3,199 research outputs found
Absolute Measurement of Elastic Waves Excited by Hertzian Contacts in Boundary Restricted Systems
Semiconductor saturable absorber mirror structures with low saturation fluence
We present two novel semiconductor saturable absorber mirror (SESAM) designs which can exhibit more than ten times lower saturation fluence than classical SESAM devices. Design considerations and characterization data are presented. These devices are particularly suited for passively mode-locked lasers with ultra-high repetition rate
Modelocked quantum dot vertical external cavity surface emitting laser
We report the first successful modelocking of a vertical external cavity surface emitting laser (VECSEL) with a quantum dot (QD) gain region. The VECSEL has a total of 35 QD-layers with an emission wavelength of about 1060 nm. In SESAM modelocked operation, we obtain an average output power of 27.4 mW with 18-ps pulses at a repetition rate of 2.57 GHz. This QD-VECSEL is used as-grown on a 450 μm thick substrate, which limits the average output powe
New Particles Working Group Report of the Snowmass 2013 Community Summer Study
This report summarizes the work of the Energy Frontier New Physics working
group of the 2013 Community Summer Study (Snowmass)
Physics at a 100 TeV pp collider: beyond the Standard Model phenomena
This report summarises the physics opportunities in the search and study of
physics beyond the Standard Model at a 100 TeV pp collider.Comment: 196 pages, 114 figures. Chapter 3 of the "Physics at the FCC-hh"
Repor
The ATLAS Data Quality Defect Database System
The ATLAS experiment at the Large Hadron Collider has implemented a new
system for recording information on detector status and data quality, and for
transmitting this information to users performing physics analysis. This system
revolves around the concept of "defects," which are well-defined, fine-grained,
unambiguous occurrences affecting the quality of recorded data. The motivation,
implementation, and operation of this system is described.Comment: 6 pages, 3 figures, published in EPJ C. (v2: as published
Binding to SMN2 pre-mRNA-protein complex elicits specificity for small molecule splicing modifiers
Small molecule splicing modifiers have been previously described that target the general splicing machinery and thus have low specificity for individual genes. Several potent molecules correcting the splicing deficit of the SMN2 (survival of motor neuron 2) gene have been identified and these molecules are moving towards a potential therapy for spinal muscular atrophy (SMA). Here by using a combination of RNA splicing, transcription, and protein chemistry techniques, we show that these molecules directly bind to two distinct sites of the SMN2 pre-mRNA, thereby stabilizing a yet unidentified ribonucleoprotein (RNP) complex that is critical to the specificity of these small molecules for SMN2 over other genes. In addition to the therapeutic potential of these molecules for treatment of SMA, our work has wide-ranging implications in understanding how small molecules can interact with specific quaternary RNA structures
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