and longevity

В статье раскрыты современные научно-практические подходы к внедрение здоровьесберегающих технологий в учебный процесс и проанализировано современное состояние образования по этому вопросуIn the article the modern scientific and practical approaches to the implementation of health-saving technologies in the learning process, and analyzes the current state of education in this regar

The Origin of Mitochondria and their Role in the Evolution of Life and Human Health

In studies of many medical and biological problems, there is a clear underestimation of the fundamental role of mitochondria in the evolution of eukaryotic organisms on the planet, including fungi, plants and fauna. It is  important to take into consideration numerous fundamental functions of mitochondria when studying the  human physiology and pathology, aging mechanisms. In this lecture, we briefly discuss the origin of mitochondria and their importance in the emergence of plants, which appeared on the planet 1–1.5 billion years later than eukaryotes with mitochondria, and served as the food basis for the rapid evolution of all species of the animal world. In the course of transformation of protobacteria into mitochondria, approximately 1000–1500 genes were transferred to the nucleus of eukaryotes, and the remaining 37 mitochondrial genes (mtDNA) exist in all types of animals. The presence of mitochondria in eukaryotes led to increased production  of reactive oxygen species and accelerated mutations in mtDNA. The spread of sexual reproduction may have been the way of protection against the accumulation of harmful mutations in mtDNA. At the same time, in all animal species mtDNA is inherited only maternally. In humans, the maternal inheritance of mtDNA led to uneven distribution, in small or inbred populations in particular, of a number of diseases with large prevalence in men, as well as male infertility, and in general accelerated aging and shorter lifespan in men, as compared with women. These negative consequences of the maternal inheritance of mtDNA were termed as “mother’s curse”. Recent studies have shown that mtDNA mutations are not the cause of human aging. The crisis of the mitochondrial free radical theory of aging is largely associated with the neglect of the protonated form of the superoxide radical, the perhydroxyl radical, which activates the peroxidation of polyunsaturated fatty acids in mitochondrial phospholipids. This results in production of various biologically active molecules and toxins. Therefore, initially aging may lack the manifestation of specific symptoms because of gradual accumulation of a wide variety of disorders and damages to the structure and functions of mitochondria and cells that finally lead to the development of diseases. The pathologies appear primarily in those organs that have a wide range of functional activity and a high dependence on oxygen consumption, namely the heart, brain, skeletal muscles and vascular epithelium

Polarized Structure Function σ\u3csub\u3eLT\u27\u3c/sub\u3e from ⁰p Electroproduction Data in the Resonance Region at 0.2 GeV² \u3c Q² \u3c 1.0 GeV²

The first results on the σLT′ structure function in exclusive π0p electroproduction at invariant masses of the final state of 1.5GeV \u3c W \u3c 1.8 GeV and in the range of photon virtualities 0.4 GeV2 \u3c Q2 \u3c 1.0 GeV2 were obtained from data on beam spin asymmetries and differential cross sections measured with the CLAS detector at Jefferson Lab. The Legendre moments determined from the σLT′ structure function have demonstrated sensitivity to the contributions from the nucleon resonances in the second and third resonance regions. These new data on the beam spin asymmetries in π0p electroproduction extend the opportunities for the extraction of the nucleon resonance electro-excitation amplitudes in the mass range above 1.6 GeV

The Quadrupole Magnets for the LHC Injection Transfer Lines

Two injection transfer lines, each about 2.8 km long, are being built to transfer protons at 450 GeV from the Super Proton Synchrotron (SPS) to the Large Hadron Collider (LHC). A total of 180 quadrupole magnets are required; they are produced in the framework of the contribution of the Russian Federation to the construction of the LHC. The classical quadrupoles, built from laminated steel cores and copper coils, have a core length of 1.4 m, an inscribed diameter of 32 mm and a strength of 53.5 T/m at a current of 530 A. The total weight of one magnet is 1.1 ton. For obtaining the required field quality at the small inscribed diameter, great care in the stamping of the laminations and the assembly of quadrants is necessary. Special instruments have been developed to measure, with a precision of some mm, the variations of the pole gaps over the full length of the magnet and correlate them to the obtained field distribution. The design has been developed in a collaboration between BINP and CERN. Fabrication and the magnetic measurements are done at BINP and should be finished at the end of the year 2000

Антифибринолитическая терапия при акушерских кровотечениях, связанных с преждевременной отслойкой плаценты

Сравнительная оценка эффективности препаратов апротинина и транексамовой кислоты по влиянию на систему гемостаза, фибринолиз, степень кровопотери. Выбор методов диагностики, профилактики и комплексной коррекции нарушений в системе гемостаза у женщин с преждевременной отслойкой плаценты в периоперационном периоде. Раннее применение ингибиторов фибринолиза при преждевременной отслойке плаценты является патогенетически оправданным и необходимым, позволяет снизить периоперационную кровопотерю. Использование метода низкочастотной вибрационной пьезоэлектрической гемовискозиметрии при акушерских кровотечениях дает возможность оперативно и достоверно выявлять нарушения в разных звеньях системы гемостаза, что позволяет своевременно и полноценно проводить их коррекцию.Comparative evaluation of efficacy of aprotinin and tranexamic acid on the effect of hemostasis, fibrinolysis, the degree of blood loss. The choice of methods of diagnosis, prevention and correction of complex disorders of hemostasis in women with placental abruption in the perioperative period. Early application of fibrinolysis inhibitors in placental abruption is pathogenetically justified and necessary, helping to reduce perioperative blood loss. The use of the method of low-frequency vibrating piezoelectric hemoviscosimetry in obstetric bleedings enables to reveal disturbances in different parts of the hemostasis system intraoperatively and reliably that allows to make their correction timely and fully

Experience in genetic testing of hypertrophic cardiomyopathy using nanopore DNA sequencing

Aim. To investigate the application of the Oxford Nanopore Technologies’ third generation sequencing for the genetic testing of hypertrophic cardiomyopathy.Material and methods. The study involved 12 patients with hypertrophic cardiomyopathy aged 18 to 67 years (women, 9; men, 3). Using the PCR barcoding amplicons (SQK-LSK109) protocol, DNA libraries were created which contained long-range PCR fragments of the MYH7, MYBPC3, TNNT2, TNNI3 and TPM1 genes. The sequencing was performed using the MinION system by Oxford Nanopore Technologies (UK). Bioinformatic algorithms for data analysis included Guppy v.5.0.7, Nanopolish and Clairvoyante. The identified genetic variants were confirmed by Sanger sequencing.Results. Data on the complete sequence of the five major sarcomeric genes for hypertrophic cardiomyopathy were obtained. We found eight potentially disease-causing sequence variants in MYH7, MYBPC3 and TNNT2 genes by monomolecular sequencing. However, only three mutations p.Arg243Cys, p.Tyr609Asn, p.Arg870His in the MYH7 gene, and one mutation p.Lys985Asn in the MYBPC3 were confirmed by Sanger sequencing. Cascade screening of pathogenic variant p.Arg870His in the MYH7 gene was performed. We found one asymptomatic carrier.Conclusion. It appears that monomolecular sequencing technology is a feasible approach to identify mutations in patients with hypertrophic cardiomyopathy. Although improvement in accuracy of DNA sequencing, as well as optimization and simplification of bioinformatic algorithms for identification of the genetic variants are needed