Distinct dynamical behavior in Erd\H{o}s-R\'enyi networks, regular random networks, ring lattices, and all-to-all neuronal networks

Neuronal network dynamics depends on network structure. In this paper we study how network topology underpins the emergence of different dynamical behaviors in neuronal networks. In particular, we consider neuronal network dynamics on Erd\H{o}s-R\'enyi (ER) networks, regular random (RR) networks, ring lattices, and all-to-all networks. We solve analytically a neuronal network model with stochastic binary-state neurons in all the network topologies, except ring lattices. Given that apart from network structure, all four models are equivalent, this allows us to understand the role of network structure in neuronal network dynamics. Whilst ER and RR networks are characterized by similar phase diagrams, we find strikingly different phase diagrams in the all-to-all network. Neuronal network dynamics is not only different within certain parameter ranges, but it also undergoes different bifurcations (with a richer repertoire of bifurcations in ER and RR compared to all-to-all networks). This suggests that local heterogeneity in the ratio between excitation and inhibition plays a crucial role on emergent dynamics. Furthermore, we also observe one subtle discrepancy between ER and RR networks, namely ER networks undergo a neuronal activity jump at lower noise levels compared to RR networks, presumably due to the degree heterogeneity in ER networks that is absent in RR networks. Finally, a comparison between network oscillations in RR networks and ring lattices shows the importance of small-world properties in sustaining stable network oscillations.Comment: 9 pages, 4 figure

Does the Universe have its own mass?

Within the framework of the previously proposed formulation of the quantum theory of gravity in terms of world histories, it was suggested that the universe has its own mass. This quantity is analogous to the mass of a particle in relativistic mechanics. The mass of the universe is a distribution of non-zero values of gravitational constraints, which arises and changes in time as a consequence of the initial conditions for fundamental dynamic variables. A formulation of the Euclidean quantum theory of gravity is also proposed to determine the initial state, which can be the source of the universe's own mass. Being unrelated to ordinary matter, the distribution of its own mass affects the geometry of space and forms a dedicated frame of reference. The existence of selected reference systems is taken into account by the corresponding modification of the system of quantum gravitational links. A variant of such a modification of the Wheeler-De Witt equation is the operator representation of gravitational constraints, which, together with the state of the universe, determines the parameters of the reference system in the form of a distribution of the spinor field on a spatial section.Comment: 8 page

No-boundary Wave Functional and Own Mass of the Universe

An alternative formulation of the no-boundary initial state of the universe in the Euclidean quantum theory of gravity is proposed. Unlike the no-boundary Hartle-Hawking wave function, in which time appears together with macroscopic space-time in the semiclassical approximation, in the proposed formalism time is present from the very beginning on an equal footing with spatial coordinates. The main element of the formalism is the wave functional, which is defined on the world histories of the universe. This ensures formal 4D covariance of the theory. The wave functional is defined independently of the wave function as an eigenvector of the action operator. The shape of the Origin region, together with the boundary conditions, is determined by the structure of the total energy, which includes the 3D invariant contribution of the expansion energy of the universe with a minus sign. The proper mass of the universe arises as a non-zero value of the expansion energy in the Origin and, over time, splits into a spectrum of proper masses of 3D invariant dynamic modes. 4D covariance is restored at zero own mass of the universe.Comment: 7 page

Amyloid precursor protein interaction network in human testis: sentinel proteins for male reproduction

Background Amyloid precursor protein (APP) is widely recognized for playing a central role in Alzheimer's disease pathogenesis. Although APP is expressed in several tissues outside the human central nervous system, the functions of APP and its family members in other tissues are still poorly understood. APP is involved in several biological functions which might be potentially important for male fertility, such as cell adhesion, cell motility, signaling, and apoptosis. Furthermore, APP superfamily members are known to be associated with fertility. Knowledge on the protein networks of APP in human testis and spermatozoa will shed light on the function of APP in the male reproductive system. Results We performed a Yeast Two-Hybrid screen and a database search to study the interaction network of APP in human testis and sperm. To gain insights into the role of APP superfamily members in fertility, the study was extended to APP-like protein 2 (APLP2). We analyzed several topological properties of the APP interaction network and the biological and physiological properties of the proteins in the APP interaction network were also specified by gene ontologyand pathways analyses. We classified significant features related to the human male reproduction for the APP interacting proteins and identified modules of proteins with similar functional roles which may show cooperative behavior for male fertility. Conclusions The present work provides the first report on the APP interactome in human testis. Our approach allowed the identification of novel interactions and recognition of key APP interacting proteins for male reproduction, particularly in sperm-oocyte interaction.publishe

Wave Functional of the Universe and Time

A version of the quantum theory of gravity based on the concept of the wave functional of the universe is proposed. To determine the physical wave functional, the quantum principle of least action is formulated as a secular equation for the corresponding action operator. Its solution, the wave functional, is an invariant of general covariant transformations of spacetime. In the new formulation, the history of the evolution of the universe is described in terms of coordinate time together with arbitrary lapse and shift functions, which makes this description close to the formulation of the principle of general covariance in the classical theory of Einstein’s gravity. In the new formulation of quantum theory, an invariant parameter of the evolutionary time of the universe is defined, which is a generalization of the classical geodesic time measured by a standard clock along time-like geodesics

Wave Functional of the Universe and Time

A version of the quantum theory of gravity based on the concept of the wave functional of the universe is proposed. To determine the physical wave functional, the quantum principle of least action is formulated as a secular equation for the corresponding action operator. Its solution, the wave functional, is an invariant of general covariant transformations of spacetime. In the new formulation, the history of the evolution of the universe is described in terms of coordinate time together with arbitrary lapse and shift functions, which makes this description close to the formulation of the principle of general covariance in the classical theory of Einstein’s gravity. In the new formulation of quantum theory, an invariant parameter of the evolutionary time of the universe is defined, which is a generalization of the classical geodesic time measured by a standard clock along time-like geodesics

No-Boundary Wave Functional and Own Mass of the Universe

An alternative formulation of the no-boundary initial state of the universe in the Euclidean quantum theory of gravity is proposed. Unlike the no-boundary Hartle–Hawking wave function, in which time appears together with macroscopic space–time in the semiclassical approximation, in the proposed formalism, time is present from the very beginning on an equal footing with spatial coordinates. The main element of the formalism is the wave functional, which is defined based on the world histories of the universe. This ensures formal 4D covariance of the theory. The wave functional is defined independently of the wave function as an eigenvector of the action operator. The shape of the Origin region, together with the boundary conditions, is determined by the structure of the total energy of the universe, which includes a 3D-invariant contribution of the expansion energy. The own mass of the universe arises as a non-zero value of the expansion energy in the Origin